Article
Multidisciplinary Sciences
Sean M. Callahan, Trevor J. Hancock, Ryan S. Doster, Caroline B. Parker, Mary E. Wakim, Jennifer A. Gaddy, Jeremiah G. Johnson
Summary: Histone modifications are involved in many processes in eukaryotes, including inflammation. Some bacterial pathogens use sirtuins to alter host histones and induce responses that promote infection. In this study, a Campylobacter jejuni deacetylase with sirtuin activities was found to contribute to activation of human neutrophils. This bacterial sirtuin is secreted into neutrophils, deacetylates host histones, and promotes neutrophil activation and extracellular trap production. The study also showed that this bacterial sirtuin is responsible for the inflammation and pathology observed during campylobacteriosis.
Article
Oncology
Danhui Liu, Yuzhen Liu, Bo Qi, Chengwei Gu, Shuhua Huo, Baosheng Zhao
Summary: Recent studies have shown that HDAC inhibitors promote cancer cell migration. However, inhibition of Slug or PAI-1 can reduce HDAC inhibitor-induced cancer cell migration. In addition, blocking ERK1/2 activation can also inhibit HDAC inhibitor-induced cancer cell migration.
Review
Pharmacology & Pharmacy
Hae Jin Kee, Inkyeom Kim, Myung Ho Jeong
Summary: This article provides an overview of the pathogenesis of hypertension, current anti-hypertensive drugs, and the need for novel drugs. It focuses on the role and regulatory mechanisms of HDACs in hypertension and discusses the progress in developing HDAC inhibitors as potential therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Agronomy
Sasipriya Sasikumar, Banur Marulasiddappa Dushyanthakumar, Shankarappa Sridhara, Nagarajappa Adivappar, Harish Babu Bheemanapalli Nagraja, Ahmed M. El-Shehawi, Salman Aloufi, Mohammed Alqurashi, Hosam O. Elansary, Khalid M. Elhindi, Eman A. Mahmoud
Summary: This study investigated the effects of Trichostatin A (TSA) on the morphological variations in okra. The results showed that TSA treatment had a negative impact on the growth and development of okra, including inhibited seedling emergence, malformed plants, abnormal flower development, and pollen sterility. However, under specific doses and incubation periods, TSA treatment can induce epigenetic variations in okra without significantly compromising its growth and vigor parameters.
Article
Developmental Biology
Min Tang, Isabel Regadas, Sergey Belikov, Olga Shilkova, Lei Xu, Erik Wernersson, Xuewen Liu, Hongmei Wu, Magda Bienko, Mattias Mannervik
Summary: In this study, the crucial functions of HDAC3 in embryo development were investigated in Drosophila. The findings demonstrate that HDAC3 is involved in both gene activation and repression, and that lysine substitution in the N terminus disrupts its catalytic activity and activator function, while a combination of substitutions enhances its repressor activity.
