Article
Microbiology
Mahendra Singh, N. Rupesh, Shashi Bhushan Pandit, Kausik Chattopadhyay
Summary: In this study, it was found that curcumin can neutralize the membrane-damaging activity of VCC, making it a potential inhibitor of this powerful bacterial toxin. Curcumin binds to VCC and reduces its ability to attack cell membranes, while the soluble extract of curcumin generated by heat treatment weakens the pore-forming activity of VCC.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anish Kumar Mondal, Kusum Lata, Mahendra Singh, Shamaita Chatterjee, Aakanksha Chauhan, Sindhoora Puravankara, Kausik Chattopadhyay
Summary: This article discusses the mechanism of pore formation by pore-forming toxins (PFTs), with a particular focus on the mechanistic details contributed by cryo-EM-based structural studies.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2022)
Article
Biochemistry & Molecular Biology
Tudor Moldoveanu
Summary: The pore-forming BCL-2 family proteins, including BOK, tBID, BAK, and BAX, play crucial roles in mitochondrial poration during apoptosis. Gene knockout studies have shown developmental phenotypes in the absence of these effectors, supporting their in vivo functions. Effector oligomers, except tBID, form arcs and rings on the mitochondria surface, and are believed to be the building blocks of apoptotic pores. The mechanism of membrane poration by effectors, which interact with lipids and bilayers, remains elusive. This article discusses effector-mediated mitochondrial poration.
Article
Biochemistry & Molecular Biology
Kusum Lata, Mahendra Singh, Shamaita Chatterjee, Kausik Chattopadhyay
Summary: Pore-forming protein toxins damage cell membranes by interacting with them, disrupting cellular homeostasis, and initiating membrane repair mechanisms.
JOURNAL OF MEMBRANE BIOLOGY
(2022)
Article
Chemistry, Physical
Tarang Gupta, Anish Kumar Mondal, Ipsita Pani, Kausik Chattopadhyay, Santanu Kumar Pal
Summary: Pore-forming toxins produced by pathogenic bacteria have potent cell-killing activity. The interactions between protein and membrane lipids play crucial roles in the process of pore formation. The cooperative action between protein and membrane lipids can alter the membrane organization, but the details are still unclear. The use of liquid crystals (LCs) as responsive interfaces provides a new platform to explore the mechanistic aspects of protein-membrane interactions in membrane-damaging toxins.
Review
Polymer Science
Xianyang Cao, Wei Chen, Ping Zhao, Yaoyao Yang, Deng-Guang Yu
Summary: This paper summarizes the pore formation mechanisms of electrospun porous nanofibers, introduces their applications in degrading pollutants in water, and briefly discusses strategies to improve their mechanical properties.
Article
Multidisciplinary Sciences
Eric H. -L. Chen, Chun-Hsiung Wang, Yi-Ting Liao, Feng-Yueh Chan, Yui Kanaoka, Takayuki Uchihashi, Koichi Kato, Longsheng Lai, Yi-Wei Chang, Meng-Chiao Ho, Rita P. -Y. Chen
Summary: The abuse of antibiotics has led to the emergence of multidrug-resistant microbial pathogens. Antimicrobial peptides (AMPs) have shown potential in combating these superbugs, but their mechanism of action is not fully understood. This study used high-resolution imaging techniques to directly observe the disruption of outer and inner membranes of Escherichia coli by a de novo-designed peptide, providing critical insights into the mechanisms of this class of antimicrobial agents.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Anish Kumar Mondal, Paras Verma, Nayanika Sengupta, Somnath Dutta, Shashi Bhushan Pandit, Kausik Chattopadhyay
Summary: This study demonstrates the crucial role of a key tyrosine residue (Y321) in the hinge region of the pore-forming motif of Vibrio cholerae cytolysin in regulating membrane binding, structural rearrangements, oligomerization, and pore-formation, providing insights into the molecular mechanism of beta-barrel pore-forming toxins.
MOLECULAR MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yadira P. Hervis, Aisel Valle, Liem Canet, Azalia Rodriguez, Maria E. Lanio, Carlos Alvarez, Heinz J. Steinhoff, Isabel F. Pazos
Summary: Sticholysin I (StI) is a water-soluble protein that binds membranes and forms pores, leading to cell death. This study investigates the assembly properties of StI and its potential applications in biotechnology. Through mutation of cysteine residues at the oligomerization interface, the stabilization of StI oligomers by disulfide bonds is examined. The results suggest that specific positions in the protein, such as 15 and 59, are important for the development of nanopore-based biosensors from StI.
