Article
Cell Biology
Yangchun Hu, Chao Li, Xiaojian Wang, Weiwei Chen, Yu Qian, Xingliang Dai
Summary: Increasing evidence suggests that TREM2 plays an important role in the pathophysiology of neuroinflammation. Knockdown of TREM2 aggravated pro-inflammatory responses and microglial activities after SAH, leading to worsened neurological dysfunction. TLR4 knockout increased TREM2 expression, resulting in improved neuroinflammation and neurological function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yangchun Hu, Chao Li, Xiaojian Wang, Weiwei Chen, Yu Qian, Xingliang Dai
Summary: Increasing evidence implicates TREM2 in neuroinflammation, particularly in the context of SAH. Knockdown of TREM2 exacerbates inflammation and microglial dysfunction after SAH, while TLR4 knockout increases TREM2 expression and improves neuroinflammation and function. These findings suggest that targeting TREM2 pharmacologically may be a promising therapeutic approach for SAH.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xia Zhao, Xiaosu Huang, Chao Yang, Yizhou Jiang, Wenshu Zhou, Wenhua Zheng
Summary: The abnormal immune response in Alzheimer's disease can be improved by regulating microglial activation and neuroinflammation using Artemisinin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Lijin Song, Qinghua Sun, Haonan Zheng, Yiming Zhang, Yujing Wang, Shuangjiang Liu, Liping Duan
Summary: The potential probiotic Roseburia hominis shows anti-neuroinflammatory effects by inhibiting microglial activation and reducing proinflammatory cytokines in the brain. Treatment with propionate or butyrate also leads to decreased neuroinflammation. This study suggests that R. hominis could be a potential psychoprobiotic to reduce neuroinflammation.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Immunology
Xiao-Long Wang, Fei Chen, Hui Shi, Man Zhang, Lin Yan, Xiu-Ying Pei, Xiao-Dong Peng
Summary: The study revealed that OMT can regulate the polarization of microglia towards the M2 phenotype by inhibiting the TLR4/NF-Kappa B signaling pathway, effectively attenuating the LPS-induced inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Neurosciences
Yunchang Mo, Lu Wang, Miao Ren, Wenjing Xie, Xiaoxiao Ye, Bingbing Zhou, Anqi Zhang, Qinxue Dai, Junlu Wang
Summary: The study suggests that electroacupuncture may reduce neuroinflammation responses, decrease inflammatory factors, and protect patients with SAE by increasing the formation of PICK1-TLR4 complexes.
BRAIN RESEARCH BULLETIN
(2021)
Article
Chemistry, Multidisciplinary
Tsogzolmaa Ganbold, Qingming Bao, Hai Xiao, Dolgorsuren Zurgaanjin, Caifeng Liu, Shuqin Han, Agula Hasi, Huricha Baigude
Summary: This study reports a novel lipid-nanoparticle-mediated delivery system for targeting TLR4 with siRNA, which successfully silences TLR4 in microglia and alleviates neuroinflammation. In a mouse model of ischemic stroke, this technique demonstrates significant neuroprotection.
Article
Neurosciences
Maria del Mar Fernandez-Arjona, Ana Leon-Rodriguez, Jesus M. Grondona, Maria Dolores Lopez-Avalos
Summary: Innate immune memory explains the plasticity of immune responses after repeated immune stimulation. Our research demonstrates the existence of immune training in the brain, which lasts at least 3 months and is largely dependent on TLR4 receptor.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Yichao Hou, Xingqi Li, Chang Liu, Ming Zhang, Xiaoying Zhang, Shaoyang Ge, Liang Zhao
Summary: The study found that sodium butyrate has the most effective alleviation of motor disorder in PD mice and can inhibit neuroinflammation, reducing neurological damage in PD.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Immunology
Lu Wang, Feihong Lin, Miao Ren, Xia Liu, Wenjing Xie, Anqi Zhang, Meizi Qian, Yunchang Mo, Junlu Wang, Ya Lv
Summary: The study revealed that while the expression levels of PICK1 protein did not significantly change in sepsis-associated encephalopathy, its deficiency led to excessive activation of microglia and the TLR4 pathways, worsening the condition. Additionally, PICK1 was observed to form a complex with TLR4 in microglial cells, providing brain protection. These findings contribute to understanding PICK1's important role in sepsis and may offer novel therapeutic targets for treating sepsis-associated encephalopathy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Jian Hu, Xue Wang, Xiongjian Chen, Yani Fang, Kun Chen, Wenshuo Peng, Zhengyi Wang, Kaiming Guo, Xianxi Tan, Fei Liang, Li Lin, Ye Xiong
