Review
Peripheral Vascular Disease
Tiago J. Costa, Braxton A. Linder, Seth Hester, Milene Fontes, Laena Pernomian, Camilla F. Wenceslau, Austin T. Robinson, Cameron G. McCarthy
Summary: Hypertension is a major risk factor for cardiovascular diseases, and ketogenic diets may have potential as a therapeutic strategy for lowering blood pressure, although their effectiveness is yet to be determined.
JOURNAL OF HYPERTENSION
(2022)
Review
Oncology
Erwan Eriau, Juliette Paillet, Guido Kroemer, Jonathan G. Pol
Summary: Reduced food intake and caloric restriction mimetics have been shown to increase healthy lifespan, reduce cancer incidence, and enhance responses to certain cancer treatments. These effects are mediated by cellular mechanisms and vary between cancer cells and healthy cells due to differences in metabolic requirements. Additionally, both reduced food intake and caloric restriction mimetics can induce autophagy, improving the efficacy of certain cancer treatments that induce immunogenic cell death and enhance the therapeutic efficacy of chemo-immunotherapies.
Review
Endocrinology & Metabolism
Olivia R. Ghosh-Swaby, Amy C. Reichelt, Paul A. S. Sheppard, Jeffrey Davies, Timothy J. Bussey, Lisa M. Saksida
Summary: This article discusses the role of metabolic hormones in neural plasticity and cognition, as well as the relationship between metabolic hormones and metabolic syndromes such as obesity and diabetes. Adjusting metabolic hormone levels can restore metabolic homeostasis and enhance cognitive function.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Rafael Ferraz-Bannitz, Rebeca A. Beraldo, A. Augusto Peluso, Morten Dall, Parizad Babaei, Rayana Cardoso Foglietti, Larissa Marfori Martins, Patricia Moreira Gomes, Julio Sergio Marchini, Vivian Marques Miguel Suen, Luiz C. Conti de Freitas, Luiz Carlos Navegantes, Marco Antonio M. Pretti, Mariana Boroni, Jonas T. Treebak, Marcelo A. Mori, Milton Cesar Foss, Maria Cristina Foss-Freitas
Summary: This study aimed to investigate the benefits of dietary restriction in patients with metabolic syndrome and determine whether it is the calorie or protein restriction that mediates the effects. The findings showed that isocaloric dietary protein restriction can achieve similar clinical outcomes as calorie restriction, making it a more attractive and less drastic dietary strategy for patients with metabolic syndrome and has potential as an adjuvant therapy.
Article
Medicine, Research & Experimental
Gladys Ferrere, Maryam Tidjani Alou, Peng Liu, Anne-Gaelle Goubet, Marine Fidelle, Oliver Kepp, Sylvere Durand, Valerio Iebba, Aurelie Fluckiger, Romain Daillere, Cassandra Thelemaque, Claudia Grajeda-Iglesias, Carolina Alves Costa Silva, Fanny Aprahamian, Deborah Lefevre, Liwei Zhao, Bernhard Ryffel, Emeline Colomba, Monica Arnedos, Damien Drubay, Conrad Rauber, Didier Raoult, Francesco Asnicar, Tim Spector, Nicola Segata, Lisa Derosa, Guido Kroemer, Laurence Zitvogel
Summary: Limited experimental evidence suggests a link between nutrition and cancer immunosurveillance. This study demonstrates that ketogenic diet induces an anti-tumor effect through 3HB-mediated T cell-mediated cancer immunosurveillance. 3HB prevents immune checkpoint inhibition and promotes the expansion of specific T cells, while KD also leads to compositional changes in gut microbiota.
Review
Nutrition & Dietetics
Xiujuan Wang, Meihong Xu, Yong Li
Summary: Adipose tissue, as the largest endocrine organ, plays a crucial role in regulating energy balance and immune function. Nutritional interventions have been proven effective in managing adipose tissue aging's adverse effects.
Review
Food Science & Technology
Luanfeng Wang, Fang Wang, Ling Xiong, Haizhao Song, Bo Ren, Xinchun Shen
Summary: In recent years, dietary restriction (DR) has gained popularity for its potential to improve metabolism and promote longevity. However, the role of gut microbiota in DR has been less explored. This review discusses the effects of different DR patterns on the gut microbiota and the underlying mechanisms by which DR affects metabolic health. It also suggests the development of personalized microbiome-directed DR and advanced sequencing technologies for accurate analysis. DR effectively modulates the gut microbiota and improves metabolic syndrome, inflammatory bowel disease, and cognitive impairment. Further research is needed to fully understand the mechanisms behind the benefits of DR.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Asma Rafiq, Sabreena Aashaq, Iqra Jan, Mushtaq A. Beigh
Summary: Sine Oculis Homeobox 1 (SIX1) is a vital member of the homeobox transcription factor family, playing crucial roles in organismal development and differentiation. Its aberrant expression has been linked to hearing impairment, renal anomalies, and tumorigenesis, highlighting its importance in various pathological conditions. As a transcription factor, SIX1 primarily regulates cellular functions by controlling the expression of different proteins.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Wasana Pratchayasakul, Busarin Arunsak, Kanokphong Suparan, Sirawit Sriwichaiin, Titikorn Chunchai, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: A combination of calorie restriction with exercise is probably the greatest lifestyle modification to diminish brain pathologies and cognitive decline in obesity with or without estrogen deprivation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wasana Pratchayasakul, Busarin Arunsak, Kanokphong Suparan, Sirawit Sriwichaiin, Titikorn Chunchai, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study suggests that a combination of calorie restriction with exercise may be the optimal approach to alleviate brain pathologies and cognitive decline associated with obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biology
Yang Lyu, Kristina J. Weaver, Humza A. Shaukat, Marta L. Plumoff, Maria Tjilos, Daniel E. L. Promislow, Scott D. Pletcher
Summary: Diet choice affects behavior, metabolism, and lifespan in Drosophila, independent of the amount of nutrients consumed. This study reveals a mechanism of aging that applies in natural conditions, including our own, in which organisms continuously perceive and evaluate nutrient availability to promote fitness and well-being.
