Article
Medicine, Research & Experimental
Samar A. Antar, Walied Abdo, Reda S. Taha, Amira E. Farage, Laila E. El-Moselhy, Mohamed E. Amer, Ahmed S. Abdel Monsef, Amer M. Abdel Hamid, Emadeldin M. Kamel, Ahmad F. Ahmeda, Ayman M. Mahmoud
Summary: This study found that telmisartan has a protective effect on renal damage in diabetic rats, reducing hyperglycemia, oxidative stress, inflammation, apoptosis, and angiogenesis. It achieves this protective effect by upregulating the Nrf2/HO-1 signaling pathway.
Article
Biochemistry & Molecular Biology
Lifu Lei, Fuwei Zhang, Juan Huang, Xinyue Yang, Xiaoxin Zhou, Hongjia Yan, Caiyu Chen, Shuo Zheng, Liangyi Si, Pedro A. Jose, Chunyu Zeng, Jian Yang
Summary: Epidemiological studies have shown an association between low body selenium and hypertension, but the causality remains unclear. In this study, rats on a selenium-deficient diet developed hypertension after 16 weeks, with decreased sodium excretion. The hypertension was associated with increased renal expression and function of the angiotensin II type 1 receptor (AT1R). Selenium deficiency also led to oxidative stress and reduced expression of glutathione peroxidase 1 (GPx1). Treatment with antioxidants or GPx1 mimics reversed the hypertension and normalized AT1R expression. The results indicate that long-term selenium deficiency causes hypertension by reducing sodium excretion and increasing AT1R expression through oxidative stress and GPx1 downregulation.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Endocrinology & Metabolism
Nathalie Sumien, J. Thomas Cunningham, Delaney L. Davis, Rachel Engelland, Oluwadarasimi Fadeyibi, George E. Farmer, Steve Mabry, Paapa Mensah-Kane, Oanh T. P. Trinh, Philip H. Vann, E. Nicole Wilson, Rebecca L. Cunningham
Summary: Neurodegenerative diseases have severe impacts on cognitive and motor function, with age and longevity being the main risk factors and sex also playing an important role. Sex hormone receptors play a crucial role in cell health, with oxidative stress associated with aging influencing this health status. Understanding these signaling cascades could lead to therapeutic targets for neurodegenerative diseases.
Review
Endocrinology & Metabolism
Nathalie Sumien, J. Thomas Cunningham, Delaney L. Davis, Rachel Engelland, Oluwadarasimi Fadeyibi, George E. Farmer, Steve Mabry, Paapa Mensah-Kane, Oanh T. P. Trinh, Philip H. Vann, E. Nicole Wilson, Rebecca L. Cunningham
Summary: Neurodegenerative diseases have significant impacts on the elderly population, influenced by factors such as gender, age, and oxidative stress. Sex hormone receptors play a role in cell health, with menopausal women potentially facing higher levels of oxidative stress. Understanding these signaling pathways may offer therapeutic targets for neurodegenerative diseases.
Article
Pharmacology & Pharmacy
Ruonan Zhai, Yuan Liu, Jiahao Tong, Ying Yu, Lin Yang, Yong Gu, Jianying Niu
Summary: The research demonstrates that in mice with AT1-AA-induced preeclampsia, EMPA treatment significantly improved high systolic blood pressure, proteinuria, and kidney injury, without affecting fetal outcomes, suggesting EMPA could be a potential pharmacological agent for PE.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Chung-Hao Lin, Po-Cheng Chang, Pao-Hsien Chu, Yi-Fang Chuang, Rong-Chi Huang, Chiao-Nan Chen
Summary: This study evaluated the effects of ARB on muscle mass and exercise capacity in healthy older animals, and found that losartan promotes the adaptions of muscle mass with exercise training.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Angel Cores, Noelia Carmona-Zafra, Olmo Martin-Camara, Juan Domingo Sanchez, Pablo Duarte, Mercedes Villacampa, Paloma Bermejo-Bescos, Sagrario Martin-Aragon, Rafael Leon, J. Carlos Menendez
Summary: Curcumin analogues with the fragment of piperlongumine showed broad-spectrum activity in the treatment of Alzheimer's disease, with good absorption, antioxidant properties, and the ability to inhibit inflammation.
