Article
Ecology
Athmanathan Senthilnathan, Rafael D'Andrea
Summary: Interactions between plants and soil play a crucial role in shaping plant community structure and spatial distribution. While traditionally considered as one-directional, recent studies have shown that plants can actively modify soil conditions through their roots and interactions with soil microbes, leading to bidirectional plant-soil feedbacks. To understand how these feedbacks influence community dynamics, researchers have developed a mathematical model that incorporates soil conditioning over time and analyzes the long-term composition and spatial patterns of plant communities. The model reveals that positive plant-soil feedbacks result in clustering of species with similar soil preferences, and the composition of these clusters is further influenced by niche width and conditioning strength.
Article
Biochemistry & Molecular Biology
Martin Porubsky, Eva Reznickova, Sona Kirupova, Vladimir Krystof, Jan Hlavac
Summary: A multi-FRET three-fluorophore probe has been synthesized and optimized for the simultaneous activity detection and quantification of two proteases. The probe shows specific fluorescence intensity changes upon enzymatic cleavage, making it a potential tool for studying cell death mechanisms.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Dapeng Ren, Ran Liu, Xiao Yan, Qiang Zhang, Xuemin Zeng, Xiao Yuan
Summary: In this study, the role of calreticulin (CRT) and plasma membrane Ca2+ transporting ATPase 1 (PMCA1) in stretch-induced apoptosis of myoblasts was investigated. The results showed that stretching stimuli increased CRT level while inhibiting PMCA1 activity, and there were bidirectional regulations between CRT and PMCA1. These two proteins formed a positive feedback loop, contributing to intracellular Ca2+ accumulation and myoblast apoptosis.
Article
Biochemistry & Molecular Biology
Pawel Pecak, Marta Switalska, Elwira Chrobak, Grzegorz Boryczka, Ewa Bebenek
Summary: Betulin, a natural triterpene, has promising antiproliferative activity. In this study, 38 betulin acid ester derivatives modified at the C-28 position were tested for antitumor activities. Some of the derivatives showed strong antiproliferative activity with IC50 values between 2 and 5 μM. Mechanistic studies revealed that some derivatives induced apoptosis by activating caspase-3/7 activity. A strong structure-activity correlation and pharmacokinetic properties were also proposed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Liang Zhu, Lechen Liu, Aoli Wang, Jinwen Liu, Xin Huang, Tao Zan
Summary: Dermal fibrosis is a global disease that affects millions of people and causes physical and psychological distress. Fibroblast dysfunction plays a crucial role in the pathogenesis of dermal fibrosis, leading to excessive deposition of extracellular matrix. The positive feedback loop of fibroblast activation further worsens the condition. This review focuses on understanding the mechanisms and potential therapeutic targets to break this cycle.
Article
Oncology
Yanbin Liu, Zhicong Huang, Yanli Wei, Mingming Zhang, Xingzhi Li, Shulan Yang, Haihe Wang
Summary: The research identified a novel positive feedback loop between STXBP6 and IRF1 in regulating PD-L1 expression, which affects the response to immunotherapy targeting PD-L1 in cancer.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Engineering, Multidisciplinary
Xiaofei Fan, Xiunan Wang, Zhenkun Wang
Summary: This study develops a reaction-diffusion model with positive feedback loop to describe gene expression. The focus is on the long-term behavior of the system, including the determination of invariant regions and the global stability of equilibria. The results contribute to understanding the heterogeneity of cell characterization.
APPLIED MATHEMATICAL MODELLING
(2023)
Article
Oncology
Boxuan Zhou, Jinhua Xue, Runxin Wu, Hongyu Meng, Ruixi Li, Zhaohong Mo, Hang Zhai, Xianyu Chen, Rongqiang Liu, Guie Lai, Xiaohong Chen, Taiyuan Li, Shiyang Zheng
Summary: This study firstly illustrated that the circPAPD4/miR-1269a/CREBZF/STAT3/ADAR1 positive feedback loop mediated breast cancer progression, and delivering CREBZF mRNA nanoparticles suppressed breast cancer progression in vitro and in vivo, which might provide novel insights into therapeutic strategies for breast cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biodiversity Conservation
Louise Emmerson, Colin Southwell
Summary: While seabirds are known for their ability to survive in harsh conditions, their capacity to adapt may be challenged by ecosystem changes. This study examines the impact of intrinsic and extrinsic factors on the decline of a large Adelie penguin metapopulation. The results suggest that the decline was triggered by environmental changes and exacerbated by feedback processes, highlighting the importance of considering both intrinsic and extrinsic factors in population models.
