Review
Medicine, Research & Experimental
Bilal Rah, Nada Mazen Farhat, Mawieh Hamad, Jibran Sualeh Muhammad
Summary: Iron metabolism plays a crucial role in hepatocellular carcinoma (HCC), and excessive iron accumulation can increase the risk of HCC. Dysregulation of iron metabolism-related proteins and signaling pathways such as the JAK/STAT pathway is observed in HCC. Understanding the crosstalk between iron metabolism and the JAK/STAT pathway is important for preventing or treating iron overload in HCC.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Camille Link, Julia D. Knopf, Oriana Marques, Marius K. Lemberg, Martina U. Muckenthaler
Summary: Iron deficiency delays hepcidin-induced Fpn degradation when cytosolic iron levels are low, indicating that iron export is necessary for efficient targeting of Fpn by hepcidin. Additionally, Fpn degradation is not involved in protecting cells from intracellular iron deficiency.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Biology
Edouard Charlebois, Carine Fillebeen, Angeliki Katsarou, Aleksandr Rabinovich, Kazimierz Wisniewski, Vivek Venkataramani, Bernhard Michalke, Anastasia Velentza, Kostas Pantopoulos
Summary: This study investigates how iron affects inflammatory hepcidin levels and the subsequent hypoferremic response, revealing the antagonistic effect of iron on hepcidin induction and the critical role of de novo ferroportin synthesis in serum iron levels.
Review
Pharmacology & Pharmacy
Poonam Sagar, Stanzin Angmo, Rajat Sandhir, Vikas Rishi, Hariom Yadav, Nitin Kumar Singhal
Summary: Iron is essential for mammals but its homeostasis must be accurately regulated for proper physiological functioning. Hepcidin plays a crucial role in maintaining iron balance in the body, while inflammatory disorders can disrupt this balance. Therapeutic approaches targeting the hepcidin-FPN axis have been developed to address iron-related disorders.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Chandrika N. Deshpande, Corbin R. Azucenas, Bo Qiao, Norimichi Nomura, Vicky Xin, Josep Font, So Iwata, Tomas Ganz, Elizabeta Nemeth, Bryan Mackenzie, Mika Jormakka
Summary: This study presents an expression and purification protocol for mouse Fpn, enabling the acquisition of pure protein for further biophysical studies, and paving the way for a better understanding of the transport mechanism of Fpn.
Review
Biochemistry & Molecular Biology
Margherita Correnti, Elena Gammella, Gaetano Cairo, Stefania Recalcati
Summary: Iron is essential for cellular processes, especially in erythropoiesis. The hormone hepcidin, produced by the liver, regulates iron homeostasis by interacting with ferroportin. During enhanced erythropoiesis, hepcidin expression is inhibited, allowing increased iron export and facilitating erythropoiesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Betty Berezovsky, Jana Frydlova, Iuliia Gurieva, Daniel W. Rogalsky, Martin Vokurka, Jan Krijt
Summary: The study aimed to investigate the expression of ferroportin protein under various treatments affecting systemic hepcidin. The results showed that the expression of heart ferroportin protein is regulated by both systemic hepcidin and heart non-heme iron content.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Feng Lin, Alex Tuffour, Guijie Hao, Frank Addai Peprah, Aixia Huang, Yang Zhou, Haiqi Zhang
Summary: Hepcidin is a crucial iron-regulating factor that regulates intestinal iron absorption and releases iron from macrophages into plasma. Tumor and non-tumor cells express and control hepcidin differently, and studying these variations could lead to potential novel cancer treatments.
FRONTIERS IN ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Thibaud Lefebvre, Muriel Coupaye, Marina Esposito-Farese, Nathalie Gault, Neila Talbi, Caroline Quintin, Caroline Schmitt, Soumeya Bekri, Andre Bado, Herve Puy, Simon Msika, Carole Brasse-Lagnel, Zoubida Karim
Summary: After sleeve gastrectomy, levels of iron-related markers such as sTfR and PPIX decreased while serum hepcidin levels increased. DMT1 abundance was negatively correlated with serum hepcidin levels, and ferroportin abundance remained unchanged. These results suggest effective iron recovery pathways post-operatively involving suppression of inflammation and improvement in iron absorption and erythropoiesis.
