Article
Food Science & Technology
Jaeeun Jung, Jeongjin Park, Minhee Lee, Jinhak Kim, Dongchan Oh, Woojin Jun, Ok-Kyung Kim, Jeongmin Lee
Summary: In this study, the potential anti-obesity effects of Salacia reticulata extracts (SC) were explored in obese mice and 3T3-L1 adipocytes, revealing that SC supplementation led to significant reductions in body weight gain, adipose tissue weight, adipose tissue mass, and adipocyte size. SC treatment also exerted inhibitory effects on adipogenesis and lipogenesis, while promoting lipolysis and thermogenesis pathways. These findings suggest that SC has a direct influence on lipid metabolism of adipocytes, making it a promising candidate for weight loss interventions.
Article
Pharmacology & Pharmacy
Hye-Young Joung, Jung-Mi Oh, Min-Suk Song, Young-Bae Kwon, Sungkun Chun
Summary: Obesity is a serious health problem associated with various chronic diseases. Increased MAO activity has been found in the adipose tissue of obese individuals. In this study, the anti-obesity effect of selegiline, a selective MAO-B inhibitor, was investigated using animal models. The results showed that selegiline reduced body weight and fat accumulation, improved glucose metabolism, and increased energy expenditure by promoting browning of white adipose tissue. These findings suggest that selegiline has the potential to be an anti-obesity treatment by inhibiting MAO-B activity.
Article
Food Science & Technology
Tengteng Ji, Bing Fang, Ming Zhang, Yaqiong Liu
Summary: Succinate supplementation can reduce fat deposition and adipocyte size, enhance lipolysis in adipose tissue, and increase the activity of brown adipose tissue in obese mice.
Article
Food Science & Technology
Seong-Hoo Park, Jeongjin Park, Minhee Lee, Jinhak Kim, Sangwon Eun, Woojin Jun, Ok-Kyung Kim, Jeongmin Lee
Summary: This study aimed to investigate the antiobesity effects of Kaempferia parviflora extracts (PF) in high-fat diet-induced obese mice and 3T3-L1 adipocytes, and to demonstrate the lipid mechanisms underlying these effects. The results showed that PF supplementation significantly reduced body weight gain, adipose tissue weight, adipose tissue mass, and size of adipocytes in HFD-fed mice. Furthermore, PF supplementation suppressed adipogenesis and lipogenesis pathways, while activating lipolysis and thermogenesis pathways in the adipose tissues of HFD-fed mice. Therefore, PF is suggested to be effective for weight loss by directly affecting the lipid metabolism of adipocytes.
FOOD & NUTRITION RESEARCH
(2023)
Article
Food Science & Technology
Jeong Moon Yun, Jaeeun Jung, Seong-Hoo Park, Young Ha Seo, Jae Kyoung Lee, Mun Hyoung Bae, Sangwon Eun, Ok-Kyung Kim, Jeongmin Lee
Summary: The study found that the extract from sunflower seed (SUNCA) can prevent obesity in high-fat diet-induced obese mice by suppressing the adipogenesis/lipogenesis pathway and stimulating the lipolysis/thermogenesis pathway.
FOOD & NUTRITION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Soo-Jeung Park, Minhee Lee, Ki-Young Kim, Su Shin, Min-Woo Choi, Eun-Jin Hong, Jeongmin Lee
Summary: This study investigated the anti-obesity effect of the Trapa japonica Flerov extract (TJ) in differentiated 3T3-L1 adipocytes. The results showed that TJ reduced lipid accumulation by promoting lipolysis and inhibiting adipogenesis and lipogenesis. The component ellagic acid in TJ might contribute to its effectiveness.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Hyo-Shim Han, Ilavenil Soundharrajan, Mariadhas Valan Arasu, Dahye Kim, Ki-Choon Choi
Summary: This study investigated the effects of Leuconostoc citreum (LSC) cell-free metabolites on adipogenesis, lipogenesis, and lipolysis in 3T3-L1 adipocytes. The results showed that LSC treatment reduced lipid droplet accumulation and the expression of key adipogenic and lipogenic markers while increasing lipolysis. Additionally, LSC treatment elevated adiponectin levels, suggesting its potential as a novel probiotic strain for treating obesity and metabolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sung Ho Lee, Jong Min Choi, Sung Yun Jung, Aaron R. Cox, Sean M. Hartig, David D. Moore, Kang Ho Kim
Summary: Bile acids have been found to play a crucial role as metabolic hormones in various metabolic diseases, with ORM identified as a key hepatokine that regulates liver-adipose tissue crosstalk. Hepatic ORM suppresses adipocyte differentiation by inhibiting the expression of adipogenic transcription factors, potentially contributing to the anti-obesity effects of bile acids.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Yu Wang, Verina H. Leung, Yunxiao Zhang, Victoria S. Nudell, Meaghan Loud, M. Rocio Servin-Vences, Dong Yang, Kristina Wang, Maria Dolores Moya-Garzon, Veronica L. Li, Jonathan Z. Long, Ardem Patapoutian, Li Ye
Summary: Adipose tissues are regulated by sensory neurons from the dorsal root ganglia, which modulate adipocyte function and energy metabolism through their communication with the central nervous system.