GLOBAL CHANGE BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Shigao Huang, Cheng Jiang, Muhammad Jameel Mughal, Guanyu Wang, Fuqiang Xing
Summary: An efficient in vivo drug screening platform based on FRET technique was established. Cancer cell lines expressing FRET-based caspase-3 sensor were validated in zebrafish embryos and nude mice models, showing effectiveness in detecting drug-induced cell death. The platform has the potential to improve drug screening efficiency through in vivo imaging.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yang Chen, Yong-yao Wu, Hai-bo Si, Yan-rong Lu, Bin Shen
Summary: Regulation of chondrocyte mitochondrial quality control may play a crucial role in the pathogenesis and progression of osteoarthritis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Haiyan Piao, Lingfeng Fu, Yuxin Wang, Yang Liu, Yue Wang, Xiangyu Meng, Dong Yang, Xiang Xiao, Jun Zhang
Summary: This study identifies a positive feedback loop between macrophages and gastric cancer cells that contributes to tumor progression and patient outcome.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Chunfeng Liu, Matjaz Rokavec, Zekai Huang, Heiko Hermeking
Summary: This study reveals that curcumin can activate the KEAP1/NRF2/ARE pathway and induce ROS to upregulate the expression of miR-34 in colorectal cancer cells. Curcumin can also inhibit migration and invasion of cancer cells and promote mesenchymal-epithelial transition by activating this pathway. Therefore, activation of the KEAP1/NRF2/miR-34 axis may contribute to the tumor suppressive effects of curcumin.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biophysics
Qiao-Yan Jiang, Ximin Cui, Yang Sun, Zhengsheng Mao, Jie Wang, Feng Chen, Jianfang Wang, Yue Cao
Summary: In this study, a new strategy for simultaneous detection of different substances on a single probe was developed. The fabricated AuNPL-crown nanoprobe allows for dual-channel and real-time tracking of the dynamic changes in caspase-3 and H2O2. This new platform provides high accuracy, sensitivity, convenience, and efficiency for the analysis of caspase-3 and H2O2 in the biological environment.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Mengting Du, Tingting Geng, Rongrong Yu, Gang Song, Hui Cheng, Yu Cao, Weidong He, Abdul Haleem, Qinglin Li, Rongfeng Hu, Shengqi Chen
Summary: This study presents a charge-reversible nanoparticle CRNP-GNA that can induce a positive feedback loop to enhance tumor vascular permeability and drug accumulation in tumors with low vascular density, thereby improving the efficacy of anti-vascular therapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Medicinal
Nobuo Kitada, Ryohei Saito, Rika Obata, Satoshi Iwano, Kazuma Karube, Atsushi Miyawaki, Takashi Hirano, Shojiro A. Maki
Article
Multidisciplinary Sciences
Shogo Miyoshi, Soh Tokunaga, Tatsuhiko Ozawa, Hiroyuki Takeda, Mitsuo Aono, Takanori Miyoshi, Hiroyuki Kishi, Atsushi Muraguchi, Shin-ichi Shimizu, Akira Nozawa, Tatsuya Sawasaki
Review
Biotechnology & Applied Microbiology
Satoshi Furukawa, Aiko Nagamatsu, Mitsuru Nenoi, Akira Fujimori, Shizuko Kakinuma, Takanori Katsube, Bing Wang, Chizuru Tsuruoka, Toshiyuki Shirai, Asako J. Nakamura, Asako Sakaue-Sawano, Atsushi Miyawaki, Hiroshi Harada, Minoru Kobayashi, Junya Kobayashi, Takekazu Kunieda, Tomoo Funayama, Michiyo Suzuki, Tatsuo Miyamoto, Jun Hidema, Yukari Yoshida, Akihisa Takahashi
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Biology
Kohki Kido, Satoshi Yamanaka, Shogo Nakano, Kou Motani, Souta Shinohara, Akira Nozawa, Hidetaka Kosako, Sohei Ito, Tatsuya Sawasaki
Article
Multidisciplinary Sciences
Shuo Chen, Linmeng He, Arthur J. Y. Huang, Roman Boehringer, Vincent Robert, Marie E. Wintzer, Denis Polygalov, Adam Z. Weitemier, Yanqiu Tao, Mingxiao Gu, Steven J. Middleton, Kana Namiki, Hiroshi Hama, Ludivine Therreau, Vivien Chevaleyre, Hiroyuki Hioki, Atsushi Miyawaki, Rebecca A. Piskorowski, Thomas J. McHugh
Article
Chemistry, Multidisciplinary
Yukino Itoh, Mitsuru Hattori, Tetsuichi Wazawa, Yoshiyuki Arai, Takeharu Nagai
Summary: Bilirubin concentration in blood reflects one's physical condition and can be used to diagnose diseases such as jaundice in newborns. A ratiometric bioluminescent indicator, BABI, allows sensitive and quantitative detection of unconjugated bilirubin using a smartphone camera, offering a simple and rapid method for blood-based diagnosis.