Article
Multidisciplinary Sciences
Michael S. S. Werner, Tobias Loschko, Thomas King, Shelley Reich, Tobias Theska, Mirita Franz-Wachtel, Boris Macek, Ralf J. J. Sommer
Summary: Development can be altered to match phenotypes with the environment, and the genetic mechanisms that direct such alternative phenotypes are beginning to be elucidated. Yet, the rules that govern environmental sensitivity vs. invariant development, and potential epigenetic memory, remain unknown. Here, we show that plasticity of nematode mouth forms is determined by histone 4 lysine 5 and 12 acetylation (H4K5/12ac). Acetylation in early larval stages provides a permissive chromatin state, which is susceptible to induction during the critical window of environmental sensitivity.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Jian-Li Chen, Xiao-Hui Jia, Xinyue Xia, Xuan Wu, Yan-Neng Xu, Gang Yuan, Ze-Yun Gu, Kathy Qian Luo, Ming-Heng Yuan, Ruibin Jiang, Jianfang Wang, Xiao-Ming Zhu
Summary: In this study, hollow ZrO2 nanoshells were synthesized to encapsulate both the autophagy inhibitor chloroquine (CQ) and the HDAC inhibitor vorinostat (Vor) for effective combinational cancer therapy. The ZrO2 nanoshells showed high loading capacities for both CQ and Vor and exhibited a controlled release profile. The codelivery system enhanced the autophagy inhibition and hyperacetylation level in the cells, resulting in a superior antitumor effect in 4T1 tumor-bearing mice.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Zhiqiang Huang, Astradeni Efthymiadou, Ning Liang, Rongrong Fan, Eckardt Treuter
Summary: This study discovered that GPS2, a core subunit of the HDAC3 corepressor complex, represses IL4-dependent enhancer activation in mouse macrophages, shedding light on the mechanism of alternative macrophage activation.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Cell Biology
Thomas Rico, Melissa Gilles, Alban Chauderlier, Thomas Comptdaer, Romain Magnez, Maggy Chwastyniak, Herve Drobecq, Florence Pinet, Xavier Thuru, Luc Buee, Marie-Christine Galas, Bruno Lefebvre
Summary: Recent studies have shown that Tau expression in breast cancer cell lines can confer resistance to histone deacetylase inhibitors by disrupting gene expression and chromatin structure remodeling. Tau is also found to bind to core histones and prevent further histone modifications induced by histone deacetylase inhibitors, suggesting a new role for Tau as a chromatin reader with potential therapeutic implications in neuronal and cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Svetlana Demyanenko, Valentina Dzreyan, Svetlana Sharifulina
Summary: Cerebral ischemia is the second leading cause of death worldwide, requiring multimodal stroke therapy. Histone deacetylase inhibitors have shown to be effective in protecting the brain from ischemic damage by inducing neurogenesis and angiogenesis in damaged brain areas, promoting functional recovery after stroke.
Article
Reproductive Biology
Naiara Z. Saraiva, Clara S. Oliveira, Nathalia N. C. Almeida, Marivaldo R. Figueiro, Carolina C. R. Quintao, Joaquim M. Garcia
Summary: This study investigated the epigenetic changes resulting from the use of histone deacetylase inhibitors in the maturation of bovine oocytes and subsequent embryo development. The results showed that the treatment with histone deacetylase inhibitors promoted the development of bovine oocytes and had a positive impact on embryo development.
Review
Obstetrics & Gynecology
Marina Ilicic, Tamas Zakar, Amy Gregson, Waleed M. Hussein, Roger Smith, Jonathan W. Paul
Summary: The article summarizes the crucial role of myometrial phenotypic transformation during pregnancy to facilitate childbirth, and the involvement of protein acetylation in this process. Studies show that histone deacetylase inhibitors have significant relaxation effects on pregnant human myometrium.
REPRODUCTIVE SCIENCES
(2022)
Article
Nutrition & Dietetics
Hyunju Kang, Shin Kim, Jin-Young Lee, Bohkyung Kim
Summary: In this study, the inhibitory effects of ginsenoside compound K (CK) on LPS-induced inflammation and metabolic alteration were examined in macrophages. CK was found to attenuate the changes in inflammatory and metabolic genes by activating SIRT1 and repressing HDAC4.
