Article
Biophysics
Alessio Ausili, Victoria Gomez-Murcia, Adela M. Candel, Andrea Beltran, Alejandro Torrecillas, Liu He, Yuqi Jiang, Shijun Zhang, Jose A. Teruel, Juan C. Gomez-Fernandez
Summary: Curcumin and two bivalent compounds were studied for their solubility and positioning in model membranes, suggesting that the curcumin moiety may be located near the polar part of the membrane. Molecular dynamics studies further supported this notion, indicating a potential role for the membrane anchorage of the bivalent compounds in facilitating the bioactivity of curcumin as anti-Alzheimer drugs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Materials Science, Textiles
Fereshteh Fadavi, Ali Abdulkhani, Zahra Echresh Zadeh, Yahya Hamzeh
Summary: This study investigated the changes in cellulose II structure in never-dried Lyocell fibers upon swelling with different solvents and aqueous solutions using FTIR, solid-state C-13 NMR spectroscopies, and DSC thermal analysis. Water retention behavior and fiber accessibility were found to be correlated with solvent-induced changes in the fiber structure, in accordance with the results obtained from FTIR and C-13 NMR spectroscopies.
JOURNAL OF NATURAL FIBERS
(2022)
Article
Chemistry, Applied
Abdelkarim Rjiba, Hassan Khoder, Jawhar Jelassi, Sabine Bouguet-Bonnet, Carole Gardiennet, El-Eulmi Bendeif, Axel Gansmueller, Rachida Dorbez-Sridi
Summary: The study compared the water-restricted properties of two mesoporous bioactive glasses prepared by different methods, revealing that the microfluidic MBG had slightly faster water molecule escaping towards the bulk, indicating a better water access to the full porous volume in the microcapsule organization of microfluidic MBG.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Chemistry, Physical
G. V. Jagadeesha Gowda, C. Devaraja, B. Eraiah, A. Dahshan, S. N. Nazrin
Summary: The structure, thermal properties, and spectroscopic properties of six glass samples with different mol% of Eu(2)O(3) were studied, and analyzed using various characterization tools. The experimental results show that these glass samples exhibit good thermal stability, and tellurium and boron play important roles in the glass network.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Biochemistry & Molecular Biology
Alessio Ausili, Ines Rodriguez-Gonzalez, Alejandro Torrecillas, Jose A. Teruel, Juan C. Gomez-Fernandez
Summary: This study investigated the interaction and localization of the synthetic estrogen DES with membranes, revealing its effects on membrane surface and enzymes. Experimental techniques including DSC, X-ray diffraction, and NMR spectroscopy provided insights into the mechanisms of action of DES in membranes.
Article
Multidisciplinary Sciences
Chunmei Huang, Miriding Mutailipu, Fangfang Zhang, Kent J. Griffith, Cong Hu, Zhihua Yang, John M. Griffin, Kenneth R. Poeppelmeier, Shilie Pan
Summary: Borates exhibit extended structural diversity and potential in various applications, with one borate containing linear BO2 structural units. The study provides a quantitative basis for identifying BO2 units in borates through NMR spectroscopy characterization.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Yury G. Kolyagin, Alexander Yakimov, Dmitry S. Zasukhin, Irina I. Ivanova
Summary: Stacking disorder and polymorphism in zeolite and zeolite-like materials pose challenges for their structural characterization. This work presents an advanced approach using pure shift solid-state 29Si nuclear magnetic resonance (NMR) spectroscopy to investigate the structure of zeolitic materials with intergrown polymorphs. The findings demonstrate that pure shift solid-state Si-29 NMR is a superior tool for elucidating polymorphism in zeolites.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Physical
Yury G. Kolyagin, Alexander V. Yakimov, Dmitry S. Zasukhin, Irina I. Ivanova
Summary: In this study, an advanced approach based on pure shift solid-state Si-29 NMR spectroscopy was proposed for the structural investigation of zeolitic materials with polymorphs. The results showed that this approach could accurately determine the polymorph composition and overcome the interference of stacking disorder and polymorphism. The study also discovered the differences in polymorph composition under different synthesis routes.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Energy & Fuels
G. C. Savulescu, S. Simon, G. Sorland, G. oye
Summary: This paper introduces three NMR methods for quantifying wax crystallization in crude oil systems, based on free induction decay and Carr-Purcell-Meiboom-Gill pulse sequences. These methods allow for the quantification of non-crystalline wax content and calculation of crystalline wax component in systems with high wax content. Through comparisons with DSC method and model systems, these methods are proved to be reliable.
