期刊
ANALYST
卷 140, 期 1, 页码 322-329出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4an01441c
关键词
-
资金
- National Natural Science Foundation of China [21173262, 21373218]
- Hundred-Talent Program of CAS
A new type of resorufin-based dual-functional fluorescent probe whose fluorescence emission features are sensitive to thiol compounds and redox homeostasis was developed. Thiols-triggered nucleophilic substitution of the probes converts the nonfluorescent probe to the highly fluorescent resorufin moiety; the released resorufin not only enables fluorescence signaling specific for thiol compounds but functions as a redox indicator with sensitive colorimetric and fluorescence emission change upon redox variation. Preliminary fluorescence imaging experiments have revealed the biocompatibility of the as-prepared probes and validated their practicability for thiol sensing and redox homeostasis mapping in living cells.
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