Article
Medicine, General & Internal
Weronika Galus, Anna Walawska-Hrycek, Michalina Rzepka, Ewa Krzystanek
Summary: This study assessed the vitamin D status and practices among MS patients and professionals in the clinical setting. Results showed that while most patients confirmed vitamin D supplementation, only a small percentage achieved optimal vitamin D levels. Lack of doctor's recommendation was the most common reason for the absence of supplementation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Ashvin Kuri, Nicola Vickaryous, Amine Awad, Benjamin Meir Jacobs, Ruth Dobson
Summary: This study demonstrates that vD supplementation is the major determinant of vD levels in people with MS, with genetic factors playing a smaller role.
JOURNAL OF NEUROLOGY
(2023)
Review
Nutrition & Dietetics
Julie Langlois, Damien Denimal
Summary: This systematic review examined the effects of vitamin D supplementation on clinical and imaging outcomes in patients with multiple sclerosis (MS). The results showed no significant impact of vitamin D supplementation on relapse events, disability progression, and magnetic resonance imaging (MRI) lesions. However, recent studies found a significant reduction in new MRI lesions in the central nervous system of MS patients during supplementation with vitamin D3.
Review
Cell Biology
Carsten Carlberg, Marcin P. Mycko
Summary: Environmental factors, such as low vitamin D levels, contribute to the susceptibility of multiple sclerosis (MS), an autoimmune disease affecting the central nervous system. Vitamin D3, through its metabolite 1,25(OH)2D3, modulates the epigenome and transcriptome of immune cells, reducing inflammatory reactions and promoting immunological tolerance in T cells, thus preventing MS.
Article
Nutrition & Dietetics
Michaela Tanja Haindl, Muammer Ucal, Willibald Wonisch, Michaela Lang, Marta Nowakowska, Milena Z. Z. Adzemovic, Michael Khalil, Christian Enzinger, Sonja Hochmeister
Summary: Vitamin D is an antioxidant supplement that has been widely discussed in relation to multiple sclerosis (MS). This study investigates the effects of vitamin D on cortical pathology, oxidative stress, and neurofilament light chain levels in a rat model of demyelination. The findings suggest a positive impact of vitamin D on cellular features of cortical pathology.
Article
Multidisciplinary Sciences
Majid Ghareghani, Kazem Zibara, Serge Rivest
Summary: Previous studies have shown that the prevalence of multiple sclerosis (MS) increases as one moves from the equator to the poles. This is due to variations in exposure to sunlight, which activates vitamin D synthesis, and absence of light, which activates melatonin synthesis. Deficiencies or excesses in vitamin D or melatonin can occur at any latitude due to specific lifestyles and diets. Northern countries with higher melatonin levels were expected to have lower MS prevalence, but this is not the case. Vitamin D deficiency and a higher MS prevalence persist in high latitudes even with supplementation. Darkness increases MS melatonin levels, causing negative effects that can be alleviated by light therapy. This review discusses the roles of melatonin and vitamin D in MS prevalence, possible causes in northern countries, and suggests strategies to treat MS using sunlight or darkness instead of supplements.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Franca Rosa Guerini, Cristina Agliardi, Letizia Oreni, Elisabetta Groppo, Elisabetta Bolognesi, Milena Zanzottera, Domenico Caputo, Marco Rovaris, Mario Clerici
Summary: The association between VDR gene polymorphisms and rehabilitation outcome in MS patients was evaluated. It was found that certain VDR gene variations were associated with better rehabilitation outcomes, suggesting that genetic profiling could be useful in identifying patients with a higher chance of recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Anna Walawska-Hrycek, Weronika Galus, Eugeniusz Hrycek, Aleksandra Kaczmarczyk, Ewa Krzystanek
Summary: The study indicated that low-dose vitamin D supplementation can normalize serum levels in patients with RRMS and increase levels of anti-inflammatory cytokines, maintaining a beneficial anti-inflammatory cytokine profile.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Michaela Tanja Haindl, Sonja Hochmeister
Summary: Multiple sclerosis is a multifactorial disease of the central nervous system with unclear disease mechanisms, and studies suggest that vitamin D may be a potential treatment approach. Animal models are essential for researching disease mechanisms and developing drugs for multiple sclerosis. When clinical studies present conflicting findings, standardized settings and mechanistic background information are necessary for further research.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Viktor Grut, Martin Bistrom, Jonatan Salzer, Pernilla Stridh, Anna Lindam, Lucia Alonso-Magdalena, Oluf Andersen, Daniel Jons, Martin Gunnarsson, Magnus Vrethem, Johan Hultdin, Peter Sundstrom
Summary: This study found that high levels of free vitamin D3 at a young age reduce the risk of MS later in life, and also implicate a role for DBP in MS etiology.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Sara E. Gombash, Priscilla W. Lee, Elizabeth Sawdai, Amy E. Lovett-Racke
Summary: Vitamin D insufficiency during childhood is associated with the development of multiple sclerosis (MS), possibly due to abnormal immune responses and vulnerability of the central nervous system.
