期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1803, 期 9, 页码 1043-1049出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2010.05.005
关键词
Morgana/CHP-1; CHORD; Co-chaperone; Heat shock protein; HSP90; stress
资金
- Polish-German [S001/P-N/2007/01, 01G20713]
- Statutory Donation for the International Institute of Molecular and Cell Biology-Decision [1789/E-529/S/2009]
- Foundation for Polish Science
- Progetto di Ricerca Sanitaria Finalizzata
- AIRC
Morgana/CHP-1 (CHORD containing protein-1) has been recently shown to be necessary for proper cell divisions. However, the presence of the protein in postmitotic tissues such as brain and striated muscle suggests that morgana/CHP-1 has additional cellular functions. Here we show that morgana/CHP-1 behaves like an HSP90 co-chaperone and possesses an independent molecular chaperone activity towards denatured proteins. The expression time profile of morgana/Chp-1 in NIH3T3 cells in response to heat stress is similar to that of Hsp70, a classical effector of Heat Shock Factor-1 mediated stress response. Moreover, overexpression of morgana/CHP-1 in NIH3T3 cells leads to the increased stress resistance of the cells. Interestingly, morgana/Chp-1 upregulation in response to transient global brain ischemia lasts longer in ischemia-resistant regions of the gerbil hippocampus than in vulnerable ones, suggesting the involvement of morgana/CHP-1 in natural protective mechanisms in vivo. (C) 2010 Elsevier B.V. All rights reserved.
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