Article
Cell Biology
Krishnendu Ghosh, Samarendranath Ghosh, Uttara Chatterjee, Pritha Bhattacharjee, Anirban Ghosh
Summary: The study finds that in glioma, proliferation is high in lower grades (LG) supported by VEGF-dependent angiogenesis maintenance, while this angiogenesis decrease is unlikely in higher grades (HG). On the other hand, invasion associated with MMP 2 and 9 is increased in HG, along with a dominant presence of CD204(+) M2 polarized macrophages and a general increase in global DNMT1-associated methylation.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Manfred J. Mueller, Steven B. Heymsfield, Anja Bosy-Westphal
Summary: This study evaluated the impact of changes in fat-free mass (FFM) composition on adaptive thermogenesis (AT), finding that changes in FFM composition had a significant effect on weight loss and weight gain. Adjusting for changes in anatomical and molecular composition reduced AT after caloric restriction (CR) and increased AT after overfeeding (OF), but the overall adjusted AT may not be enough to prevent weight loss or resist weight gain.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Medicine, Research & Experimental
Hye-Jin Lee, Bo-Yeong Jin, Mi-Rae Park, Nam Hoon Kim, Kwan Sik Seo, Yong Taek Jeong, Tsutomu Wada, Jun-Seok Lee, Sang-Hyun Choi, Dong-Hoon Kim
Summary: This study investigated the role of modulation of the WAT vasculature in regulating RWG after CR and found that it can attenuate RWG by suppressing hyperphagia and increasing BAT thermogenesis and WAT browning.
Article
Multidisciplinary Sciences
Elite Possik, Laura-Lee Klein, Perla Sanjab, Ruyuan Zhu, Laurence Cote, Ying Bai, Dongwei Zhang, Howard Sun, Anfal Al-Mass, Abel Oppong, Rasheed Ahmad, Alex Parker, S. R. Murthy Madiraju, Fahd Al-Mulla, Marc Prentki
Summary: Excess nutrients can accelerate aging, but the newly discovered enzyme G3PP can counter metabolic stress and promote healthy aging in C. elegans. Overexpression of the C. elegans G3PP homolog, PGPH-2, decreases fat levels and mimics the effects of calorie restriction, particularly in glucotoxicity conditions, without reducing food intake. This overexpression depletes glycogen stores and activates AMPK, HLH-30, and autophagy, promoting healthy aging.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Hannah E. Rockwell, Victoria J. McCurdy, Samuel C. Eaton, Diane U. Wilson, Aime K. Johnson, Ashley N. Randle, Allison M. Bradbury, Heather L. Gray-Edwards, Henry J. Baker, Judith A. Hudson, Nancy R. Cox, Miguel Sena-Esteves, Thomas N. Seyfried, Douglas R. Martin
Article
Neurosciences
Karie A. Heinecke, Adrienne Luoma, Alessandra d'Azzo, Daniel A. Kirschner, Thomas N. Seyfried
Article
Biochemistry & Molecular Biology
Emily Chen, Michael A. Kiebish, Justice McDaniel, Fei Gao, Niven R. Narain, Rangaprasad Sarangarajan, Gergely Kacso, Dora Ravasz, Thomas N. Seyfried, Vera Adam-Vizi, Christos Chinopoulos
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2016)
Editorial Material
Biochemistry & Molecular Biology
Michelle A. Puchowicz, Thomas N. Seyfried
JOURNAL OF NEUROCHEMISTRY
(2017)
Letter
Oncology
Rainer J. Klement, Richard D. Feinman, Elena C. Gross, Colin E. Champ, Dominic P. D'Agostino, Eugene J. Fine, Ulrike Kaemmerer, Angela Poff, Jong M. Rho, Thomas N. Seyfried, Adrienne C. Scheck
Article
Nutrition & Dietetics
Thomas N. Seyfried, George Yu, Joseph C. Maroon, Dominic P. D'Agostino
NUTRITION & METABOLISM
(2017)
Review
Oncology
Laurent Schwartz, Thomas Seyfried, Khalid O. Alfarouk, Jorgelindo Da Veiga Moreira, Stefano Fais
SEMINARS IN CANCER BIOLOGY
(2017)
Article
Microscopy
Gabriel Arismendi-Morillo, Alan Castellano-Ramirez, Thomas N. Seyfried
ULTRASTRUCTURAL PATHOLOGY
(2017)
Article
Biology
Stefano Garofalo, Alessandra Porzia, Fabrizio Mainiero, Silivia Di Angelantonio, Barbara Cortese, Bernadette Basilico, Francesca Pagani, Giorgio Cignitti, Giuseppina Chece, Roberta Maggio, Marie-Eve Tremblay, Julie Savage, Kanchan Bisht, Vincenzo Esposito, Giovanni Bernardini, Thomas Seyfried, Jakub Mieczkowski, Karolina Stepniak, Bozena Kaminska, Angela Santoni, Cristina Limatola
