期刊
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
卷 1834, 期 8, 页码 1581-1590出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbapap.2013.04.001
关键词
Quantitative proteomics; Label-free proteomics; Clinical proteomics; Disease biomarker
资金
- PROFILE-consortium Ruhr
- European Regional Development Fund (ERDF), North Rhine-Westphalia (Germany)
- P.U.R.E. (Protein Unit for Research in Europe), a project of North Rhine-Westphalia
Nowadays, proteomic studies no longer focus only on identifying as many proteins as possible in a given sample, but aiming for an accurate quantification of them. Especially in clinical proteomics, the investigation of variable protein expression profiles can yield useful information on pathological pathways or biomarkers and drug targets related to a particular disease. Over the time, many quantitative proteomic approaches have been established allowing researchers in the field of proteomics to refer to a comprehensive toolbox of different methodologies. In this review we will give an overview of different methods of quantitative proteomics with focus on label-free proteomics and its use in clinical proteomics. (C) 2013 Elsevier B.V. All rights reserved.
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