期刊
BIOCHEMISTRY-MOSCOW
卷 79, 期 7, 页码 608-618出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0006297914070037
关键词
nuclear matrix; chromatin; functional compartmentalization of cell nucleus; architecture of interphase chromosomes; interchromatin domain; DNA loops
资金
- Presidium of the Russian Academy of Sciences
- Russian Foundation for Basic Research [12-04-93109, 14-04-00010, 13-04-93105]
- INCa (ERABL)
- ANRS [1154]
Becoming popular at the end of the 20th century, the concept of the nuclear matrix implies the existence of a nuclear skeleton that organizes functional elements in the cell nucleus. This review presents a critical analysis of the results obtained in the study of nuclear matrix in the light of current views on the organization of the cell nucleus. Numerous studies of nuclear matrix have failed to provide evidence of the existence of such a structure. Moreover, the existence of a filamentous structure that supports the nuclear compartmentalization appears to be unnecessary, since this function is performed by the folded genome itself.
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