Article
Nanoscience & Nanotechnology
Toshiki Kubo, Kenta Temma, Kazunori Sugiura, Hajime Shinoda, Kai Lu, Nicholas Isaac Smith, Tomoki Matsuda, Takeharu Nagai, Katsumasa Fujita
Summary: This study utilized two-photon excitation to activate negatively switching reversibly photoswitchable fluorescent proteins, introducing nonlinear relationships to enhance spatial resolution in laser scanning microscopy. Experimental confirmation showed that certain RSFPs can be activated within a specific wavelength range for observation using confocal scanning microscopy on HeLa cells.
Article
Chemistry, Analytical
Mitsuru Hattori, Nae Sugiura, Tetsuichi Wazawa, Tomoki Matsuda, Takeharu Nagai
Summary: Hemostasis is crucial for tissue repair and organism survival. Periodic blood tests are important to prevent diseases from blood coagulation abnormalities. A novel ratiometric bioluminescent indicator, Thrombastor, was developed to reflect thrombin cleavage activity, offering faster detection and effective diagnosis for coagulation disorders.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Le Zhai, Ryosuke Nakashima, Hajime Shinoda, Yoshimasa Ike, Tomoki Matsuda, Takeharu Nagai
Summary: Researchers cloned GFP-like chromoproteins (CPs) from the jellyfish and developed a completely non-fluorescent red CP called R-Velour. The crystal structure analysis revealed that R-Velour has a trans-chromophore similar to that of another jellyfish-derived protein, Gamillus. Mutagenesis studies identified a key residue, Ser155, that contributes to the generation of four-color variants with different absorption peaks.
Article
Chemistry, Multidisciplinary
Kai Lu, Tetsuichi Wazawa, Joe Sakamoto, Cong Quang Vu, Masahiro Nakano, Yasuhiro Kamei, Takeharu Nagai
Summary: In this study, researchers successfully visualized the propagation of heat inside cells by developing a nanothermometer called BgTEMP, which is based on the fusion of fluorescent proteins. They also estimated the thermal diffusivity of live cells.
Article
Plant Sciences
Quang Tran, Kenji Osabe, Tetsuyuki Entani, Tetsuichi Wazawa, Mitsuru Hattori, Takeharu Nagai
Summary: The acidity of root apoplastic fluid is crucial for the growth of plant roots. This study developed a novel pH indicator and successfully quantified the pH of root apoplastic fluid, providing evidence for the acid growth theory.
PLANT CELL AND ENVIRONMENT
(2022)
Editorial Material
Chemistry, Multidisciplinary
Takeharu Nagai, Mitsuru Hattori
Summary: Ten years ago, the engineering breakthrough of NanoLuc, a small luciferase, overcame a common limitation in bioluminescence. It is currently the brightest known bioluminescent protein and has been widely used for measurements in single cells and whole living organisms.
