期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1828, 期 7, 页码 1530-1540出版社
ELSEVIER
DOI: 10.1016/j.bbamem.2012.08.028
关键词
Ion channel; Auxiliary subunit; Calcium channel; Neuron; Synapse; Voltage-gated
资金
- National Institutes of Health grant [RO1 NS053494]
The voltage-gated Ca2+ channel beta subunit (Ca-v beta) is a cytosolic auxiliary subunit that plays an essential role in regulating the surface expression and gating properties of high-voltage activated (HVA) Ca2+ channels. It is also crucial for the modulation of HVA Ca2+ channels by G proteins, kinases, Ras-related RGK GTPases, and other proteins. There are indications that Ca-v beta may carry out Ca2+ channel-independent functions. Ca-v beta knockouts are either non-viable or result in a severe pathophysiology, and mutations in Ca-v beta have been implicated in disease. In this article, we review the structure and various biological functions of Ca-v beta as well as recent advances. This article is part of a Special Issue entitled: Calcium channels. (c) 2012 Elsevier B.V. All rights reserved.
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