Article
Chemistry, Inorganic & Nuclear
Shuyang Hu, Xinlu Ning, Jie Lv, Yuxin Wei, Huiran Zhang, Meng Li
Summary: Preventing Aβ aggregation is a promising strategy for Alzheimer's disease treatment. In this study, chiral polyoxometalates (POMs) were designed as novel chiral Aβ inhibitors. The chiral POM enantiomers exhibited different binding behavior with Aβ40, leading to enantioselective inhibitory effects on Aβ aggregation. The d-POM enantiomer showed higher Aβ40-binding affinity, greater brain biodistribution, and better rescue of memory deficits in AD mice.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Biochemistry & Molecular Biology
Sol Guerra-Ojeda, Patricia Marchio, Cristina Rueda, Andrea Suarez, Hermenegildo Garcia, Victor M. Victor, Marina Juez, Ivan Martin-Gonzalez, Jose M. Vila, Maria D. Mauricio
Summary: This study evaluated the effects of cerium dioxide nanoparticles on human blood vessels and found that they have antioxidant properties and could potentially be used as adjuvants for the treatment of cardiovascular diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ahmet Ozer Sehirli, Serkan Sayiner, Ugochukwu Chukwunyere, Nedime Serakinci
Summary: The utilization of oxygen in cells leads to the generation of free radicals, contributing to aging and age-related diseases. Angiotensin II activates the oxidative pathway, causing DNA damage and production of reactive oxygen species, while melatonin may relieve induced stress by enhancing the mitochondrial calcium uptake pathway.
Article
Biochemistry & Molecular Biology
Rita Valenzuela, Ana Rodriguez-Perez, Maria A. Costa-Besada, Rafael Rivas-Santisteban, Pablo Garrido-Gil, Andrea Lopez-Lopez, Gemma Navarro, Jose L. Lanciego, Rafael Franco, Jose L. Labandeira-Garcia
Summary: ACE2 plays a crucial role in balancing oxidative stress and inflammation, especially in relation to SARS-CoV-2. The mitochondrial ACE2/MrgE/NO axis may play a significant role in regulating oxidative stress in neurons, contributing to neurodegenerative processes and potentially SARS-CoV-2 cellular effects.
Article
Medicine, Research & Experimental
Elshymaa A. Abdel-Hakeem, Sara Mohamed Naguib Abdel Hafez, Bothina A. Kamel, Heba A. Abdel-Hamid
Summary: The study demonstrated the potential protective effect of Angiotensin 1-7 in rhabdomyolysis-induced kidney injury in rats, possibly through modulation of multiple pathways.
Article
Integrative & Complementary Medicine
Chih-Chia Chang, Kun-Ling Tsai, Hui-Ching Cheng, Wan-Ching Chou, Yu-Ting Huang, Pei-Ling Hsieh, Shin-Da Lee
Summary: Mangiferin (MGN) has the potential to alleviate cardiac hypertrophy. By suppressing the MAPK signaling and NF-kappa Bp65/iNOS axis, MGN can attenuate cell size, expression of hypertrophy markers, and oxidative stress in cardiomyocytes.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Environmental Sciences
Yen-Lun Kung, Cheng-You Lu, Khan Fareen Badrealam, Wei-Wen Kuo, Marthandam Asokan Shibu, Cecilia Hsuan Day, Ray-Jade Chen, Shang-Yeh Lu, Viswanadha Vijaya Padma, Chih-Yang Huang
Summary: The study demonstrates that AMG can alleviate Ang II-induced cardiomyocyte enlargement, reduce the expression of hypertrophic and inflammatory markers, and increase oxidative stress related proteins. These findings highlight the cardio-protective role of AMG against Ang II-induced cardiomyopathies.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Qingsheng Cao, Wenbo Sun, Tian Yang, Zhu Zhu, Yinan Jiang, Wenlong Hu, Wenzhi Wei, Yingying Zhang, Hui Yang
Summary: This study explores the toxic effects of different sizes of microplastics on Chlorella pyrenoidosa, finding that 1 micrometer microplastics significantly inhibit the growth of the algae and alter the expression of genes related to photosynthesis and energy metabolism.
