期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1831, 期 10, 页码 1542-1554出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2013.03.001
关键词
Metabolism; Lipid; Apoptosis; BCL-2 protein; Mitochondrion
资金
- Lilly Fellowship
- Searle Scholar Award
- Burroughs Wellcome Fund Career Award in the Biomedical Sciences
Apoptosis is an intricately regulated process required for the health and homeostasis of living systems. The mitochondrial apoptotic pathway depends on the BCL-2 family of pro- and anti-apoptotic members whose interactions form a complex network of checks and balances in regulating cell fate. A diverse set of signals recruits distinct BH3-domain only BCL-2 proteins to trigger activation of the executioner proteins BAX and BAK. In addition to protein components of the apoptotic machinery, literature of the past several decades supports crucial functions for lipids in apoptosis and cooperation between lipid metabolism and BCL-2 proteins. In this review we present the two key examples of ceramide and cardiolipin in apoptosis, focusing particularly on BCL-2 family-regulated pathways at the mitochondrial level. This article is part of a Special Issue entitled Lipid Metabolism in Cancer. (C) 2013 Elsevier B.V. All rights reserved.
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