Formation and functions of the corneocyte lipid envelope (CLE)

Corneocytes in mammalian stratum corneum are surrounded by a monolayer of covalently bound omega-OH-ceramides that form the corneocyte (-bound) lipid envelope (CLE). We review here the structure, composition, and possible functions of this structure, with insights provided by inherited and acquired disorders of lipid metabolism. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias. (C) 2013 Elsevier B.V. All rights reserved.