Article
Energy & Fuels
V. Vishal Malolan, C. Trilokesh, Kiran Babu Uppuluri, A. Arumugam
Summary: This study reported the extraction and characterization of cellulose from Calophyllum inophyllum de-oiled cake using the ionic liquid, 1-butyl-3-methylimidazolium chloride [BMIM] Cl. The yield of the cellulose from the extraction was approximately 23.81 +/- 1.72% w/w of the de-oiled cake, and SEM imaging revealed the swollen nature of cellulose fibers. FTIR and XRD analysis confirmed the presence and purity of cellulose, and the thermal degradation pattern of extracted cellulose was consistent with previous literature. Overall, this study demonstrated that a high-quality cellulose fraction could be obtained using the ionic liquid [BMIM] Cl.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Biochemical Research Methods
Marion Maravat, Marylene Bertrand, Celine Landon, Franck Fayon, Severine Morisset-Lopez, Vincent Sarou-Kanian, Martine Decoville
Summary: The study successfully induced gliomas in Drosophila and obtained metabolic profiles using nuclear magnetic resonance techniques. Statistical analyses revealed different metabolic signatures, impacted pathways, and glioma biomarkers.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biophysics
Ameeq Ul Mushtaq, Jorgen Aden, Katan Ali, Gerhard Grobner
Summary: Programmed mammalian cell death is regulated by the Bcl-2 protein, which plays a crucial role in recognizing and inhibiting apoptotic proteins to protect cells. By using nuclear magnetic resonance, the molecular functioning of Bcl-2 at the membrane level was studied, providing insights into its residue-specific response and affinity.
BIOPHYSICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Francine S. Ke, Steven Holloway, Rachel T. Uren, Agnes W. Wong, Melissa H. Little, Ruth M. Kluck, Anne K. Voss, Andreas Strasser
Summary: BID functions as an effector of the intrinsic apoptosis pathway, playing a role both upstream and parallel to BAX, BAK, and BOK, and it may exert its function by releasing cytochrome c.
Article
Biochemistry & Molecular Biology
Qiling Tang, Hongce Chen, Zihao Mai, Han Sun, LingJun Xu, Guihao Wu, Zhuang Tu, Xuecheng Cheng, Xiaoping Wang, Tongsheng Chen
Summary: Abivertinib (AC) is a novel epidermal growth factor receptor tyrosine kinase inhibitor that exhibits highly efficient antitumor activity. This study demonstrates that AC can induce both reactive oxygen species (ROS)-dependent apoptosis and ferroptosis in tumor cells. The Bim- and Bax-mediated mitochondrial pathways play a dominant role in AC-induced ferroptosis and apoptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Physical
Mariya L. Kalapsazova, Krassimir L. Kostov, Rositsa R. Kukeva, Ekaterina N. Zhecheva, Radostina K. Stoyanova
Summary: To enhance the energy density of lithium and sodium ion batteries, both cationic and anionic redox reactions at intercalation-type electrodes need to be activated simultaneously. Oxygen redox activity can lead to poor stability due to increased surface reactivity of the oxides. Using oxygen-storage materials as buffers can help stabilize the oxygen redox activity and increase reversible capacity.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Physical
Lech Sznitko, Luigi Romano, Andrea Camposeo, Dominika Wawrzynczyk, Konrad Cyprych, Jaroslaw Mysliwiec, Dario Pisignano
JOURNAL OF PHYSICAL CHEMISTRY C
(2018)
Article
Optics
Konrad Cyprych, Pawel S. Jung, Yana Izdebskaya, Vladlen Shvedov, Demetrios N. Christodoulides, Wieslaw Krolikowski
Article
Chemistry, Multidisciplinary
Konrad Cyprych, Denis Chateau, Anthony Desert, Stephane Parola, Jaroslaw Mysliwiec
Article
Biochemistry & Molecular Biology
Jenny Marie Andersson, Quoc Dat Pham, Helena Mateos, Sylvia Eriksson, Pia Harryson, Emma Sparr
JOURNAL OF LIPID RESEARCH