NATURE REVIEWS CHEMISTRY
(2022)
Article
Biology
Takashi Kanadome, Kanehiro Hayashi, Yusuke Seto, Mototsugu Eiraku, Kazunori Nakajima, Takeharu Nagai, Tomoki Matsuda
Summary: This study successfully visualizes cell-cell interactions of NCad using INCIDERs, which have a higher signal contrast compared to FRET-based indicators. It provides new tools and methods for studying NCad interactions.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biology
Kazunori Sugiura, Takeharu Nagai
Summary: We report the development of a violet fluorescent protein, Sumire, emitting at a wavelength of 414 nm, which can be used for multi-parameter analysis simultaneously with CFP-YFP based FRET probes.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biophysics
Tetsuichi Wazawa, Takeharu Nagai
Summary: Ion currents through channel proteins can generate Joule heating, which has been largely overlooked in biology. This study demonstrates the theoretical investigation of Joule heating involving channel proteins, showing that heat production and absorption can occur. Simulation results indicate that the temperature increase caused by Joule heating in a single channel protein is small, but a noticeable temperature increase is observed in an ensemble of channel proteins. Furthermore, the study extends the theory of Joule heating to UCP1, a transporter protein involved in thermogenesis, and the calculations show that the Joule heat involving UCP1 is comparable to experimental data. The findings suggest that Joule heating of ion transport proteins is an important mechanism of cellular thermogenesis.
BIOPHYSICS AND PHYSICOBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
G. F. Senguel, R. Mishra, E. Candiello, P. Schu
Summary: AP2 forms AP2 CCV with clathrin and other coat proteins, and synapses contain different types of CCV. The stability and composition of CCV are regulated by various factors, including Hsc70 and phosphorylation patterns. The knockout of the AP1/O1B complex disrupts synaptic vesicle recycling and endosomal protein sorting, leading to upregulation of endocytosis. Stable CCV, termed stCCV, have distinct characteristics and specialized functions in synaptic plasticity. The phosphorylation of Hsc70 and the levels of kinases play a crucial role in regulating the stability and disassembly of clathrin in CCV.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Martin Fluck, Colline Sanchez, Vincent Jacquemond, Christine Berthier, Marie-Noelle Giraud, Daniel Jacko, Kathe Bersiner, Sebastian Gehlert, Guus Baan, Richard T. Jaspers
Summary: Enhancing CaMKII signaling improves fatigue resistance and contractile characteristics of skeletal muscle by enhancing calcium release.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Letter
Biochemistry & Molecular Biology
Federica Coppola, Sara Monaci, Alessandro Falsini, Carlo Aldinucci, Irene Filippi, Daniela Rossi, Fabio Carraro, Antonella Naldini
Summary: The adaptor protein p62 plays a crucial role in maintaining the survival of dendritic cells (DCs) under hypoxic conditions by preserving Erk1/2 phosphorylation and reducing AMPK activation, thus extending their lifespan to ensure their functions in hypoxic microenvironments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Jenifer Pendiuk Goncalves, Jorvani Cruz Villarreal, Sierra A. Walker, Xuan Ning Sharon Tan, Chad Borges, Joy Wolfram
Summary: This study used a mass spectrometry-based approach to assess the differences in glycan features between extracellular vesicles (EVs) and originating cells. The results showed that EVs selectively enriched specific glycan features, particularly those associated with binding to the extracellular matrix. The study also found differences in EV glycan sorting between different metastatic cell lines and mouse models, indicating a potential role of glycan diversity in the metastatic process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
De-ao Gong, Peng Zhou, Wen-yi Chang, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang, Kai Wang
Summary: Liver cancer, ranked sixth globally, is a major contributor to cancer-related mortality. Metastasis is the main cause of treatment failure and deaths in liver cancer. The SPOP-CREB5-MET axis plays a significant role in liver cancer metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ning Huang, Jun Tang, Xiaoyao Yi, Maoxin Zhang, Bin Li, Yuan Cheng, Jin Chen
Summary: This study reveals that glioma-derived S100A9 can induce microglial M2 polarization, inhibit CD8+ T lymphocytes, and promote immunosuppression. The mechanism is related to the interaction with alpha v133 integrin and subsequent activation of AKT1 in microglia. The expression of S100A9 is positively associated with CD206 expression and negatively correlated with CD8+ T lymphocyte accumulation in the TME, suggesting a potential role of S100A9 in regulating the tumor microenvironment and immune evasion in glioma.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Yomna S. Abd El-Aziz, Matthew J. McKay, Mark P. Molloy, Betty McDowell, Elizabeth Moon, Loretta Sioson, Amy Sheen, Angela Chou, Anthony J. Gill, Patric J. Jansson, Sumit Sahni
