Article
Virology
Yifei Yang, Jijing Tian, Haijing Zhang, Meng Ma, Han Li, Tianlong Liu, Yue Yang, Ting Liu, Ruiping She
Summary: This study investigated mitochondrial function and mitophagy-related mRNA transcripts and protein expression in an HEV-infected Mongolian gerbil model. The results indicated that HEV infection induced mitochondrial dysfunction and the activation of the mitophagy pathway, potentially playing a key role in liver cell injury.
Article
Biochemistry & Molecular Biology
Spiro Khoury, Antoine Beauvais, Jenny Colas, Anais Saint-Martin Willer, Frederic Perros, Marc Humbert, Clarisse Vandebrouck, David Montani, Thierry Ferreira, Fabrice Antigny
Summary: Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary arterial hypertension (PAH) characterized by remodeling of the pulmonary venous system and venous obstruction. There is currently no effective medical therapy for PVOD and lung transplantation is the only available treatment option. Recent research suggests that PVOD patients exhibit lung lipointoxication, potentially playing a role in the development of the disease.
Article
Medicine, Research & Experimental
Lin Zhu, Jianfeng Huang, Yi Wang, Zaiqing Yang, Xiaodong Chen
Summary: The study revealed the important role of chemerin in hepatic lipid metabolism, with its effects on lipid synthesis being mediated through GPR1. Free fatty acids and insulin were found to inhibit chemerin expression, while the key lipogenic transcription factor SREBP1c suppressed chemerin mRNA expression.
Review
Pharmacology & Pharmacy
Haripriya Kuchi Bhotla, Arun Meyyazhagan, Manikantan Pappusamy, Sungkwon Park, Vijaya Anand Arumugam, Karthika Pushparaj, Kannan Rr Rengasamy, Wenchao Liu, Balamuralikrishnan Balasubramanian
Summary: Electron exchange through redox reactions in cells plays a crucial role in cellular processes, cell growth, and disease development. Understanding redox dynamics can offer opportunities for early diagnosis and personalized therapy, highlighting the importance of natural antioxidants in diet.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Bijun Wen, James M. Njunge, Celine Bourdon, Gerard Bryan Gonzales, Bonface M. Gichuki, Dorothy Lee, David S. Wishart, Moses Ngari, Emmanuel Chimwezi, Johnstone Thitiri, Laura Mwalekwa, Wieger Voskuijl, James A. Berkley, Robert H. J. Bandsma
Summary: Blood metabolomic and proteomic profiles can differentiate between children with severe malnutrition who survive and those who die. The profiles of children who died show increased metabolic substrates, microbial metabolites, acute phase proteins, and inflammatory markers, indicating disruptions in bioenergetic pathways and sepsis-like responses.
Article
Medicine, Research & Experimental
Lanlan Zhang, Jianlong Wu, Ziguan Zhu, Yuchen He, Renpeng Fang
Summary: Aging is a natural process characterized by physical decline and increased vulnerability to death. Despite efforts to understand and delay aging, limited progress has been made in the field of anti-aging. Recent studies have focused on the role of mitochondrial dysfunction in aging and related degenerative diseases, suggesting that restoring mitochondrial function can promote healthy aging. This paper provides an overview of mitochondrial changes during aging and summarizes advanced studies on mitochondrial therapies for degenerative diseases, offering novel directions for future research.
Article
Cell Biology
Johannes F. Fahrmann, Neeraj Y. Saini, Chang Chia-Chi, Ehsan Irajizad, Paolo Strati, Ranjit Nair, Luis E. Fayad, Sairah Ahmed, Hun Ju Lee, Swaminathan Iyer, Raphael Steiner, Jody Vykoukal, Ranran Wu, Jennifer B. Dennison, Loretta Nastoupil, Preetesh Jain, Michael Wang, Michael Green, Jason Westin, Viktoria Blumenberg, Marco Davila, Richard Champlin, Elizabeth J. Shpall, Partow Kebriaei, Christopher R. Flowers, Michael Jain, Robert Jenq, Christoph K. Stein-Thoeringer, Marion Subklewe, Sattva S. Neelapu, Sam Hanash
Summary: This study found that an MYC-driven polyamine signature can be used as a liquid biopsy to predict the response to anti-CD19 CAR-T therapy in patients with relapsed or refractory large B cell lymphoma. Elevated levels of acetylated polyamines in plasma were associated with non-durable response, while increased expression of spermidine synthase was prognostic for survival. A 6-marker panel consisting of acetylspermidine, diacetylspermidine, and lysophospholipids was validated as predictive of non-durable response in an independent set of patients. A polyamine centric metabolomics liquid biopsy panel has predictive value for response to CAR-T therapy in relapsed or refractory large B cell lymphoma.