(2020)
Article
Materials Science, Multidisciplinary
Martyna Janeczko, Konrad Cyprych, Malgorzata Kozbial, Jaroslaw Mysliwiec
ORGANIC ELECTRONICS
(2020)
Article
Polymer Science
Konrad Cyprych, Lech Sznitko
Summary: This study investigates the random lasing phenomenon in a dye-doped polymeric double-phase system and explores how relative concentrations of polymers can influence lasing parameters. The influence of phase separation-induced disorder on supporting RL, the ability to switch between waveguiding and quasi-waveguiding regimes, and the fabrication of efficient materials for RL using a simple phase separation technique are highlighted. The technique offers a fast, cheap, and easy way to tailor lasing properties in the laser material fabrication process.
Article
Pharmacology & Pharmacy
Quoc Dat Pham, Sofi Nojd, Martin Edman, Katarina Lindell, Daniel Topgaard, Marie Wahlgren
Summary: Mucoadhesion is a common method employed in drug delivery to prolong the contact of drugs with absorption sites and improve drug absorption. By studying the molecular interactions between different polymers and mucin, researchers can gain insights into the mechanisms of how different polymers affect mucin.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Quoc Dat Pham, Sebastien Gregoire, Bruno Biatry, Guillaume Cassin, Daniel Topgaard, Emma Sparr
Summary: By altering the hydration of the skin, molecules with reasonable solubility in both hydrophobic and hydrophilic environments can be directed to specific regions in the stratum corneum (SC), affecting their distribution and behavior in varying hydration conditions. Hydration serves as a switch to control the location and action of molecules in complex materials like SC, impacting fluid-solid lipid transitions in drying conditions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Physical
Yoshihiko Sonoki, Quoc Dat Pham, Emma Sparr
Summary: The barrier function of the skin relies on the outermost layer, the stratum corneum (SC). Adding a mixture of chemicals to the SC has more significant effects than adding single components, increasing the mobility of skin lipids and proteins. This synergistic effect may have implications for the complex mixture of natural moisturizing factor (NMF) in dry conditions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Optics
Lukasz Ryglowski, Konrad Cyprych, Jaroslaw Mysliwiec
Summary: This article presents a straightforward procedure to differentiate between amplified spontaneous emission (ASE) and random lasing, in order to determine their respective properties and performance simultaneously.
OPTICS COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Agata Koziol, Kamila Sroda-Pomianek, Agata Gorniak, Agnieszka Wikiera, Konrad Cyprych, Magdalena Malik
Summary: This study tested and compared the physicochemical properties of apple pectin and citrus pectin, and the results showed that the pectins isolated using different enzymes have similar structure to the commercially available pectin.
Article
Biochemistry & Molecular Biology
Simon Fridolf, Quoc Dat Pham, Jon Pallbo, Katja Bernfur, Sara Linse, Daniel Topgaard, Emma Sparr
Summary: Parkinson's disease is characterized by the aggregation of the presynaptic protein alpha-synuclein (alpha Syn) and its co-assembly with lipids and other cellular matter in the brain. This study investigated the co-assembly of alpha Syn with model membranes containing the glycolipid ganglioside GM3 and found that the overall uptake of lipids in the co-assembled aggregates increases with the molar ratio of GM3 in the vesicles. The lipids present in the co-assembled aggregates exhibit reduced molecular dynamics compared to the protein-free bilayer system, which may have implications for the formation of amyloid in vivo.
BIOPHYSICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Quoc Dat Pham, Goran Carlstrom, Olivier Lafon, Emma Sparr, Daniel Topgaard
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2020)
Article
Chemistry, Physical
Amanuel Wolde-Kidan, Quoc Dat Pham, Alexander Schlaich, Philip Loche, Emma Sparr, Roland R. Netz, Emanuel Schneck
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2019)
Article
Optics
Vladlen Shvedov, Konrad Cyprych, M. Yadira Salazar-Romero, Yana Izdebskaya, Wieslaw Krolikowski
Article
Biochemistry & Molecular Biology
Philipp Grad, Katarina Edwards, Lars Gedda, Victor Agmo Hernandez
Summary: This study investigates the effects of polyethylene glycol-(PEG) modified lipids and gangliosides on the Ca2+ induced interaction between liposomes composed of palmitoyl-oleoyl phosphatidylethanolamine (POPE) and palmitoyl-oleoyl phosphatidylserine (POPS) at physiological ionic strength. The results show that naked liposomes tend to adhere, rupture, and collapse on each other's surfaces upon addition of Ca2+, eventually resulting in the formation of large multilamellar aggregates and bilayer sheets. However, the presence of gangliosides or PEGylated lipids leads to the formation of small, long-lived bilayer fragments/disks. PEGylated lipids seem to be more effective than gangliosides at stabilizing these structures. The study suggests that direct liposome-liposome fusion is not the dominating process triggered by Ca2+ in the systems studied.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Saurabh Saraswat, Archana Chugh
Summary: Cell penetrating peptides (CPP) are important tools for intracellular delivery of molecules. In this study, a novel marine-derived CPP from Engraulis japonicus, called Engraulisin, was reported. Engraulisin demonstrated successful cellular uptake and selective antimicrobial activity against Methicillin-resistant Staphylococcus aureus (MRSA), making it a potential candidate for drug delivery.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Emanuela Efodili, Ashlynn Knight, Maryem Mirza, Cedric Briones, Il-Hyung Lee
Summary: This study demonstrates the spontaneous transfer of small membrane-bound peptides between a supported lipid bilayer and giant unilamellar vesicles in vitro. The transfer occurs through the formation of hemi-fusion stalks and is limited to small peptides due to the highly curved structure of the stalk. This system provides a synthetic platform for studying peptide trafficking between synthetic membranes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Niu, Si Jia Chen, Jeffery B. Klauda
Summary: Macrophage membranes in the activated state are more tightly packed, exhibit increased chain order across lipid species, and form specific lipid clusters. These findings provide physiologically accurate models for future computational studies of macrophage membranes and their proteins.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Niki Baccile, Vincent Chaleix, Ingo Hoffmann
Summary: This study measured the bending rigidity of self-assembled structures formed by a new biobased glucolipid bioamphiphile using neutron spin-echo (NSE) technology. The results showed that the bending rigidity of these structures is lower or higher compared to phospholipid membranes, providing a new theoretical basis for the application of these new molecular systems.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Alain Bolano Alvares, Pablo E. A. Rodriguez, Gerardo D. Fidelio
Summary: The behavior of amphiphilic molecules at the air/water interface was studied to evaluate the arrangement formed in a confined area. The surface properties of zwitterionic DPPC lipid and A beta(1-40) amyloid peptide in mixed films were investigated at different temperatures. DPPC undergoes a phase transition depending on temperature and lateral pressure, which allows for the study of its influence on amyloid structure formation.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Lukasz Plachta, Marzena Mach, Magdalena Kowalska, Pawel Wydro
Summary: Resveratrol, a popular phytoalexin found in grapes and red wine, has beneficial effects on the cardiovascular system, exhibits antiviral, antibacterial, and antifungal properties, and may have therapeutic effects against cancer. This study investigates the interaction of resveratrol with model cell membranes, demonstrating changes in their physicochemical parameters and highlighting the role of cholesterol content in resveratrol incorporation. The findings suggest that the molecular mechanism of action of resveratrol may involve interactions with lipid rafts.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Edurne Rujas, Beatriz Apellaniz, Johana Torralba, David Andreu, Jose M. M. Caaveiro, Shixia Wang, Shan Lu, Jose L. Nieva
