期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1841, 期 7, 页码 1003-1011出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2014.04.004
关键词
Aging; Cardiolipin; Fatty acid; Mitochondrion; Danio rerio; Oxidative stress
资金
- Marie Curie Intra-European Fellowship within the 7th Community Framework Programme (OLDMITO) [PIEF-GA-2011-297964]
- Instituto de Salud Carlos III (RETICEF) [RD12/0043/0011]
- Fundacion Seneca [12005/PI/09]
Considering membranes and membrane components as possible pacemakers of the main processes taking place inside mitochondria, changes in phospholipids or fatty acids could play a central role linking different mechanisms involved in cumulative damage to cell molecules and dysfunction during periods of high stress, such as rapid growth and aging. Changes affecting either lipid class or fatty acid compositions could affect phospholipid and membrane properties and alter mitochondrial function and cell viability. In the present study, mitochondrial oxidative status and mitochondrial membrane phospholipid compositions were analyzed throughout the lifecycle of zebrafish. TBARS content significantly increased in 18-month-old fish while aconitase activity decreased in 24-month-old fish, which have been related with oxidative damage to molecules. Mitochondria-specific superoxide dismutase decreased in 24-month-old animals although this change was not statistically significant. Age affected both mitochondrial phospholipid content and the peroxidation index of most phospholipid classes suggesting that oxidative damage to mitochondrial lipids was occurring. (C) 2014 Elsevier B.V. All rights reserved.
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