Review
Biochemistry & Molecular Biology
Pratima Verma, Kausik Chattopadhyay
Summary: Thermostable direct hemolysin (TDH) is the major virulence determinant of the gastroenteric bacterial pathogen Vibrio parahaemolyticus. TDH is a unique tetrameric pore-forming toxin with structural similarity to eukaryotic PFTs produced by sea anemones. The specific membrane pore structure and interaction mechanisms of TDH remain unclear.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Energy & Fuels
Qing-qing Sun, Hui-yong Niu, Hai-yan Wang, Yan-xiao Yang, Si-wei Sun
Summary: This study investigates the effects of water immersion on the macrostructure and microgroup of lignite. The results show that water immersion leads to changes in the pore structure and enhanced adsorption capacity of coal. The highest content of active functional groups is observed in samples immersed in water for 90-120 days.
Review
Biochemistry & Molecular Biology
Laxmi Kumari Gupta, Johiruddin Molla, Ashish A. Prabhu
Summary: Animal venoms are complex mixtures of specialized toxic molecules. Pore-forming proteins (PFPs) or toxins (PFTs) are major disease-causing elements. PFPs have unique defense and toxicity abilities through pore formation, making them attractive for academic and research purposes. Despite poor sequence similarity, PFPs share a common mechanism of attacking host cells and forming water-filled pores. They are prevalent in various organisms and have potential biotechnological applications.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Zoology
Chris J. Lacomel, Michelle A. Dunstone, Bradley A. Spicer
Summary: Organisms have evolved mechanisms utilizing pore forming proteins to kill targeted cells, with variations in pore structure leading to different mechanisms. 8-PFPs and α-PFPs are two common families of pore forming proteins with distinct structural features.
JOURNAL OF INVERTEBRATE PATHOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Wen-Zhu Bi, Yang Geng, Wen-Jie Zhang, Chen-Yu Li, Chu-Sen Ni, Qiu-Juan Ma, Su-Xiang Feng, Xiao-Lan Chen, Ling-Bo Qu
Summary: A new fluorescent probe, 4-AHBI, was synthesized and demonstrated high sensitivity and selectivity towards triphosgene. It can be used for practical detection of triphosgene.
Article
Materials Science, Ceramics
Yang Huang, Nanyan Hu, Yicheng Ye, Zhibing Ou, Xin Shi
Summary: A simple strategy for preparing MgO-Al2O3-CaO-based porous ceramics (MACPC) with high strength and ultralow thermal conductivity using phosphorus tailings as raw material is proposed. The effects of phosphorus tailings content, carbon black addition, and heat treatment temperature on the properties of MACPC are investigated. The results show that MACPC with excellent comprehensive properties can be achieved by adding 60 wt% phosphorus tailings and 40 wt% alumina.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Medicinal
Massimiliano Anselmi, Paolo Calligari, Jochen S. Hub, Marco Tartaglia, Gianfranco Bocchinfuso, Lorenzo Stella
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2020)
Article
Genetics & Heredity
Marialetizia Motta, Luca Pannone, Francesca Pantaleoni, Gianfranco Bocchinfuso, Francesca Clementina Radio, Serena Cecchetti, Andrea Ciolfi, Martina Di Rocco, Mariet W. Elting, Eva H. Brilstra, Stefania Boni, Laura Mazzanti, Federica Tamburrino, Larry Walsh, Katelyn Payne, Alberto Fernandez-Jaen, Mythily Ganapathi, Wendy K. Chung, Dorothy K. Grange, Ashita Dave-Wala, Shalini C. Reshmi, Dennis W. Bartholomew, Danielle Mouhlas, Giovanna Carpentieri, Alessandro Bruselles, Simone Pizzi, Emanuele Bellacchio, Francesca Piceci-Sparascio, Christina Lissewski, Julia Brinkmann, Ronald R. Waclaw, Quinten Waisfisz, Koen van Gassen, Ingrid M. Wentzensen, Michelle M. Morrow, Sara Alvarez, Monica Martinez-Garcia, Alessandro De Luca, Luigi Memo, Giuseppe Zampino, Cesare Rossi, Marco Seri, Bruce D. Gelb, Martin Zenker, Bruno Dallapiccola, Lorenzo Stella, Carlos E. Prada, Simone Martinelli, Elisabetta Flex, Marco Tartaglia
AMERICAN JOURNAL OF HUMAN GENETICS
(2020)
Article
Biochemistry & Molecular Biology
F. Savini, M. R. Loffredo, C. Troiano, S. Bobone, N. Malanovic, T. O. Eichmann, L. Caprio, V. C. Canale, Y. Park, M. L. Mangoni, L. Stella
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2020)
Article
Chemistry, Multidisciplinary
Marianna Rossetti, Lorenzo Stella, Judit Morla-Folch, Sara Bobone, Ariadna Boloix, Lorena Baranda, Danila Moscone, Monica Roldan, Jaume Veciana, Miguel F. Segura, Mariana Kober, Nora Ventosa, Alessandro Porchetta
