Article
Agriculture, Dairy & Animal Science
Krzysztof Tereszkiewicz, Lukasz Kulig, Piotr Antos, Karolina Kowalczyk
Summary: The study aimed to investigate the impact of hormone levels during the reproductive cycle of gilts on slaughter characteristics and meat quality. The results showed that increased levels of LH affected some properties of meat and blood. The concentration of LH also influenced the post-slaughter temperature of certain muscles.
Article
Biochemistry & Molecular Biology
Kusumika Saha, Benoit Chevalier, Stephane Doly, Nesrine Baatallah, Thomas Guilbert, Iwona Pranke, Mark G. H. Scott, Herve Enslen, Chiara Guerrera, Cerina Chuon, Aleksander Edelman, Isabelle Sermet-Gaudelus, Alexandre Hinzpeter, Stefano Marullo
Summary: The exit of certain plasma membrane proteins from the endoplasmic reticulum is regulated by arginine-based retention motifs. PRAF2, a gatekeeper protein, recognizes these motifs and retains specific proteins in the ER. It has been found that PRAF2 can interact with mutant CFTR, preventing it from reaching the ER exit sites. Pharmacological chaperones have also been shown to rescue CFTR-F508del retention by PRAF2 through various mechanisms. These findings provide new therapeutic perspectives for diseases caused by impaired cell surface trafficking of mutant proteins.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Peik M. A. Brundin, Britt-Marie Landgren, Peter Fjallstrom, Mohamed M. M. Shamekh, Jan-Ake Gustafsson, Anders F. F. Johansson, Ivan Nalvarte
Summary: The study reveals the expression patterns of sex hormone receptors in different immune cells and the lack of significant correlation between sex hormone levels and expression of SHR or immune response genes. However, there is a positive correlation between sex hormone-binding globulin and the expression of certain genes. Additionally, immune response genes show significant differences in expression between different phases of the menstrual cycle, suggesting a potential role for sex hormones in immune response.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Lovlesh Thakur, Sunil Thakur
Summary: This review summarizes the role of miRNAs in endometrial cancer regulated by sex steroid hormone pathways. Dysregulation of miRNAs has been linked to abnormal sex steroid hormone signaling and the development of endometrial cancer. Various miRNAs have been identified as modulators of estrogen and progesterone receptor expression, and the miRNA expression profile has been shown to be a predictor of response to hormone therapy. Future studies should focus on elucidating the functional roles of specific miRNAs in sex steroid hormone signaling and identifying novel miRNA targets for hormone therapy in endometrial cancer management.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Joanna Sadowska, Wioleta Dudzinska, Izabela Dziaduch
Summary: This study explores the relationships between diet, sex hormone concentrations, and the estrous cycle, which are important for understanding infertility and estrogen-dependent diseases. The findings indicate that both the amount and pattern of dietary sucrose intake affect the estrous cycle and sex hormone concentrations in female rats.
Article
Agriculture, Dairy & Animal Science
Leticia Martinez, Paloma Jimena de Andres, Jose Manuel Caperos, Gema Silvan, Jesus Fernandez-Moran, Miguel Casares, Belen Crespo, Daniel Velez, Luis Sanz, Sara Caceres, Juan Carlos Illera
Summary: Ensuring effective management of rhinoceros populations is crucial for species' future, given the escalating threat of poaching and challenges in captive breeding. Fecal hormonal determinations can monitor adrenal and gonadal endocrinologies, making them valuable for endangered species. This study developed a statistical model for predicting white rhinoceros sex using hormonal determinations from a single fecal sample, achieving an impressive accuracy rate of nearly 80%. Implementing this model would enhance conservation efforts and increase understanding of wild populations' dynamics and structure.
Article
Cell Biology
Rosanne Wouters, Christine Michiels, Ragna Sannerud, Bertrand Kleizen, Katleen Dillen, Wendy Vermeire, Abril Escamilla Ayala, David Demedts, Randy Schekman, Wim Annaert
Summary: gamma-secretase plays a role in various physiological processes by targeting over 100 substrates, with dysfunction linking it to cancer and Alzheimer's disease. The spatiotemporal regulation of its assembly remains unclear, but evidence suggests a stepwise process controlled by selective sorting mechanisms, leading to final levels in postGolgi compartments.