Review
Gastroenterology & Hepatology
Jalal Taneera, Amjad Ali, Mawieh Hamad
Summary: This review examines the link between estrogen and cellular iron metabolism in pancreatic beta cells, discussing the impact of this connection on beta cell survival and function.
Article
Biology
Elena Knatko, Cecilia Castro, Maureen Higgins, Ying Zhang, Tadashi Honda, Colin J. Henderson, C. Roland Wolf, Julian L. Griffin, Albena T. Dinkova-Kostova
Summary: The study examined the role of Nrf2 in the development of colorectal adenomas and found that Nrf2 activation had little impact on the early stages of carcinogenesis.
COMMUNICATIONS BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yanmeng Li, Qin Ouyang, Zhibin Chen, Wei Chen, Bei Zhang, Song Zhang, Min Cong, Anjian Xu
Summary: Intracellular labile iron has a dual function in regulating iron metabolism, inducing hepcidin expression in hepatocytes and stimulating the expression of bone morphogenic protein 6 (BMP6) in liver sinusoidal endothelial cells (LSECs) through the secretion of TNF alpha by hepatocytes. TNF alpha blockade dysregulates iron metabolism during iron overload and TNF alpha administration reduces iron burden in Hfe knockout hemochromatosis mice. TNF alpha could be a potential therapeutic target for HFE-associated hemochromatosis.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Sandro Altamura, Katja Muedder, Andrea Schlotterer, Thomas Fleming, Elena Heidenreich, Ruiyue Qiu, Hans-Peter Hammes, Peter Nawroth, Martina U. Muckenthaler
Summary: The study reveals that hepatic iron accumulation may exacerbate symptoms related to metabolic syndrome and type 2 diabetes. It suggests that iron depletion strategies in combination with anti-diabetic drugs could potentially improve insulin resistance and diabetic late complications.
MOLECULAR METABOLISM
(2021)
Article
Agriculture, Multidisciplinary
Bolun Sun, Panxue Zhang, Jinjie Zhang, Tao Huang, Chao Li, Wenge Yang
Summary: This study evaluated the iron absorption of hemoglobin and ferritin from Tegillarca granosa and explored the relationship between protein structure and iron absorption. The results showed that both hemoglobin and ferritin contained abundant iron-binding sites. Hemoglobin had higher iron absorption due to its better digestibility and release of available iron. The use of hemoglobin and ferritin did not induce oxidative stress.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Public, Environmental & Occupational Health
Denggao Peng, Yanzhang Gao, Li Zhang, Zhichao Liu, Huan Wang, Yingxia Liu
Summary: This study re-evaluated the relationship between hepcidin-mediated iron dysmetabolism and the severity of COVID-19. The results showed that severe COVID-19 cases had higher levels of hepcidin and ferritin, and lower serum iron, with no significant differences in transferrin saturation.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Gastroenterology & Hepatology
Chloe Latour, Celine Besson-Fournier, Delphine Meynard, Laura Silvestri, Ophelie Gourbeyre, Patricia Aguilar-Martinez, Paul J. Schmidt, Mark D. Fleming, Marie-Paule Roth, Helene Coppin
Article
Genetics & Heredity
Haifa H. Jabara, Steven E. Boyden, Janet Chou, Narayanaswamy Ramesh, Michel J. Massaad, Halli Benson, Wayne Bainter, David Fraulino, Fedik Rahimov, Colin Sieff, Zhi-Jian Liu, Salem H. Alshemmari, Basel K. Al-Ramadi, Hasan Al-Dhekri, Rand Arnaout, Mohammad Abu-Shukair, Anant Vatsayan, Eli Silver, Sanjay Ahuja, E. Graham Davies, Martha Sola-Visner, Toshiro K. Ohsumi, Nancy C. Andrews, Luigi D. Notarangelo, Mark D. Fleming, Waleed Al-Herz, Louis M. Kunkel, Raif S. Geha
Article
Hematology
Daniel A. Lichtenstein, Andrew W. Crispin, Anoop K. Sendamarai, Dean R. Campagna, Klaus Schmitz-Abe, Cristovao M. Sousa, Martin D. Kafina, Paul J. Schmidt, Charlotte M. Niemeyer, John Porter, Alison May, Mrinal M. Patnaik, Matthew M. Heeney, Alec Kimmelman, Sylvia S. Bottomley, Barry H. Paw, Kyriacos Markianos, Mark D. Fleming