Article
Agriculture, Multidisciplinary
Liu Yang, Deyin Guo, Chengpeng Fan
Summary: This study identified 24 dietary flavonoids that could inhibit the tautomerase activity of human macrophage migration inhibitory factor (MIF), with five of them showing lower IC50 values than the positive control ISO-1. X-ray crystallography, molecular docking, and cellular experiments were used to illustrate the molecular binding details and structure-activity relationships. Flavonoids were found to suppress cell chemotaxis and nitric oxide production in RAW264.7 cells, shedding light on potential lead compounds against MIF-related diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agricultural Engineering
Xuefeng Lu, Tae Kyung Hyun
Summary: Post-translational histone modifications, such as histone acetylation, play key roles in regulating gene expression in plant growth, development, and stress responses. The research found that HDAC inhibitors led to hyperacetylation of histone H3, enhancing MeJA-induced ginsenoside production in ginseng adventitious roots. Additionally, the study identified specific PgHDACs that may serve as crucial factors in controlling MeJA-induced ginsenoside production.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Infectious Diseases
Jacobus Herderschee, Tytti Heinonen, Craig Fenwick, Irene T. Schrijver, Khalid Ohmiti, Darius Moradpour, Matthias Cavassini, Giuseppe Pantaleo, Thierry Roger, Thierry Calandra
Summary: Chronic hepatitis C virus (HCV) and HCV/HIV infections have profound and durable effects on immune homeostasis, which persist even after treatment with direct-acting antivirals (DAA).
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Letter
Infectious Diseases
C. Lazor-Blanchet, P. Zygoura, U. Dafni, F. Lamoth, Z. Tsourti, M. A. Lobritz, J. Regina, B. Grandbastien, C. Fenwick, G. Pantaleo, T. Calandra, S. Meylan
JOURNAL OF INFECTION
(2022)
Editorial Material
Immunology
Natalie Katzmarski, Jorge Dominguez-Andres, Branko Cirovic, Georgios Renieris, Eleonora Ciarlo, Didier Le Roy, Konstantin Lepikhov, Kathrin Kattler, Gilles Gasparoni, Kristian Haendler, Heidi Theis, Marc Beyer, Jos W. M. van der Meer, Leo A. B. Joosten, Jorn Walter, Joachim L. Schultze, Thierry Roger, Evangelos J. Giamarellos-Bourboulis, Andreas Schlitzer, Mihai G. Netea
Article
Critical Care Medicine
Irene T. Schrijver, Eleni Karakike, Charlotte Theroude, Petra Baumgartner, Alexandre Harari, Evangelos J. Giamarellos-Bourboulis, Thierry Calandra, Thierry Roger
Summary: This is the first study to associate high levels of M-MDSCs with improved survival in sepsis patients.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2022)
Correction
Oncology
Georg Maschmeyer, Lars Bullinger, Carolina Garcia-Vidal, Raoul Herbrecht, Johan Maertens, Pierantonio Menna, Livio Pagano, Anne Thiebaut-Bertrand, Thierry Calandra
Review
Oncology
Georg Maschmeyer, Lars Bullinger, Carolina Garcia-Vidal, Raoul Herbrecht, Johan Maertens, Pierantonio Menna, Livio Pagano, Anne Thiebaut-Bertrand, Thierry Calandra
Summary: The 9th web-based European Conference on Infections in Leukemia (ECIL-9) reviewed the risk of infections and febrile neutropenia associated with newer immunotherapeutic agents and molecular targeted drugs for the treatment of AML and ALL. Evidence-based recommendations were developed and discussed for prevention and management of infectious complications, as well as drug-drug interactions.
