期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1803, 期 2, 页码 226-233出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2009.11.006
关键词
Formin; Actin; Microtubule; Rho GTPase; Non-syndromic deafness; Cancer; Myelodysplasia; Tumor suppression; Premature ovarian failure; Limb deformity; Metastasis; Immune response; Oncosome; Microvesicle
Formins are a conserved family of proteins that play key roles in cytoskeletal remodeling. They nucleate and processively elongate non-branched actin filaments and also modulate microtubule dynamics. Despite their significant contributions to cell biology and development, few studies have directly implicated formins in disease pathogenesis. This review highlights the roles of formins in cell division, migration, immunity, and microvesicle formation in the context of human disease. In addition, we discuss the importance of controlling formin activity and protein expression to maintain cell homeostasis. (C) 2009 Elsevier B.V. All rights reserved.
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