期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1812, 期 8, 页码 879-887出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2010.11.001
关键词
Metabolism; Pregnancy; Nuclear receptors; Bile acids; Oestrogens; Cholestasis
资金
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Genesis Research Trust
- Biomedical Research Centre at Imperial College Healthcare NHS Trust
- GlaxoSmithKline
Nuclear receptor signalling is essential for physiological processes such as metabolism, development, and reproduction. Alterations in the endocrine state that naturally occur during pregnancy result in maternal adaptations to support the feto-placental unit. A series of studies have shown that nuclear receptor signalling is involved in maternal adaptations of bile acid, cholesterol, and lipid homeostasis pathways to ensure maintenance of the nutritional demands of the fetus. We discuss regulation of hepatic nuclear receptors and their target genes in pregnancy and their impact on the development of disorders such as intrahepatic cholestasis of pregnancy and oestrogen-induced hepatotoxicity. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease. (C) 2010 Elsevier B.V. All rights reserved.
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