Summary: This study identified a novel combination of autophagy inhibitors that can effectively inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells, including both chemosensitive and chemoresistant cells. This research is important for the development of new therapies for advanced OSCC tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Luojia Liu, Xiaoqiang Liu, Ying Chen, Meng Kong, Jinghong Zhang, Min Jiang, Hongling Zhou, Jinrui Yang, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jiaping Zhang
Summary: Our study revealed that the Paxillin/HDAC6 signaling pathway regulates microtubule acetylation in electric field-guided keratinocyte migration.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Julia Weikum, Jeroen F. van Dyck, Saranya Subramani, David P. Klebl, Merete Storflor, Stephen P. Muench, Soren Abel, Frank Sobott, J. Preben Morth
Summary: The study reveals the complex interaction between bacterial magnesium transporter A (MgtA) and cardiolipin 18:1 and cardiolipin 16:0, highlighting the importance of lipid environment in protein activity and stability. Further understanding of Mg2+ homeostasis in bacteria will provide insights into bacterial infections.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Sumit Kinger, Yuvraj Anandrao Jagtap, Ankur Rakesh Dubey, Prashant Kumar, Akash Choudhary, Rohan Dhiman, Vijay Kumar Prajapati, Deepak Chitkara, Krishna Mohan Poluri, Amit Mishra
Summary: Efficient protein synthesis and quality control mechanisms are crucial for maintaining proteostasis and preventing neurodegeneration. This study demonstrates that treating cells with Lanosterol can enhance the proteolytic activity of Proteasome and promote the removal of misfolded proteins, suggesting a potential therapeutic approach for abnormal protein accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Karolina Stepien, Adrianna Skoneczna, Monika Kula-Maximenko, Lukasz Jurczyk, Mateusz Molon
Summary: The replication of DNA requires a complex machinery called the replisome, which is highly conserved across species. One crucial component of the replisome is the CMG helicase complex, which unwinds DNA and coordinates the assembly and function of other replisome components. In this study, the impact of the absence of one copy of the CMG complex genes on the physiology and aging of yeast cells was investigated. The findings showed disruptions in the cell cycle, extended doubling times, and alterations in the biochemical profile of these cells. Importantly, it was found that heterozygous cells for CMG helicase genes exhibited increased reproductive potential and delayed aging. The study also highlighted potential therapeutic targets for cancer treatment using yeast.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S. Young, L. Michel Espinoza-Fonseca
Summary: This study reveals that replacing Lys27 with Asn enhances the inhibitory potency of MLN without affecting SERCA's affinity for Ca2+. The findings suggest that the SERCA site modulating Ca2+ affinity also functions as a catalytic activity switch.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Can Jiang, Chunyang Zhang, Min Dai, Fuyan Wang, Sa Xu, Dan Han, Yanyan Wang, Yajie Cao, Yanyan Liang, Ziyu Zhang, Lina Yan, Yujun Shen, Kewu He, Yuxian Shen, Jun Liu
Summary: The phosphorylation of p65 and the expression of SUMO1 are increased in cancer tissues of HCC patients, and there is a positive correlation between SUMO1 and phosphorylated p65. SUMOylation of p65 by SUMO1 promotes p65 nuclear import and enhances NF-xB activity. Both SUMOylation and phosphorylation of p65 increase the viability and invasion of hepatoma cells, and decrease cell apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan Wells, Kuang-Yu Jen, Tzu-Ching Meng, Fawaz G. Haj
Summary: This study identified alpha-actinin4 as a novel substrate of PTP1B in podocytes and demonstrated their interaction in regulating podocyte function. Targeting PTP1B and alpha-actinin4 could be a potential therapeutic approach for podocyte injury.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Paulo F. V. Bizerra, Eduardo H. Gilglioni, Hang Lam Li, Simei Go, Ronald P. J. Oude Elferink, Arthur J. Verhoeven, Jung -Chin Chang
Summary: This study investigates the role of cyclic AMP (cAMP) in glycogen metabolism and reveals that cAMP regulates glycogenolysis in opposite directions depending on its site of synthesis within cells and downstream effectors. The canonical tmAC-cAMP-PKA signaling promotes glycogenolysis, while the non-canonical sAC-cAMP-Epac1 signaling suppresses glycogenolysis. This highlights the importance of cAMP microdomain organization for distinct metabolic regulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)