期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
卷 1790, 期 6, 页码 409-415出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagen.2009.04.004
关键词
Evolution; Mitochondria; Protein import; SAM; TIM; TOM
资金
- Deutsche Forschungsgerneinschaft
- Sonderforschungsbereich [746]
- Trinationales Gracluiertenkolleg [GRK 1478]
- Excellence Initiative of the German Federal and State Governments [EXC 294]
- Gottfried Wilhelm Leibniz Program
- Fonds der Chernischen Industrie
Mitochondria and the nucleus are key features that distinguish eukaryotic cells from prokaryotic cells. Mitochondria originated from a bacterium that was endosymbiotically taken up by another cell more than a billion years ago. Subsequently, most mitochondrial genes were transferred and integrated into the host cell's genome, making the evolution of pathways for specific import of mitochondrial proteins necessary. The mitochondrial protein translocation machineries are composed of numerous subunits. Interestingly, many of these subunits are at least in part derived from bacterial proteins, although only few of them functioned in bacterial protein translocation. We propose that the primitive alpha-proteobacterium, which was once taken up by the eukaryote ancestor cell, contained a number of components that were utilized for the generation of mitochondrial import machineries. Many bacterial components of seemingly unrelated pathways were integrated to form the modern cooperative mitochondria-specific protein translocation system. (C) 2009 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据