Editorial Material
Immunology
Irene T. Schrijver, Charlotte Theroude, Nikolaos Antonakos, Jean Regina, Didier Le Roy, Pierre-Alexandre Bart, Jean-Daniel Chiche, Matthieu Perreau, Giuseppe Pantaleo, Thierry Calandra, Thierry Roger
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Correction
Immunology
Natalie Katzmarski, Jorge Dominguez-Andres, Branko Cirovic, Georgios Renieris, Eleonora Ciarlo, Didier Le Roy, Konstantin Lepikhov, Kathrin Kattler, Gilles Gasparoni, Kristian Haendler, Heidi Theis, Marc Beyer, Jos W. M. van der Meer, Leo A. B. Joosten, Joern Walter, Joachim L. Schultze, Thierry Roger, Evangelos J. Giamarellos-Bourboulis, Andreas Schlitzer, Mihai G. Netea
Article
Oncology
Marc Pfefferle, Irina L. Dubach, Raphael M. Buzzi, Elena Duerst, Nadja Schulthess-Lutz, Livio Baselgia, Kerstin Hansen, Larissa Imhof, Sandra Koernig, Didier Le Roy, Thierry Roger, Rok Humar, Dominik J. Schaer, Florence Vallelian
Summary: The study revealed that CD40 signaling in Clec4f(+) Kupffer cells triggers anti-CD40 antibody-induced liver toxicity. However, controlled erythrophagocytosis and the linked anti-inflammatory signaling by the endogenous metabolite heme can be exploited to reprogram liver macrophages and prevent necroinflammatory liver disease caused by high-dose administration of anti-CD40 antibodies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Surgery
Amaia Ojanguren, Roumen Parapanov, Anne Debonneville, Jerome Lugrin, Csaba Szabo, Arpad Hasenauer, Lorenzo Rosner, Michel Gonzalez, Jean-Yannis Perentes, Thorsten Krueger, Lucas Liaudet
Summary: Ex vivo lung perfusion (EVLP) serves as a platform for pharmacologic repair before lung transplantation (LTx). This study demonstrates that transient heat application during EVLP can effectively recondition damaged lungs and improve their outcomes after transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Editorial Material
Immunology
Lokesh Sharma, Shaon Sengupta, Thierry Roger
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Christoph Thomssen, Martina Vetter, Eva J. J. Kantelhardt, Christoph Meisner, Marcus Schmidt, Pierre M. M. Martin, Florian Clatot, Doris Augustin, Volker Hanf, Daniela Paepke, Wolfgang Meinerz, Gerald Hoffmann, Wolfgang Wiest, Fred C. G. J. Sweep, Manfred Schmitt, Fritz Jaenicke, Sibylle Loibl, Gunter von Minckwitz, Nadia Harbeck
Summary: The NNBC-3 Europe trial aimed to assess the risk of recurrence in node-negative breast cancer patients and to determine whether taxanes can improve disease-free survival in high-risk patients. The study found that patients with high-risk node-negative breast cancer have a favorable prognosis in the first few years after diagnosis regardless of the type of chemotherapy.
Review
Microbiology
Francois Danion, Anne Coste, Coralie Le Hyaric, Clea Melenotte, Frederic Lamoth, Thierry Calandra, Dea Garcia-Hermoso, Vishukumar Aimanianda, Fanny Lanternier, Olivier Lortholary
Summary: Mucormycosis is a rare and life-threatening fungal infection caused by molds of the order Mucorales. It mainly affects the lungs, following the rhino-orbito-cerebral (ROC) areas and the skin. Risk factors for pulmonary mucormycosis (PM) include hematological malignancies and solid organ transplantation, while ROC infections are commonly associated with diabetes mellitus. The diagnosis of PM relies on CT scans, cultures, PCR tests, and histology, and treatment involves liposomal amphotericin B as the first-line therapy.
Article
Critical Care Medicine
Eleni Karakike, Brendon P. Scicluna, Maria Roumpoutsou, Ioannis Mitrou, Niki Karampela, Athanasios Karageorgos, Konstantinos Psaroulis, Eleni Massa, Achillefs Pitsoulis, Panagiotis Chaloulis, Evanthia Pappa, Irene T. Schrijver, Frantzeska Frantzeskaki, Malvina Lada, Nicolas Dauby, David De Bels, Ioannis Floros, Souzana Anisoglou, Eleni Antoniadou, Maria Patrani, Glykeria Vlachogianni, Eleni Mouloudi, Anastasia Antoniadou, David Grimaldi, Thierry Roger, W. Joost Wiersinga, Iraklis Tsangaris, Evangelos J. Giamarellos-Bourboulis
Summary: Clarithromycin did not reduce mortality in patients with sepsis with respiratory and multiple organ dysfunction. Clarithromycin was associated with lower sepsis recurrence, possibly through a mechanism of immune restoration.
