Article
Neurosciences
Matthieu Drouyer, Marc F. Bolliger, Evy Lobbestael, Chris Van den Haute, Marco Emanuele, Reginald Lefebvre, William Sibran, Tina De Wit, Coline Leghay, Eugenie Mutez, Nicolas Dzamko, Glenda M. Halliday, Shigeo Murayama, Alain Martoriati, Katia Cailliau, Jean-Francois Bodart, Marie-Christine Chartier-Harlin, Veerle Baekelandt, R. Jeremy Nichols, Jean-Marc Taymans
Summary: Through a comprehensive screening and testing of phosphatases involved in dephosphorylation of LRRK2, we found that regulators linked to PP1 and PP2A holoenzyme complexes as well as CDC25 phosphatases can modulate LRRK2 phosphorylation. Pharmacological inhibition-induced dephosphorylation leads to relocalization of PP1 and PP2A in LRRK2 subcellular compartments, and we identified PPP2CA:PPP2R2 as a potent phosphoregulator of pS935-LRRK2.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Margaret Hayne, Aaron DiAntonio
Summary: Protein phosphatase 2A (PP2A) is a cellular phosphatase that, when inhibited, disrupts multiple aspects of cellular physiology. This study demonstrates that loss of PP2A function leads to hyperphosphorylation of Tau and activation of the DLK pathway, causing neuronal cell death.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Oncology
Masmudur M. Rahman, Grant McFadden
Summary: Oncolytic viruses (OVs) are a novel cancer treatment modality that selectively target and kill cancer cells while sparing normal ones. Engineered OVs show great potential in clinical trials, but combination therapies with other treatments may further improve their efficacy.
Article
Pharmacology & Pharmacy
Seyed-Mahmood Seyed-Khorrami, Arezou Azadi, Nasrin Rastegarvand, Ala Habibian, Hoorieh Soleimanjahi, Marek J. Los
Summary: Immunotherapy and virotherapy have emerged as new methods for cancer treatment, with better specificity and outcomes. Applying these strategies in the treatment of malignancies is of great significance, based on advances in understanding cancer cell biology and oncolytic viruses.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Medical Laboratory Technology
Noraini Abd-Aziz, Chit Laa Poh
Summary: Oncolytic virotherapy is a therapeutic approach that utilizes replication-competent viruses to selectively kill cancer cells, but it faces limitations such as viral delivery, tumor penetration, and antiviral immune responses. Strategies to overcome these limitations are crucial for its effective application in preclinical and clinical trials.
TRANSLATIONAL RESEARCH
(2021)
Review
Immunology
Vicent Tur-Planells, Adolfo Garcia-Sastre, Sara Cuadrado-Castano, Estanislao Nistal-Villan
Summary: This review provides an overview of non-human-adapted RNA viruses used in cancer therapy and the diverse strategies employed to optimize their therapeutic capabilities. Through this article, we gain insights into the promising advancements in virotherapy and its potential to revolutionize cancer treatment.
Article
Biochemistry & Molecular Biology
Rachel L. Dannenberg, Joseph A. Cardina, Kara G. Pytko, Mark Hedglin
Summary: This study re-constitutes human lagging strand replication and quantitatively characterizes the initial encounters of pol δ holoenzymes with DNA lesions. The results show that pol δ holoenzymes can support dNTP incorporation at multiple lesions and beyond, and these activities depend on the type of lesion and the proofreading function of pol δ.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Neurosciences
Christine Roemer
Summary: Many neurodegenerative diseases are linked to chronic inflammation in the brain and periphery, with activation of transposable elements and endogenous retroviruses playing a role in disease progression. Endogenous retroviruses are remnants of viral infections in the human genome, producing transcripts upon activation and potentially triggering neuroinflammation.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Oncology
Elham Kashani, Erik Vassella
Summary: GBM is a highly heterogeneous tumor with dynamic oncogenic pathways driving subclonal alterations. PP2A can target multiple key inducers of these pathways and modulate the response of GBM cells, potentially serving as an adjunct therapy. This review emphasizes the importance of PP2A modulation in the context of GBM.
Review
Virology
Davide Zella, Robert C. Gallo
Summary: Viruses and bacteria have evolved mechanisms to interfere with cell integrity and promote cell transformation into cancer cells, reducing the ability to repair damage and decreasing the effectiveness of anti-cancer drugs. Understanding these molecular mechanisms is crucial for cancer prevention and developing new treatments.
Review
Biochemistry & Molecular Biology
Irene Peris, Silvia Romero-Murillo, Carmen Vicente, Goutham Narla, Maria D. Odero
Summary: Protein phosphatase 2A (PP2A) inactivation is common in cancer due to the presence of regulatory B-subunits which determine substrate specificity and subcellular localization. Developing targeted therapies for specific PP2A complexes is a challenge in cancer treatment. The development of small molecules targeting PP2A-B56α has shown promise in treating solid and hematological tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Microbiology
Ugo Moens, Carla Prezioso, Valeria Pietropaolo
Summary: Polyomaviruses can induce tumors, with some strains classified as carcinogenic to humans and others possibly carcinogenic. Whether novel HPyVs play a role in cancer is still under question, as they share common features with known PyVs but their role in oncogenic processes is not fully understood. Studies have examined the functional domains of early proteins in novel HPyVs and presented experimental evidence of their potential oncogenic properties. Detection of novel HPyV in human tumors has also been reviewed in the literature.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Oncology
Mobarakeh Ajam-Hosseini, Fatemeh Akhoondi, Mohammad Doroudian
Summary: Oncolytic viruses show promise as a dual attack therapy for cancer, but their effectiveness is hindered by elimination in the body. Nanoparticles have the potential for targeted drug delivery, but face challenges in non-specificity. By encapsulating oncolytic viruses with nanoparticles, the efficacy of both treatments can be improved and successful clinical results have been achieved. In this review, we will discuss the mechanisms and benefits of each treatment method.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Chrong-Reen Wang, Hung-Wen Tsai
Summary: Human hepatitis viruses can cause liver inflammation and progress to chronic hepatitis, cirrhosis, and liver cancer, as well as complications in other organs. Vascular involvement, such as cutaneous and systemic vasculitis, is a common extrahepatic manifestation, which may be treated with antiviral therapy and corticosteroids. Therapeutic guidelines for HHV-associated vasculitis are still under development, with considerations for plasma exchange and immunosuppressive therapy in severe cases.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Oncology
Shengye Jin, Qin Wang, Hao Wu, Da Pang, Shouping Xu
Summary: Biological therapy, particularly oncolytic viruses (OVs), has shown promising therapeutic effects in various cancers, including triple negative breast cancer (TNBC). TNBC, lacking conventional treatment targets, benefits from the emerging concept of OVs for potential treatment options.
BIOMARKER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
