Article
Medicine, Research & Experimental
Sabrina Qader Kudsi, Bruna Candia Piccoli, Daniel Ardisson-Araujo, Gabriela Trevisan
Summary: This article aims to analyze the baseline distribution of TRPA1, TRPV1, TRPV4, and TRPM8 channels in human systems at the transcriptional level. Using the RNA-seq dataset, the transcriptional levels of these channels were investigated and compared in 95 human subjects representing 33 different tissues, providing essential suggestions for further studies on these proteins.
Review
Biochemistry & Molecular Biology
Roberto Maglie, Daniel Souza Monteiro de Araujo, Emiliano Antiga, Pierangelo Geppetti, Romina Nassini, Francesco De Logu
Summary: TRPA1, a member of the TRP superfamily, plays a crucial role in sensory neurons and has been found to be expressed in various skin cells, contributing to skin physiology and pathophysiology. Recent studies have highlighted the potential use of TRPA1 antagonists in the treatment of inflammatory and immunological skin disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Maximilian L. Mager, Cosmin I. Ciotu, Markus Gold-Binder, Stefan Heber, Michael J. M. Fischer
Summary: Several preservatives commonly used in pharmaceuticals can activate the TRPA1 channel, especially when combined with proinflammatory mediators.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qi Jia, Weifeng Tian, Binbin Li, Wen Chen, Wenjie Zhang, Yang Xie, Na Cheng, Qi Chen, Jianru Xiao, Yiwang Zhang, Jian Yang, Shu Wang
Summary: The activation of TRPV1 and TRPA1 channels plays a key role in melanogenesis, helping melanocytes receive extrinsic and intrinsic signals for pigment production. Inhibition of TRPV1 and TRPA1 channels leads to reduced melanin content in melanoma cells, highlighting their potential as therapeutic targets for pigmentary disorders.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mariana A. Freitas, Amanda Vasconcelos, Elaine C. D. Goncalves, Eduarda G. Ferrarini, Gabriela B. Vieira, Donatella Cicia, Maira Cola, Raffaele Capasso, Rafael C. Dutra
Summary: Spirulina platensis is a super-food with anti-inflammatory, antioxidant, and analgesic properties, showing significant analgesic effects in rodent models of inflammatory pain by potentially modulating TRMP8 and TRPA1.
Editorial Material
Cell Biology
Brie Trusiano, Juselyn D. Tupik, Irving C. Allen
Summary: Understanding the role of membrane bound transient receptor potential (TRP) ion channels, specifically TRPM8, is crucial for the management and treatment of hyperinflammatory conditions, including inflammatory bowel disease. TRPM8 plays a significant role in prostate cancer and cold sensing neurons, as well as the release of calcitonin gene-related peptide (CGRP) by sensory neurons.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leevi Halonen, Antti Pemmari, Elina Nummenmaa, Mari Haemaelaeinen, Teemu Moilanen, Katriina Vuolteenaho, Eeva Moilanen
Summary: This study found that human osteoarthritic chondrocytes express 19 different TRP genes, with significant expression of TRPM8. In addition, menthol and dexamethasone can regulate the expression of TRP channels. These results support the concept of TRPA1 and TRPM8 as potential novel drug targets in arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Tomoyuki Kuwaki, Nobuaki Takahashi
Summary: TRPA1 is a member of the TRP superfamily of cation channels and is widely expressed in sensory neural pathways. It detects irritant chemicals, hypoxia, and hyperoxia. Its role in respiratory and behavioral modulation has been studied using Trpa1 knockout mice. The results show that TRPA1 is necessary for protective responses in respiration and behavior, suggesting that TRPA1 channels in the airway may play a sentinel role for environmental threats.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Cell Biology
Juan C. Henao, Adriana Grismaldo, Alfonso Barreto, Viviana M. Rodriguez-Pardo, Claudia Camila Mejia-Cruz, Efrain Leal-Garcia, Rafael Perez-Nunez, Patricio Rojas, Ramon Latorre, Ingrid Carvacho, Yolima P. Torres
Summary: The study demonstrates that TRPM8 channels are expressed in human bone marrow MSCs and are involved in osteogenic differentiation, with agonists promoting osteogenic differentiation and antagonists leading to a decrease in osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Tusar K. Acharya, Ankit Tiwari, Rakesh K. Majhi, Chandan Goswami
