Article
Cardiac & Cardiovascular Systems
Christine Hirschhaeuser, Alessio Lissoni, Philipp Maximilian Goerge, Paul D. Lampe, Jacqueline Heger, Klaus-Dieter Schlueter, Luc Leybaert, Rainer Schulz, Kerstin Boengler
Summary: The study shows that alterations of Cx43 phosphorylation affect specific cellular functions and highlights the importance of Cx43 phosphorylation by CK1 for IPC's cardioprotection.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Review
Physiology
Kerstin Boengler, Luc Leybaert, Marisol Ruiz-Meana, Rainer Schulz
Summary: This review discusses the role of Connexins in cell-cell communication and their presence and function in mitochondria. The emphasis is on Cx43 and its impact on mitochondrial function, as well as its involvement in pathological conditions.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Tingting Zhang, Yanyan Wang, Qin Xia, Zhiyi Tu, Jiajun Sun, Qi Jing, Pei Chen, Xuan Zhao
Summary: Cerebral ischemia/reperfusion (I/R) injury results in increased apoptosis of microglial cells and neurons, with propofol protecting the brain against I/R injury by downregulating Cx43.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Magda C. Diaz-Vesga, Ursula Zuniga-Cuevas, Andres Ramirez-Reyes, Nicolas Herrera-Zelada, Ivan Palomo, Roberto Bravo-Sagua, Jaime A. Riquelme
Summary: Despite advances in treating myocardial infarction, limiting infarct size after reperfusion to prevent heart failure remains a challenge, with factors such as comorbidities and experimental models needing to be considered for effective cardioprotection studies. Studies show that current therapeutic strategies may not fully protect the aging heart from myocardial infarction, prompting the need for potential new cardioprotective strategies targeting the aging heart.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Alice E. Zemljic-Harpf, Louise E. See Hoe, Jan M. Schilling, Juan P. Zuniga-Hertz, Alexander Nguyen, Yash J. Vaishnav, Gianna J. Belza, Boris P. Budiono, Piyush M. Patel, Brian P. Head, Wolfgang H. Dillmann, Sushil K. Mahata, Jason N. Peart, David M. Roth, John P. Headrick, Hemal H. Patel
Summary: The study demonstrates that morphine treatment can improve cardiac function and structure, enhance tolerance to ischemia-reperfusion injury, and potentially have translational value in diabetic patients.
Article
Cardiac & Cardiovascular Systems
Petra Kleinbongard
Summary: Activation of STAT3 has been identified as a key cardioprotective signal, both in animal studies and in humans. It upregulates the expression of cardioprotective and anti-apoptotic proteins and also plays a role in mitochondrial function. Two novel aspects of STAT activation in cardioprotection are discussed: genetic variance as a potential confounding variable and the potential cardioprotective effects of sodium-glucose cotransporter 2 inhibitors.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Lulin Wu, Tianhui Jiang, Zhiping Fu, Luqi Wang, Hongjie You, Jingyi Xue, Dali Luo
Summary: This study reveals that Cx43 S282 dephosphorylation plays a critical role in regulating cardiomyocyte survival and cardiac electrical homeostasis, and contributes to myocardium injury in ischemia/reperfusion. Spontaneous arrhythmias, cardiomyocyte apoptosis and deaths can be induced by Cx43 S282 dephosphorylation based on the degree of dephosphorylation.
Article
Biochemistry & Molecular Biology
Rolf Schreckenberg, Annemarie Wolf, Tamara Szabados, Kamilla Gomori, Istvan Adorjan Szabo, Gergely Agoston, Gabor Brenner, Peter Bencsik, Peter Ferdinandy, Rainer Schulz, Klaus-Dieter Schlueter
Summary: Hypoxia upregulates PCSK9 in the heart, which affects myocyte function. Genetic deletion of PCSK9 or antagonism of circulating PCSK9 reduces reperfusion injury. A high-fat diet decreases survival rate during reperfusion, likely due to increased MMP9 activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alejandro Martin Ibanez, Luisa Fernanda Gonzalez Arbelaez, Alejandro Ciocci Pardo, Susana Mosca, Juan Manuel Lofeudo, Jorge Omar Velez Rueda, Ernesto Alejandro Aiello, Veronica Celeste De Giusti
Summary: In menopause, women face an increased risk of cardiovascular complications. This study explored the protective effects of GPER and its agonist G1 in OVX rats exposed to I/R, finding that chronic G1 treatment improved mitochondrial function and prevented mechanical alterations after injury. These findings suggest a potential therapeutic role for GPER modulation in cardiovascular health during menopause.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Biochemistry & Molecular Biology
Vicente Castrejon-Tellez, Leonardo del Valle-Mondragon, Israel Perez-Torres, Veronica Guarner-Lans, Gustavo Pastelin-Hernandez, Angelica Ruiz-Ramirez, Julieta Anabell Diaz-Juarez, Elvira Varela-Lopez, Victor Hugo Oidor-Chan, Alvaro Vargas-Gonzalez, Raul Martinez-Memije, Pedro Flores-Chavez, Bruno Leon-Ruiz, Sergio Arriaga-Carrillo, Juan Carlos Torres-Narvaez
Summary: TRPV1 activation regulates the NO pathway to counteract myocardial injury caused by ischemia-reperfusion.