Article
Biochemistry & Molecular Biology
Roberto E. Flores, Ashley K. Brown, Luke Taus, Julianna Khoury, Frank Glover, Kenjiro Kami, Rangaprasad Sarangarajan, Tony E. Walshe, Niven R. Narain, Michael A. Kiebish, Laura M. Shelton, Christos Chinopoulos, Thomas N. Seyfried
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2018)
Article
Multidisciplinary Sciences
Emily Chen, Michael A. Kiebish, Justice McDaniel, Katarzyna Niedzwiecka, Roza Kucharczyk, Dora Ravasz, Fei Gao, Niven R. Narain, Rangaprasad Sarangarajan, Thomas N. Seyfried, Vera Adam-Vizi, Christos Chinopoulos
SCIENTIFIC REPORTS
(2018)
Article
Pharmacology & Pharmacy
Victoria R. Gabriele, Robabeh M. Mazhabi, Natalie Alexander, Purna Mukherjee, Thomas N. Seyfried, Njemuwa Nwaji, Eser M. Akinoglu, Andrzej Mackiewicz, Guofu Zhou, Michael Giersig, Michael J. Naughton, Krzysztof Kempa
Summary: The study reveals that melanin nanoparticles exhibit cytotoxicity at high glucose concentrations. Metastatic cancer cells can ingest a large amount of these nanoparticles, with glucose coating enhancing ingestion and slowing down cell death, whereas non-accumulating cells are less susceptible to laser illumination.
Article
Nutrition & Dietetics
Ahmed M. A. Elsakka, Mohamed Abdel Bary, Eman Abdelzaher, Mostafa Elnaggar, Miriam Kalamian, Purna Mukherjee, Thomas N. Seyfried
FRONTIERS IN NUTRITION
(2018)
Article
Oncology
Luke J. Taus, Roberto E. Flores, Thomas N. Seyfried
Article
Medicine, General & Internal
Mehmet Salih Iyikesici, Abdul Kadir Slocum, Ayshe Slocum, Ferhan Bulent Berkarda, Miriam Kalamian, Thomas N. Seyfried
CUREUS JOURNAL OF MEDICAL SCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Brandon P. Russell, David J. Vinyard
Summary: The Mn4CaO5 oxygen-evolving complex in Photosystem II is crucial for water oxidation. D1 residue R334 participates in proton release and interacts with PsbO. A D1-R334G mutant destabilizes the OEC but stabilizes the S2 intermediate.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2024)
Article
Biochemistry & Molecular Biology
Alexander A. Bulychev, Tatiana S. Strelets
Summary: Excitable cells of higher plants and characean algae respond to stressful stimuli by generating action potentials that influence chlorophyll fluorescence and photosynthesis for an extended period of time. While plant leaves exhibit a reversible depression in the efficiency of photosystem II reaction after an individual action potential, characean algae show long-lasting oscillations of photosystem II reaction efficiency after firing an action potential. This study investigates the possible mechanisms behind these oscillations and suggests that they are a result of metabolic rearrangements in chloroplasts and the cyclosis cessation-recovery cycle induced by calcium influx during action potentials. The findings also indicate that fluidic communications between different cell regions play a role in these oscillations, and the inhibition of oscillations occurs when these communications are restricted or eliminated.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2024)
Article
Biochemistry & Molecular Biology
Dmitry Zlenko, Elena A. Protasova, Georgy Tsoraev, Nikolai N. Sluchanko, Dmitry A. Cherepanov, Thomas Friedrich, Baosheng Ge, Song Qin, Eugene G. Maksimov, Andrew B. Rubin
Summary: The conformation of chromophores in isolated phycobiliproteins is heterogeneous, but not in the entire phycobilisome (PBS). Under low-energy excitation, there is no significant uphill energy transfer from the core to the peripheral rods of the PBS, while transfer from the terminal emitters to bulk allophycocyanin chromophores is highly probable.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2024)
Article
Biochemistry & Molecular Biology
Makio Yokono, Chiyo Noda, Jun Minagawa
Summary: This paper investigates the energy transfer between Photosystem II and Photosystem I in Arabidopsis thaliana, and finds that the fast spillover is reversibly regulated depending on pH.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2024)