期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1799, 期 10-12, 页码 671-680出版社
ELSEVIER
DOI: 10.1016/j.bbagrm.2010.05.007
关键词
Chromatin remodeling; ATP; AcCoA; SAM; NAD; Poly-ADP-ribosylation; Phosphatidylinositide; Inositol polyphosphates
资金
- FIRC
- Telethon
- Fondazione Telethon
- Giovanni Armenise Harvard Foundation
- FIRB-MIUR
- AIRC
- Compagnia San Paolo
The eukaryotic genome is a highly organized nucleoprotein structure comprising of DNA, histones, nonhistone proteins, and RNAs, referred to as chromatin. The chromatin exists as a dynamic entity, shuttling between the open and closed forms at specific nuclear regions and loci based on the requirement of the cell. This dynamicity is essential for the various DNA-templated phenomena like transcription, replication, and repair and is achieved through the activity of ATP-dependent chromatin remodeling complexes and covalent modifiers of chromatin. A growing body of data indicates that chromatin enzymatic activities are finely and specifically regulated by a variety of small molecules derived from the intermediary metabolism. This review tries to summarize the work conducted in many laboratories and on different model organisms showing how ATP-dependent chromatin remodeling complexes are regulated by small molecules and metabolites such as adenosine triphosphate (ATP), acetyl coenzyme A (AcCoA), S-adenosyl methionine (SAM), nicotinamide adenine dinucleotide (NAD), and inositol polyphosphates (IPs). (C) 2010 Elsevier B.V. All rights reserved.
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