Article
Multidisciplinary Sciences
Wenfei Sun, Hua Dong, Christian Wolfrum
Summary: The study reveals that local acetate directly inhibits brown adipose tissue thermogenesis, decreases energy expenditure, and down-regulates genes related to the tricarboxylic acid cycle and brown adipocyte formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Anna Fosch, Maria Rodriguez-Garcia, Cristina Miralpeix, Sebastian Zagmutt, Maite Larranaga, Ana Cristina Reguera, Jesus Garcia-Chica, Laura Herrero, Dolors Serra, Nuria Casals, Rosalia Rodriguez-Rodriguez
Summary: Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance and disruption leads to obesity. The effects of saturated or unsaturated LCFA on hypothalamic-brown adipose tissue (BAT) axis and underlying mechanisms were investigated. Unsaturated LCFA increased BAT thermogenesis through CPT1C-mediated FA metabolism shift, while saturated LCFA did not. These findings provide new insight into neuronal circuitries activated by LCFA to drive thermogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Nazmul Hasan, Naoto Nagata, Jun-ichi Morishige, Md Tarikul Islam, Zheng Jing, Ken-ichi Harada, Michihiro Mieda, Masanori Ono, Hiroshi Fujiwara, Takiko Daikoku, Tomoko Fujiwara, Yoshiko Maida, Tsuguhito Ota, Shigeki Shimba, Shuichi Kaneko, Akio Fujimura, Hitoshi Ando
Summary: This study demonstrates the impact of impaired BAT clock on energy metabolism and obesity development. Disruption of BAT clock helps maintain normal core body temperatures but may lead to reduced energy expenditure and obesity development.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Lei Hao, Yong-Hui Nie, Chih-Yu Chen, Xiang-Yong Li, Kanakaraju Kaliannan, Jing X. Kang
Summary: This study utilized a transgenic fat-1 mouse model to investigate the regulation of brown adipose tissue (BAT) morphology and function by n-3 polyunsaturated fatty acids (n-3 PUFAs). The findings showed that elevated tissue levels of n-3 PUFAs can alleviate high-fat diet-induced obesity by enhancing thermogenesis and reducing inflammation in BAT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Lloyd Noriega, Cheng-Ying Yang, Chih-Hao Wang
Summary: Brown and beige adipocytes have the ability to generate heat and can be activated by various methods. Understanding the molecular mechanisms of their differentiation and function is crucial for developing clinical therapies. Drugs and nutritional interventions can activate these adipocytes while minimizing potential side effects.
Article
Endocrinology & Metabolism
Chao Cao, Han-Chow E. Koh, Stephan Van Vliet, Bruce W. Patterson, Dominic N. Reeds, Richard Laforest, Robert J. Gropler, Bettina Mittendorfer
Summary: This study found that enhanced FFA clearance in people with obesity is negatively correlated with muscle insulin sensitivity, and the stimulatory effect of insulin on FFA clearance is more significant in obese individuals.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Nutrition & Dietetics
Yunxiao Gao, Yiwen Liu, Xue Han, Fang Zhou, Jielong Guo, Weidong Huang, Jicheng Zhan, Yilin You
Summary: This study compared the anti-obesity effects of coconut oil (CO) and medium-chain fatty acids (MCFA) and found that CO is more effective than MCFA in activating brown adipose tissue, increasing thermogenesis, and combating obesity.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Susana Castelo Branco Ramos Nakandakari, Rafael Calais Gaspar, Gabriel Keine Kuga, Camila de Oliveira Ramos, Renan Fudoli Vieira, Thaiane da Silva Rios, Vitor Rosetto Munoz, Marcella Ramos Sant'ana, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Leandro Pereira Moura, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Dennys Esper Cintra
Summary: Long-term high-fat diet affects adipose tissue and leads to metabolic disorders. Short-term high-fat diet affects neuronal signaling pathways. Flaxseed oil containing omega-3 fatty acids protects against increased food intake and fasting glucose, but not inflammation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Emanuel Fryk, Josefin Olausson, Karin Mossberg, Lena Strindberg, Martin Schmelz, Helen Brogren, Li-Ming Gan, Silvano Piazza, Alessandro Provenzani, Barbara Becattini, Lars Lind, Giovanni Solinas, Per-Anders Jansson
Summary: The study suggests that in obese individuals, hyperinsulinemia is mainly caused by elevated free fatty acids, which is a significant factor in the development of insulin resistance in obesity. Additionally, obese subjects with normal glycemia do not show significant differences in lipolysis compared to lean individuals.