Article
Biochemistry & Molecular Biology
G. F. Senguel, R. Mishra, E. Candiello, P. Schu
Summary: AP2 forms AP2 CCV with clathrin and other coat proteins, and synapses contain different types of CCV. The stability and composition of CCV are regulated by various factors, including Hsc70 and phosphorylation patterns. The knockout of the AP1/O1B complex disrupts synaptic vesicle recycling and endosomal protein sorting, leading to upregulation of endocytosis. Stable CCV, termed stCCV, have distinct characteristics and specialized functions in synaptic plasticity. The phosphorylation of Hsc70 and the levels of kinases play a crucial role in regulating the stability and disassembly of clathrin in CCV.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Martin Fluck, Colline Sanchez, Vincent Jacquemond, Christine Berthier, Marie-Noelle Giraud, Daniel Jacko, Kathe Bersiner, Sebastian Gehlert, Guus Baan, Richard T. Jaspers
Summary: Enhancing CaMKII signaling improves fatigue resistance and contractile characteristics of skeletal muscle by enhancing calcium release.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Letter
Biochemistry & Molecular Biology
Federica Coppola, Sara Monaci, Alessandro Falsini, Carlo Aldinucci, Irene Filippi, Daniela Rossi, Fabio Carraro, Antonella Naldini
Summary: The adaptor protein p62 plays a crucial role in maintaining the survival of dendritic cells (DCs) under hypoxic conditions by preserving Erk1/2 phosphorylation and reducing AMPK activation, thus extending their lifespan to ensure their functions in hypoxic microenvironments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Jenifer Pendiuk Goncalves, Jorvani Cruz Villarreal, Sierra A. Walker, Xuan Ning Sharon Tan, Chad Borges, Joy Wolfram
Summary: This study used a mass spectrometry-based approach to assess the differences in glycan features between extracellular vesicles (EVs) and originating cells. The results showed that EVs selectively enriched specific glycan features, particularly those associated with binding to the extracellular matrix. The study also found differences in EV glycan sorting between different metastatic cell lines and mouse models, indicating a potential role of glycan diversity in the metastatic process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
De-ao Gong, Peng Zhou, Wen-yi Chang, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang, Kai Wang
Summary: Liver cancer, ranked sixth globally, is a major contributor to cancer-related mortality. Metastasis is the main cause of treatment failure and deaths in liver cancer. The SPOP-CREB5-MET axis plays a significant role in liver cancer metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ning Huang, Jun Tang, Xiaoyao Yi, Maoxin Zhang, Bin Li, Yuan Cheng, Jin Chen
Summary: This study reveals that glioma-derived S100A9 can induce microglial M2 polarization, inhibit CD8+ T lymphocytes, and promote immunosuppression. The mechanism is related to the interaction with alpha v133 integrin and subsequent activation of AKT1 in microglia. The expression of S100A9 is positively associated with CD206 expression and negatively correlated with CD8+ T lymphocyte accumulation in the TME, suggesting a potential role of S100A9 in regulating the tumor microenvironment and immune evasion in glioma.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Yomna S. Abd El-Aziz, Matthew J. McKay, Mark P. Molloy, Betty McDowell, Elizabeth Moon, Loretta Sioson, Amy Sheen, Angela Chou, Anthony J. Gill, Patric J. Jansson, Sumit Sahni
Summary: This study identified a novel combination of autophagy inhibitors that can effectively inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells, including both chemosensitive and chemoresistant cells. This research is important for the development of new therapies for advanced OSCC tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Luojia Liu, Xiaoqiang Liu, Ying Chen, Meng Kong, Jinghong Zhang, Min Jiang, Hongling Zhou, Jinrui Yang, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jiaping Zhang