CELL REPORTS MEDICINE
(2022)
Article
Cell Biology
Soi Jeong, Bora Kim, Da Jeong Byun, Sunmin Jin, Bo Seung Seo, Mi Hwa Shin, Ah Young Leem, Jai Jun Choung, Moo Suk Park, Young-Min Hyun
Summary: This study assessed the effectiveness of lysophosphatidylcholine (LPC) as a treatment for acute lung inflammation caused by sepsis. The researchers found that LPC can alleviate inflammation and reduce the infiltration of neutrophils into the lungs, leading to improved lung function. These findings provide evidence for the potential therapeutic application of LPC treatment for sepsis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Xiaojuan Du, Qian Chen, Xiaofei Yan, Dan Gao, Litao Wu, Jiajun Ren, Lina Feng, Nan Wu, Kaikai Lu, Xudong Yang, Bo Zhong, Yan Han, Fujun Zhang, Dongmin Li, Xi Lan, Shemin Lu, Ezra Kombo Osoro
Summary: This study found that the abundance of PDCD4 under high-fat conditions facilitates hepatocellular lipid accumulation by decreasing PPAR alpha-dependent fatty acid peroxisomal beta-oxidation.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alexander Blagov, Elena B. Zhigmitova, Margarita A. Sazonova, Liudmila M. Mikhaleva, Vladislav Kalmykov, Nikolay K. Shakhpazyan, Varvara A. Orekhova, Alexander N. Orekhov
Summary: Crohn's disease is a challenging problem in modern medicine, and understanding its molecular and cellular pathologic processes is crucial for the development of new and safer therapies. Recent research has shown the involvement of mitochondrial dysfunction and chronic inflammation in these processes. This review discusses published works on pathogenetic models of Crohn's disease, which provides insights into the role of mitochondrial dysfunction in the disease's development and advances the development of novel therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Misato Fukaya, Yoriko Sato, Shinji Kondo, Shin-ichi Adachi, Fumiaki Yoshizawa, Yusuke Sato
Summary: This study demonstrates that quercetin enhances energy metabolism in hepatocytes by promoting lipophagy, leading to increased fatty acid beta-oxidation. Additionally, quercetin can activate AMPK signaling to regulate autophagy even under nutrient-sufficient conditions.
Article
Marine & Freshwater Biology
Jianqing Chen, Dechun Chen, Jingxin Li, Yuanlong Liu, Xianhong Gu, Xiaohua Teng
Summary: Cadmium-induced damage in carp gills is associated with apoptosis, mainly involving oxidative stress, immunosuppression, and apoptosis-related genes. Cadmium exposure resulted in cadmium accumulation and apoptotic injury caused by mitochondrion, along with oxidative stress and immunosuppression mediated through the JNK-FoxO3a-PUMA pathway.
AQUATIC TOXICOLOGY
(2021)
Article
Rheumatology
Salem Werdyani, Ming Liu, Hongwei Zhang, Guang Sun, Andrew Furey, Edward W. Randell, Proton Rahman, Guangju Zhai
Summary: This study identified three potential clinically actionable endotypes in primary osteoarthritis (OA): muscle weakness, arginine deficit, and low inflammatory OA. These endotypes were associated with specific metabolite concentrations and clinical characteristics such as BMI and prevalence of certain diseases.
Article
Multidisciplinary Sciences
Yan-Zhuo Yang, Xin-Yuan Liu, Jiao-Jiao Tang, Yong Wang, Chunhui Xu, Bao-Cai Tan
Summary: The GLUTAMINE-RICH PROTEIN23 (GRP23) plays an essential role in mitochondrial RNA editing by interacting with MORF proteins and atypical DYW-type PPR proteins. GRP23 is targeted to mitochondria, plastids, and nuclei. The interactions between GRP23, MORF proteins, and PPR-DYW proteins increase the stability of the editing complex and facilitate the formation of the editosome.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Surgery
Jiang Liu, Li Pang, Kevin T. P. Ng, T. L. Shirley Chiu, Hui Liu, Xiaobing Liu, Aimin Xu, Chung-Mau Lo, Kwan Man
Summary: This study investigated the association of graft steatosis with long-term outcome in adult living donor liver transplantation (LDLT) and elucidated the mechanism of steatotic graft injury. The findings indicated that graft with >10% steatosis was an independent risk factor for long-term graft loss after LDLT, and was associated with shorter cancer recurrence-free survival and acute phase liver injury. The study also revealed distinct mitochondrial dysfunction in steatotic graft and identified AMPK-PGC1 alpha axis as a mechanism that exacerbates graft injury by dysregulating mitochondrial homeostasis through impairment of biogenesis.