Summary: This study investigates the role of fusion peptide and Trp-rich membrane proximal external region in HIV-1 fusion and demonstrates that liposome-based formulations containing FP-MPER hybrid peptides can induce the production of specific neutralizing antibodies in rabbits. The results support the use of liposomes as vaccine carriers and the inclusion of lipid membranes in immunogens to elicit specific humoral responses.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Dailin Li, Dingyuan Shi, Lei Wang
Summary: G protein-gated inwardly rectifying potassium (GIRK) channels play a significant role in regulating cell excitability. This study investigated the ion permeation mechanism in GIRK2 mutants using molecular dynamic simulations and QM/MM methods. The results revealed the importance of a multi-ion distribution for ion conduction.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Max J. den Uijl, Arnold J. M. Driessen
Summary: Membrane protein insertion into and translocation across the bacterial cytoplasmic membrane are essential processes facilitated by the Sec translocon. The phospholipid dependence of membrane protein insertion has remained mostly unknown. This study reveals that the insertion of the mannitol permease MtlA into the membrane depends on the presence of phosphatidylglycerol and is stimulated by phosphatidylethanolamine.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick Allen, Adam C. Smith, Vernon Benedicto, Abbas Abdulhasan, Vasanthy Narayanaswami, Enrico Tapavicza
Summary: We explore the stability, size, and structure of nanodiscs formed by the N-terminal domain of apolipoprotein E3 and a variable number of 1,2-dimyristoyl-sn-glycero-3-phosphocholine molecules. Our simulations suggest that nanodiscs containing 240 to 420 DMPC molecules are stable. The antiparallel configuration shows more protein-protein interactions and ionic contacts, as well as greater stability and rigidity compared to the parallel configuration.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick M. Keating, Nicholas P. Schifano, Xinrui Wei, Matthew Y. Kong, Jinwoo Lee
Summary: Lassa virus (LASV) infection is dependent on the fusion of its viral membrane with the host cell membrane, and our study reveals that this fusion process involves pH-dependent conformational changes in the transmembrane domain of LASV. These findings provide valuable insights into the fusion mechanism of LASV and can be utilized in the design of therapeutics to combat Lassa virus infections and prevent its potential spread.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Ashley L. Bennett, Kristen N. Cranford, Austin L. Bates, Christopher R. Sabatini, Hee-Seung Lee
Summary: This study employed molecular dynamics simulations to elucidate the binding, folding, and insertion details of TP10W in the cell membrane. The simulations revealed that TP10W can translocate across the lipid membrane as a monomer, and the charged amino acid side chains can move between lipid leaflets. Comparison with point mutated variants demonstrated significant conformational changes due to charge distribution.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Jessica H. van Wonderen, Jason C. Crack, Marcus J. Edwards, Thomas A. Clarke, Gerhard Saalbach, Carlo Martins, Julea N. Butt
Summary: Electrogenic bacteria transfer excess respiratory electrons to metal oxide particles and electrodes through the MtrCAB complex. The crystal structure of MtrCAB from S. baltica OS185 was resolved, and liquid chromatography mass spectrometry was used to determine the mass values of the three proteins in purified MtrCAB complexes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Review
Biochemistry & Molecular Biology
Yi-Ming Chen, Ching-Tai Lu, Chia-Wen Wang, Wolfgang B. Fischer
Summary: A series of dye ligands were ranked based on docking experiments, selecting the most suitable ligands for binding with different proteins. Additionally, a comparison study was conducted on a series of repurposing drugs and known antivirals.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)