期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1793, 期 5, 页码 888-892出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2008.12.012
关键词
Extracellular matrix; Growth factor; Transforming growth factor beta; Development; Tumor stroma; Fibroblast growth factor
Tenascins are a family of four extracellular matrix proteins: tenascin-C, X, R and W. The four members of the family have strikingly diverse patterns of expression during development and in the adult organism indicating independent mechanisms of regulation. In this review we illustrate that there are two types of tenascins, those that are significantly regulated by the tissue microenvironment (tenascin-C and tenascin-W), and those that have stabile, restricted expression patterns (tenascin-R and tenascin-X). We summarize what is known about the regulation of tenascin expression by transforming growth factor betas, fibroblast growth factors, platelet derived growth factors, as well as pro- and anti-inflammatory cytokines or hormones that either induce or inhibit expression of tenascins. (C) 2009 Elsevier B.V. All rights reserved.
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