Summary: The study found that hydroxychloroquine (HCQ) can improve neurological recovery in mice post-TBI by inhibiting the inflammatory response through the TLR4/NF-kappa B signaling pathway. HCQ reduces the expression of proinflammatory cytokines, attenuates blood-brain barrier (BBB) disruption and brain edema, and upregulates tight junction expression. This suggests that HCQ could be a potential therapeutic agent for TBI treatment.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Yao Wang, Dilinuer Sadike, Bo Huang, Ping Li, Qiao Wu, Na Jiang, Yongkang Fang, Guini Song, Li Xu, Wei Wang, Minjie Xie
Summary: Regulatory T cells alleviate myelin loss and improve cognitive function by inhibiting pyroptosis in microglia in LPC-induced demyelination via the TLR4/MyD88/NF-kappa B pathway.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
Lu Luo, Meixi Liu, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Hongyu Xie, Congyu Jiang, Junfa Wu, Xiao Xiao, Yi Wu
Summary: The study revealed that repetitive transcranial magnetic stimulation (rTMS) can alleviate ischemia/reperfusion (I/R) injury-induced motor deficits and neuronal pyroptosis by modulating microglial polarization, providing novel insights into the mechanisms of rTMS in protecting against cerebral I/R injury and potential targets underlying neuronal pyroptosis in the early phase of stroke.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Chemistry, Medicinal
Waimei Si, Xin Li, Bei Jing, Shiquan Chang, Yachun Zheng, Zhenni Chen, Guoping Zhao, Di Zhang
Summary: This study investigates the potential therapeutic use of stigmasterol for treating neuropathic pain. It finds that stigmasterol can regulate microglial M1/M2 polarization to alleviate neuropathic pain. The research demonstrates the modulatory effects of stigmasterol on pain-related markers and inflammatory factors in animal and cell experiments.
PHYTOTHERAPY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Leo Victor G. Castro, Cassiano F. Goncalves-de-Albuquerque, Adriana R. Silva
Summary: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. One of the most affected regions is the central nervous system (CNS), where neurons are exposed to oxidative stress, leading to dysfunction and apoptosis. Sepsis-associated encephalopathy (SAE) is a common type of organ dysfunction that has limited treatment options. Microglia polarization, with a focus on peroxisome proliferator-activated receptor gamma (PPAR gamma), holds potential for therapeutic intervention in sepsis-related neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jin A. Shin, Sae Im Jeong, Minsuk Kim, Joo Chun Yoon, Hee-Sun Kim, Eun-Mi Park
BRAIN BEHAVIOR AND IMMUNITY
(2015)
Article
Immunology
Eun-Jung Lee, Hyun-Myung Ko, Yeon-Hui Jeong, Eun-Mi Park, Hee-Sun Kim
JOURNAL OF NEUROINFLAMMATION
(2015)
Article
Physics, Multidisciplinary
Soo Mee Lim, Eun Mi Park, In Kyoon Lyoo, Junghyun Lee, Bo Mi Han, Jeong Kyong Lee, Su Bin Lee
JOURNAL OF THE KOREAN PHYSICAL SOCIETY
(2015)
Article
Geriatrics & Gerontology
Jin A. Shin, Seikwan Oh, Jung-Hyuck Ahn, Eun-Mi Park
NEUROBIOLOGY OF AGING
(2015)
Article
Biochemistry & Molecular Biology
Jin A. Shin, Joo Chun Yoon, Minsuk Kim, Eun-Mi Park
FREE RADICAL BIOLOGY AND MEDICINE
(2016)
Article
Geriatrics & Gerontology
Sae Im Jeong, Jin A. Shin, Sunghee Cho, Hye Won Kim, Ji Yoon Lee, Jihee Lee Kang, Eun-Mi Park
NEUROBIOLOGY OF AGING
(2016)
Article
Multidisciplinary Sciences
Si-Yoon Kim, Eun-Jin Lim, Young-So Yoon, Young-Ho Ahn, Eun-Mi Park, Hee-Sun Kim, Jihee Lee Kang
SCIENTIFIC REPORTS
(2016)
Article
Geriatrics & Gerontology
Jin A. Shin, Sae Im Jeong, Hye Won Kim, Gyeonghui Jang, Dong-Ryeol Ryu, Young-Ho Ahn, Ji Ha Choi, Youn-Hee Choi, Eun-Mi Park
NEUROBIOLOGY OF AGING
(2018)
Article
Neurosciences
Jin A. Shin, Yul A. Kim, Hye Won Kim, Hee-Sun Kim, Kyung-Eun Lee, Jihee Lee Kang, Eun-Mi Park
Article
Immunology
Jin A. Shin, Soo Mee Lim, Sae Im Jeong, Jihee Lee Kang, Eun-Mi Park
BRAIN BEHAVIOR AND IMMUNITY
(2014)