Article
Endocrinology & Metabolism
Ivan Liakh, Agata Janczy, Alicja Pakiet, Justyna Korczynska, Monika Proczko-Stepaniak, Lukasz Kaska, Tomasz Sledzinski, Adriana Mika
Summary: In patients with obesity, metabolism of oxylipins is dysregulated in adipose tissue, with altered concentrations in serum. Bariatric surgery modulates levels of pro- and anti-inflammatory oxylipins, potentially contributing to resolution of inflammation.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Review
Endocrinology & Metabolism
Ruping Pan, Yong Chen
Summary: Obesity is characterized by the overaccumulation of white adipose tissue in the body, leading to various metabolic disorders. Targeting human thermogenic adipose tissues shows promise in combating obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Medicinal
Long Cheng, Lu Shi, Changhao He, Chen Wang, Yinglan Lv, Huimin Li, Yongcheng An, Hongyu Dai, Yuhui Duan, Huilin Zhang, Yan Huang, Wanxin Fu, Yanyan Meng, Baosheng Zhao
Summary: The study found that rutin can activate thermogenesis in brown and white adipose tissue by increasing the concentration of short-chain fatty acids, thereby improving obesity and diabetes.
PHYTOTHERAPY RESEARCH
(2022)
Article
Food Science & Technology
Stefanie F. Maurer, Sebastian Dieckmann, Jens Lund, Tobias Fromme, Anne Lundby Hess, Cecilia Colson, Louise Kjolbaek, Arne Astrup, Matthew Paul Gillum, Lesli Hingstrup Larsen, Gerhard Liebisch, Ez-Zoubir Amri, Martin Klingenspor
Summary: The study suggests that dietary fish oil supplementation may enhance the recruitment of thermogenic capacity in adipocytes, but does not significantly affect body weight or adiposity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Oncology
Lea A. Moukarzel, Lorenzo Ferrando, Anthe Stylianou, Stephanie Lobaugh, Michelle Wu, Silvana Pedra Nobre, Alexia Iasonos, Gabriele Zoppoli, Dilip D. Giri, Nadeem R. Abu-Rustum, Vance A. Broach, Neil M. Iyengar, Britta Weigelt, Vicky Makker
Summary: This study investigated the relationship between white adipose tissue (WAT) inflammation and endometrial cancer (EC). It found that WAT inflammation was associated with metabolic syndrome, obesity, and increased levels of inflammatory markers, as well as upregulation of proinflammatory and proneoplastic genes.
Article
Chemistry, Medicinal
Jussara J. Simao, Maysa M. Cruz, Fernanda M. Abdala, Andressa Bolsoni-Lopes, Lucia Armelin-Correa, Maria Isabel C. Alonso-Vale
Summary: The study demonstrates that palmitoleic acid (n7) can alleviate or prevent low-grade chronic inflammation caused by obesity by inducing adipocyte differentiation and reducing the expression of inflammatory cytokines.
Review
Cell Biology
Rabin Dhakal, Mohammad Yosofvand, Mahsa Yavari, Ramzi Abdulrahman, Ryan Schurr, Naima Moustaid-Moussa, Hanna Moussa
Summary: This paper reviewed the use of C. elegans as a model organism to study the biological effects of radiation, discussing the impact of radiation types, doses, and chemical substances on biological responses. Additionally, it explored how dietary components may enhance C. elegans resistance to ionizing radiation and increase their lifespan after exposure.
Article
Biochemistry & Molecular Biology
Emily K. Miller, Mandana Pahlavani, Latha Ramalingam, Shane Scoggin, Naima Moustaid-Moussa
Summary: The study showed that in female mice, UCP1 deficiency in thermoneutral conditions has a negative impact on energy metabolism. Surprisingly, the protective effects of EPA against diet-induced obesity and glucose intolerance were found to be independent of UCP1.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Mostafa M. Abbas, Paul Soto, Latha Ramalingam, Yasser El-Manzalawy, Halima Bensmail, Naima Moustaid-Moussa
Summary: This study evaluated changes in gut bacteria in adult mice following early life treatment with olanzapine (OLZ) and high-fat diet with or without fish oil supplementation. The results showed that fish oil reduced dietary obesity and inflammation in male mice and increased the Bacteroidetes-to-Firmicutes (B/F) ratio, but had no benefit for female mice.
Article
Plant Sciences
Abishkar Regmi, Sukhbir Singh, Naima Moustaid-Moussa, Cade Coldren, Catherine Simpson
Summary: The use of biochar can reduce the excessive use of peat moss and improve the growth and flowering of Viola plants in greenhouse production. However, the optimal biochar rate varies depending on plant cultivars and fertilization. Results suggest that up to 50% biochar can be used with the addition of fertilizer without negatively impacting plant growth, thus reducing the environmental and economic burden of peat moss.
