Neutrophil Extracellular Traps: Mechanisms of formation and role in health and disease

Histone Deimination As a Response to Inflammatory Stimuli in Neutrophils

(2014) I. Neeli et al.   JOURNAL OF IMMUNOLOGY

Host-Derived Extracellular Nucleic Acids Enhance Innate Immune Responses, Induce Coagulation, and Prolong Survival upon Infection in Insects

(2014) B. Altincicek et al.   JOURNAL OF IMMUNOLOGY

Release of Cystic Fibrosis Airway Inflammatory Markers from Pseudomonas aeruginosa-Stimulated Human Neutrophils Involves NADPH Oxidase-Dependent Extracellular DNA Trap Formation

(2014) D.-g. Yoo et al.   JOURNAL OF IMMUNOLOGY

New players in haemostasis and thrombosis

(2014) Julia Geddings et al.   THROMBOSIS AND HAEMOSTASIS

The Human Antimicrobial Peptide LL-37, but Not the Mouse Ortholog, mCRAMP, Can Stimulate Signaling by Poly(I:C) through a FPRL1-dependent Pathway

(2013) Divyendu Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease

(2013) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37

(2012) G. Chamilos et al.   BLOOD

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

MUNC13-4 Protein Regulates the Oxidative Response and Is Essential for Phagosomal Maturation and Bacterial Killing in Neutrophils

(2012) Jlenia Monfregola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

A SerpinB1 Regulatory Mechanism Is Essential for Restricting Neutrophil Extracellular Trap Generation

(2012) Kalamo Farley et al.   JOURNAL OF IMMUNOLOGY

Periodontitis, Porphyromonas and the pathogenesis of rheumatoid arthritis

(2012) D Farquharson et al.   Mucosal Immunology

Hypochlorous acid regulates neutrophil extracellular trap release in humans

(2011) L. J. Palmer et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent

(2011) Matteo Bianchi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide

(2011) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Rac2 is required for the formation of neutrophil extracellular traps

(2011) Michael Byung H. Lim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophils in the pathogenesis and manifestations of SLE

(2011) Mariana J. Kaplan   Nature Reviews Rheumatology

Extracellular DNA: The tip of root defenses?

(2011) Martha C. Hawes et al.   PLANT SCIENCE

PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection

(2011) Saskia Hemmers et al.   PLoS One

LL37 and Cationic Peptides Enhance TLR3 Signaling by Viral Double-stranded RNAs

(2011) Yvonne Lai et al.   PLoS One

Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

(2011) Venizelos Papayannopoulos et al.   PLoS One

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

(2010) K. D. Metzler et al.   BLOOD

Statins Enhance Formation of Phagocyte Extracellular Traps

(2010) Ohn A. Chow et al.   Cell Host & Microbe

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs

(2010) M. F. Denny et al.   JOURNAL OF IMMUNOLOGY

Nuclease Expression by Staphylococcus aureus Facilitates Escape from Neutrophil Extracellular Traps

(2010) Evelien T.M. Berends et al.   Journal of Innate Immunity

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

(2010) Abdul Hakkim et al.   Nature Chemical Biology

CXCR2 mediates NADPH oxidase–independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation

(2010) Veronica Marcos et al.   NATURE MEDICINE

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Response: Gestational age as a factor in neutrophil extracellular trap formation

(2009) C. C. Yost et al.   BLOOD

Babies born without safety NET

(2009) B. Fadeel   BLOOD

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates

(2009) C. C. Yost et al.   BLOOD

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Treatment with LL-37 Peptide Enhances Antitumor Effects Induced by CpG Oligodeoxynucleotides Against Ovarian Cancer

(2009) Chi-Mu Chuang et al.   HUMAN GENE THERAPY

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of the Human Contact System on Neutrophil Extracellular Traps

(2009) Sonja Oehmcke et al.   Journal of Innate Immunity

Regulation of Extracellular Chromatin Release from Neutrophils

(2009) Indira Neeli et al.   Journal of Innate Immunity

Extracellular neutrophil traps in periodontitis

(2009) L. Vitkov et al.   JOURNAL OF PERIODONTAL RESEARCH

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Extracellular DNA Is Required for Root Tip Resistance to Fungal Infection

(2009) F. Wen et al.   PLANT PHYSIOLOGY

Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps

(2009) A. B. Guimaraes-Costa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation

(2008) M. von Kockritz-Blickwede et al.   BLOOD

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE

Chicken heterophil extracellular traps (HETs): Novel defense mechanism of chicken heterophils

(2008) Phongsakorn Chuammitri et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Single Residue Determines the Specificity of Neutrophil Elastase for Shigella Virulence Factors

(2007) Petra Averhoff et al.   JOURNAL OF MOLECULAR BIOLOGY