Summary: This article introduces a rational design of DNA-grafted nanovesicles for biomedical applications, which can sensitively sense the presence of specific target molecules in the biological environment and produce optical outputs. This design has potential applications as functional nanodevices for sensing and targeted biomedical applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Maria Rosa Loffredo, Filippo Savini, Sara Bobone, Bruno Casciaro, Henrik Franzyk, Maria Luisa Mangoni, Lorenzo Stella
Summary: The activity of many antibiotics depends on the initial cell density used in bacterial growth inhibition assays, with a significant inoculum effect observed for higher cell densities. Antimicrobial peptides perturb cell membranes and the inoculum effect can impact their bacterial killing ability. Routine evaluation of the dependence of antimicrobial peptides and peptidomimetics on inoculum density should be considered.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Medicinal
Sara Bobone, Luca Pannone, Barbara Biondi, Maja Solman, Elisabetta Flex, Viviana Claudia Canale, Paolo Calligari, Chiara De Faveri, Tommaso Gandini, Andrea Quercioli, Giuseppe Torini, Martina Venditti, Antonella Lauri, Giulia Fasano, Jelmer Hoeksma, Valerio Santucci, Giada Cattani, Alessio Bocedi, Giovanna Carpentieri, Valentina Tirelli, Massimo Sanchez, Cristina Peggion, Fernando Formaggio, Jeroen den Hertog, Simone Martinelli, Gianfranco Bocchinfuso, Marco Tartaglia, Lorenzo Stella
Summary: A new class of inhibitors targeting protein-protein interactions of the SHP2 phosphatase were developed, showing potential for cancer and rare disease therapy. These inhibitors exhibit high affinity and selectivity, with stronger affinity for pathogenic SHP2 mutants. The best peptide inhibitor demonstrated promising effects in zebrafish embryos, indicating a novel route for SHP2-targeted therapies and further research into protein-protein interactions in SHP2 function.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
A. Bortolotti, C. Troiano, S. Bobone, M. M. Konai, C. Ghosh, G. Bocchinfuso, Y. Acharya, V. Santucci, S. Bonacorsi, C. Di Stefano, J. Haldar, L. Stella
Summary: Membrane-active small molecules (MASMs) are a class of small organic molecules that mimic the physicochemical properties of natural antimicrobial peptides. They have broad antimicrobial activity by binding to bacterial membranes and causing defects, as well as inducing membrane aggregation.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2023)
Article
Chemistry, Organic
Mattia Forchetta, Federica Sabuzi, Lorenzo Stella, Valeria Conte, Pierluca Galloni
Summary: A selective photocatalytic system for the oxidation of thioethers to sulfoxides has been developed. The system shows high catalytic activity and selectivity, and can be recycled without loss of performance. It offers potential applications in the field of organic synthesis.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Francesca Cantini, Paola Gianni, Sara Bobone, Cassandra Troiano, Hugo van Ingen, Renato Massoud, Nicoletta Perini, Luciana Migliore, Philippe Savarin, Charles Sanders, Lorenzo Stella, Marco Sette
Summary: Antimicrobial resistance is a pressing public health issue, and the development of new antimicrobial agents is actively pursued. In this study, an improved version of the crabrolin peptide was designed and characterized for its functional and structural properties using various techniques. The newly designed crabrolin21 exhibited enhanced antimicrobial activity and specific selectivity towards bacterial cells. These findings suggest that further investigations on crabrolin21 are warranted.
Article
Chemistry, Multidisciplinary
Cassandra Troiano, Adele De Ninno, Bruno Casciaro, Francesco Riccitelli, Yoonkyung Park, Luca Businaro, Renato Massoud, Maria Luisa Mangoni, Paolo Bisegna, Lorenzo Stella, Federica Caselli
Summary: Antimicrobial peptides (AMPs) are promising compounds to combat antibiotic-resistant infections, as they kill bacteria by permeabilizing their membrane and exhibit low propensity for inducing bacterial resistance. However, limited understanding of AMPs' interactions with bacteria and human cells hinders their clinical applications. This study proposes the use of microfluidic impedance cytometry to rapidly explore the action of AMPs on bacteria and host cells, providing single-cell resolution.