Letter
Hematology
Baris Boyraz, Courtney M. Bellomo, Mark D. Fleming, Corey S. Cutler, Suneet Agarwal
Article
Oncology
Esther A. Obeng, Ryan J. Chappell, Michael Seiler, Michelle C. Chen, Dean R. Campagna, Paul J. Schmidt, Rebekka K. Schneider, Allegra M. Lord, Lili Wang, Rutendo G. Gambe, Marie E. McConkey, Abdullah M. Ali, Azra Raza, Lihua Yu, Silvia Buonamici, Peter G. Smith, Ann Mullally, Catherine J. Wu, Mark D. Fleming, Benjamin L. Eberts
Article
Oncology
Kim Cattivelli, Dean R. Campagna, Klaus Schmitz-Abe, MatthewM. Heeney, Hassan M. Yaish, Amy E. Caruso Brown, Susan Kearney, Kelly Walkovich, Kyriacos Markianos, Mark D. Fleming, Ellis J. Neufeld
PEDIATRIC BLOOD & CANCER
(2017)
Article
Medicine, Research & Experimental
Raphael Carapito, Martina Konantz, Catherine Paillard, Zhichao Miao, Angelique Pichot, Magalie S. Leduc, Yaping Yang, Katie L. Bergstrom, Donald H. Mahoney, Deborah L. Shardy, Ghada Alsaleh, Lydie Naegely, Aline Kolmer, Nicodeme Paul, Antoine Hanauer, Veronique Rolli, Joelle S. Mueller, Elisa Alghisi, Loic Sauteur, Cecile Macquin, Aurore Morlon, Consuelo Sebastia Sancho, Patrizia Amati-Bonneau, Vincent Procaccio, Anne-Laure Mosca-Boidron, Nathalie Marle, Nael Osmani, Olivier Lefebvre, Jacky G. Goetz, Sule Unal, Nurten A. Akarsu, Mirjana Radosavljevic, Marie-Pierre Chenard, Fanny Rialland, Audrey Grain, Marie-Christine Bene, Marion Eveillard, Marie Vincent, Julien Guy, Laurence Faivre, Christel Thauvin-Robinet, Julien Thevenon, Kasiani Myers, Mark D. Fleming, Akiko Shimamura, Elodie Bottollier-Lemallaz, Eric Westhof, Claudia Lengerke, Bertrand Isidor, Seiamak Bahram
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Multidisciplinary Sciences
Anthony T. Nguyen, Miguel A. Prado, Paul J. Schmidt, Anoop K. Sendamarai, Joshua T. Wilson-Grady, Mingwei Min, Dean R. Campagna, Geng Tian, Yuan Shi, Verena Dederer, Mona Kawan, Nathalie Kuehnle, Joao A. Paulo, Yu Yao, Mitchell J. Weiss, Monica J. Justice, Steven P. Gygi, Mark D. Fleming, Daniel Finley
Article
Hematology
Paul J. Schmidt, Kaifeng Liu, Gary Visner, Kevin Fitzgerald, Shannon Fishman, Tim Racie, Julia L. Hettinger, James S. Butler, Mark D. Fleming
AMERICAN JOURNAL OF HEMATOLOGY
(2018)
Editorial Material
Hematology
John M. Gansner, Elissa Furutani, Dean R. Campagna, Mark D. Fleming, Akiko Shimamura
AMERICAN JOURNAL OF HEMATOLOGY
(2018)
Article
Hematology
Inga Hofmann, Mitchell J. Geer, Timo Vogtle, Andrew Crispin, Dean R. Campagna, Alastair Barr, Monica L. Calicchio, Silke Heising, Johanna P. van Geffen, Marijke J. E. Kuijpers, Johan W. M. Heemskerk, Johannes A. Eble, Klaus Schmitz-Abe, Esther A. Obeng, Michael Douglas, Kathleen Freson, Corinne Pondarre, Remi Favier, Gavin E. Jarvis, Kyriacos Markianos, Ernest Turro, Willem H. Ouwehand, Alexandra Mazharian, Mark D. Fleming, Yotis A. Senis
Letter
Hematology
Matthew M. Heeney, Dongjing Guo, Luigia De Falco, Dean R. Campagna, Gordana Olbina, Paige P. -C. Kao, Klaus Schmitz-Abe, Fedik Rahimov, Patrick Gutschow, Keith Westerman, Vaughn Ostland, Tracy Jackson, Robert E. Klaassen, Kyriacos Markianos, Karin E. Finberg, Achille Iolascon, Mark Westerman, Wendy B. London, Mark D. Fleming
Review
Hematology
Sarah Ducamp, Mark D. Fleming
Article
Hematology
Juliana Xavier-Ferrucio, Vanessa Scanlon, Xiuqi Li, Ping-Xia Zhang, Larisa Lozovatsky, Nadia Ayala-Lopez, Toma Tebaldi, Stephanie Halene, Chang Cao, Mark D. Fleming, Karin E. Finberg, Diane S. Krause
Letter
Oncology
Jamie Heather Oakley, Dean R. Campagna, Liang Sun, Shira Rockowitz, Piotr Sliz, Jeanne Boudreaux, Gary Woods, Mark D. Fleming
PEDIATRIC BLOOD & CANCER
(2022)
Article
Biochemistry & Molecular Biology
G. F. Senguel, R. Mishra, E. Candiello, P. Schu