Article
Cell Biology
Annie Turkieh, Yara El Masri, Florence Pinet, Emilie Dubois-Deruy
Summary: Mitophagy plays a crucial role in maintaining cardiac homeostasis by selectively eliminating dysfunctional mitochondria. It is mainly regulated by the PINK1/parkin pathway and also by the FUNDC1, BNIP3, and BNIP3L/NIX pathways. Dysregulated mitophagy is associated with cardiac dysfunction, while moderate mitophagy has a cardioprotective effect.
Article
Cardiac & Cardiovascular Systems
Ping Zhou, Xiaoli Yang, Dezhong Yang, Xin Jiang, Wei Eric Wang, Rongchuan Yue, Yuqiang Fang
Summary: Ischemia reperfusion-induced ventricular arrhythmias can be regulated by ILK agonists and inhibitors, with ILK activation potentially preventing arrhythmias through Akt activation to inhibit Cx43 remodeling.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Alex Gallinat, Guiomar Mendieta, Gemma Vilahur, Teresa Padro, Lina Badimon
Summary: Cardiovascular diseases, especially acute myocardial infarction (MI), are major causes of death worldwide. DJ-1 protein has been found to play a crucial role in cardioprotection, and systemic administration of recombinant DJ-1 has been shown to reduce infarct size, leukocyte infiltration, apoptosis, and oxidative stress in a mouse model of MI. These effects may be mediated by G-protein-coupled receptor signaling and modulation of immune response. This study provides the first evidence for the extracellular activity of DJ-1 in regulating cardiac injury in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Kanokwan Demeekul, Wichit Suthammarak, Soontaree Petchdee
Summary: The study demonstrated that pretreatment with GBR significantly reduced cell death and apoptosis in H9c2 cells during simulated ischemic/reperfusion stimulation. Additionally, GBR pretreatment stabilized mitochondrial membrane potential and improved impaired mitochondrial respiration.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Chemistry, Multidisciplinary
Zelin Chen, Xu Tan, Taotao Jin, Yu Wang, Linyong Dai, Gufang Shen, Can Zhang, Langfan Qu, Lei Long, Chongxing Shen, Xiaohui Cao, Jianwu Wang, Huijuan Li, Xiaofeng Yue, Chunmeng Shi
Summary: This study presents the potential of near infrared dye IR-780 for monitoring and protecting ischemic myocardium from injury. IR-780 selectively enters cardiomyocytes in at-risk heart tissues and can preconditon or administer timely to protect against cell death, myocardial remodeling, and heart failure induced by ischemia and oxidative stress. The dye binds to F0F1-ATP synthase in cardiomyocytes, decreases mitochondrial membrane potential, and slows down mitochondrial energy metabolism, leading to a quiescent mitochondria state and inhibition of mitochondrial permeability transition pore. Moderating mitochondrial function depression could be a targeted approach for developing cardioprotective reagents.
