Article
Plant Sciences
Olga A. A. Rozentsvet, Elena S. S. Bogdanova, Vadim N. N. Nurminsky, Viktor N. N. Nesterov, Michael Yu. Chernyshov
Summary: Halophytes are important models for studying salt tolerance mechanisms. This study investigates the lipid profiles of detergent-resistant membranes (DRMs) in chloroplasts and mitochondria of the euhalophyte Salicornia perennans before and after exposure to high salt concentrations. The results show that cerebrosides (CERs) are enriched in chloroplast DRMs, while sterols (STs) dominate mitochondrial DRMs. Salinity also increases the content of saturated and monounsaturated fatty acids (FAs). The authors conclude that the plant cells of euhalophyte S. perennans exhibit a specific protective response by altering lipid and FA composition in the membrane under salinity.
Article
Microbiology
Simon Czolkoss, Xenia Safronov, Sascha Rexroth, Lisa R. Knoke, Meriyem Aktas, Franz Narberhaus
Summary: Research has shown that the cell membranes of Agrobacterium tumefaciens contain specialized microdomains enriched with specific proteins related to cell envelope biogenesis, transport, secretion, bacterial motility and chemotaxis. Additionally, proteins associated with the pathogenicity of A. tumefaciens were found to be compartmentalized into these functional microdomains.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Engineering, Environmental
Elham Shokri, Parastoo Taherafshar, Habib Etemadi, Soleyman Hoseinzadeh
Summary: Chitosan grafted on graphene oxide composite incorporated in polycarbonate membrane improves its antifouling and arsenate removal capabilities. The presence of fine amine groups of CS on GO sheets and their effect on the fabricated membranes were confirmed. The concentration of CS/GO composite affects the structural properties, AsV removal efficiency, and fouling resistance of the membranes.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Engineering, Chemical
Seong-Joong Kim, Jeong F. Kim, Young Hoon Cho, Seung-Eun Nam, Hosik Park, You-In Park
Summary: The study found that pre-crosslinking density is critical for the aging suppression of CMS membranes, resulting in a significant improvement in long-term stability.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Engineering, Environmental
Yu-Ting Lin, Jing-Yi Li, Hui-Hsin Tseng, Ming-Yen Wey
Summary: The aim of this study is to determine the optimal carbonization conditions for carbon hollow fiber membranes for hydrogen purification. Three different carbonization atmospheres were examined, and their effects on the microstructure and gas permeation properties of the membranes were analyzed. The results showed that the carbon membrane with an ordered microstructure and larger pore volume exhibited the best separation capability and aging resistance.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Review
Pharmacology & Pharmacy
Vipin Dhote, Prem Samundre, Aditya Ganeshpurkar, Aman Upaganlawar
Summary: As individuals age, the risk of neurodegenerative diseases increases due to neuronal damage and mitochondrial dysfunctions. Mitochondrial impairment is considered a key factor in accelerating the progression of aging-related neurodegeneration, while environmental chemicals and metabolic morbidities also play a role in affecting mitochondrial functions.
CURRENT DRUG TARGETS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeremie Calais, Andrei Gafita, Matthias Eiber, Wesley R. Armstrong, Jeannine Gartmann, Pan Thin, Kathleen Nguyen, Vincent Lok, Laura Gosa, Tristan Grogan, Rouzbeh Esfandiari, Martin Allen-Auerbach, Andrew Quon, Shadfar Bahri, Pawan Gupta, Linda Gardner, David Ranganathan, Roger Slavik, Magnus Dahlbom, Ken Herrmann, Ebrahim Delpassand, Wolfgang P. Fendler, Johannes Czernin
Summary: This prospective phase 2 trial aimed to assess the efficacy of Lu-177-PSMA therapy in patients with progressive metastatic castrate-resistant prostate cancer. The results suggest that the efficacy profile of Lu-177-PSMA appeared to be favorable with comparable outcomes between the two activity regimens (6.0 vs. 7.4 GBq).