Summary: AP2 forms AP2 CCV with clathrin and other coat proteins, and synapses contain different types of CCV. The stability and composition of CCV are regulated by various factors, including Hsc70 and phosphorylation patterns. The knockout of the AP1/O1B complex disrupts synaptic vesicle recycling and endosomal protein sorting, leading to upregulation of endocytosis. Stable CCV, termed stCCV, have distinct characteristics and specialized functions in synaptic plasticity. The phosphorylation of Hsc70 and the levels of kinases play a crucial role in regulating the stability and disassembly of clathrin in CCV.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Martin Fluck, Colline Sanchez, Vincent Jacquemond, Christine Berthier, Marie-Noelle Giraud, Daniel Jacko, Kathe Bersiner, Sebastian Gehlert, Guus Baan, Richard T. Jaspers
Summary: Enhancing CaMKII signaling improves fatigue resistance and contractile characteristics of skeletal muscle by enhancing calcium release.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Letter
Biochemistry & Molecular Biology
Federica Coppola, Sara Monaci, Alessandro Falsini, Carlo Aldinucci, Irene Filippi, Daniela Rossi, Fabio Carraro, Antonella Naldini
Summary: The adaptor protein p62 plays a crucial role in maintaining the survival of dendritic cells (DCs) under hypoxic conditions by preserving Erk1/2 phosphorylation and reducing AMPK activation, thus extending their lifespan to ensure their functions in hypoxic microenvironments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Jenifer Pendiuk Goncalves, Jorvani Cruz Villarreal, Sierra A. Walker, Xuan Ning Sharon Tan, Chad Borges, Joy Wolfram
Summary: This study used a mass spectrometry-based approach to assess the differences in glycan features between extracellular vesicles (EVs) and originating cells. The results showed that EVs selectively enriched specific glycan features, particularly those associated with binding to the extracellular matrix. The study also found differences in EV glycan sorting between different metastatic cell lines and mouse models, indicating a potential role of glycan diversity in the metastatic process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
De-ao Gong, Peng Zhou, Wen-yi Chang, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang, Kai Wang
Summary: Liver cancer, ranked sixth globally, is a major contributor to cancer-related mortality. Metastasis is the main cause of treatment failure and deaths in liver cancer. The SPOP-CREB5-MET axis plays a significant role in liver cancer metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ning Huang, Jun Tang, Xiaoyao Yi, Maoxin Zhang, Bin Li, Yuan Cheng, Jin Chen
Summary: This study reveals that glioma-derived S100A9 can induce microglial M2 polarization, inhibit CD8+ T lymphocytes, and promote immunosuppression. The mechanism is related to the interaction with alpha v133 integrin and subsequent activation of AKT1 in microglia. The expression of S100A9 is positively associated with CD206 expression and negatively correlated with CD8+ T lymphocyte accumulation in the TME, suggesting a potential role of S100A9 in regulating the tumor microenvironment and immune evasion in glioma.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Yomna S. Abd El-Aziz, Matthew J. McKay, Mark P. Molloy, Betty McDowell, Elizabeth Moon, Loretta Sioson, Amy Sheen, Angela Chou, Anthony J. Gill, Patric J. Jansson, Sumit Sahni
Summary: This study identified a novel combination of autophagy inhibitors that can effectively inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells, including both chemosensitive and chemoresistant cells. This research is important for the development of new therapies for advanced OSCC tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Luojia Liu, Xiaoqiang Liu, Ying Chen, Meng Kong, Jinghong Zhang, Min Jiang, Hongling Zhou, Jinrui Yang, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jiaping Zhang
Summary: Our study revealed that the Paxillin/HDAC6 signaling pathway regulates microtubule acetylation in electric field-guided keratinocyte migration.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Julia Weikum, Jeroen F. van Dyck, Saranya Subramani, David P. Klebl, Merete Storflor, Stephen P. Muench, Soren Abel, Frank Sobott, J. Preben Morth