Review
Cardiac & Cardiovascular Systems
Sandrine Lecour, Bastiaan C. Du Pre, Hans Erik Botker, Bianca J. J. M. Brundel, Andreas Daiber, Sean M. Davidson, Peter Ferdinandy, Henrique Girao, Can Gollmann-Tepekoeylu, Mariann Gyoengyoesi, Derek J. Hausenloy, Rosalinda Madonna, Michael Marber, Cinzia Perrino, Maurizio Pesce, Rainer Schulz, Joost P. G. Sluijter, Sabine Steffens, Sophie Van Linthout, Martin E. Young, Linda W. Van Laake
Summary: Circadian rhythms play a crucial role in cardiovascular diseases and should be considered as a key research parameter to improve understanding of cardiac physiology/pathology and enhance the translation and efficacy of cardiac therapies. The aim is to highlight key aspects of circadian rhythms for the improvement of preclinical and translational studies related to ischemic heart disease and cardioprotection, which may lead to better clinical outcomes.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Andreas Daiber, Katie Frenis, Marin Kuntic, Huige Li, Eva Wolf, Aoife B. Kilgallen, Sandrine Lecour, Linda W. Van Laake, Rainer Schulz, Omar Hahad, Thomas Muenzel
Summary: Risk factors in the environment, such as air pollution and traffic noise, play a significant role in the development of chronic noncommunicable diseases. Recent data suggest that these factors are associated with a higher risk for cardiovascular, metabolic, and mental diseases, mainly through stress hormone signaling, inflammation, and oxidative stress.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Cardiac & Cardiovascular Systems
Jolanda van der Velden, Folkert W. Asselbergs, Jeroen Bakkers, Sandor Batkai, Luc Bertrand, Connie R. Bezzina, Ilze Bot, Bianca J. J. M. Brundel, Lucie Carrier, Steven Chamuleau, Michele Ciccarelli Dana Dawson, Sean M. Davidson, Andreas Dendorfer, Dirk J. Duncker, Thomas Eschenhagen, Larissa Fabritz, Ines Falcao-Pires, Peter Ferdinandy, Mauro Giacca, Henrique Girao, Can Gollmann-Tepekoeylue, Mariann Gyongyosi, Tomasz J. Guzik, Nazha Hamdani, Stephane Heymans, Andres Hilfiker, Denise Hilfiker-Kleiner, Alfons G. Hoekstra, Jean-Sebastien Hulot, Diederik W. D. Kuster, Linda W. van Laake, Sandrine Lecour, Tim Leiner, Wolfgang A. Linke, Joost Lumens, Esther Lutgens, Rosalinda Madonna, Lars Maegdefessel, Manuel Mayr, Peter van der Meer, Robert Passier, Filippo Perbellini, Cinzia Perrino, Maurizio Pesce, Silvia Priori, Carol Ann Remme, Bodo Rosenhahn, Ulrich Schotten, Rainer Schulz, Karin R. Sipido, Joost P. G. Sluijter, Frank van Steenbeek, Sabine Steffens, Cesare M. Terracciano, Carlo Gabriele Tocchetti, Patricia Vlasman, Kak Khee Yeung, Serena Zacchigna, Dayenne Zwaagman, Thomas Thum, Michele Ciccarelli
Summary: Cardiovascular diseases are a major cause of illness and death, and research is needed to improve diagnostics and discover new preventive and curative therapies. Translating basic science to clinical practice is challenging for complex conditions like cardiovascular diseases, which are often caused by multiple risk factors and comorbidities. Animal models play a vital role in providing important pathophysiological insights into disease mechanisms, particularly on an organ and systemic level.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Tobias Heer, Moritz von Scheidt, Andreas Boening, Clarissa Heyken, Friederike Gusmini, Antoinette de Waha, Constantin Kuna, Andreas Fach, Christina Grothusen, Martin Oberhoffer, Christoph Knosalla, Thomas Walther, Bernhard C. Danner, Martin Misfeld, Gerhard Wimmer-Greinecker, Matthias Siepe, Herko Grubitzsch, Alexander Joost, Andreas Schaefer, Lenard Conradi, Jochen Cremer, Christian Hamm, Ruediger Lange, Peter W. Radke, Rainer Schulz, Gunther Laufer, Philippe Grieshaber, Tim Attmann, Michael Schmoeckel, Alexander Meyer, Tibor Ziegelhoeffer, Rainer Hambrecht, Sigrid E. Sandner, Adnan Kastrati, Heribert Schunkert, Uwe Zeymer
Summary: Guideline-adherent medical secondary prevention after CABG is associated with lower mortality and fewer adverse cardiovascular events after 12 months.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Aslam, Hafiza Idrees, Peter Ferdinandy, Zsuzsanna Helyes, Christian Hamm, Rainer Schulz
Summary: Somatostatin primes HUVECs for thrombin-induced hyperpermeability via MEK/ERK signaling and promotes HUVEC proliferation and angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Nils Kremer, Zvonimir Rako, Philipp Douschan, Henning Gall, Hossein A. Ghofrani, Friedrich Grimminger, Stefan Guth, Robert Naeije, Andreas Rieth, Rainer Schulz, Werner Seeger, Ryan J. Tedford, Istvan Vadasz, Rebecca Vanderpool, Christoph B. Wiedenroth, Manuel J. Richter, Khodr Tello
Summary: This study aimed to assess the physiological and prognostic impact of right ventricular (RV)-pulmonary arterial (PA) uncoupling during volume challenge in patients with precapillary pulmonary hypertension (PH). The results showed that RV-PA coupling significantly declined during fluid challenge in patients with PH and was associated with pulmonary resting hemodynamics and RV ejection fraction (RVEF). Furthermore, RV-PA uncoupling during fluid challenge and RVEF were predictors of clinical worsening.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Biology
Bernd Niemann, Ruping Pan, Hassan Issa, Andreas Simm, Rainer Schulz, Susanne Rohrbach
Summary: This study investigated the impact of caloric restriction on heart failure progression and found that caloric restriction inhibits the loss of heart function, even in established heart failure. These findings deepen our understanding of the mechanisms behind the cardioprotective effects of caloric restriction.
