Review
Endocrinology & Metabolism
Alexandra S. Aaldijk, Cristy R. C. Verzijl, Johan W. Jonker, Dicky Struik
Summary: Beta klotho (KLB) is a crucial component in fibroblast growth factor receptor (FGFR) signaling, serving as an essential coreceptor for the hormones fibroblast growth factor 19 (FGF19) and fibroblast growth factor 21 (FGF21). It has emerged as a potential drug target for treating metabolic diseases, but clinical trials have raised questions about human KLB biology and the variable responses in patients. Understanding human KLB biology could improve the efficacy and safety of KLB-targeting drugs.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Kyle H. Flippo, Matthew J. Potthoff
Summary: FGF21, a non-canonical fibroblast growth factor, acts as an endocrine hormone signaling to various targets in the body. Initially recognized for its potential in correcting metabolic dysfunction and reducing body weight associated with diabetes and obesity, new functions of FGF21 signaling have emerged, demonstrating its ability to regulate macronutrient preference and energy balance.
Article
Biochemistry & Molecular Biology
Yung-Wen Cheng, Chun-Chi Hung, Wen-Hui Fang, Wei-Liang Chen
Summary: Klotho protein is associated with metabolic syndrome, with its concentration negatively correlated with central obesity and high TG levels.
Article
Biology
Kanako Kobayashi, Kazuko Iwasa, Rika Azuma-Suzuki, Takeshi Kawauchi, Yo-ichi Nabeshima
Summary: 13-Klotho (13-KL) is crucial for metabolic regulation during embryonic development, as it mediates fetomaternal cholesterol transport through FGF15 signaling. Impairment of the 13-KL-FGF15 axis leads to fetal growth restriction and reduced body weight in mice.
LIFE SCIENCE ALLIANCE
(2023)
Article
Biochemistry & Molecular Biology
Anna Danielewicz, Magdalena Wojciak, Ireneusz Sowa, Monika Kusz, Joanna Wessely-Szponder, Slawomir Dresler, Michal Latalski
Summary: This study investigated the concentrations of bone remodeling-related agents in adolescent idiopathic scoliosis (AIS) patients, and found that the levels of vitamin D, N-terminal propeptide of type I procollagen, and fibroblast growth factor-23 were altered in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Marlou Klein Hazebroek, Susanne Keipert
Summary: Metabolic diseases are a major health burden in modern society, but fibroblast growth factor 21 (FGF21) shows promise as a therapeutic target. However, obesity leads to increased resistance to FGF21, reducing its effectiveness. Interestingly, certain gene knockout mice show improved FGF21 sensitivity and resistance to obesity. These findings suggest that FGF21 sensitivity in adipose tissue is crucial for metabolic improvements.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Kyle H. Flippo, Samuel A. J. Trammell, Matthew P. Gillum, Iltan Aklan, Misty B. Perez, Yavuz Yavuz, Nicholas K. Smith, Sharon O. Jensen-Cody, Bolu Zhou, Kristin E. Claflin, Amy Beierschmitt, Anders Fink-Jensen, Filip K. Knop, Roberta M. Palmour, Brad A. Grueter, Deniz Atasoy, Matthew J. Potthoff
Summary: Excessive alcohol consumption is a major issue, and FGF21 can suppress alcohol intake by acting on specific neurons in the basolateral amygdala.
Article
Cell Biology
Mihwa Choi, Marc Schneeberger, Wei Fan, Abhijit Bugde, Laurent Gautron, Kevin Vale, Robert E. Hammer, Yuan Zhang, Jeffrey M. Friedman, David J. Mangelsdorf, Steven A. Kliewer
Summary: Animals that consume fermenting fruit and nectar are at risk of exposure to ethanol and the detrimental effects of inebriation. This report demonstrates that the hormone FGF21 plays a role in stimulating arousal from intoxication without affecting ethanol metabolism. FGF21 activates noradrenergic neurons in the locus coeruleus region, suggesting that it could be targeted pharmacologically for treating acute alcohol poisoning.
