期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1811, 期 9, 页码 508-512出版社
ELSEVIER
DOI: 10.1016/j.bbalip.2011.06.020
关键词
N-acyl-phosphatidylethanolamine; Anorectic lipid; Phosphatidylethanolamine N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D; Ether analogue; N-palmitoylethanolamine
资金
- Novo Nordisk Foundation
- Rodent Metabolic Phenotyping Center
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- fund for Kagawa University Young Scientists
- Danish Ministry of Science, Technology, and Innovation
- Grants-in-Aid for Scientific Research [21590310, 22790295] Funding Source: KAKEN
N-acyl-phosphatidylethanolamine is a precursor phospholipid for anandamide, oleoylethanolamide, and other N-acylethanolamines, and it may in itself have biological functions in cell membranes. Recently, N-palmitoyl-phosphatidylethanolamine (NAPE) has been reported to function as an anorectic hormone secreted from the gut and acting on the brain (Gillum et al., [5]). In the current study, two of our laboratories independently investigated whether NAPE metabolites may be involved in mediating the anorectic action of NAPE i.p. injected in mice. Thus, the anorectic activity of a non-hydrolysable NAPE analogue, having ether bonds instead of ester bonds at sn1 and sn2 was compared with that of NAPE in molar equivalent doses. Furthermore, the anorectic effect of NAPE in NAPE-hydrolysing phospholipase D knockout animals was investigated. As negative controls, the NAPE precursor phosphatidylethanolamine and the related phospholipids phosphatidylcholine and phosphatidic acid were also tested. All compounds except one were found to inhibit food intake, raising the possibility that the effect of NAPE is non-specific. (C) 2011 Elsevier B.V. All rights reserved.
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