期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1799, 期 10-12, 页码 702-716出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2010.10.002
关键词
Acetylation; Cancer; Acetyltransferases; Tumor suppressor
资金
- Council of Scientific and Industrial Research
- Jawaharlal Nehru Centre for Advanced Scientific Research
- Department for Biotechnology, Government of India
Lysine acetylation appears to be crucial for diverse biological phenomena, including all the DNA-templated processes, metabolism, cytoskeleton dynamics, cell signaling, and circadian rhythm. A growing number of cellular proteins have now been identified to be acetylated and constitute the complex cellular acetylome. Cross-talk among protein acetylation together with other post-translational modifications fine-tune the cellular functions of different protein machineries. Dysfunction of acetylation process is often associated with several diseases, especially cancer. This review focuses on the recent advances in the role of protein lysine acetylation in diverse cellular functions and its implications in cancer manifestation. (C) 2010 Elsevier B.V. All rights reserved.
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