Review
Cardiac & Cardiovascular Systems
Iyad H. Manaserh, Kamila M. Bledzka, Isaac Ampong, Alex Junker, Jessica Grondolsky, Sarah M. Schumacher
Summary: Obesity and metabolic disorders are on the rise, negatively impacting heart health. Previous studies have shown that cardiac expression of the peptide 8ARKnt can improve metabolic function. However, the role of sex differences in cardiac and metabolic responses to these disorders is still not well understood.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qianfen Wan, Carmen Calhoun, Tarik Zahr, Li Qiang
Summary: Obesity is caused by the expansion of adipose tissue, which regulates energy balance, adipokine secretion, thermogenesis, and inflammation. Adipocytes are traditionally believed to store lipids through lipid synthesis, but they can still function and respond to nutrients even when depleted of lipid droplets. This raises the question of whether lipid synthesis and storage can be separated from adipocyte development and function.
Article
Biochemistry & Molecular Biology
Jie Cai, Gu Qiong, Chanjuan Li, Lulu Sun, Yuhong Luo, Shengheng Yuan, Frank J. Gonzalez, Jun Xu
Summary: MNSB isolated from Saururus chinensis has been identified as a potent inhibitor of adipogenesis/lipogenesis by increasing phosphorylation of AMPK. In animal studies, MNSB showed preventive and therapeutic effects on obesity, along with decreasing adipocyte size. Additionally, MNSB was found to increase AMPK phosphorylation in subcutaneous white adipose tissue and brown adipose tissue in vivo.
Article
Pharmacology & Pharmacy
Gangadharan Leela Shyni, Kaithathara Francis Sajin, Sivasankaran Nair Mangalam, Kozhiparambil Gopalan Raghu
Summary: TM from Myristica fragrans has shown anti-obesity effects in 3T3-L1 adipocytes by reducing lipid accumulation, promoting lipolysis, and regulating genes and proteins involved in lipid metabolism. It also enhances glucose uptake and increases carnitine palmitoyltransferase levels, suggesting its potential as an anti-obesity therapeutic.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Food Science & Technology
Gloria Itzel Pena-Vazquez, Maria Teresa Dominguez-Fernandez, Bianka Dianey Camacho-Zamora, Marcelo Hernandez-Salazar, Vania Urias-Orona, Maria-Paz De Pena, Ana Laura de la Garza
Summary: This study simulated the bioaccessibility of polyphenols in sweet orange during the digestion process and found that the bioaccessibility of polyphenols decreased in the intestinal phase. Flavanones were found to be the most abundant subgroup of polyphenols in sweet orange.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Medicine, Research & Experimental
Jeong Won Choi, Hyeok Jin Choi, Gwang Hyeon Ryu, Jae Won Lee, Jin Boo Jeong
Summary: It is reported that Solanum nigrum has anti-obesity effects in animal models induced by a high-fat diet. However, the research on its mechanism of action is limited. This study focused on the anti-obesity activity of Solanum nigrum aerial part (SNAP) and found that it inhibited lipid droplet accumulation by suppressing adipogenesis and promoting lipolysis, thermogenesis, and autophagy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Endocrinology & Metabolism
Catalina Pico, Mariona Palou, Catalina Amadora Pomar, Ana Maria Rodriguez, Andreu Palou
Summary: Leptin, primarily produced by adipose tissue, plays a crucial role in controlling lipid reserves and regulating energy homeostasis. It exerts regulatory actions at various levels and has important effects on the development and function of adipose tissue. Understanding how leptin regulates adipose tissue can provide insights into the pathophysiology of obesity and related diseases.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Nutrition & Dietetics
Sebastia Galmes, Andreu Palou, Francisca Serra
Summary: This study evaluates micronutrient intakes in Spain and their relationship with COVID-19 epidemiological indicators. The results show insufficient intakes of vitamin D, A, B-9, and zinc in Spain, and these inadequate intakes are associated with higher COVID-19 incidence and mortality rates in certain regions.