JOURNAL OF CELL BIOLOGY
(2021)
Review
Immunology
Larissa K. Ratten, Erica L. Plummer, Catriona S. Bradshaw, Christopher K. Fairley, Gerald L. Murray, Suzanne M. Garland, Deborah Bateson, Gilda Tachedjian, Lindi Masson, Lenka A. Vodstrcil
Summary: The use of exogenous sex steroids, especially estrogen-containing compounds, may have a positive effect on the vaginal microbiota, promoting an optimal composition. However, the impact of progestin-only contraceptives on the vaginal microbiota is still unclear and requires more research for potential adverse effects on reproductive and sexual health.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Masahiro Ogawa, Junya Kitamoto, Takeo Takeda, Megumi Terada
Summary: This study investigated the effects of BPA on P4 signaling and TRIM22 and TP53 expression in human breast carcinoma cells. The results showed that BPA inhibited P4-induced apoptosis by inhibiting P4 receptor transactivation. Additionally, the TRIM22 gene has potential as a biomarker for investigating the disruption of P4 signaling by chemicals.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Review
Biochemical Research Methods
Amy Gravitte, Timothy Archibald, Allison Cobble, Benjamin Kennard, Stacy Brown
Summary: Liquid chromatography coupled with tandem mass spectrometry is a powerful tool for accurate quantification of sex steroid hormones, essential for understanding the role of these regulators in human development, fertility, and disease risk. LC-MS/MS offers advantages in specificity and sensitivity over immunoassay techniques, making it a growing method for clinically relevant quantification of sex steroid hormones.
BIOMEDICAL CHROMATOGRAPHY
(2021)
Article
Multidisciplinary Sciences
Jeel Moya-Salazar, Sandra P. Cerda, Betsy Canari, Marcia M. Moya-Salazar, Hans Contreras-Pulache
Summary: The female hormonal profile is crucial for assessing endocrinological function and diagnosing diseases. Reference intervals for five female sex hormones were determined using electrochemiluminescence technology. Four out of five hormones were found within the manufacturer's reference intervals, but there were errors in the transfer of reference intervals for estradiol.
Article
Agriculture, Dairy & Animal Science
K. Hazano, S. Haneda, M. Kayano, M. Matsui
Summary: This study characterized the local endocrine environment of the oviduct by examining the concentrations of E2 and P4 and their receptors' mRNA expression. The results showed that the oviductal endocrine milieu varies according to the estrous cycle phase and the oviductal region and side.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2021)
Review
Immunology
Rebecca Shepherd, Ada S. Cheung, Ken Pang, Richard Saffery, Boris Novakovic
Summary: Sexual dimorphism in immune response is well demonstrated in humans, with females exhibiting lower infection rates and higher incidence of autoimmune diseases compared to males, potentially linked to the effects of sex hormones like estrogen, progesterone, and testosterone. Studies have shown sex-specific transcriptome and epigenetic changes, which may contribute to the sexually dimorphic immune response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Parasitology
Jorge Morales-Montor, Alvaro Colin-Oviedo, Gloria M. Gonzalez, Jose Prisco Palma-Nicolas, Alejandro Sanchez-Gonzalez, Karen Elizabeth Nava-Castro, Lenin Dominguez-Ramirez, Martin Garcia-Varela, Victor Hugo Del Rio-Araiza, Romel Hernandez-Bello
Summary: This study reveals that progesterone may act on Trichinella spiralis eggs by binding to the parasite protein PGRMC2-Ts. The findings have implications in the co-evolution between parasites and hosts, as well as the susceptibility to this infection based on gender. Additionally, these results may contribute to the development of new anti-parasite drugs.