Article
Cell Biology
Bolu Zhou, Kristin E. Claflin, Kyle H. Flippo, Andrew I. Sullivan, Arvand Asghari, Satya M. Tadinada, Sharon O. Jensen-Cody, Ted Abel, Matthew J. Potthoff
Summary: The study reveals that FGF21 is not expressed in the hypothalamus, but in the retrosplenial cortex (RSC), and it enhances spatial memory in the hippocampus without regulating energy homeostasis or sugar intake.
Article
Neurosciences
Mimi Tang, Shuqiao Cheng, Lu Wang, Hui Tang, Ting Liu, Tingyu Zhao, Ruili Dang
Summary: This study found that the levels of FGF19 and FGF21 were significantly decreased in patients with MDD, and this abnormality was linked to metabolic and cognitive dysregulation. The alterations of FGF19 and FGF21 levels may be a common pathogenic mechanism of metabolic and cognitive disturbances in patients with MDD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Teodora V. V. Grigore, Malou Zuidscherwoude, Anna Witasp, Peter Barany, Annika Wernerson, Annette Bruchfeld, Hong Xu, Hannes Olauson, Joost Hoenderop
Summary: Disturbances in magnesium homeostasis are common in chronic kidney disease (CKD) patients and are associated with increased mortality. This study found that Fibroblast Growth Factor 23 (FGF23) is associated with renal magnesium handling in CKD patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Jaimarie Sostre-Colon, Kahealani Uehara, Anna E. Garcia Whitlock, Matthew J. Gavin, Jeff Ishibashi, Matthew J. Potthoff, Patrick Seale, Paul M. Titchenell
Summary: The study identifies a role for hepatic insulin signaling via the AKT-FOXO1 axis in regulating WAT lipolysis, promoting BAT thermogenic capacity, and ensuring a proper thermogenic response to acute cold exposure.
Article
Medicine, Research & Experimental
Aki T. Chaffin, Karlton R. Larson, Kuei-Pin Huang, Chih-Ting Wu, Nadejda Godoroja, Yanbin Fang, Devi Jayakrishnan, Karla A. Soto Sauza, Landon C. Sims, Niloufar Mohajerani, Michael L. Goodson, Karen K. Ryan
Summary: The hepatokine FGF21 alters hepatic metabolism and reduces liver triglycerides in a sex-dependent manner, with a weight loss-independent effect in obese male mice but no effect in female littermates. The effect of FGF21 on hepatosteatosis is thought to be mediated by increased adiponectin secretion, which is stimulated in males and inhibited in females.
Review
Cell Biology
Phuc Phan, Bibhuti Ballav Saikia, Shivakumar Sonnaila, Shilpi Agrawal, Zeina Alraawi, Thallapuranam Krishnaswamy Suresh Kumar, Shilpa Iyer
Summary: Fibroblast growth factors (FGFs) are a class of cell signaling proteins with diverse functions in cell development, repair, and metabolism. The human FGF family can be classified into three separate groups based on their mechanisms of action, and FGF19, FGF21, and FGF23 belong to the hormone-like/endocrine FGF subfamily. These endocrine FGFs mainly regulate cell metabolic activities and function through a unique protein family called klotho. Ongoing studies aim to provide insights into the physiological and pathophysiological roles of endocrine FGFs and potential therapeutic strategies for metabolic diseases.
Article
Endocrinology & Metabolism
Wei Liu, Chao Sun, Ying Yan, Hongchao Cao, Zhoumin Niu, Siyi Shen, Shengnan Liu, Yuting Wu, Yan Li, Lijian Hui, Yuying Li, Lin Zhao, Cheng Hu, Qiurong Ding, Jingjing Jiang, Hao Ying
Summary: This study uncovers the effects of hepatic p38 activation on systemic metabolism and provides new insights into the pathogenesis of nonalcoholic fatty liver disease.