Article
Chemistry, Multidisciplinary
Swagatam Barman, Sudip Mukherjee, Logia Jolly, Cassandra Troiano, Alessandro Grottesi, Debajyoti Basak, Paolo Calligari, Brinta Bhattacharjee, Gianfranco Bocchinfuso, Lorenzo Stella, Jayanta Haldar
Summary: New isoamphipathic antibacterial molecules with positional isomerism were designed and showed good antibacterial activity with low toxicity towards mammalian cells. The ortho isomer, IAM-1, exhibited strong selective activity towards bacterial membranes. Furthermore, IAM-1 demonstrated efficacy against dormant bacteria and mature biofilms, as well as moderate in vivo activity against MRSA wound infection with no detectable dermal toxicity.
Article
Biochemistry & Molecular Biology
Giancarlo Morelli, Maria Luisa Mangoni, Lorenzo Stella
JOURNAL OF PEPTIDE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Paolo Calligari, Valerio Santucci, Lorenzo Stella, Gianfranco Bocchinfuso
Summary: SHP2 is a critical player in signaling pathways, with activation involving rearrangement of domains and binding to proteins containing phosphotyrosines. Studies show the crystallographic conformation is unstable in solution, with multiple interdomain arrangements present, and activation is coupled to changes in the N-SH2 binding site.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Meeting Abstract
Biophysics
Sara Bobone, Cassandra Troiano, Francesco Riccitelli, Filippo Savini, Daniela Roversi, Yoonkyung Park, Maria Rosa Loffredo, Bruno Casciaro, Maria Luisa Mangoni, Lorenzo Stella
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2021)
Meeting Abstract
Biophysics
Cassandra Troiano, Francesco Riccitelli, Maria Rosa Loffredo, Maria Luisa Mangoni, Yoonkyung Park, Sara Bobone, Lorenzo Stella
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Philipp Grad, Katarina Edwards, Lars Gedda, Victor Agmo Hernandez
Summary: This study investigates the effects of polyethylene glycol-(PEG) modified lipids and gangliosides on the Ca2+ induced interaction between liposomes composed of palmitoyl-oleoyl phosphatidylethanolamine (POPE) and palmitoyl-oleoyl phosphatidylserine (POPS) at physiological ionic strength. The results show that naked liposomes tend to adhere, rupture, and collapse on each other's surfaces upon addition of Ca2+, eventually resulting in the formation of large multilamellar aggregates and bilayer sheets. However, the presence of gangliosides or PEGylated lipids leads to the formation of small, long-lived bilayer fragments/disks. PEGylated lipids seem to be more effective than gangliosides at stabilizing these structures. The study suggests that direct liposome-liposome fusion is not the dominating process triggered by Ca2+ in the systems studied.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Saurabh Saraswat, Archana Chugh
Summary: Cell penetrating peptides (CPP) are important tools for intracellular delivery of molecules. In this study, a novel marine-derived CPP from Engraulis japonicus, called Engraulisin, was reported. Engraulisin demonstrated successful cellular uptake and selective antimicrobial activity against Methicillin-resistant Staphylococcus aureus (MRSA), making it a potential candidate for drug delivery.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Emanuela Efodili, Ashlynn Knight, Maryem Mirza, Cedric Briones, Il-Hyung Lee
Summary: This study demonstrates the spontaneous transfer of small membrane-bound peptides between a supported lipid bilayer and giant unilamellar vesicles in vitro. The transfer occurs through the formation of hemi-fusion stalks and is limited to small peptides due to the highly curved structure of the stalk. This system provides a synthetic platform for studying peptide trafficking between synthetic membranes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Niu, Si Jia Chen, Jeffery B. Klauda
Summary: Macrophage membranes in the activated state are more tightly packed, exhibit increased chain order across lipid species, and form specific lipid clusters. These findings provide physiologically accurate models for future computational studies of macrophage membranes and their proteins.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Niki Baccile, Vincent Chaleix, Ingo Hoffmann
Summary: This study measured the bending rigidity of self-assembled structures formed by a new biobased glucolipid bioamphiphile using neutron spin-echo (NSE) technology. The results showed that the bending rigidity of these structures is lower or higher compared to phospholipid membranes, providing a new theoretical basis for the application of these new molecular systems.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Alain Bolano Alvares, Pablo E. A. Rodriguez, Gerardo D. Fidelio
Summary: The behavior of amphiphilic molecules at the air/water interface was studied to evaluate the arrangement formed in a confined area. The surface properties of zwitterionic DPPC lipid and A beta(1-40) amyloid peptide in mixed films were investigated at different temperatures. DPPC undergoes a phase transition depending on temperature and lateral pressure, which allows for the study of its influence on amyloid structure formation.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Lukasz Plachta, Marzena Mach, Magdalena Kowalska, Pawel Wydro