Article
Biochemistry & Molecular Biology
Noshin Mubtasim, Naima Moustaid-Moussa, Lauren Gollahon
Summary: Breast cancer is one of the most prevalent cancers in women, and obesity is closely related to its development and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Caroline Schuster, Nicholas Wolpert, Naima Moustaid-Moussa, Lauren S. Gollahon
Summary: The major obstacles in breast cancer treatment are drug resistance and cytotoxicity on normal cells. This study explored the potential of phytochemicals as alternative treatment options for breast cancer based on metabolic differences between cancer cells and normal cells. The combination treatment of cinnamaldehyde (CA) and chlorogenic acid (CGA) showed the best anti-breast-cancer effects without strong adverse effects on normal mammary epithelial cells.
Article
Nutrition & Dietetics
Kalhara R. Menikdiwela, Joao Pedro Torres Guimaraes, Shane Scoggin, Lauren S. Gollahon, Naima Moustaid-Moussa
Summary: This study aims to investigate the effects of pH enhancement on high fat diet-induced obese mice, using beef or casein as protein sources, compared to low fat diet-fed mice. The findings show that pH enhancement can reduce adiposity and improve glucose clearance, while high fat intake is the major contributor to metabolic dysfunctions.
Article
Environmental Sciences
Nadeeja N. Wijayatunga, Heontae Kim, Harry M. Hays, Minsoo Kang
Summary: This study aimed to determine the differences in body composition and physical activity between normal weight obesity (NWO) and normal weight lean (NWL) individuals in the United States. The results showed that NWO and overweight/obese (OB) individuals had significantly lower levels of moderate to vigorous physical activity compared to NWL individuals, while sedentary time was not different.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Chwan-Li Shen, Jannette M. Dufour, Jonathan M. Miranda, Gurvinder Kaur, Eunhee Chung, Latha Ramalingam, Naima Moustaid-Moussa, Jay J. Cao
Summary: This study examined the combined effects of green tea polyphenols and geranylgeraniol on glucose homeostasis and bone remodeling in obese mice. Results showed that green tea polyphenols supplementation improved glucose tolerance in obese mice. However, the combined supplementation of geranylgeraniol and green tea polyphenols compromised the effects on glucose homeostasis and bone remodeling in obese mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kalhara. R. R. Menikdiwela, Chanaka Kahathuduwa, Michelle. L. L. Bolner, Rakhshanda Layeequr Rahman, Naima Moustaid-Moussa
Summary: This study found that Black/African American race and obesity are associated with an increased risk of more aggressive Luminal B breast carcinomas, while postmenopausal status is associated with a decreased risk.
Article
Biochemistry & Molecular Biology
Yujiao Zu, Mandana Pahlavani, Latha Ramalingam, Shasika Jayarathne, Jose Andrade, Shane Scoggin, William T. Festuccia, Nishan S. Kalupahana, Naima Moustaid-Moussa
Summary: Uncoupling protein 1 (UCP1) is a central player in thermogenic tissues, but eicosapentaenoic acid (EPA) can induce thermogenic effects independently of UCP1. In this study, the impact of ambient temperature on EPA-induced thermogenesis in subcutaneous adipose tissue (SAT) was investigated in both wild-type (WT) and UCP1 knockout (KO) male mice. The results showed that the thermogenic effects of EPA occurred in a temperature-dependent manner and were independent of UCP1 in SAT-derived adipocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Tariful Islam, Kembra Albracht-Schulte, Latha Ramalingam, Natalia Schlabritz-Lutsevich, Oak-Hee Park, Masoud Zabet-Moghaddam, Nishan S. Kalupahana, Naima Moustaid-Moussa
Summary: Obesity is linked to nutrient imbalance, gut dysbiosis, and a leaky gut. Polyphenols like curcumin, resveratrol, and anthocyanins can help improve gut microbiota, intestinal barrier integrity, and zinc homeostasis, alleviating the effects of obesity. The review focuses on the role of intestinal barrier integrity in polyphenol-mediated protection against obesity-related inflammation, and how polyphenols interact with inflammatory signaling and zinc homeostasis to reduce inflammation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Green & Sustainable Science & Technology
Abishkar Regmi, Shital Poudyal, Sukhbir Singh, Cade Coldren, Naima Moustaid-Moussa, Catherine Simpson
Summary: Edible flowers are a valuable source of phytochemicals, but the composition of these compounds can be influenced by production practices. The effects of biochar on the phytochemical composition of Viola cornuta flowers were investigated, and it was found that different rates of biochar had varying effects on polyphenol and flavonoid concentrations. Fertilization was found to counteract the negative effects of biochar.