Summary: TRPM8 is an ion channel that influences T-cell activation and differentiation by promoting calcium increase and proinflammatory cytokine secretion. Its surface accumulation in activated T cells enhances TCR-induced responses, but inhibition does not prevent T-cell activation, suggesting it may be dispensable in this process, unlike other channels like TRPV1 and TRPV4.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Loretta Ferrera, Raffaella Barbieri, Cristiana Picco, Paolo Zuccolini, Alessia Remigante, Sara Bertelli, Maria Rita Fumagalli, Giovanni Zifarelli, Caterina A. M. La Porta, Paola Gavazzo, Michael Pusch
Summary: The response to oxidative stimulation in melanoma cells involves the activation of potassium currents and an increase in intracellular calcium levels, mediated by BK, KCa3.1, and TRPM2 channels. Differences in the expression levels of these channels in different cell lines may play a crucial role in melanoma progression. Targeting these ion channels pharmacologically could be a novel strategy to reduce the metastatic potential of melanoma cells alongside traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shasha Feng, Ruth A. Pumroy, Anna D. Protopopova, Vera Y. Moiseenkova-Bell, Wonpil Im
Summary: TRPV channels interact with endogenous lipids and cannabidiol, affecting channel stability and gating. The C-terminal of TRPV2 has a strong interaction preference for PIP lipids. In addition, simulation shows different effects of vanilloid lipid and VSLD lipid on protein dynamics.
Article
Chemistry, Medicinal
Sho Sanechika, Chika Shimobori, Katsuya Ohbuchi
Summary: This study evaluated the effects of flavonoid aglycones and their glycosides on TRP channel subtypes, finding that certain compounds can activate TRPA1 and inhibit TRPM8. The metabolization of these compounds in the intestines could potentially lead to the generation of TRPA1 agonists and TRPM8 antagonists.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Multidisciplinary Sciences
Cheng Zhao, Yuan Xie, Lizhen Xu, Fan Ye, Ximing Xu, Wei Yang, Fan Yang, Jiangtao Guo
Summary: The TRPM8 channel acts as the primary cold sensor in humans and can be activated by ligands such as menthol, icilin, and PIP2. This study determined the structures of mouse TRPM8 in different states, revealing its overall architecture and the basis for ligand recognition.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Winnie Maria Riekehr, Simon Sander, Jelena Pick, Henning Tidow, Andreas Bauche, Andreas H. Guse, Ralf Fliegert
Summary: The activation of TRPM2 by cADPR has been a controversial topic for more than 15 years. This study provides experimental evidence that specific domains of TRPM2, MHR1/2 and NUDT9H, are required for the activation by ADPR and 2dADPR, while pure cADPR does not activate TRPM2 under various conditions. These findings suggest that previous observations of cADPR activation of TRPM2 may be due to contamination of ADPR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Biophysics
Elisa Venturi, Fiona O'Brien, David Eberhardt, Katja Witschas, Sam El-Ajouz, Tsunaki Iida, Miyuki Takeshima, Hiroshi Takeshima, Rebecca Sitsapesan
BIOPHYSICAL JOURNAL
(2019)
Article
Neurosciences
Fiona O'Brien, David Eberhardt, Katja Witschas, Sam El-Ajouz, Tsunaki Iida, Miyuki Nishi, Hiroshi Takeshima, Rebecca Sitsapesan, Elisa Venturi
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Cardiac & Cardiovascular Systems
Alessio Lissoni, Paco Hulpiau, Tania Martins-Marques, Nan Wang, Geert Bultynck, Rainer Schulz, Katja Witschas, Henrique Girao, Maarten De Smet, Luc Leybaert
Summary: The research revealed that the activation of ryanodine receptors (RyRs) triggers unitary currents with a single-channel conductance of around 220 pS, which are significantly reduced by knocking down connexin 43 (Cx43). The study also showed that both RyR activation and intracellular Ca2+ elevation are necessary for the opening of Cx43 hemichannels.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Alessio Lissoni, Nan Wang, Timur Nezlobinskii, Maarten De Smet, Alexander V. Panfilov, Nele Vandersickel, Luc Leybaert, Katja Witschas
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Thomas Heimburg
Summary: Research has shown that the heat production associated with nerve pulses is biphasic, with heat release in the first phase being balanced by heat reabsorption in the second phase. The characteristics of nerve pulses may be related to adiabatic processes, rather than the traditional theory of irreversible charging and discharging of membrane capacitors proposed by the Hodgkin-Huxley model.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2021)
Article
Chemistry, Physical
Andrew D. Jackson, Thomas Heimburg
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION A-A JOURNAL OF PHYSICAL SCIENCES
(2020)
Article
Cell Biology
Karis Amata Zecchi, Thomas Heimburg