Article
Endocrinology & Metabolism
Nicholas Douris, Darko M. Stevanovic, Ffolliott M. Fisher, Theodore I. Cisu, Melissa J. Chee, Ngoc L. Nguyen, Eleen Zarebidaki, Andrew C. Adams, Alexei Kharitonenkov, Jeffrey S. Flier, Timothy J. Bartness, Eleftheria Maratos-Flier
Article
Endocrinology & Metabolism
Julia M. Assini, Erin E. Mulvihill, Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Sanjiv S. Chhoker, Cynthia G. Sawyez, Maria Drangova, Andrew C. Adams, Alexei Kharitonenkov, Christopher L. Pin, Murray W. Huff
Correction
Medicine, Research & Experimental
Brice Emanuelli, Sara G. Vienberg, Graham Smyth, Christine Cheng, Kristin I. Stanford, Manimozhiyan Arumugam, Mervyn D. Michael, Andrew C. Adams, Alexei Kharitonenkov, C. Ronald Kahn
JOURNAL OF CLINICAL INVESTIGATION
(2015)
Article
Endocrinology & Metabolism
Ricardo J. Samms, Michelle Murphy, Maxine J. Fowler, Scott Cooper, Paul Emmerson, Tamer Coskun, Andrew C. Adams, Alexei Kharitonenkov, Francis J. P. Ebling, Kostas Tsintzas
JOURNAL OF ENDOCRINOLOGY
(2015)
Review
Endocrinology & Metabolism
Alexei Kharitonenkov, Richard DiMarchi
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2015)
Article
Endocrinology & Metabolism
Ricardo J. Samms, Christine C. Cheng, Alexei Kharitonenkov, Ruth E. Gimeno, Andrew C. Adams
Article
Biochemistry & Molecular Biology
Jennifer Jager, Fenfen Wang, Bin Fang, Hee-Woon Lim, Lindsey C. Peed, David J. Steger, Kyoung-Jae Won, Alexei Kharitonenkov, Andrew C. Adams, Mitchell A. Lazar
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Review
Medicine, General & Internal
A. Kharitonenkov, R. DiMarchi
JOURNAL OF INTERNAL MEDICINE
(2017)
Article
Endocrinology & Metabolism
Miguel Angel Sanchez-Garrido, Kirk M. Habegger, Christoffer Clemmensen, Cassie Holleman, Timo D. Mueller, Diego Perez-Tilve, Pengyun Li, Archita S. Agrawal, Brian Finan, Daniel J. Drucker, Matthias H. Tschoep, Richard D. DiMarchi, Alexei Kharitonenkov
MOLECULAR METABOLISM
(2016)
Article
Nutrition & Dietetics
Siri M. Ippagunta, Alexei Kharitonenkov, Andrew C. Adams, F. Bradley Hillgartner
JOURNAL OF NUTRITION
(2018)
Article
Endocrinology & Metabolism
Archita Agrawal, Sebastian Parlee, Diego Perez-Tilve, Pengyun Li, Jia Pan, Piotr A. Mroz, Ann Maria Kruse Hansen, Birgitte Andersen, Brian Finan, Alexei Kharitonenkov, Richard D. DiMarchi
MOLECULAR METABOLISM
(2018)
Retraction
Biochemistry & Molecular Biology
Shufang Wu, Tal Grunwald, Alexei Kharitonenkov, Julie Dam, Ralf Jockers, Francesco De Luca
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Editorial Material
Endocrinology & Metabolism
Ranyao Yang, Aimin Xu, Alexei Kharitonenkov
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Meeting Abstract
Endocrinology & Metabolism
Y. Y. Zhang, A. Kharitonenkov, X. Y. Zhao, X. N. Dong, Y. Y. Zhang, H. X. Zou, Y. G. Jin, W. Guo, P. Zhai, X. Chen
Article
Chemistry, Medicinal
Jia Pan, Sebastian D. Parlee, Florence M. Brunel, Pengyun Li, Wei Lu, Diego Perez-Tilve, Fa Liu, Brian Finan, Alexei Kharitonenkov, Richard D. DiMarchi
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2020)
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)