期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1828, 期 2, 页码 309-316出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2012.10.022
关键词
Quercetin; Resveratrol; Sodium deoxycholate; Elastic liposome; Experimental design; Nanotechnology
资金
- Foundation for Science and Technology Development of the Pernambuco State of Brazil - FACEPE
- Brazilian Council for Research and Technological Development, CNPq [477463]
- FACEPE [APQ0676-4.03/10]
Based on the fact that quercetin (QUE) and resveratrol (RES) induce a synergic inhibition of the adipogenesis and increase apoptosis in adipocytes, and that sodium deoxycholate (SDC) has necrotic effects, the nanoencapsulation of QUE and RES into SDC-elastic liposomes is proposed as a new approach for dissolving the subcutaneous fat. The concentration of constituents and the effect of the drug incorporation into cyclodextrin inclusion complexes on the stability of QUE/RES-loaded liposomes were studied. The best liposomal formulation reduced the use of phosphatidylcholine and cholesterol in 17.7% and 68.4%, respectively. Liposomes presented a mean diameter of 149 nm with a polydispersion index of 0.3. The zeta potential of liposomes was slightly negative (-13.3 mV) due to the presence of SDC in the phospholipid bilayer. Encapsulation efficiency of QUE and RES into liposomes was almost 97%. To summarize, QUE/RES-loaded elastic liposomes are stable and suitable for subcutaneous injection, thereby providing a new strategy for reducing subcutaneous fat. (C) 2012 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据