期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1783, 期 11, 页码 2124-2129出版社
ELSEVIER
DOI: 10.1016/j.bbamcr.2008.06.006
关键词
HIPK; HIPK domain; PML-body; p53; Pc2; DNA-damage response
资金
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
- European Comunity [503576]
- Fondazione Italiana per la Ricerca sul Cancro (FIRC)
Over the past decade several investigators have reported on the physical interaction of serine/threonine kinases of the homeodomain interacting-protein family (HIPKs) with increasing number of nuclear factors and on their localization in different nuclear sub-compartments. Although we are still far from a global understanding of the molecular consequences of HIPK subnuclear compartmentalization, the spatial description of particular interactions and posttranslational modifications promoted by these kinases on key cellular regulators might provide relevant insights. Here we will discuss the possible implications of the HIM subnuclear localization in the regulation of gene transcription and in the cell response to stress. (c) 2008 Elsevier B.V. All rights reserved.
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