FRONTIERS IN NEUROLOGY
(2022)
Review
Nutrition & Dietetics
Mattia Perazzi, Enrico Gallina, Giulia Francesca Manfredi, Filippo Patrucco, Antonio Acquaviva, Donato Colangelo, Mario Pirisi, Mattia Bellan
Summary: This paper reviews the potential role of vitamin D in the pathogenesis and management of systemic sclerosis (SSc). Pre-clinical data suggest that vitamin D and its analogs may suppress fibrogenesis, while clinical data show a high prevalence of hypovitaminosis D and osteoporosis in SSc patients, but inconsistent findings regarding the association with clinical manifestations and phenotypes of SSc.
Article
Clinical Neurology
Zhila Maghbooli, Abolfazl Omidifar, Tarlan Varzandi, Tayebeh Salehnezhad, Mohammad Ali Sahraian
Summary: The study found lower circulating VDBP levels in MS patients, even after adjusting for vitamin D levels, BMI, and vitamin D supplement intake. However, the causal role of VDBP in the development of MS remains unclear, necessitating further research.
Review
Nutrition & Dietetics
Amarpreet Sangha, Michaela Quon, Gerald Pfeffer, Sarah-Michelle Orton
Summary: Multiple sclerosis (MS) is a complex neurological condition involving both inflammation and neurodegeneration. Vitamin D has been found to have anti-inflammatory effects in MS, and recent research suggests it may also play a role in neuroprotection. The active form of vitamin D, 1,25(OH)(2)D-3, has neuroprotective properties that promote stem cell proliferation, remyelination, and prevent neurodegeneration.
Review
Biochemistry & Molecular Biology
Concetta Scazzone, Luisa Agnello, Giulia Bivona, Bruna Lo Sasso, Marcello Ciaccio
Summary: The association between vitamin D and multiple sclerosis is complex and controversial, with conflicting evidence on the influence of vitamin D-related genes in MS susceptibility. More research is needed to clarify the extent to which gene variants can impact the risk of developing MS.