Summary: Our study revealed that the Paxillin/HDAC6 signaling pathway regulates microtubule acetylation in electric field-guided keratinocyte migration.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Julia Weikum, Jeroen F. van Dyck, Saranya Subramani, David P. Klebl, Merete Storflor, Stephen P. Muench, Soren Abel, Frank Sobott, J. Preben Morth
Summary: The study reveals the complex interaction between bacterial magnesium transporter A (MgtA) and cardiolipin 18:1 and cardiolipin 16:0, highlighting the importance of lipid environment in protein activity and stability. Further understanding of Mg2+ homeostasis in bacteria will provide insights into bacterial infections.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Sumit Kinger, Yuvraj Anandrao Jagtap, Ankur Rakesh Dubey, Prashant Kumar, Akash Choudhary, Rohan Dhiman, Vijay Kumar Prajapati, Deepak Chitkara, Krishna Mohan Poluri, Amit Mishra
Summary: Efficient protein synthesis and quality control mechanisms are crucial for maintaining proteostasis and preventing neurodegeneration. This study demonstrates that treating cells with Lanosterol can enhance the proteolytic activity of Proteasome and promote the removal of misfolded proteins, suggesting a potential therapeutic approach for abnormal protein accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Karolina Stepien, Adrianna Skoneczna, Monika Kula-Maximenko, Lukasz Jurczyk, Mateusz Molon
Summary: The replication of DNA requires a complex machinery called the replisome, which is highly conserved across species. One crucial component of the replisome is the CMG helicase complex, which unwinds DNA and coordinates the assembly and function of other replisome components. In this study, the impact of the absence of one copy of the CMG complex genes on the physiology and aging of yeast cells was investigated. The findings showed disruptions in the cell cycle, extended doubling times, and alterations in the biochemical profile of these cells. Importantly, it was found that heterozygous cells for CMG helicase genes exhibited increased reproductive potential and delayed aging. The study also highlighted potential therapeutic targets for cancer treatment using yeast.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S. Young, L. Michel Espinoza-Fonseca
Summary: This study reveals that replacing Lys27 with Asn enhances the inhibitory potency of MLN without affecting SERCA's affinity for Ca2+. The findings suggest that the SERCA site modulating Ca2+ affinity also functions as a catalytic activity switch.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Can Jiang, Chunyang Zhang, Min Dai, Fuyan Wang, Sa Xu, Dan Han, Yanyan Wang, Yajie Cao, Yanyan Liang, Ziyu Zhang, Lina Yan, Yujun Shen, Kewu He, Yuxian Shen, Jun Liu
Summary: The phosphorylation of p65 and the expression of SUMO1 are increased in cancer tissues of HCC patients, and there is a positive correlation between SUMO1 and phosphorylated p65. SUMOylation of p65 by SUMO1 promotes p65 nuclear import and enhances NF-xB activity. Both SUMOylation and phosphorylation of p65 increase the viability and invasion of hepatoma cells, and decrease cell apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan Wells, Kuang-Yu Jen, Tzu-Ching Meng, Fawaz G. Haj
Summary: This study identified alpha-actinin4 as a novel substrate of PTP1B in podocytes and demonstrated their interaction in regulating podocyte function. Targeting PTP1B and alpha-actinin4 could be a potential therapeutic approach for podocyte injury.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Paulo F. V. Bizerra, Eduardo H. Gilglioni, Hang Lam Li, Simei Go, Ronald P. J. Oude Elferink, Arthur J. Verhoeven, Jung -Chin Chang
Summary: This study investigates the role of cyclic AMP (cAMP) in glycogen metabolism and reveals that cAMP regulates glycogenolysis in opposite directions depending on its site of synthesis within cells and downstream effectors. The canonical tmAC-cAMP-PKA signaling promotes glycogenolysis, while the non-canonical sAC-cAMP-Epac1 signaling suppresses glycogenolysis. This highlights the importance of cAMP microdomain organization for distinct metabolic regulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)