Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Cardiac & Cardiovascular Systems
Sarah E. Basehore, Samantha Bohlman, Callie Weber, Swathi Swaminathan, Yuji Zhang, Cholsoon Jang, Zoltan Arany, Alisa Morss Clyne
Summary: The study found that steady laminar flow reduces eNOS O-GlcNAcylation by limiting glycolysis and the availability of UDP-GlcNAc, leading to increased eNOS phosphorylation and NO production. This research demonstrates for the first time that O-GlcNAcylation is regulated by mechanical stimuli, which has implications for cardiovascular disease.
CIRCULATION RESEARCH
(2021)
Article
Plant Sciences
Xiyang Yang, Xingbing Li, Minghao Luo, Yongzheng Guo, Chang Li, Dingyi Lv, Zhe Cheng, Longxiang Huang, Fei-Fei Shang, Bi Huang, Jian Shen, Suxin Luo, Jianghong Yan
Summary: Tubeimoside I (TBM) promotes angiogenesis through the activation of the eNOS-VEGF signaling pathway, making it a potential novel therapeutic agent for ischemic diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thomas Jansen, Miroslava Kvandova, Isabella Schmal, Sanela Kalinovic, Paul Stamm, Marin Kuntic, Marc Foretz, Benoit Viollet, Andreas Daiber, Matthias Oelze, John F. Keaney Jr, Thomas Muenzel, Eberhard Schulz, Swenja Kroeller-Schoen
Summary: The study demonstrates that mice with endothelial-specific deletion of alpha 1AMPK have detrimental effects during voluntary exercise training, including increased reactive oxygen species production, eNOS uncoupling, and endothelial dysfunction. These results suggest that endothelial alpha 1AMPK plays a critical role in vascular protection and determines whether the effects of exercise on the vasculature are beneficial or harmful.
Article
Cell Biology
Wenhua Lei, Junli Li, Changming Li, Li Chen, Fangyang Huang, Dan Xiao, Jialiang Zhang, Jiahao Zhao, Guoyong Li, Tianyi Qu, Hao Zhou, Yanbiao Liao, Mao Chen
Summary: The study demonstrated that MARCH5 acts as a protective factor in myocardial infarction-related endothelial cell injury and hypoxia-induced endothelial cell injury, potentially through the Akt/eNOS signaling pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Xiaowan Han, Tong Li, Tieshan Wang, Baofu Wang, Yang Li, Lei Wang, Ziwen Lu, Aiming Wu, Lisong Liu, Guozhong Pan, Mingjing Zhao
Summary: This study evaluated the correlation between different microparticle phenotypes and plaque burden, and investigated the role of microparticles in atherosclerosis. The results showed that CD11a(+) LMP and CD11a(+)/CD45(+) LMP may be potential biomarkers for predicting carotid atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Tao Yan, Shun Guo, Tian Zhang, Zhimin Zhang, An Liu, Song Zhang, Yuan Xu, Yuhong Qi, Weihe Zhao, Qinhui Wang, Lei Shi, Linna Liu
Summary: The study evaluated the protective effects of LIG on radiation enteritis (RE), showing that LIG significantly improved body weights, stool morphologies, intestinal villi lengths, perfusion, and vasodilatory functions in IR rats. LIG also improved Gch1/BH4/eNOS pathway-related proteins and regulatory molecules, indicating it as a preferred compound for the prevention and treatment of RE by improving intestinal ischemia. This study provides new research ideas for the development of new drugs for RE.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Marta Sanz-Gomez, Elnaz Aledavood, Marina Beroiz-Salaverri, Laura Lagartera, Elena Vega-Martin, Marta Gil-Ortega, Jose Cumella, Concepcion Perez, Francisco Javier Luque, Carolina Estarellas, Maria S. Fernandez-Alfonso, Ana Castro
Summary: In this study, a novel AMPK modulator, IND6, was identified to activate AMPK in endothelial cells and restore vascular function through increased NO production and vasodilation. These findings suggest the therapeutic potential of IND6 in treating vascular complications associated with obesity.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Tzu-Ling Tseng, Wen-Yueh Ho, Po-Jui Huang, Jin-Zhi Liao, Kuan-Han Lee
Summary: The study successfully synthesized OroA from baicalin using a one-pot reaction and demonstrated the positive effects of OroA and OroA-OET on vascular function, promoting vasorelaxation responses.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Shuang Li, Xuejun Zheng, Chaobo Huang, Yi Cao
Summary: Titanate nanofibers (TiNFs) and titanate nanotubes (TiNTs) were found to be non-cytotoxic to endothelial monolayer model, but they decreased KLF2 resulting in reduced eNOS proteins and NO production. This study provides new insights into the toxicity of TiNFs and other Ti-based NMs to endothelium.