Summary: The study reveals the complex interaction between bacterial magnesium transporter A (MgtA) and cardiolipin 18:1 and cardiolipin 16:0, highlighting the importance of lipid environment in protein activity and stability. Further understanding of Mg2+ homeostasis in bacteria will provide insights into bacterial infections.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Sumit Kinger, Yuvraj Anandrao Jagtap, Ankur Rakesh Dubey, Prashant Kumar, Akash Choudhary, Rohan Dhiman, Vijay Kumar Prajapati, Deepak Chitkara, Krishna Mohan Poluri, Amit Mishra
Summary: Efficient protein synthesis and quality control mechanisms are crucial for maintaining proteostasis and preventing neurodegeneration. This study demonstrates that treating cells with Lanosterol can enhance the proteolytic activity of Proteasome and promote the removal of misfolded proteins, suggesting a potential therapeutic approach for abnormal protein accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Karolina Stepien, Adrianna Skoneczna, Monika Kula-Maximenko, Lukasz Jurczyk, Mateusz Molon
Summary: The replication of DNA requires a complex machinery called the replisome, which is highly conserved across species. One crucial component of the replisome is the CMG helicase complex, which unwinds DNA and coordinates the assembly and function of other replisome components. In this study, the impact of the absence of one copy of the CMG complex genes on the physiology and aging of yeast cells was investigated. The findings showed disruptions in the cell cycle, extended doubling times, and alterations in the biochemical profile of these cells. Importantly, it was found that heterozygous cells for CMG helicase genes exhibited increased reproductive potential and delayed aging. The study also highlighted potential therapeutic targets for cancer treatment using yeast.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S. Young, L. Michel Espinoza-Fonseca
Summary: This study reveals that replacing Lys27 with Asn enhances the inhibitory potency of MLN without affecting SERCA's affinity for Ca2+. The findings suggest that the SERCA site modulating Ca2+ affinity also functions as a catalytic activity switch.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Can Jiang, Chunyang Zhang, Min Dai, Fuyan Wang, Sa Xu, Dan Han, Yanyan Wang, Yajie Cao, Yanyan Liang, Ziyu Zhang, Lina Yan, Yujun Shen, Kewu He, Yuxian Shen, Jun Liu
Summary: The phosphorylation of p65 and the expression of SUMO1 are increased in cancer tissues of HCC patients, and there is a positive correlation between SUMO1 and phosphorylated p65. SUMOylation of p65 by SUMO1 promotes p65 nuclear import and enhances NF-xB activity. Both SUMOylation and phosphorylation of p65 increase the viability and invasion of hepatoma cells, and decrease cell apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan Wells, Kuang-Yu Jen, Tzu-Ching Meng, Fawaz G. Haj
Summary: This study identified alpha-actinin4 as a novel substrate of PTP1B in podocytes and demonstrated their interaction in regulating podocyte function. Targeting PTP1B and alpha-actinin4 could be a potential therapeutic approach for podocyte injury.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Paulo F. V. Bizerra, Eduardo H. Gilglioni, Hang Lam Li, Simei Go, Ronald P. J. Oude Elferink, Arthur J. Verhoeven, Jung -Chin Chang
Summary: This study investigates the role of cyclic AMP (cAMP) in glycogen metabolism and reveals that cAMP regulates glycogenolysis in opposite directions depending on its site of synthesis within cells and downstream effectors. The canonical tmAC-cAMP-PKA signaling promotes glycogenolysis, while the non-canonical sAC-cAMP-Epac1 signaling suppresses glycogenolysis. This highlights the importance of cAMP microdomain organization for distinct metabolic regulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)