Article
Endocrinology & Metabolism
Sandra Lyga, Silvia Volpe, Ruth C. Werthmann, Konrad Goetz, Titiwat Sungkaworn, Martin J. Lohse, Davide Calebiro
Article
Multidisciplinary Sciences
Titiwat Sungkaworn, Marie-Lise Jobin, Krzysztof Burnecki, Aleksander Weron, Martin J. Lohse, Davide Calebiro
Review
Pharmacology & Pharmacy
Davide Calebiro, Titiwat Sungkaworn
TRENDS IN PHARMACOLOGICAL SCIENCES
(2018)
Article
Chemistry, Medicinal
Titiwat Sungkaworn, Chutima Jiarpinitnun, Pongkorn Chaiyakunvat, Varanuj Chatsudthipong
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2013)
Review
Endocrinology & Metabolism
D. Calebiro, T. Sungkaworn, I. Maiellaro
HORMONE AND METABOLIC RESEARCH
(2014)
Article
Multidisciplinary Sciences
Davide Calebiro, Finn Rieken, Julia Wagner, Titiwat Sungkaworn, Ulrike Zabel, Alfio Borzi, Emanuele Cocucci, Alexander Zuern, Martin J. Lohse
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Multidisciplinary Sciences
Titiwat Sungkaworn, Finn Rieken, Martin J. Lohse, Davide Calebiro
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2014)
Article
Biochemistry & Molecular Biology
Jan Moeller, Ali Isbilir, Titiwat Sungkaworn, Brendan Osberg, Christos Karathanasis, Vikram Sunkara, Eugene O. Grushevskyi, Andreas Bock, Paolo Annibale, Mike Heilemann, Christof Schuette, Martin J. Lohse
NATURE CHEMICAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Suchada Kaewin, Karn Changsorn, Titiwat Sungkaworn, Peraya Hiranmartsuwan, Wiriya Yaosanit, Vatcharin Rukachaisirikul, Chatchai Muanprasat
Summary: Diabetic nephropathy is a leading cause of end-stage renal disease. This study identified and characterized two natural compounds, 3-hydroxyterphenyllin and candidusin A, derived from a marine fungus, which can protect human podocytes from palmitic acid-induced injury through mechanisms involving free radical scavenging and upregulation of the anti-apoptotic Bcl2 protein.
Article
Physics, Fluids & Plasmas
Aleksander Weron, Joanna Janczura, Ewa Boryczka, Titiwat Sungkaworn, Davide Calebiro
Article
Endocrinology & Metabolism
Donatella Treppiedi, Marie-Lise Jobin, Erika Peverelli, Elena Giardino, Titiwat Sungkaworn, Ulrike Zabel, Maura Arosio, Anna Spada, Giovanna Mantovani, Davide Calebiro
Article
Biochemistry & Molecular Biology
Philipp Grad, Katarina Edwards, Lars Gedda, Victor Agmo Hernandez
Summary: This study investigates the effects of polyethylene glycol-(PEG) modified lipids and gangliosides on the Ca2+ induced interaction between liposomes composed of palmitoyl-oleoyl phosphatidylethanolamine (POPE) and palmitoyl-oleoyl phosphatidylserine (POPS) at physiological ionic strength. The results show that naked liposomes tend to adhere, rupture, and collapse on each other's surfaces upon addition of Ca2+, eventually resulting in the formation of large multilamellar aggregates and bilayer sheets. However, the presence of gangliosides or PEGylated lipids leads to the formation of small, long-lived bilayer fragments/disks. PEGylated lipids seem to be more effective than gangliosides at stabilizing these structures. The study suggests that direct liposome-liposome fusion is not the dominating process triggered by Ca2+ in the systems studied.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Saurabh Saraswat, Archana Chugh
Summary: Cell penetrating peptides (CPP) are important tools for intracellular delivery of molecules. In this study, a novel marine-derived CPP from Engraulis japonicus, called Engraulisin, was reported. Engraulisin demonstrated successful cellular uptake and selective antimicrobial activity against Methicillin-resistant Staphylococcus aureus (MRSA), making it a potential candidate for drug delivery.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Emanuela Efodili, Ashlynn Knight, Maryem Mirza, Cedric Briones, Il-Hyung Lee
Summary: This study demonstrates the spontaneous transfer of small membrane-bound peptides between a supported lipid bilayer and giant unilamellar vesicles in vitro. The transfer occurs through the formation of hemi-fusion stalks and is limited to small peptides due to the highly curved structure of the stalk. This system provides a synthetic platform for studying peptide trafficking between synthetic membranes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Niu, Si Jia Chen, Jeffery B. Klauda
Summary: Macrophage membranes in the activated state are more tightly packed, exhibit increased chain order across lipid species, and form specific lipid clusters. These findings provide physiologically accurate models for future computational studies of macrophage membranes and their proteins.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Niki Baccile, Vincent Chaleix, Ingo Hoffmann
Summary: This study measured the bending rigidity of self-assembled structures formed by a new biobased glucolipid bioamphiphile using neutron spin-echo (NSE) technology. The results showed that the bending rigidity of these structures is lower or higher compared to phospholipid membranes, providing a new theoretical basis for the application of these new molecular systems.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Alain Bolano Alvares, Pablo E. A. Rodriguez, Gerardo D. Fidelio