BIOCHEMICAL GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Lauren Sham, E. Ann Yeh, Sandra Magalhaes, Esteban J. Parra, Agnes Gozdzik, Brenda Banwell, Heather E. Hanwell
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2015)
Article
Clinical Neurology
Emmanuelle Waubant, Anne-Louise Ponsonby, Maura Pugliatti, Heather Hanwell, Ellen M. Mowry, Rogier Q. Hintzen
Meeting Abstract
Immunology
Mukanthu Nyirenda, Laurence Poliquin-lasnier, Heather Hanwell, Alexander Saveriano, Ayal Rozenberg, Rui Li, Craig Moore, Chahrazed Belabani, Trina Johnson, Julia O'mahony, Ruth Ann Marrie, Shannon Dunn, Brenda Banwell, Amit Bar-or
JOURNAL OF NEUROIMMUNOLOGY
(2014)
Letter
Clinical Neurology
S. Kimball, H. E. Hanwell, J. M. Burton, R. P. Heaney, M. F. Holick, B. Hollis, R. Lewanczuk, N. Makhani, S. Venkateswaran
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2014)
Article
Clinical Neurology
Colleen Guimond, Joshua D. Lee, Sreeram V. Ramagopalan, David A. Dyment, Heather Hanwell, Gavin Giovannoni, Maria Criscuoli, Irene M. Yee, Galina Vorobeychik, George C. Ebers, A. Dessa Sadovnick
MULTIPLE SCLEROSIS JOURNAL
(2014)
Article
Clinical Neurology
Jeeyoon Jennifer Ahn, Julia O'Mahony, Marina Moshkova, Heather E. Hanwell, Hargurinder Singh, Monan Angela Zhang, Ruth Ann Marrie, Amit Bar-Or, Dessa A. Sadovnick, Shannon E. Dunn, Brenda L. Banwell
MULTIPLE SCLEROSIS JOURNAL
(2015)
Meeting Abstract
Clinical Neurology
C. Dunn, H. Hanwell, N. Ebrahimi, B. Banwell, A. Bar-Or, R. A. Marrie, E. A. Yeh, C. Yea, J. O'Mahony
MULTIPLE SCLEROSIS JOURNAL
(2018)
Meeting Abstract
Clinical Neurology
G. Fadda, M. Nyirenda, I. Mexhitaj, L. Healy, L. Poliquin-Lasnier, H. Hanwell, A. Saveriano, A. Rozenberg, R. Li, C. S. Moore, C. Belabani, T. Johnson, J. O'Mahony, R. A. Marrie, S. Dunn, B. Banwell, A. Bar-Or
MULTIPLE SCLEROSIS JOURNAL
(2017)
Meeting Abstract
Clinical Neurology
Sandra Magalhaes, Brenda Banwell, Amit Bar-Or, Isabel Fortier, Heather C. Hanwell, Ming Lim, Georg E. Matt, Rinze F. Neuteboom, David L. O'Riordan, Maura Pugliatti, Paul K. Schneider, Catherine M. Tansey, Bryna Shatenstein, Evangeline Wassmer, Christina Wolfson
MULTIPLE SCLEROSIS JOURNAL
(2017)
Meeting Abstract
Clinical Neurology
Kristen Krysko, E. Ann Yeh, Heather Hanwell, Ashley Cohen, Dalia Rotstein
Meeting Abstract
Clinical Neurology
H. E. Hanwell, E. A. Yeh, B. -L. Chang, H. Hakonarson, S. Ramagopalan, G. Disanto, D. L. Arnold, A. Bar-Or, R. A. Marrie, A. D. Sadovnick, B. Banwell
MULTIPLE SCLEROSIS JOURNAL
(2015)
Meeting Abstract
Clinical Neurology
S. Magalhaes, C. Tansey, B. Banwell, A. Bar-Or, I. Fortier, H. E. Hanwell, M. Pugliatti, C. Wolfson
MULTIPLE SCLEROSIS JOURNAL
(2015)
Meeting Abstract
Clinical Neurology
M. Nyirenda, L. Poliquin-Lasnier, H. Hanwell, A. Saveriano, A. Rozenberg, R. Li, C. S. Moore, C. Belabani, T. Johnson, J. O'Mahony, R. A. Marrie, S. Dunn, B. Banwell, A. Bar-Or
MULTIPLE SCLEROSIS JOURNAL
(2014)
Meeting Abstract
Clinical Neurology
H. Hanwell, R. A. Marrie, G. Disanto, S. Ramagopalan, S. Magalhaes, L. H. Verhey, R. Vieth, A. D. Sadvovnick, D. L. Arnold, A. Bar-Or, B. Banwell
MULTIPLE SCLEROSIS JOURNAL
(2014)
Meeting Abstract
Clinical Neurology
A. D. Sadovnick, J. D. Lee, S. V. Ramagopalan, D. A. Dyment, H. Hanwell, G. Giovannoni, M. Criscuoli, I. M. Yee, G. Vorobeychik, G. C. Ebers, C. Guimond
MULTIPLE SCLEROSIS JOURNAL
(2014)
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
