期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1799, 期 1-2, 页码 74-79出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2009.11.006
关键词
HMGN; Chromatin; Transcription; Transcription factor; Chromatin remodeling; Protein modification
资金
- National Institutes of Health [R01 GM54808]
- Boston University
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM054808] Funding Source: NIH RePORTER
High mobility group nucleosomal proteins (HMGNs) are small non-histone proteins associated with chromatin. HMGNs have the unique ability to bind to nucleosomes with higher affinity than to naked DNA [1]. They have been studied extensively for their ability to modulate transcription. Although initially viewed as general transcriptional activators on chromatin templates, it is now appreciated that they are instead highly specific modulators of gene expression. We review the mechanisms for targeting HMGNs to specific genes and for how they subsequently regulate transcription. (C) 2009 Elsevier B.V. All rights reserved.
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