期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1818, 期 5, 页码 1410-1419出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2012.02.013
关键词
Ethanol; H-2 NMR; IR; DSC; Ceramide; Stratum corneum
资金
- Natural Sciences and Engineering Research Council of Canada
- Fond Quebecois de la Recherche sur la Nature et les Technologies (FQRNT)
Ethanol is used in a variety of topical products. It is known to enhance the permeability of the skin by altering the ability of the stratum corneum (SC) intercellular membranes to form an effective barrier. In addition, ethanol and other alcohols are key components of antiseptic gels currently used for hand wash. Using infrared and deuterium NMR spectroscopy as well as calorimetry, we have investigated the effect of ethanol on a model membrane composed of lipids representing the three classes of SC lipids, an equimolar mixture of N-palmitoylsphingosine (ceramide), palmitic acid and cholesterol. Ethanol is found to influence the membrane in a dose dependent manner, disrupting packing and increasing lipid motion at low concentrations and selectively extracting lipids at moderate concentrations. (C) 2012 Elsevier B.V. All rights reserved.
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