Article
Biophysics
M. R. Poorna, R. Jayakumar, Jyh-Ping Chen, Ullas Mony
Summary: Induced pluripotent stem cells (iPSCs) have great potential in regenerative medicine, and improving culture methods, such as using hydrogels as substrates, can support iPSC adhesion, proliferation, and differentiation. Using hydrogels may help generate large numbers of clinical-grade cells for potential clinical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Sarah M. Hull, Lucia G. Brunel, Sarah C. Heilshorn
Summary: Using gel-phase materials as bioinks offers advantages in providing cell protection and biological signals. Challenges remain in terms of cell compatibility and biological functionality of bioink materials.
ADVANCED MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Aaqil Rifai, D. Kavindi Weerasinghe, Gebreselassie Addisu Tilaye, David Nisbet, Jason M. M. Hodge, Julie A. A. Pasco, Lana J. J. Williams, Rasika M. M. Samarasinghe, Richard J. J. Williams
Summary: Damage to bone can lead to pain and restricted movement. Tissue engineering is being explored as a clinical solution for bone defects. However, there are still significant challenges in creating complex bone substitutes that can mimic the natural growth and differentiation of bone cells. This review provides an overview of bone structure, the role of bone cells, and the development of tissue-engineered bone designs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Engineering, Biomedical
Kamil Elkhoury, Margaretha Morsink, Laura Sanchez-Gonzalez, Cyril Kahn, Ali Tamayol, Elmira Arab-Tehrany
Summary: Natural hydrogels are highlighted as promising biomaterials in tissue engineering applications due to their biocompatibility and biodegradability. Innovative biofabrication techniques, such as textile techniques and 3D bioprinting, play a significant role in developing advanced scaffolds for tissue engineering. This review also discusses the emerging applications of biofabricated natural hydrogels in cardiac, neural, and bone tissue engineering.
BIOACTIVE MATERIALS
(2021)
Review
Engineering, Biomedical
Chaojie Yu, Fanglian Yao, Junjie Li
Summary: Recently, injectable conducting polymer-based hydrogels have gained attention in tissue engineering due to their controlled conductivity and minimally invasive procedures. Functional CPs play a crucial role in designing these hydrogels and have potential applications in neurological treatment, myocardial repair, and skeletal muscle regeneration.
ACTA BIOMATERIALIA
(2022)
Review
Biotechnology & Applied Microbiology
Fatemeh Dadkhah Tehrani, Arezoo Firouzeh, Iman Shabani, Azadeh Shabani
Summary: The amniotic membrane, as the innermost layer of the fetal placenta, has unique properties that make it valuable in regenerative medicine applications. Beyond sterilization and preservation, additional modifications are being explored to enhance its properties and durability, presenting a new area of study in its applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Danni Gong, Fei Yu, Meng Zhou, Wei Dong, Dan Yan, Siyi Zhang, Yan Yan, Huijing Wang, Yao Tan, Ying Chen, Bei Feng, Wei Fu, Yao Fu, Yang Lu
Summary: dcECM hydrogels derived from porcine ears through enzymatic digestion show good biocompatibility for delivering chondrocytes and forming subcutaneous cartilage in vivo. The structural and gelation kinetics of the hydrogels vary with ECM concentrations, with 10 mg/ml hydrogels supporting adhesion and proliferation of chondrocytes in vitro. In vivo, 10 mg/ml dcECM hydrogel grafts exhibit similar qualities to native cartilage, indicating their potential for tissue engineering applications in ear cartilage regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chaymaa Hachimi Alaoui, Gildas Rethore, Pierre Weiss, Ahmed Fatimi
Summary: Different techniques have been developed to extract lignin biopolymer from lignocellulosic biomass. Lignin has gained considerable interest in the biomedical field due to its attractive properties and has been used in the preparation of value-added products such as hydrogels. Lignin-based hydrogels have shown great potential for various biomedical applications, and their copolymerization with other polymers and biopolymers further expands their possibilities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Ziba Naghizadeh, Akbar Karkhaneh, Hanieh Nokhbatolfoghahaei, Saeed Farzad-Mohajeri, Maryam Rezai-Rad, Mohammad M. Dehghan, Pouyan Aminishakib, Arash Khojasteh
Summary: An injectable hydrogel/microparticle system containing melatonin and methylprednisolone was developed for chondrogenesis in vitro and in vivo. The system showed promising results in promoting cartilage regeneration, with improved properties and gene expression when loaded with cells. Overall, the study demonstrated the potential of the developed system for cartilage regeneration.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yanbing Gao, Xiaobo Zhang, Haiyu Zhou
Summary: Biomimetic hydrogels have great potential in tissue engineering and regenerative medicine for tissue repair and regeneration. They can tune mechanical and biological properties, provide three-dimensional network structures, and imitate normal tissue microenvironments to integrate cells, scaffolds, and bioactive substances. However, further research is needed for the biomedical and clinical trial applications of biomimetic hydrogels.
Review
Materials Science, Biomaterials
Mymuna Ashna, Neeharika Senthilkumar, Pallab Sanpui
Summary: Regenerative medicine utilizes the regenerative potential of human cells to generate acceptable human tissues and organs, and biomaterial scaffolds play a vital role in this process. Hydrogels, especially keratin-based ones, are versatile materials for tissue engineering and regenerative medicine applications. This review focuses on the suitability and applications of keratin-based hydrogels in regenerative medicine.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Priti Gupta, Shilpa Sharma, Shagufta Jabin, Sapana Jadoun
Summary: Regenerative medicine and tissue engineering have great potential in addressing the limitations of traditional medical approaches. Chitosan, as a naturally derived biocompatible biomaterial, has played a significant role in tissue regeneration. It has unique properties and can be applied in various fields, such as agriculture, nutraceuticals, biomedicine, and food. Chitosan is also an important material for developing next-generation hydrogels and bio-scaffolds. Furthermore, chitosan can be easily modified to enhance its mechanical strength, biodegradability, and controlled release of bioactive molecules. Blending chitosan with other polymers or incorporating nanoparticles expands its possibilities in tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Engineering, Biomedical
Adrianna Wierzbicka, Marek Krakos, Piotr Wilczek, Dorota Bociaga
Summary: Hydrogel materials have great potential in treating urinary system conditions, including intravesical drug delivery, ureteral stents design, and reconstruction of urinary bladder and urethral defects. They also find applications in educational simulation models for medical personnel training.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Engineering, Biomedical
Qi Feng, Dingguo Li, Qingtao Li, Xiaodong Cao, Hua Dong
Summary: This mini-review summarizes the fabrication strategies, unique characteristics, and applications of microgel assembly in tissue engineering and regenerative medicine, with a focus on 3D printing. The challenges for further applications of microgel assembly are also discussed.
BIOACTIVE MATERIALS
(2022)
Review
Polymer Science
Martine Tarsitano, Maria Chiara Cristiano, Massimo Fresta, Donatella Paolino, Concetta Rafaniello
Summary: Corneal transplantation has been the preferred treatment for irreversible damage to the anterior part of the eye. However, limited cornea donors and cases of graft rejection have led to the exploration of new biomaterials. Tissue engineering is crucial in developing a construct that mimics all the necessary properties of the cornea for proper vision. This review discusses the anatomy and physiology of the cornea, the roles of different corneal layers, and the requirements for manufacturing materials. Alginate has emerged as a promising candidate for corneal regeneration due to its adaptability, transparency, and low immunogenicity. Chemical modifications and blending with other compounds can further enhance its mechanical properties and cell-proliferation features.