Article
Nutrition & Dietetics
Barbara Reynes, Margalida Cifre, Andreu Palou, Paula Oliver
Summary: Perinatal administration of leptin provides protection against the consequences of dietary imbalances leading to metabolically obese, normal-weight (MONW) phenotype, while celastrol treatment does not provide the same protective effect and may even have negative effects on adipose tissue. Co-administration of leptin improves the negative effects of celastrol on adipose tissue.
Article
Nutrition & Dietetics
Catalina Amadora Pomar, Catalina Pico, Andreu Palou, Juana Sanchez
Summary: This study finds that the diet of nursing mothers can affect lipid metabolism in their offspring and attenuate their ability to burn calories from an obesogenic diet in adulthood.
Article
Nutrition & Dietetics
Alba Serrano, Andreu Palou, M. Luisa Bonet, Joan Ribot
Summary: This study found that mild NR supplementation during early postnatal life has beneficial effects on lipid and energy metabolism in skeletal muscle and liver in adulthood, with potential preventive strategies against obesity-related disorders.
Article
Biochemistry & Molecular Biology
Catalina A. Pomar, Pedro Castillo, Andreu Palou, Mariona Palou, Catalina Pico
Summary: This study aimed to evaluate the impact of improving maternal nutrition during lactation on the levels of specific miRNA in the mammary gland and milk of diet-induced obese rats. The results showed that implementing a healthy diet during lactation can normalize the expression levels of specific miRNA and some target genes in the mammary gland of obese dams but not in milk.
Article
Biochemistry & Molecular Biology
Marta Alonso-Bernaldez, Antoni Asensio, Andreu Palou-March, Juana Sanchez, Andreu Palou, Francisca Serra, Mariona Palou
Summary: This study investigated the effects of maternal diet during lactation on the expression of leptin, adiponectin, and related miRNAs in breast milk, as well as their impact on dams and their offspring. The results showed that a diet enriched with oleic acid, betaine, and leucine during lactation can affect the ratio of leptin to adiponectin in breast milk, leading to increased body fat in offspring and higher insulin resistance in adulthood. Additionally, specific miRNAs in breast milk were also influenced by the maternal diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pere Bibiloni, Catalina A. Pomar, Andreu Palou, Juana Sanchez, Francisca Serra
Summary: Elevated miR-222 levels are linked to metabolic syndrome, insulin resistance, and diabetes. Rats fed an obesogenic diet during lactation have higher miR-222 content in breast milk, leading to increased body fat mass and impaired insulin sensitivity in their offspring. Transfection experiments with miR-222 mimics or inhibitors on 3T3-L1 preadipocytes reveal that miR-222 plays a role in pathways related to insulin signaling, lipid metabolism, and adipogenesis.
Article
Biochemistry & Molecular Biology
Catalina A. Pomar, M. Luisa Bonet, Adrian Ferre-Beltran, Pablo A. Fraile-Ribot, Mercedes Garcia-Gasalla, Melchor Riera, Catalina Pico, Andreu Palou
Summary: The study reveals that gene expression patterns in blood cells from SARS-CoV-2 infected individuals are associated with clinical phenotypes and body mass index (BMI) in COVID-19 patients. mRNA levels of several genes were found to be increased in the blood cells of COVID-19 patients compared to controls, and some genes were also associated with disease severity and obesity status.
Article
Nutrition & Dietetics
Pedro Castillo, Catalina Amadora Pomar, Andreu Palou, Mariona Palou, Catalina Pico
Summary: The study aimed to analyze the long-term metabolic effects of leptin supplementation during suckling in the offspring of diet-induced obese rats and the potential benefits of improving maternal diet during lactation. The results showed that leptin treatment significantly improved metabolic profile and body fat accumulation under standard diet conditions, with stronger effects in male offspring. However, under high-fat diet conditions, the offspring of dams fed as high-fat diet showed metabolic alterations that were not observed in the offspring of dams switched to standard diet during lactation. Leptin supplementation improved glucose homeostasis in male offspring but impaired insulin sensitivity in female offspring born to high-fat diet-fed dams. These findings highlight the importance of balanced maternal diet during the perinatal period, especially lactation, for the metabolic health of offspring, and the beneficial effects of leptin supplementation during suckling, particularly in male offspring.
Article
Biochemistry & Molecular Biology
Pedro Castillo, Ondrej Kuda, Jan Kopecky, Catalina Amadora Pomar, Andreu Palou, Mariona Palou, Catalina Pico
Summary: The study evaluated the impact of improving maternal diet during lactation on the metabolome of milk and offspring plasma in diet-induced obese rats. The results showed that the milk of rats fed a western diet had altered amino acid and carnitine profiles, as well as changes in other metabolites. These alterations were also observed in the plasma of the offspring, but were largely normalized in rats that switched to a standard diet during lactation.
