期刊
BIOCHIMIE
卷 90, 期 8, 页码 1184-1196出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2008.03.003
关键词
quadruplex; crystallography; drugs
资金
- Cancer Research UK [C129/A4489]
- School of Pharmacy
Crystallographic studies of G-quadruplex nucleic acids have resulted in a small group of structures to date. Their morphological and detailed conformational features are described here, emphasizing the stability of the G-tetrad core and the flexibility of loops, especially upon ligand binding. Implications for drug design are discussed, in the context of the druggability of both telomeric and non-telomeric quadruplex DNAs. (C) 2008 Elsevier Masson SAS. All rights reserved.
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