Article
Cardiac & Cardiovascular Systems
Nabil Sayour, Gabor B. Brenner, Andras Makkos, Bernadett Kiss, Csenger Kovacshazi, Tamas G. Gergely, Sverre Groever Aukrust, Huimin Tian, Viktoria Zenkl, Kamilla Gomori, Tamara Szabados, Peter Bencsik, Andre Heinen, Rainer Schulz, Gary F. Baxter, Coert J. Zuurbier, Zoltan Voko, Peter Ferdinandy, Zoltan Giricz
Summary: In this study, RIPC was found to have no cardioprotective effect in rats, based on randomized and blinded in vivo studies in three study centres using different RIPC protocols. However, a systematic review and meta-analysis of in vivo rat models showed that RIPC could reduce infarct size by an average of 21.28%. These results highlight the need for more well-designed and well-reported studies to confirm these findings and develop clinically translatable cardioprotective interventions.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Tamas G. Gergely, Gabor B. Brenner, Regina N. Nagy, Nabil V. Sayour, Andras Makkos, Csenger Kovacshazi, Huimin Tian, Rainer Schulz, Zoltan Giricz, Aniko Goerbe, Peter Ferdinandy
Summary: This study aimed to investigate the potential cardiotoxic and/or cardioprotective effects of the novel lipid-lowering drug bempedoic acid (BA) in a rat model of acute myocardial infarction (AMI). The results showed that chronic BA treatment did not affect cardiac function or infarct size, but significantly reduced the incidence of reperfusion-induced arrhythmias. Therefore, BA treatment may not have cardioprotective effects but demonstrates safety in the ischemic/reperfused heart.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Peter Ferdinandy, Ioanna Andreadou, Gary F. Baxter, Hans Erik Botker, Sean M. Davidson, Dobromir Dobrev, Bernard J. Gersh, Gerd Heusch, Sandrine Lecour, Marisol Ruiz-Meana, Coert J. Zuurbier, Derek J. Hausenloy, Rainer Schulz
Summary: Preconditioning, postconditioning, and remote conditioning of the myocardium have the potential to provide novel therapeutic paradigms for cardioprotection. However, the lack of rigorous preclinical evaluation and consideration of cardiovascular risk factors and comorbidities may be a major reason for the failure to develop cardioprotective drugs.