Summary: Recent evidence suggests that lipid bilayers exhibit conductive properties but are commonly considered inert insulators. Under voltage-clamp conditions, lipid bilayers display current traces with discrete conduction-steps and outward rectification. The non-linear conduction in lipid membranes at different depths indicates voltage-gated and mechanosensitive channels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Maarten A. J. De Smet, Alessio Lissoni, Timur Nezlobinsky, Nan Wang, Eef Dries, Marta Perez-Hernandez, Xianming Lin, Matthew Amoni, Tim Vervliet, Katja Witschas, Eli Rothenberg, Geert Bultynck, Rainer Schulz, Alexander V. Panfilov, Mario Delmar, Karin R. Sipido, Luc Leybaert
Summary: Cx43 hemichannels are activated during diastolic Ca2+ release in ventricular cardiomyocytes, contributing to enhanced Ca2+ dynamics due to Ca2+ entry and coupling to release microdomains. Hemichannel opening also leads to delayed afterdepolarizations and triggered action potentials. Increased hemichannel activity is associated with electrical instability in failing human hearts compared to nonfailing donor hearts, suggesting a potentially novel mechanism of cardiac arrhythmogenesis in heart failure.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Biochemistry & Molecular Biology
T. Heimburg
Summary: The textbook view of nerve activity as a propagating voltage pulse driven by electrical currents through ion channel proteins is incomplete. The nerve pulse can also be understood as a thermodynamic phenomenon influenced by multiple variables. Understanding the thermodynamic nature of nerve activity has important implications for medical treatment and the response of nerve activity to various stimuli.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Marijke De Bock, Maarten De Smet, Stijn Verwaerde, Hanane Tahiri, Steffi Schumacher, Valerie Van Haver, Katja Witschas, Christian Steinhaeuser, Nathalie Rouach, Roosmarijn E. Vandenbroucke, Luc Leybaert
Summary: The study reveals that targeting endothelial and astrocytic connexins is an effective approach to prevent barrier leakage and astrogliosis caused by systemic inflammation induced by LPS.
Article
Biochemistry & Molecular Biology
Thomas Heimburg
Summary: The Fluid Mosaic Model proposed by Singer & Nicolson describes biological membranes as fluid lipid layers with embedded integral proteins. The membrane acts as a liquid where proteins can freely move and interact. However, there are melting transitions in biomembranes that occur slightly below physiological temperatures, and these transitions can be influenced by various factors. This melting transition affects the overall excitable nature of the membrane, leading to phase behavior, domain formation, and changes in membrane function. The lipids in the membrane play an active role and affect the elastic constants of the membrane, allowing for the generation of pulses and ion-channel-like pores. This goes beyond the original concept of Singer & Nicolson.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2023)
Article
Neurosciences
Steffi Schumacher, Hanane Tahiri, Pascal Ezan, Nathalie Rouach, Katja Witschas, Luc Leybaert
Summary: Therapeutic brain irradiation induces reorganization of astrocytic vesicular transport, leading to VEGF-A release and barrier leakage, and this process can be inhibited by targeting astrocyte connexin 43 (Cx43).
Article
Biochemistry & Molecular Biology
Alessio Lissoni, Siyu Tao, Rosalie Allewaert, Katja Witschas, Luc Leybaert
Summary: Cx43 hemichannels (HCs) and Panx1 channels, two genetically distant protein families, have been debated for their similarities in expression, membrane topology, and electrical properties. This study used mimetic peptides Gap19 and (10)Panx1 to investigate their cross-effects on Cx43 HCs and Panx1 channels. The results showed that Gap19 significantly inhibited Panx1 channels, while high concentrations of (10)Panx1 significantly reduced the activity of Cx43 HCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tania Martins-Marques, Katja Witschas, Ilda Ribeiro, Monica Zuzarte, Steve Catarino, Teresa Ribeiro-Rodrigues, Francisco Caramelo, Trond Aasen, Isabel Marques Carreira, Lino Goncalves, Luc Leybaert, Henrique Girao
Summary: This study provides new evidence for the localization and functional role of connexin43 (Cx43) in the nucleus, particularly in transcription modulation. The findings show that Cx43 localizes to the nuclear envelope and impacts the cellular transcriptome by interacting with transcriptional regulators. The study also demonstrates that Cx43 forms active channels at the nuclear envelope, suggesting its involvement in nucleocytoplasmic shuttling. These findings have important implications for understanding the role of Cx43 in cardiac pathophysiology.