Summary: Resveratrol, a popular phytoalexin found in grapes and red wine, has beneficial effects on the cardiovascular system, exhibits antiviral, antibacterial, and antifungal properties, and may have therapeutic effects against cancer. This study investigates the interaction of resveratrol with model cell membranes, demonstrating changes in their physicochemical parameters and highlighting the role of cholesterol content in resveratrol incorporation. The findings suggest that the molecular mechanism of action of resveratrol may involve interactions with lipid rafts.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Edurne Rujas, Beatriz Apellaniz, Johana Torralba, David Andreu, Jose M. M. Caaveiro, Shixia Wang, Shan Lu, Jose L. Nieva
Summary: This study investigates the role of fusion peptide and Trp-rich membrane proximal external region in HIV-1 fusion and demonstrates that liposome-based formulations containing FP-MPER hybrid peptides can induce the production of specific neutralizing antibodies in rabbits. The results support the use of liposomes as vaccine carriers and the inclusion of lipid membranes in immunogens to elicit specific humoral responses.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Dailin Li, Dingyuan Shi, Lei Wang
Summary: G protein-gated inwardly rectifying potassium (GIRK) channels play a significant role in regulating cell excitability. This study investigated the ion permeation mechanism in GIRK2 mutants using molecular dynamic simulations and QM/MM methods. The results revealed the importance of a multi-ion distribution for ion conduction.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Max J. den Uijl, Arnold J. M. Driessen
Summary: Membrane protein insertion into and translocation across the bacterial cytoplasmic membrane are essential processes facilitated by the Sec translocon. The phospholipid dependence of membrane protein insertion has remained mostly unknown. This study reveals that the insertion of the mannitol permease MtlA into the membrane depends on the presence of phosphatidylglycerol and is stimulated by phosphatidylethanolamine.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick Allen, Adam C. Smith, Vernon Benedicto, Abbas Abdulhasan, Vasanthy Narayanaswami, Enrico Tapavicza
Summary: We explore the stability, size, and structure of nanodiscs formed by the N-terminal domain of apolipoprotein E3 and a variable number of 1,2-dimyristoyl-sn-glycero-3-phosphocholine molecules. Our simulations suggest that nanodiscs containing 240 to 420 DMPC molecules are stable. The antiparallel configuration shows more protein-protein interactions and ionic contacts, as well as greater stability and rigidity compared to the parallel configuration.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Patrick M. Keating, Nicholas P. Schifano, Xinrui Wei, Matthew Y. Kong, Jinwoo Lee
Summary: Lassa virus (LASV) infection is dependent on the fusion of its viral membrane with the host cell membrane, and our study reveals that this fusion process involves pH-dependent conformational changes in the transmembrane domain of LASV. These findings provide valuable insights into the fusion mechanism of LASV and can be utilized in the design of therapeutics to combat Lassa virus infections and prevent its potential spread.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Ashley L. Bennett, Kristen N. Cranford, Austin L. Bates, Christopher R. Sabatini, Hee-Seung Lee
Summary: This study employed molecular dynamics simulations to elucidate the binding, folding, and insertion details of TP10W in the cell membrane. The simulations revealed that TP10W can translocate across the lipid membrane as a monomer, and the charged amino acid side chains can move between lipid leaflets. Comparison with point mutated variants demonstrated significant conformational changes due to charge distribution.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Article
Biochemistry & Molecular Biology
Jessica H. van Wonderen, Jason C. Crack, Marcus J. Edwards, Thomas A. Clarke, Gerhard Saalbach, Carlo Martins, Julea N. Butt
Summary: Electrogenic bacteria transfer excess respiratory electrons to metal oxide particles and electrodes through the MtrCAB complex. The crystal structure of MtrCAB from S. baltica OS185 was resolved, and liquid chromatography mass spectrometry was used to determine the mass values of the three proteins in purified MtrCAB complexes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)
Review
Biochemistry & Molecular Biology
Yi-Ming Chen, Ching-Tai Lu, Chia-Wen Wang, Wolfgang B. Fischer
Summary: A series of dye ligands were ranked based on docking experiments, selecting the most suitable ligands for binding with different proteins. Additionally, a comparison study was conducted on a series of repurposing drugs and known antivirals.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2024)