VETERINARY PARASITOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Parisa Koutsifeli, Upasna Varma, Lorna J. Daniels, Marco Annandale, Xun Li, Joshua P. H. Neale, Sarah Hayes, Kate L. Weeks, Samuel James, Lea M. D. Delbridge, Kimberley M. Mellor
Summary: Autophagy is an essential cellular process that involves the degradation of excess or defective macromolecules and organelles to maintain homeostatic recycling. Recent studies have revealed a more complex understanding of selective autophagy pathways. Glycophagy, as a selective degradation process of glycogen, plays a crucial metabolic role in the transport and delivery of glycolytic fuel substrate. Although the study of glycophagy is still in its early stages, it provides important insights into cellular energy metabolism. Moreover, glycogen metabolic mishandling is linked to various metabolic diseases in different tissues such as the liver, skeletal muscle, cardiac muscle, and brain. Therefore, advancements in this field hold broad multidisciplinary interest for different cell types and metabolic states.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Lise Bankir, Nadine Bouby, Robert C. Speth, Gilberto Velho, Gilles Crambert
DIABETES RESEARCH AND CLINICAL PRACTICE
(2018)
Article
Transplantation
Anne Blanchard, Sylvie Brailly Tabard, Antonin Lamaziere, Damien Bergerot, Valentina Zhygalina, Aurelien Lorthioir, Antoine Jacques, Delphine Hourton, Michel Azizi, Gilles Crambert
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2020)
Article
Multidisciplinary Sciences
Juliette Simonin, Emmanuelle Bille, Gilles Crambert, Sabrina Noel, Elise Dreano, Aurelie Edwards, Aurelie Hatton, Iwona Pranke, Berengere Villeret, Charles-Henry Cattart, Jean-Patrick Vrel, Valerie Urbach, Nesrine Baatallah, Alexandre Hinzpeter, Anita Golec, Lhousseine Touqui, Xavier Nassif, Luis J. Galietta, Gabrielle Planelles, Jean-Michel Sallenave, Aleksander Edelman, Isabelle Sermet-Gaudelus
SCIENTIFIC REPORTS
(2019)
Article
Physiology
Christine Walter, Chloe Rafael, Samia Lasaad, Stephanie Baron, Amel Salhi, Gilles Crambert
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Anna Keppner, Darko Maric, Chloe Sergi, Camille Ansermet, Damien De Bellis, Denise Kratschmar, Jeremie Canonica, Petra Klusonova, Robert A. Fenton, Alex Odermatt, Gilles Crambert, David Hoogewijs, Edith Hummler
SCIENTIFIC REPORTS
(2019)
Article
Urology & Nephrology
Ali Sassi, Yubao Wang, Alexandra Chassot, Olga Komarynets, Isabelle Roth, Valerie Olivier, Gilles Crambert, Eva Dizin, Emilie Boscardin, Edith Hummler, Eric Feraille
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Multidisciplinary Sciences
Christine Walter, Chloe Rafael, Anthony Genna, Stephanie Baron, Gilles Crambert
Summary: Inhibiting HKA2 can reduce hyperkalemia in patients with chronic kidney disease by increasing fecal excretion of K+. The absence of HKA2 also increases fecal excretion of Na+, aiding in the regulation of potassium levels in the body.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Lydie Cheval, Benoit Viollet, Christophe Klein, Chloe Rafael, Lucile Figueres, Estelle Devevre, Georges Zadigue, Anie Azroyan, Gilles Crambert, Bruno Vogt, Alain Doucet
Summary: The study reveals the mechanism of proliferation of intercalated cells in the renal collecting duct, showing that acid load induces the secretion of Gdf15, which further activates the growth of intercalated cells. This response is mediated through the stimulation of principal cells by vasopressin.
Article
Medicine, Research & Experimental
Marc Fila, Ali Sassi, Gaelle Brideau, Lydie Cheval, Luciana Morla, Pascal Houillier, Christine Walter, Michel Gennaoui, Laure Collignon, Mathilde Keck, Gabrielle Planelles, Naziha Bakouh, Michel Peuchmaur, Georges Deschenes, Ignacio Anegon, Severine Remy, Bruno Vogt, Gilles Crambert, Alain Doucet
Summary: The study identified a variant of ASIC2b responsible for renal sodium retention in the pathological context of idiopathic nephrotic syndrome (INS).
Article
Cell Biology
Thi An Vu, Ingrid Lema, Imene Hani, Lydie Cheval, Laura Atger-Lallier, Vilayvane Souvannarath, Julie Perrot, Melanie Souvanheuane, Yannick Marie, Sylvie Fabrega, Anne Blanchard, Jerome Bouligand, Peter Kamenicky, Gilles Crambert, Laetitia Martinerie, Marc Lombes, Say Viengchareun
Summary: Under hypertonicity, miR-324-5p and miR-30c-2-3p are recruited to regulate MR expression and signaling, affecting renal function and sodium retention.