PHARMACOLOGICAL REVIEWS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Gerd Heusch, Hans Erik Botker, Peter Ferdinandy, Rainer Schulz
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Jacqueline Heger, Tamara Szabados, Paulin Brosinsky, Peter Bencsik, Peter Ferdinandy, Rainer Schulz
Summary: The knockout of monoamine oxidase (MAO)-B specifically in cardiomyocytes reduces myocardial ischemia/reperfusion (I/R) injury in vitro. In this study, the researchers investigated the impact of MAO-B knockout on myocardial infarction (MI) following I/R in male and female mice. They found that MAO-B knockout protected male mice against MI, but had no effect on infarct size in female mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Rainer Schulz, Klaus-Dieter Schlueter
Summary: Reactive oxygen species (ROS) play dual roles in disease development and cell signaling pathways. Cardiomyocytes generate the largest amount of ROS through mitochondria. Uncoupling protein (UCP) and monoamine oxidases (MAO) have been identified as modifiers of mitochondrial ROS formation. This review highlights the role of UCP and MAO in cardiac injuries induced by ischemia-reperfusion (I/R) and their potential for protection from I/R and heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Mareike Gierhardt, Oleg Pak, Akylbek Sydykov, Simone Kraut, Julia Schaeffer, Claudia Garcia, Christine Veith, Esraa M. Zeidan, Monika Brosien, Karin Quanz, Azadeh Esfandiary, Alireza Saraji, Stefan Hadzic, Baktybek Kojonazarov, Jochen Wilhelm, Hossein A. Ghofrani, Ralph T. Schermuly, Werner Seeger, Friedrich Grimminger, Christiane Herden, Rainer Schulz, Norbert Weissmann, Jacqueline Heger, Natascha Sommer
Summary: This study found that the mitochondrial proteins p66shc and CypD regulate pulmonary vascular tone through the modulation of mPTP opening. Specifically, p66shc controls pulmonary vascular tone, while CypD also affects systemic pressure. Furthermore, CypD regulates mPTP opening and mitochondrial calcium regulation.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
G. F. Senguel, R. Mishra, E. Candiello, P. Schu
Summary: AP2 forms AP2 CCV with clathrin and other coat proteins, and synapses contain different types of CCV. The stability and composition of CCV are regulated by various factors, including Hsc70 and phosphorylation patterns. The knockout of the AP1/O1B complex disrupts synaptic vesicle recycling and endosomal protein sorting, leading to upregulation of endocytosis. Stable CCV, termed stCCV, have distinct characteristics and specialized functions in synaptic plasticity. The phosphorylation of Hsc70 and the levels of kinases play a crucial role in regulating the stability and disassembly of clathrin in CCV.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Martin Fluck, Colline Sanchez, Vincent Jacquemond, Christine Berthier, Marie-Noelle Giraud, Daniel Jacko, Kathe Bersiner, Sebastian Gehlert, Guus Baan, Richard T. Jaspers
Summary: Enhancing CaMKII signaling improves fatigue resistance and contractile characteristics of skeletal muscle by enhancing calcium release.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Letter
Biochemistry & Molecular Biology
Federica Coppola, Sara Monaci, Alessandro Falsini, Carlo Aldinucci, Irene Filippi, Daniela Rossi, Fabio Carraro, Antonella Naldini
Summary: The adaptor protein p62 plays a crucial role in maintaining the survival of dendritic cells (DCs) under hypoxic conditions by preserving Erk1/2 phosphorylation and reducing AMPK activation, thus extending their lifespan to ensure their functions in hypoxic microenvironments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Jenifer Pendiuk Goncalves, Jorvani Cruz Villarreal, Sierra A. Walker, Xuan Ning Sharon Tan, Chad Borges, Joy Wolfram
Summary: This study used a mass spectrometry-based approach to assess the differences in glycan features between extracellular vesicles (EVs) and originating cells. The results showed that EVs selectively enriched specific glycan features, particularly those associated with binding to the extracellular matrix. The study also found differences in EV glycan sorting between different metastatic cell lines and mouse models, indicating a potential role of glycan diversity in the metastatic process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
De-ao Gong, Peng Zhou, Wen-yi Chang, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang, Kai Wang
Summary: Liver cancer, ranked sixth globally, is a major contributor to cancer-related mortality. Metastasis is the main cause of treatment failure and deaths in liver cancer. The SPOP-CREB5-MET axis plays a significant role in liver cancer metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ning Huang, Jun Tang, Xiaoyao Yi, Maoxin Zhang, Bin Li, Yuan Cheng, Jin Chen
