期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1793, 期 6, 页码 959-970出版社
ELSEVIER
DOI: 10.1016/j.bbamcr.2008.12.003
关键词
Inositol 1,4,5-trisphosphate; Inositol 1,4,5-trisphosphate receptor; Ca2+ signaling; Protein kinase; Protein phosphatase
资金
- NICHD NIH HHS [R01 HD051872, R01 HD051872-01A2] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD051872] Funding Source: NIH RePORTER
The inositol 1,4,5-trisphosphate OPA receptor (IP3R) is a universal intracellular Ca2+-release channel. It is activated after cell stimulation and plays a crucial role in the initiation and propagation of the complex spatio-temporal Ca2+ signals that control cellular processes as different as fertilization. cell division, cell migration, differentiation, metabolism, muscle contraction, secretion, neuronal processing, and ultimately cell death. To achieve these various functions, often in a single cell, exquisite control of the Ca2+ release is needed. This review aims to highlight how protein kinases and protein phosphatases can interact with the IP3R or with associated proteins and so provide a large potential for fine tuning the Ca2+-release activity and for creating efficient Ca2+ signals in subcellular microdomains. (C) 2008 Elsevier B.V. All rights reserved.
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