Review
Medicine, General & Internal
Nahid Tabibzadeh, Gilles Crambert
Summary: The kidneys play a crucial role in maintaining the constant volume, pH, and electrolyte composition of the internal milieu by balancing outputs and inputs. Dysfunctions in the kidney, either due to internal alterations or external factors, can lead to various pathologies and affect other organ functions. Studying the alterations in the functions of the collecting duct has provided better understanding and management of related diseases, and the development of therapeutic tools.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Physiology
Lise Bankir, Lucile Figueres, Caroline Prot-Bertoye, Nadine Bouby, Gilles Crambert, J. Howard Pratt, Pascal Houillier
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2020)
Article
Physiology
Lydie Cheval, Naziha Bakouh, Christine Walter, Digne Tembely, Luciana Morla, Genevieve Escher, Bruno Vogt, Gilles Crambert, Gabrielle Planelles, Alain Doucet
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)
Article
Medicine, Research & Experimental
Paolo Scudieri, Ilaria Musante, Emanuela Caci, Arianna Venturini, Patrizia Morelli, Christine Walter, Davide Tosi, Alessandro Palleschi, Pablo Martin-Vasallo, Isabelle Sermet-Gaudelus, Gabrielle Planelles, Gilles Crambert, Luis J. V. Galietta
Article
Physiology
Lise Bankir, Antonio Barbato, Ornella Russo, Gilles Crambert, Roberto Iacone, Nadine Bouby, Ludovica Perna, Pasquale Strazzullo
PHYSIOLOGICAL REPORTS
(2018)
Article
Biochemistry & Molecular Biology
G. F. Senguel, R. Mishra, E. Candiello, P. Schu
Summary: AP2 forms AP2 CCV with clathrin and other coat proteins, and synapses contain different types of CCV. The stability and composition of CCV are regulated by various factors, including Hsc70 and phosphorylation patterns. The knockout of the AP1/O1B complex disrupts synaptic vesicle recycling and endosomal protein sorting, leading to upregulation of endocytosis. Stable CCV, termed stCCV, have distinct characteristics and specialized functions in synaptic plasticity. The phosphorylation of Hsc70 and the levels of kinases play a crucial role in regulating the stability and disassembly of clathrin in CCV.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Martin Fluck, Colline Sanchez, Vincent Jacquemond, Christine Berthier, Marie-Noelle Giraud, Daniel Jacko, Kathe Bersiner, Sebastian Gehlert, Guus Baan, Richard T. Jaspers
Summary: Enhancing CaMKII signaling improves fatigue resistance and contractile characteristics of skeletal muscle by enhancing calcium release.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Letter
Biochemistry & Molecular Biology
Federica Coppola, Sara Monaci, Alessandro Falsini, Carlo Aldinucci, Irene Filippi, Daniela Rossi, Fabio Carraro, Antonella Naldini
Summary: The adaptor protein p62 plays a crucial role in maintaining the survival of dendritic cells (DCs) under hypoxic conditions by preserving Erk1/2 phosphorylation and reducing AMPK activation, thus extending their lifespan to ensure their functions in hypoxic microenvironments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Jenifer Pendiuk Goncalves, Jorvani Cruz Villarreal, Sierra A. Walker, Xuan Ning Sharon Tan, Chad Borges, Joy Wolfram
Summary: This study used a mass spectrometry-based approach to assess the differences in glycan features between extracellular vesicles (EVs) and originating cells. The results showed that EVs selectively enriched specific glycan features, particularly those associated with binding to the extracellular matrix. The study also found differences in EV glycan sorting between different metastatic cell lines and mouse models, indicating a potential role of glycan diversity in the metastatic process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
De-ao Gong, Peng Zhou, Wen-yi Chang, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang, Kai Wang
Summary: Liver cancer, ranked sixth globally, is a major contributor to cancer-related mortality. Metastasis is the main cause of treatment failure and deaths in liver cancer. The SPOP-CREB5-MET axis plays a significant role in liver cancer metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ning Huang, Jun Tang, Xiaoyao Yi, Maoxin Zhang, Bin Li, Yuan Cheng, Jin Chen
Summary: This study reveals that glioma-derived S100A9 can induce microglial M2 polarization, inhibit CD8+ T lymphocytes, and promote immunosuppression. The mechanism is related to the interaction with alpha v133 integrin and subsequent activation of AKT1 in microglia. The expression of S100A9 is positively associated with CD206 expression and negatively correlated with CD8+ T lymphocyte accumulation in the TME, suggesting a potential role of S100A9 in regulating the tumor microenvironment and immune evasion in glioma.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Yomna S. Abd El-Aziz, Matthew J. McKay, Mark P. Molloy, Betty McDowell, Elizabeth Moon, Loretta Sioson, Amy Sheen, Angela Chou, Anthony J. Gill, Patric J. Jansson, Sumit Sahni