Summary: This study reveals that glioma-derived S100A9 can induce microglial M2 polarization, inhibit CD8+ T lymphocytes, and promote immunosuppression. The mechanism is related to the interaction with alpha v133 integrin and subsequent activation of AKT1 in microglia. The expression of S100A9 is positively associated with CD206 expression and negatively correlated with CD8+ T lymphocyte accumulation in the TME, suggesting a potential role of S100A9 in regulating the tumor microenvironment and immune evasion in glioma.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Yomna S. Abd El-Aziz, Matthew J. McKay, Mark P. Molloy, Betty McDowell, Elizabeth Moon, Loretta Sioson, Amy Sheen, Angela Chou, Anthony J. Gill, Patric J. Jansson, Sumit Sahni
Summary: This study identified a novel combination of autophagy inhibitors that can effectively inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells, including both chemosensitive and chemoresistant cells. This research is important for the development of new therapies for advanced OSCC tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Luojia Liu, Xiaoqiang Liu, Ying Chen, Meng Kong, Jinghong Zhang, Min Jiang, Hongling Zhou, Jinrui Yang, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jiaping Zhang
Summary: Our study revealed that the Paxillin/HDAC6 signaling pathway regulates microtubule acetylation in electric field-guided keratinocyte migration.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Julia Weikum, Jeroen F. van Dyck, Saranya Subramani, David P. Klebl, Merete Storflor, Stephen P. Muench, Soren Abel, Frank Sobott, J. Preben Morth
Summary: The study reveals the complex interaction between bacterial magnesium transporter A (MgtA) and cardiolipin 18:1 and cardiolipin 16:0, highlighting the importance of lipid environment in protein activity and stability. Further understanding of Mg2+ homeostasis in bacteria will provide insights into bacterial infections.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Sumit Kinger, Yuvraj Anandrao Jagtap, Ankur Rakesh Dubey, Prashant Kumar, Akash Choudhary, Rohan Dhiman, Vijay Kumar Prajapati, Deepak Chitkara, Krishna Mohan Poluri, Amit Mishra
Summary: Efficient protein synthesis and quality control mechanisms are crucial for maintaining proteostasis and preventing neurodegeneration. This study demonstrates that treating cells with Lanosterol can enhance the proteolytic activity of Proteasome and promote the removal of misfolded proteins, suggesting a potential therapeutic approach for abnormal protein accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Karolina Stepien, Adrianna Skoneczna, Monika Kula-Maximenko, Lukasz Jurczyk, Mateusz Molon
Summary: The replication of DNA requires a complex machinery called the replisome, which is highly conserved across species. One crucial component of the replisome is the CMG helicase complex, which unwinds DNA and coordinates the assembly and function of other replisome components. In this study, the impact of the absence of one copy of the CMG complex genes on the physiology and aging of yeast cells was investigated. The findings showed disruptions in the cell cycle, extended doubling times, and alterations in the biochemical profile of these cells. Importantly, it was found that heterozygous cells for CMG helicase genes exhibited increased reproductive potential and delayed aging. The study also highlighted potential therapeutic targets for cancer treatment using yeast.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S. Young, L. Michel Espinoza-Fonseca
Summary: This study reveals that replacing Lys27 with Asn enhances the inhibitory potency of MLN without affecting SERCA's affinity for Ca2+. The findings suggest that the SERCA site modulating Ca2+ affinity also functions as a catalytic activity switch.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Can Jiang, Chunyang Zhang, Min Dai, Fuyan Wang, Sa Xu, Dan Han, Yanyan Wang, Yajie Cao, Yanyan Liang, Ziyu Zhang, Lina Yan, Yujun Shen, Kewu He, Yuxian Shen, Jun Liu
Summary: The phosphorylation of p65 and the expression of SUMO1 are increased in cancer tissues of HCC patients, and there is a positive correlation between SUMO1 and phosphorylated p65. SUMOylation of p65 by SUMO1 promotes p65 nuclear import and enhances NF-xB activity. Both SUMOylation and phosphorylation of p65 increase the viability and invasion of hepatoma cells, and decrease cell apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan Wells, Kuang-Yu Jen, Tzu-Ching Meng, Fawaz G. Haj
Summary: This study identified alpha-actinin4 as a novel substrate of PTP1B in podocytes and demonstrated their interaction in regulating podocyte function. Targeting PTP1B and alpha-actinin4 could be a potential therapeutic approach for podocyte injury.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Paulo F. V. Bizerra, Eduardo H. Gilglioni, Hang Lam Li, Simei Go, Ronald P. J. Oude Elferink, Arthur J. Verhoeven, Jung -Chin Chang
Summary: This study investigates the role of cyclic AMP (cAMP) in glycogen metabolism and reveals that cAMP regulates glycogenolysis in opposite directions depending on its site of synthesis within cells and downstream effectors. The canonical tmAC-cAMP-PKA signaling promotes glycogenolysis, while the non-canonical sAC-cAMP-Epac1 signaling suppresses glycogenolysis. This highlights the importance of cAMP microdomain organization for distinct metabolic regulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