CHINESE CHEMICAL LETTERS
(2021)
Article
Cardiac & Cardiovascular Systems
Kyung Ha Ku, Michelle K. Dubinsky, Aravin N. Sukumar, Noeline Subramaniam, Manon Y. M. Feasson, Ranju Nair, Eileen Tran, Brent M. Steer, Britta J. Knight, Philip A. Marsden
Summary: The study reveals that the SSRE and KLF elements in the eNOS promoter play critical roles in endothelial cells, providing new mechanistic insights into the transcription of the eNOS gene under chronic shear stress in vivo.
Article
Biochemistry & Molecular Biology
Chih-Hsien Wu, Yi-Lin Chiu, Chung-Yueh Hsieh, Guo-Shiang Tsung, Lian-Shan Wu, Cheng-Chung Cheng, Tsung-Neng Tsai
Summary: Cilostazol exerts antithrombotic and vasculoprotective effects in endothelial cells by activating KLF2 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yongpan Huang, Xiaodong Han, Jiayu Tang, Xian Long, Xiaoye Wang
Summary: This study revealed that SAL may inhibit Hcy-induced EndMT by regulating the KLF4/eNOS signaling pathway, thus improving the development of atherosclerosis.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cell Biology
Michael G. Stencel, Mark VerMeer, Jennifer Giles, Quang-Kim Tran
Summary: Calmodulin (CaM) is a crucial protein for multiple functions of vascular smooth muscle cells (VSMCs) and its expression and interactions with target proteins in VSMCs can be regulated by endothelial cells (ECs). In this study, it was discovered that proliferating ECs can upregulate total CaM expression and enhance Ca2+-bound CaM levels in VSMCs co-cultured with ECs. This endothelium-dependent upregulation of CaM in VSMCs is mediated by vascular endothelial growth factor receptors. These findings reveal a new role of ECs in regulating vascular functions through upregulating CaM and its interactions in VSMCs.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Plant Sciences
Tae-Hoon Kim, Ji-Yoon Kim, Jieun Bae, Young-Mi Kim, Moo-Ho Won, Kwon-Soo Ha, Young-Guen Kwon, Young-Myeong Kim
Summary: The study demonstrated that Korean Red ginseng extract (KRGE) delayed or prevented the senescence of human umbilical vein endothelial cells (HUVECs) through a signaling cascade involving the induction of HO-1, inhibition of NF-kappa B-dependent miR-155-5p biogenesis, and maintenance of the eNOS/NO axis activity.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Brandon P. Russell, David J. Vinyard
Summary: The Mn4CaO5 oxygen-evolving complex in Photosystem II is crucial for water oxidation. D1 residue R334 participates in proton release and interacts with PsbO. A D1-R334G mutant destabilizes the OEC but stabilizes the S2 intermediate.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2024)
Article
Biochemistry & Molecular Biology
Alexander A. Bulychev, Tatiana S. Strelets
Summary: Excitable cells of higher plants and characean algae respond to stressful stimuli by generating action potentials that influence chlorophyll fluorescence and photosynthesis for an extended period of time. While plant leaves exhibit a reversible depression in the efficiency of photosystem II reaction after an individual action potential, characean algae show long-lasting oscillations of photosystem II reaction efficiency after firing an action potential. This study investigates the possible mechanisms behind these oscillations and suggests that they are a result of metabolic rearrangements in chloroplasts and the cyclosis cessation-recovery cycle induced by calcium influx during action potentials. The findings also indicate that fluidic communications between different cell regions play a role in these oscillations, and the inhibition of oscillations occurs when these communications are restricted or eliminated.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2024)
Article
Biochemistry & Molecular Biology
Dmitry Zlenko, Elena A. Protasova, Georgy Tsoraev, Nikolai N. Sluchanko, Dmitry A. Cherepanov, Thomas Friedrich, Baosheng Ge, Song Qin, Eugene G. Maksimov, Andrew B. Rubin
Summary: The conformation of chromophores in isolated phycobiliproteins is heterogeneous, but not in the entire phycobilisome (PBS). Under low-energy excitation, there is no significant uphill energy transfer from the core to the peripheral rods of the PBS, while transfer from the terminal emitters to bulk allophycocyanin chromophores is highly probable.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2024)
Article
Biochemistry & Molecular Biology
Makio Yokono, Chiyo Noda, Jun Minagawa
Summary: This paper investigates the energy transfer between Photosystem II and Photosystem I in Arabidopsis thaliana, and finds that the fast spillover is reversibly regulated depending on pH.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2024)