Summary: This study identified a novel combination of autophagy inhibitors that can effectively inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells, including both chemosensitive and chemoresistant cells. This research is important for the development of new therapies for advanced OSCC tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Luojia Liu, Xiaoqiang Liu, Ying Chen, Meng Kong, Jinghong Zhang, Min Jiang, Hongling Zhou, Jinrui Yang, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jiaping Zhang
Summary: Our study revealed that the Paxillin/HDAC6 signaling pathway regulates microtubule acetylation in electric field-guided keratinocyte migration.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Julia Weikum, Jeroen F. van Dyck, Saranya Subramani, David P. Klebl, Merete Storflor, Stephen P. Muench, Soren Abel, Frank Sobott, J. Preben Morth
Summary: The study reveals the complex interaction between bacterial magnesium transporter A (MgtA) and cardiolipin 18:1 and cardiolipin 16:0, highlighting the importance of lipid environment in protein activity and stability. Further understanding of Mg2+ homeostasis in bacteria will provide insights into bacterial infections.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Sumit Kinger, Yuvraj Anandrao Jagtap, Ankur Rakesh Dubey, Prashant Kumar, Akash Choudhary, Rohan Dhiman, Vijay Kumar Prajapati, Deepak Chitkara, Krishna Mohan Poluri, Amit Mishra
Summary: Efficient protein synthesis and quality control mechanisms are crucial for maintaining proteostasis and preventing neurodegeneration. This study demonstrates that treating cells with Lanosterol can enhance the proteolytic activity of Proteasome and promote the removal of misfolded proteins, suggesting a potential therapeutic approach for abnormal protein accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Karolina Stepien, Adrianna Skoneczna, Monika Kula-Maximenko, Lukasz Jurczyk, Mateusz Molon
Summary: The replication of DNA requires a complex machinery called the replisome, which is highly conserved across species. One crucial component of the replisome is the CMG helicase complex, which unwinds DNA and coordinates the assembly and function of other replisome components. In this study, the impact of the absence of one copy of the CMG complex genes on the physiology and aging of yeast cells was investigated. The findings showed disruptions in the cell cycle, extended doubling times, and alterations in the biochemical profile of these cells. Importantly, it was found that heterozygous cells for CMG helicase genes exhibited increased reproductive potential and delayed aging. The study also highlighted potential therapeutic targets for cancer treatment using yeast.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S. Young, L. Michel Espinoza-Fonseca
Summary: This study reveals that replacing Lys27 with Asn enhances the inhibitory potency of MLN without affecting SERCA's affinity for Ca2+. The findings suggest that the SERCA site modulating Ca2+ affinity also functions as a catalytic activity switch.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Can Jiang, Chunyang Zhang, Min Dai, Fuyan Wang, Sa Xu, Dan Han, Yanyan Wang, Yajie Cao, Yanyan Liang, Ziyu Zhang, Lina Yan, Yujun Shen, Kewu He, Yuxian Shen, Jun Liu
Summary: The phosphorylation of p65 and the expression of SUMO1 are increased in cancer tissues of HCC patients, and there is a positive correlation between SUMO1 and phosphorylated p65. SUMOylation of p65 by SUMO1 promotes p65 nuclear import and enhances NF-xB activity. Both SUMOylation and phosphorylation of p65 increase the viability and invasion of hepatoma cells, and decrease cell apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan Wells, Kuang-Yu Jen, Tzu-Ching Meng, Fawaz G. Haj
Summary: This study identified alpha-actinin4 as a novel substrate of PTP1B in podocytes and demonstrated their interaction in regulating podocyte function. Targeting PTP1B and alpha-actinin4 could be a potential therapeutic approach for podocyte injury.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Paulo F. V. Bizerra, Eduardo H. Gilglioni, Hang Lam Li, Simei Go, Ronald P. J. Oude Elferink, Arthur J. Verhoeven, Jung -Chin Chang
Summary: This study investigates the role of cyclic AMP (cAMP) in glycogen metabolism and reveals that cAMP regulates glycogenolysis in opposite directions depending on its site of synthesis within cells and downstream effectors. The canonical tmAC-cAMP-PKA signaling promotes glycogenolysis, while the non-canonical sAC-cAMP-Epac1 signaling suppresses glycogenolysis. This highlights the importance of cAMP microdomain organization for distinct metabolic regulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)