Article
Medicine, Research & Experimental
Luc Leybaert, Maarten A. J. De Smet, Alessio Lissoni, Rosalie Allewaert, H. Llewelyn Roderick, Geert Bultynck, Mario Delmar, Karin R. Sipido, Katja Witschas
Summary: This paragraph mainly discusses the role of connexins in cardiac function. Connexins form hemichannels and gap junctions, and gap junctions are responsible for transmitting electrical and chemical signals between myocardial cells and specialized conduction system cells to synchronize the cardiac cycle and control cardiac pump function. Under pathological conditions, gap junctions close and hemichannels open, leading to disruption of cardiac function and homeostasis. Current evidence shows that hemichannels play an emerging role in myocardial ischemia and arrhythmia, and there are now tools available to selectively inhibit hemichannels without inhibiting gap junctions, as well as to stimulate the incorporation of hemichannels into gap junctions. We review experimental evidence for the contribution of hemichannels to pro-arrhythmic events in ventricular and atrial cardiomyocytes, and link these findings to the molecular control of connexin-43-based hemichannel opening. We conclude that a double-edged approach of both preventing hemichannel opening and preserving gap junctional function will be crucial for further research and development of new connexin-based experimental approaches for treating heart disease.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Philipp Grad, Katarina Edwards, Lars Gedda, Victor Agmo Hernandez
Summary: This study investigates the effects of polyethylene glycol-(PEG) modified lipids and gangliosides on the Ca2+ induced interaction between liposomes composed of palmitoyl-oleoyl phosphatidylethanolamine (POPE) and palmitoyl-oleoyl phosphatidylserine (POPS) at physiological ionic strength. The results show that naked liposomes tend to adhere, rupture, and collapse on each other's surfaces upon addition of Ca2+, eventually resulting in the formation of large multilamellar aggregates and bilayer sheets. However, the presence of gangliosides or PEGylated lipids leads to the formation of small, long-lived bilayer fragments/disks. PEGylated lipids seem to be more effective than gangliosides at stabilizing these structures. The study suggests that direct liposome-liposome fusion is not the dominating process triggered by Ca2+ in the systems studied.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Saurabh Saraswat, Archana Chugh
Summary: Cell penetrating peptides (CPP) are important tools for intracellular delivery of molecules. In this study, a novel marine-derived CPP from Engraulis japonicus, called Engraulisin, was reported. Engraulisin demonstrated successful cellular uptake and selective antimicrobial activity against Methicillin-resistant Staphylococcus aureus (MRSA), making it a potential candidate for drug delivery.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Emanuela Efodili, Ashlynn Knight, Maryem Mirza, Cedric Briones, Il-Hyung Lee
Summary: This study demonstrates the spontaneous transfer of small membrane-bound peptides between a supported lipid bilayer and giant unilamellar vesicles in vitro. The transfer occurs through the formation of hemi-fusion stalks and is limited to small peptides due to the highly curved structure of the stalk. This system provides a synthetic platform for studying peptide trafficking between synthetic membranes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Niu, Si Jia Chen, Jeffery B. Klauda
Summary: Macrophage membranes in the activated state are more tightly packed, exhibit increased chain order across lipid species, and form specific lipid clusters. These findings provide physiologically accurate models for future computational studies of macrophage membranes and their proteins.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Niki Baccile, Vincent Chaleix, Ingo Hoffmann
Summary: This study measured the bending rigidity of self-assembled structures formed by a new biobased glucolipid bioamphiphile using neutron spin-echo (NSE) technology. The results showed that the bending rigidity of these structures is lower or higher compared to phospholipid membranes, providing a new theoretical basis for the application of these new molecular systems.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Alain Bolano Alvares, Pablo E. A. Rodriguez, Gerardo D. Fidelio
Summary: The behavior of amphiphilic molecules at the air/water interface was studied to evaluate the arrangement formed in a confined area. The surface properties of zwitterionic DPPC lipid and A beta(1-40) amyloid peptide in mixed films were investigated at different temperatures. DPPC undergoes a phase transition depending on temperature and lateral pressure, which allows for the study of its influence on amyloid structure formation.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Lukasz Plachta, Marzena Mach, Magdalena Kowalska, Pawel Wydro