Article
Anatomy & Morphology
Jin A. Shin, Yul A. Kim, Sae Im Jeong, Kyung-Eun Lee, Hee-Sun Kim, Eun-Mi Park
BRAIN STRUCTURE & FUNCTION
(2015)
Article
Immunology
Eun-Jung Lee, Jeong Eun Han, Moon-Sook Woo, Jin A. Shin, Eun-Mi Park, Jihee Lee Kang, Pyong Gon Moon, Moon-Chang Baek, Woo-Sung Son, Young Tag Ko, Ji Woong Choi, Hee-Sun Kim
JOURNAL OF IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Ara Jo, Hyunju Park, Sung-Hee Lee, So-Hee Ahn, Hee Ja Kim, Eun-Mi Park, Youn-Hee Choi
Article
Geriatrics & Gerontology
Jin A. Shin, Hee-Sun Kim, Jihee Lee Kang, Eun-Mi Park
NEUROBIOLOGY OF AGING
(2020)
Article
Pharmacology & Pharmacy
Ye-Ji Lee, Hyun-Jung Park, So-Youn Woo, Eun-Mi Park, Jihee Lee Kang
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2014)
Article
Biochemistry & Molecular Biology
Chenchen Bian, Xiangtong Yuan, Caihong Zeng, Jian Sun, Gen Kaneko, Hong Ji
Summary: This study investigated the mechanism of docosahexaenoic acid (DHA)-induced apoptosis mediated by mitophagy, using grass carp as an animal model. The results showed that inhibition of mitophagy alleviated apoptosis and eliminated the inhibition of lipid accumulation induced by DHA. Mechanistically, DHA induced mitophagy by activating the PPAR gamma-LC3-BNIP3 pathway. Inhibition of PPAR gamma decreased autophagy-related gene expression and prevented BNIP3/NIX-mediated mitophagy-induced apoptosis, thereby alleviating the inhibition of lipid accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Venkatesan Ramya, Karuppiah Prakash Shyam, Arulanandu Angelmary, Balamuthu Kadalmani
Summary: This study reveals that Lauric acid (LA) exerts an epigenetic regulation and metabolic reprogramming on SH-SY5Y neuroblastoma cells through modulation of lncRNA HOTAIR, remodeling of chromatin H3K4 tri-methylation and regulation of glucose uptake by controlling NF-kappa B activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
Summary: This study investigates the intricate interplay between angiogenic regulation and the browning of white adipocytes. The findings reveal that concurrent activation of angiogenesis is necessary for inducing browning of white adipocytes. The study also highlights the role of Vascular endothelial growth factor (VEGF) in promoting angiogenesis and triggering the browning process through the activation of Estrogen receptor alpha (ER alpha) signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Zanxia Cao, Liling Zhao, Mingcui Chen, Zhihong Shi, Lei Liu
Summary: This study investigated the translocation process of cholesterol/calcitriol in bacterial membranes and their effects on membrane structure. Calcitriol facilitated water transport across the membrane, while cholesterol had the opposite effect. These findings contribute to a better understanding of the relationship between cholesterol/calcitriol concentrations, lipid bilayer structure, and water permeation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Xiaozhen Guo, Jiawen Wang, Hualing Xu, Yangyang Wang, Yutang Cao, Yingquan Wen, Jiaqi Li, Yameng Liu, Kanglong Wang, Jue Wang, Xianchun Zhong, Chuying Sun, Yongxin Zhang, Jingyi Xu, Cuina Li, Pengxiang Mu, Lingyan Xu, Cen Xie
Summary: This study aims to investigate the role of the gut microbiota-bile acid axis in regulating the diurnal rhythms of metabolic homeostasis and assess the impact of obesity on them. The results show that high fat diet feeding and Leptin gene deficiency disrupt the rhythmic patterns of insulin sensitivity and serum total cholesterol levels. The study provides compelling evidence for the association between diurnal rhythm of insulin sensitivity and gut microbiota-bile acid axis, and elucidates the deleterious effects of obesity on gut microbiome-bile acid metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Maria Cotugno, Federico Marracino, Luca Capocci, Ludovica Pizzati, Maurizio Forte, Rosita Stanzione, Pamela Scarselli, Alba Di Pardo, Sebastiano Sciarretta, Massimo Volpe, Speranza Rubattu, Vittorio Maglione
Summary: The study found that enzymes involved in sphingolipid metabolism show abnormal expression in the cardiac tissue of hypertensive rat models, which may be related to the susceptibility to cardiac damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)