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Ophthalmology
Paola M. Natalini, Melina V. Mateos, Monica G. Ilincheta de Boschero, Norma M. Giusto
EXPERIMENTAL EYE RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Constanza B. Kamerbeek, Melina V. Mateos, Ana S. Valles, Maria F. Pediconi, Francisco J. Barrantes, Virginia Borroni
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Paula E. Tenconi, Norma M. Giusto, Gabriela A. Salvador, Melina V. Mateos
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Florencia X. Santiago Valtierra, Melina V. Mateos, Marta I. Aveldano, Gerardo M. Oresti
JOURNAL OF LIPID RESEARCH
(2017)
Article
Ophthalmology
Paola M. Natalini, Melina V. Mateos, Monica G. Ilincheta de Boschero, Norma M. Giusto
EXPERIMENTAL EYE RESEARCH
(2014)
Article
Biochemistry & Molecular Biology
Melina V. Mateos, Constanza B. Kamerbeek, Norma M. Giusto, Gabriela A. Salvador
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2014)
Article
Pharmacology & Pharmacy
Nazareth Eliana Ceschan, Veronica Bucala, Melina Valeria Mateos, Hugh David Charles Smyth, Maria Veronica Ramirez-Rigo
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2018)
Article
Multidisciplinary Sciences
Milagros Griet, Hortensia Zelaya, Melina Valeria Mateos, Susana Salva, Guillermo Esteban Juarez, Graciela Font de Valdez, Julio Villena, Gabriela Alejandra Salvador, Ana Virginia Rodriguez
Article
Neurosciences
Vicente Bermudez, Paula Estefania Tenconi, Norma Maria Giusto, Melina Valeria Mateos
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Ophthalmology
Paula E. Tenconi, Vicente Bermudez, Gerardo M. Oresti, Norma M. Giusto, Gabriela A. Salvador, Melina V. Mateos
EXPERIMENTAL EYE RESEARCH
(2019)
Review
Ophthalmology
Vicente Bermudez, Paula E. Tenconi, Norma M. Giusto, Melina Mateos
Summary: This review summarizes the involvement of classical PLD isoforms in physiological and pathological responses in the eye. The PLD pathway can modulate various cellular events through the generation of lipid messengers. Understanding the role of PLD1 and PLD2 in ocular diseases opens new avenues for potential therapeutic exploration.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Neurosciences
Aram Asatryan, Jorgelina M. Calandria, Marie-Audrey I. Kautzmann, Bokkyoo Jun, William C. Gordon, Khanh V. Do, Surjyadipta Bhattacharjee, Thang L. Pham, Vicente Bermudez, Melina Valeria Mateos, Jessica Heap, Nicolas G. Bazan
Summary: A new cell line ABC derived from human RPE cells was characterized in this study, which remarkably recapitulates the characteristics of native human eye cells. These cells display higher resistance to oxidative stress and can be protected from senescence through mTOR inhibition. They are also responsive to Neuroprotectin D1, which downregulates inflammasomes and upregulates antioxidant and anti-inflammatory genes.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Ophthalmology
M. Victoria Simon, Marcela S. Vera, Paula E. Tenconi, Tamara Soto, Facundo H. Prado Spalm, Camila Torlaschi, Melina Mateos, Nora P. Rotstein
Summary: Retinal pigment epithelium (RPE) cells play a crucial role in maintaining retina homeostasis but also contribute to the development of retina proliferative diseases. Recent studies have revealed that Sphingosine-1-phosphate (S1P) and ceramide-1-phosphate (C1P) can stimulate migration and inflammation in RPE cells, suggesting their potential as targets for treating these pathologies.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Vicente Bermudez, Paula Estefania Tenconi, Maria Sol Echevarria, Aram Asatrian, Jorgelina Muriel Calandria, Norma Maria Giusto, Nicolas Guillermo Bazan, Melina Valeria Mateos
Summary: This study found that PLD1i and PLD2i can prevent the effects of high glucose concentrations on the phagocytic function of RPE cells, without affecting cell function and viability under non-inflammatory conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Melina V. Mateos, Constanza B. Kamerbeek, Norma M. Giusto, Gabriela A. Salvador
Article
Biochemistry & Molecular Biology
Philipp Grad, Katarina Edwards, Lars Gedda, Victor Agmo Hernandez
Summary: This study investigates the effects of polyethylene glycol-(PEG) modified lipids and gangliosides on the Ca2+ induced interaction between liposomes composed of palmitoyl-oleoyl phosphatidylethanolamine (POPE) and palmitoyl-oleoyl phosphatidylserine (POPS) at physiological ionic strength. The results show that naked liposomes tend to adhere, rupture, and collapse on each other's surfaces upon addition of Ca2+, eventually resulting in the formation of large multilamellar aggregates and bilayer sheets. However, the presence of gangliosides or PEGylated lipids leads to the formation of small, long-lived bilayer fragments/disks. PEGylated lipids seem to be more effective than gangliosides at stabilizing these structures. The study suggests that direct liposome-liposome fusion is not the dominating process triggered by Ca2+ in the systems studied.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Saurabh Saraswat, Archana Chugh
Summary: Cell penetrating peptides (CPP) are important tools for intracellular delivery of molecules. In this study, a novel marine-derived CPP from Engraulis japonicus, called Engraulisin, was reported. Engraulisin demonstrated successful cellular uptake and selective antimicrobial activity against Methicillin-resistant Staphylococcus aureus (MRSA), making it a potential candidate for drug delivery.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Emanuela Efodili, Ashlynn Knight, Maryem Mirza, Cedric Briones, Il-Hyung Lee
Summary: This study demonstrates the spontaneous transfer of small membrane-bound peptides between a supported lipid bilayer and giant unilamellar vesicles in vitro. The transfer occurs through the formation of hemi-fusion stalks and is limited to small peptides due to the highly curved structure of the stalk. This system provides a synthetic platform for studying peptide trafficking between synthetic membranes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Niu, Si Jia Chen, Jeffery B. Klauda