Summary: Resveratrol, a popular phytoalexin found in grapes and red wine, has beneficial effects on the cardiovascular system, exhibits antiviral, antibacterial, and antifungal properties, and may have therapeutic effects against cancer. This study investigates the interaction of resveratrol with model cell membranes, demonstrating changes in their physicochemical parameters and highlighting the role of cholesterol content in resveratrol incorporation. The findings suggest that the molecular mechanism of action of resveratrol may involve interactions with lipid rafts.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Edurne Rujas, Beatriz Apellaniz, Johana Torralba, David Andreu, Jose M. M. Caaveiro, Shixia Wang, Shan Lu, Jose L. Nieva
Summary: This study investigates the role of fusion peptide and Trp-rich membrane proximal external region in HIV-1 fusion and demonstrates that liposome-based formulations containing FP-MPER hybrid peptides can induce the production of specific neutralizing antibodies in rabbits. The results support the use of liposomes as vaccine carriers and the inclusion of lipid membranes in immunogens to elicit specific humoral responses.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Dailin Li, Dingyuan Shi, Lei Wang
Summary: G protein-gated inwardly rectifying potassium (GIRK) channels play a significant role in regulating cell excitability. This study investigated the ion permeation mechanism in GIRK2 mutants using molecular dynamic simulations and QM/MM methods. The results revealed the importance of a multi-ion distribution for ion conduction.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Max J. den Uijl, Arnold J. M. Driessen
Summary: Membrane protein insertion into and translocation across the bacterial cytoplasmic membrane are essential processes facilitated by the Sec translocon. The phospholipid dependence of membrane protein insertion has remained mostly unknown. This study reveals that the insertion of the mannitol permease MtlA into the membrane depends on the presence of phosphatidylglycerol and is stimulated by phosphatidylethanolamine.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick Allen, Adam C. Smith, Vernon Benedicto, Abbas Abdulhasan, Vasanthy Narayanaswami, Enrico Tapavicza
Summary: We explore the stability, size, and structure of nanodiscs formed by the N-terminal domain of apolipoprotein E3 and a variable number of 1,2-dimyristoyl-sn-glycero-3-phosphocholine molecules. Our simulations suggest that nanodiscs containing 240 to 420 DMPC molecules are stable. The antiparallel configuration shows more protein-protein interactions and ionic contacts, as well as greater stability and rigidity compared to the parallel configuration.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick M. Keating, Nicholas P. Schifano, Xinrui Wei, Matthew Y. Kong, Jinwoo Lee
Summary: Lassa virus (LASV) infection is dependent on the fusion of its viral membrane with the host cell membrane, and our study reveals that this fusion process involves pH-dependent conformational changes in the transmembrane domain of LASV. These findings provide valuable insights into the fusion mechanism of LASV and can be utilized in the design of therapeutics to combat Lassa virus infections and prevent its potential spread.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Ashley L. Bennett, Kristen N. Cranford, Austin L. Bates, Christopher R. Sabatini, Hee-Seung Lee
Summary: This study employed molecular dynamics simulations to elucidate the binding, folding, and insertion details of TP10W in the cell membrane. The simulations revealed that TP10W can translocate across the lipid membrane as a monomer, and the charged amino acid side chains can move between lipid leaflets. Comparison with point mutated variants demonstrated significant conformational changes due to charge distribution.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Jessica H. van Wonderen, Jason C. Crack, Marcus J. Edwards, Thomas A. Clarke, Gerhard Saalbach, Carlo Martins, Julea N. Butt
Summary: Electrogenic bacteria transfer excess respiratory electrons to metal oxide particles and electrodes through the MtrCAB complex. The crystal structure of MtrCAB from S. baltica OS185 was resolved, and liquid chromatography mass spectrometry was used to determine the mass values of the three proteins in purified MtrCAB complexes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Review
Biochemistry & Molecular Biology
Yi-Ming Chen, Ching-Tai Lu, Chia-Wen Wang, Wolfgang B. Fischer
Summary: A series of dye ligands were ranked based on docking experiments, selecting the most suitable ligands for binding with different proteins. Additionally, a comparison study was conducted on a series of repurposing drugs and known antivirals.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)