Article
Physiology
Clara Cooper-Mullin, Ana Gabriela Jimenez, Nicholas B. Anthony, Matthew Wortman, Joseph B. Williams
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2015)
Article
Multidisciplinary Sciences
Ana Gabriela Jimenez, James Van Brocklyn, Matthew Wortman, Joseph B. Williams
Article
Multidisciplinary Sciences
Xun Shang, Fillipo Marchioni, Chris R. Evelyn, Nisha Sipes, Xuan Zhou, William Seibel, Matthew Wortman, Yi Zheng
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Multidisciplinary Sciences
Xiaona Liu, Rishi Raj Chhipa, Shabnam Pooya, Matthew Wortman, Sara Yachyshin, Lionel M. L. Chow, Ashish Kumar, Xuan Zhou, Ying Sun, Brian Quinn, Christopher McPherson, Ronald E. Warnick, Ady Kendlerf, Shailendra Giri, Jeroen Poels, Koenraad Norga, Benoit Viollet, Gregory A. Grabowski, Biplab Dasgupta
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Multidisciplinary Sciences
Agnes Dodacki, Matthew Wortman, Bruno Saubamea, Stephanie Chasseigneaux, Sophie Nicolic, Nathalie Prince, Murielle Lochus, Anne-Laure Raveu, Xavier Decleves, Jean-Michel Scherrmann, Shailendra B. Patel, Fanchon Bourasset
SCIENTIFIC REPORTS
(2017)
Meeting Abstract
Biochemistry & Molecular Biology
Terence L. Kirley, William L. Seibel, Matthew D. Wortman
PURINERGIC SIGNALLING
(2014)
Meeting Abstract
Endocrinology & Metabolism
Dana C. Borcherding, Eric M. Jacobson, Eric R. Hugo, Matthew D. Wortman, William L. Seibel, Chris R. Evelyn, Nira Ben-Jonathan
Article
Biochemical Research Methods
Jennifer N. Cash, Elizabeth B. Angerman, R. Jason Kirby, Lisa Merck, William L. Seibel, Matthew D. Wortman, Ruben Papoian, Sandra Nelson, Thomas B. Thompson
JOURNAL OF BIOMOLECULAR SCREENING
(2013)
Correction
Pharmacology & Pharmacy
Z. Tan, M. Wortman, K. L. Dillehay, W. L. Seibel, C. R. Evelyn, S. J. Smith, L. H. Malkas, Y. Zheng, S. Lu, Z. Dong
MOLECULAR PHARMACOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Chenchen Bian, Xiangtong Yuan, Caihong Zeng, Jian Sun, Gen Kaneko, Hong Ji
Summary: This study investigated the mechanism of docosahexaenoic acid (DHA)-induced apoptosis mediated by mitophagy, using grass carp as an animal model. The results showed that inhibition of mitophagy alleviated apoptosis and eliminated the inhibition of lipid accumulation induced by DHA. Mechanistically, DHA induced mitophagy by activating the PPAR gamma-LC3-BNIP3 pathway. Inhibition of PPAR gamma decreased autophagy-related gene expression and prevented BNIP3/NIX-mediated mitophagy-induced apoptosis, thereby alleviating the inhibition of lipid accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Venkatesan Ramya, Karuppiah Prakash Shyam, Arulanandu Angelmary, Balamuthu Kadalmani
Summary: This study reveals that Lauric acid (LA) exerts an epigenetic regulation and metabolic reprogramming on SH-SY5Y neuroblastoma cells through modulation of lncRNA HOTAIR, remodeling of chromatin H3K4 tri-methylation and regulation of glucose uptake by controlling NF-kappa B activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
Summary: This study investigates the intricate interplay between angiogenic regulation and the browning of white adipocytes. The findings reveal that concurrent activation of angiogenesis is necessary for inducing browning of white adipocytes. The study also highlights the role of Vascular endothelial growth factor (VEGF) in promoting angiogenesis and triggering the browning process through the activation of Estrogen receptor alpha (ER alpha) signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Zanxia Cao, Liling Zhao, Mingcui Chen, Zhihong Shi, Lei Liu
Summary: This study investigated the translocation process of cholesterol/calcitriol in bacterial membranes and their effects on membrane structure. Calcitriol facilitated water transport across the membrane, while cholesterol had the opposite effect. These findings contribute to a better understanding of the relationship between cholesterol/calcitriol concentrations, lipid bilayer structure, and water permeation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Xiaozhen Guo, Jiawen Wang, Hualing Xu, Yangyang Wang, Yutang Cao, Yingquan Wen, Jiaqi Li, Yameng Liu, Kanglong Wang, Jue Wang, Xianchun Zhong, Chuying Sun, Yongxin Zhang, Jingyi Xu, Cuina Li, Pengxiang Mu, Lingyan Xu, Cen Xie
Summary: This study aims to investigate the role of the gut microbiota-bile acid axis in regulating the diurnal rhythms of metabolic homeostasis and assess the impact of obesity on them. The results show that high fat diet feeding and Leptin gene deficiency disrupt the rhythmic patterns of insulin sensitivity and serum total cholesterol levels. The study provides compelling evidence for the association between diurnal rhythm of insulin sensitivity and gut microbiota-bile acid axis, and elucidates the deleterious effects of obesity on gut microbiome-bile acid metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Maria Cotugno, Federico Marracino, Luca Capocci, Ludovica Pizzati, Maurizio Forte, Rosita Stanzione, Pamela Scarselli, Alba Di Pardo, Sebastiano Sciarretta, Massimo Volpe, Speranza Rubattu, Vittorio Maglione
Summary: The study found that enzymes involved in sphingolipid metabolism show abnormal expression in the cardiac tissue of hypertensive rat models, which may be related to the susceptibility to cardiac damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)