Summary: Macrophage membranes in the activated state are more tightly packed, exhibit increased chain order across lipid species, and form specific lipid clusters. These findings provide physiologically accurate models for future computational studies of macrophage membranes and their proteins.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Niki Baccile, Vincent Chaleix, Ingo Hoffmann
Summary: This study measured the bending rigidity of self-assembled structures formed by a new biobased glucolipid bioamphiphile using neutron spin-echo (NSE) technology. The results showed that the bending rigidity of these structures is lower or higher compared to phospholipid membranes, providing a new theoretical basis for the application of these new molecular systems.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Alain Bolano Alvares, Pablo E. A. Rodriguez, Gerardo D. Fidelio
Summary: The behavior of amphiphilic molecules at the air/water interface was studied to evaluate the arrangement formed in a confined area. The surface properties of zwitterionic DPPC lipid and A beta(1-40) amyloid peptide in mixed films were investigated at different temperatures. DPPC undergoes a phase transition depending on temperature and lateral pressure, which allows for the study of its influence on amyloid structure formation.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Lukasz Plachta, Marzena Mach, Magdalena Kowalska, Pawel Wydro
Summary: Resveratrol, a popular phytoalexin found in grapes and red wine, has beneficial effects on the cardiovascular system, exhibits antiviral, antibacterial, and antifungal properties, and may have therapeutic effects against cancer. This study investigates the interaction of resveratrol with model cell membranes, demonstrating changes in their physicochemical parameters and highlighting the role of cholesterol content in resveratrol incorporation. The findings suggest that the molecular mechanism of action of resveratrol may involve interactions with lipid rafts.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Edurne Rujas, Beatriz Apellaniz, Johana Torralba, David Andreu, Jose M. M. Caaveiro, Shixia Wang, Shan Lu, Jose L. Nieva
Summary: This study investigates the role of fusion peptide and Trp-rich membrane proximal external region in HIV-1 fusion and demonstrates that liposome-based formulations containing FP-MPER hybrid peptides can induce the production of specific neutralizing antibodies in rabbits. The results support the use of liposomes as vaccine carriers and the inclusion of lipid membranes in immunogens to elicit specific humoral responses.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Dailin Li, Dingyuan Shi, Lei Wang
Summary: G protein-gated inwardly rectifying potassium (GIRK) channels play a significant role in regulating cell excitability. This study investigated the ion permeation mechanism in GIRK2 mutants using molecular dynamic simulations and QM/MM methods. The results revealed the importance of a multi-ion distribution for ion conduction.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Max J. den Uijl, Arnold J. M. Driessen
Summary: Membrane protein insertion into and translocation across the bacterial cytoplasmic membrane are essential processes facilitated by the Sec translocon. The phospholipid dependence of membrane protein insertion has remained mostly unknown. This study reveals that the insertion of the mannitol permease MtlA into the membrane depends on the presence of phosphatidylglycerol and is stimulated by phosphatidylethanolamine.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick Allen, Adam C. Smith, Vernon Benedicto, Abbas Abdulhasan, Vasanthy Narayanaswami, Enrico Tapavicza
Summary: We explore the stability, size, and structure of nanodiscs formed by the N-terminal domain of apolipoprotein E3 and a variable number of 1,2-dimyristoyl-sn-glycero-3-phosphocholine molecules. Our simulations suggest that nanodiscs containing 240 to 420 DMPC molecules are stable. The antiparallel configuration shows more protein-protein interactions and ionic contacts, as well as greater stability and rigidity compared to the parallel configuration.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick M. Keating, Nicholas P. Schifano, Xinrui Wei, Matthew Y. Kong, Jinwoo Lee
Summary: Lassa virus (LASV) infection is dependent on the fusion of its viral membrane with the host cell membrane, and our study reveals that this fusion process involves pH-dependent conformational changes in the transmembrane domain of LASV. These findings provide valuable insights into the fusion mechanism of LASV and can be utilized in the design of therapeutics to combat Lassa virus infections and prevent its potential spread.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Ashley L. Bennett, Kristen N. Cranford, Austin L. Bates, Christopher R. Sabatini, Hee-Seung Lee
Summary: This study employed molecular dynamics simulations to elucidate the binding, folding, and insertion details of TP10W in the cell membrane. The simulations revealed that TP10W can translocate across the lipid membrane as a monomer, and the charged amino acid side chains can move between lipid leaflets. Comparison with point mutated variants demonstrated significant conformational changes due to charge distribution.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Jessica H. van Wonderen, Jason C. Crack, Marcus J. Edwards, Thomas A. Clarke, Gerhard Saalbach, Carlo Martins, Julea N. Butt
Summary: Electrogenic bacteria transfer excess respiratory electrons to metal oxide particles and electrodes through the MtrCAB complex. The crystal structure of MtrCAB from S. baltica OS185 was resolved, and liquid chromatography mass spectrometry was used to determine the mass values of the three proteins in purified MtrCAB complexes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Review
Biochemistry & Molecular Biology
Yi-Ming Chen, Ching-Tai Lu, Chia-Wen Wang, Wolfgang B. Fischer
Summary: A series of dye ligands were ranked based on docking experiments, selecting the most suitable ligands for binding with different proteins. Additionally, a comparison study was conducted on a series of repurposing drugs and known antivirals.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)