Summary: The behavior of amphiphilic molecules at the air/water interface was studied to evaluate the arrangement formed in a confined area. The surface properties of zwitterionic DPPC lipid and A beta(1-40) amyloid peptide in mixed films were investigated at different temperatures. DPPC undergoes a phase transition depending on temperature and lateral pressure, which allows for the study of its influence on amyloid structure formation.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Lukasz Plachta, Marzena Mach, Magdalena Kowalska, Pawel Wydro
Summary: Resveratrol, a popular phytoalexin found in grapes and red wine, has beneficial effects on the cardiovascular system, exhibits antiviral, antibacterial, and antifungal properties, and may have therapeutic effects against cancer. This study investigates the interaction of resveratrol with model cell membranes, demonstrating changes in their physicochemical parameters and highlighting the role of cholesterol content in resveratrol incorporation. The findings suggest that the molecular mechanism of action of resveratrol may involve interactions with lipid rafts.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Edurne Rujas, Beatriz Apellaniz, Johana Torralba, David Andreu, Jose M. M. Caaveiro, Shixia Wang, Shan Lu, Jose L. Nieva
Summary: This study investigates the role of fusion peptide and Trp-rich membrane proximal external region in HIV-1 fusion and demonstrates that liposome-based formulations containing FP-MPER hybrid peptides can induce the production of specific neutralizing antibodies in rabbits. The results support the use of liposomes as vaccine carriers and the inclusion of lipid membranes in immunogens to elicit specific humoral responses.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Dailin Li, Dingyuan Shi, Lei Wang
Summary: G protein-gated inwardly rectifying potassium (GIRK) channels play a significant role in regulating cell excitability. This study investigated the ion permeation mechanism in GIRK2 mutants using molecular dynamic simulations and QM/MM methods. The results revealed the importance of a multi-ion distribution for ion conduction.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Max J. den Uijl, Arnold J. M. Driessen
Summary: Membrane protein insertion into and translocation across the bacterial cytoplasmic membrane are essential processes facilitated by the Sec translocon. The phospholipid dependence of membrane protein insertion has remained mostly unknown. This study reveals that the insertion of the mannitol permease MtlA into the membrane depends on the presence of phosphatidylglycerol and is stimulated by phosphatidylethanolamine.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick Allen, Adam C. Smith, Vernon Benedicto, Abbas Abdulhasan, Vasanthy Narayanaswami, Enrico Tapavicza
Summary: We explore the stability, size, and structure of nanodiscs formed by the N-terminal domain of apolipoprotein E3 and a variable number of 1,2-dimyristoyl-sn-glycero-3-phosphocholine molecules. Our simulations suggest that nanodiscs containing 240 to 420 DMPC molecules are stable. The antiparallel configuration shows more protein-protein interactions and ionic contacts, as well as greater stability and rigidity compared to the parallel configuration.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick M. Keating, Nicholas P. Schifano, Xinrui Wei, Matthew Y. Kong, Jinwoo Lee
Summary: Lassa virus (LASV) infection is dependent on the fusion of its viral membrane with the host cell membrane, and our study reveals that this fusion process involves pH-dependent conformational changes in the transmembrane domain of LASV. These findings provide valuable insights into the fusion mechanism of LASV and can be utilized in the design of therapeutics to combat Lassa virus infections and prevent its potential spread.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Ashley L. Bennett, Kristen N. Cranford, Austin L. Bates, Christopher R. Sabatini, Hee-Seung Lee
Summary: This study employed molecular dynamics simulations to elucidate the binding, folding, and insertion details of TP10W in the cell membrane. The simulations revealed that TP10W can translocate across the lipid membrane as a monomer, and the charged amino acid side chains can move between lipid leaflets. Comparison with point mutated variants demonstrated significant conformational changes due to charge distribution.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Jessica H. van Wonderen, Jason C. Crack, Marcus J. Edwards, Thomas A. Clarke, Gerhard Saalbach, Carlo Martins, Julea N. Butt
Summary: Electrogenic bacteria transfer excess respiratory electrons to metal oxide particles and electrodes through the MtrCAB complex. The crystal structure of MtrCAB from S. baltica OS185 was resolved, and liquid chromatography mass spectrometry was used to determine the mass values of the three proteins in purified MtrCAB complexes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Review
Biochemistry & Molecular Biology
Yi-Ming Chen, Ching-Tai Lu, Chia-Wen Wang, Wolfgang B. Fischer
Summary: A series of dye ligands were ranked based on docking experiments, selecting the most suitable ligands for binding with different proteins. Additionally, a comparison study was conducted on a series of repurposing drugs and known antivirals.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)