Article
Nutrition & Dietetics
Marta Alonso-Bernaldez, Andreu Palou-March, Rocio Zamanillo-Campos, Andreu Palou, Mariona Palou, Francisca Serra
Summary: Although nutrient profiling systems are helpful for healthier food choices, assessing overall diet quality is still necessary. This study developed a diet profiling algorithm (DPA) to evaluate nutritional quality, giving a final score and color coding. The DPA considers various factors such as carbohydrate/fiber ratio and energy from saturated fats and sodium, as well as fiber, protein, and macronutrient distribution.
Article
Biochemistry & Molecular Biology
Sebastia Galmes, Andreu Palou, Francisca Serra
Summary: The study found that suboptimal vitamin A intake is associated with cardiometabolic risk, with differences observed between sexes and genetic backgrounds. The findings highlight the importance of personalized nutritional advice regarding vitamin A and cardiometabolic risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Catalina Pico, Empar Lurbe, Jaap Keijer, Jan Kopecky, Jean-Francois Landrier, Julio Alvarez-Pitti, Jean Charles Martin, Paula Oliver, Andreu Palou, Mariona Palou, Petr Zouhar, Joan Ribot, Ana M. Rodriguez, Juana Sanchez, Francisca Serra, M. Luisa Bonet
Summary: The objective of the INTEGRActiv study is to identify novel integrative biomarkers of PA and its effects on body health in children and adolescents, and to validate these biomarkers through an educational intervention.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Chenchen Bian, Xiangtong Yuan, Caihong Zeng, Jian Sun, Gen Kaneko, Hong Ji
Summary: This study investigated the mechanism of docosahexaenoic acid (DHA)-induced apoptosis mediated by mitophagy, using grass carp as an animal model. The results showed that inhibition of mitophagy alleviated apoptosis and eliminated the inhibition of lipid accumulation induced by DHA. Mechanistically, DHA induced mitophagy by activating the PPAR gamma-LC3-BNIP3 pathway. Inhibition of PPAR gamma decreased autophagy-related gene expression and prevented BNIP3/NIX-mediated mitophagy-induced apoptosis, thereby alleviating the inhibition of lipid accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Venkatesan Ramya, Karuppiah Prakash Shyam, Arulanandu Angelmary, Balamuthu Kadalmani
Summary: This study reveals that Lauric acid (LA) exerts an epigenetic regulation and metabolic reprogramming on SH-SY5Y neuroblastoma cells through modulation of lncRNA HOTAIR, remodeling of chromatin H3K4 tri-methylation and regulation of glucose uptake by controlling NF-kappa B activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
Summary: This study investigates the intricate interplay between angiogenic regulation and the browning of white adipocytes. The findings reveal that concurrent activation of angiogenesis is necessary for inducing browning of white adipocytes. The study also highlights the role of Vascular endothelial growth factor (VEGF) in promoting angiogenesis and triggering the browning process through the activation of Estrogen receptor alpha (ER alpha) signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Zanxia Cao, Liling Zhao, Mingcui Chen, Zhihong Shi, Lei Liu
Summary: This study investigated the translocation process of cholesterol/calcitriol in bacterial membranes and their effects on membrane structure. Calcitriol facilitated water transport across the membrane, while cholesterol had the opposite effect. These findings contribute to a better understanding of the relationship between cholesterol/calcitriol concentrations, lipid bilayer structure, and water permeation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Xiaozhen Guo, Jiawen Wang, Hualing Xu, Yangyang Wang, Yutang Cao, Yingquan Wen, Jiaqi Li, Yameng Liu, Kanglong Wang, Jue Wang, Xianchun Zhong, Chuying Sun, Yongxin Zhang, Jingyi Xu, Cuina Li, Pengxiang Mu, Lingyan Xu, Cen Xie
Summary: This study aims to investigate the role of the gut microbiota-bile acid axis in regulating the diurnal rhythms of metabolic homeostasis and assess the impact of obesity on them. The results show that high fat diet feeding and Leptin gene deficiency disrupt the rhythmic patterns of insulin sensitivity and serum total cholesterol levels. The study provides compelling evidence for the association between diurnal rhythm of insulin sensitivity and gut microbiota-bile acid axis, and elucidates the deleterious effects of obesity on gut microbiome-bile acid metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Maria Cotugno, Federico Marracino, Luca Capocci, Ludovica Pizzati, Maurizio Forte, Rosita Stanzione, Pamela Scarselli, Alba Di Pardo, Sebastiano Sciarretta, Massimo Volpe, Speranza Rubattu, Vittorio Maglione
Summary: The study found that enzymes involved in sphingolipid metabolism show abnormal expression in the cardiac tissue of hypertensive rat models, which may be related to the susceptibility to cardiac damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)