Article
Genetics & Heredity
Shadi Nejat, Kalhara R. Menikdiwela, Aliyah Efotte, Shane Scoggin, Bolormaa Vandanmagsar, Paul J. Thornalley, Mohammed Dehbi, Naima Moustaid-Moussa
Summary: This study confirms the findings in human studies using a mouse model and suggests that DNAJB3 may play a crucial role in metabolic functions and glucose homeostasis.
Article
Oncology
Mohammad Yosofvand, Sonia Y. Khan, Rabin Dhakal, Ali Nejat, Naima Moustaid-Moussa, Rakhshanda Layeequr Rahman, Hanna Moussa
Summary: Tumor-infiltrating lymphocytes play a critical role in cancer immunotherapy, and in this study, an automated method using a two-stage deep learning model was developed to score lymphocytes in breast cancer histopathology slides. The accuracy of the method was verified by comparing results with those from expert pathologists.
Article
Biochemistry & Molecular Biology
Chenchen Bian, Xiangtong Yuan, Caihong Zeng, Jian Sun, Gen Kaneko, Hong Ji
Summary: This study investigated the mechanism of docosahexaenoic acid (DHA)-induced apoptosis mediated by mitophagy, using grass carp as an animal model. The results showed that inhibition of mitophagy alleviated apoptosis and eliminated the inhibition of lipid accumulation induced by DHA. Mechanistically, DHA induced mitophagy by activating the PPAR gamma-LC3-BNIP3 pathway. Inhibition of PPAR gamma decreased autophagy-related gene expression and prevented BNIP3/NIX-mediated mitophagy-induced apoptosis, thereby alleviating the inhibition of lipid accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Venkatesan Ramya, Karuppiah Prakash Shyam, Arulanandu Angelmary, Balamuthu Kadalmani
Summary: This study reveals that Lauric acid (LA) exerts an epigenetic regulation and metabolic reprogramming on SH-SY5Y neuroblastoma cells through modulation of lncRNA HOTAIR, remodeling of chromatin H3K4 tri-methylation and regulation of glucose uptake by controlling NF-kappa B activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
Summary: This study investigates the intricate interplay between angiogenic regulation and the browning of white adipocytes. The findings reveal that concurrent activation of angiogenesis is necessary for inducing browning of white adipocytes. The study also highlights the role of Vascular endothelial growth factor (VEGF) in promoting angiogenesis and triggering the browning process through the activation of Estrogen receptor alpha (ER alpha) signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Zanxia Cao, Liling Zhao, Mingcui Chen, Zhihong Shi, Lei Liu
Summary: This study investigated the translocation process of cholesterol/calcitriol in bacterial membranes and their effects on membrane structure. Calcitriol facilitated water transport across the membrane, while cholesterol had the opposite effect. These findings contribute to a better understanding of the relationship between cholesterol/calcitriol concentrations, lipid bilayer structure, and water permeation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Xiaozhen Guo, Jiawen Wang, Hualing Xu, Yangyang Wang, Yutang Cao, Yingquan Wen, Jiaqi Li, Yameng Liu, Kanglong Wang, Jue Wang, Xianchun Zhong, Chuying Sun, Yongxin Zhang, Jingyi Xu, Cuina Li, Pengxiang Mu, Lingyan Xu, Cen Xie
Summary: This study aims to investigate the role of the gut microbiota-bile acid axis in regulating the diurnal rhythms of metabolic homeostasis and assess the impact of obesity on them. The results show that high fat diet feeding and Leptin gene deficiency disrupt the rhythmic patterns of insulin sensitivity and serum total cholesterol levels. The study provides compelling evidence for the association between diurnal rhythm of insulin sensitivity and gut microbiota-bile acid axis, and elucidates the deleterious effects of obesity on gut microbiome-bile acid metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Maria Cotugno, Federico Marracino, Luca Capocci, Ludovica Pizzati, Maurizio Forte, Rosita Stanzione, Pamela Scarselli, Alba Di Pardo, Sebastiano Sciarretta, Massimo Volpe, Speranza Rubattu, Vittorio Maglione
Summary: The study found that enzymes involved in sphingolipid metabolism show abnormal expression in the cardiac tissue of hypertensive rat models, which may be related to the susceptibility to cardiac damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)