Article
Immunology
Edward B. Irvine, Anthony O'Neil, Patricia A. Darrah, Sally Shin, Alok Choudhary, Wenjun Li, William Honnen, Smriti Mehra, Deepak Kaushal, Hannah Priyadarshini Gideon, JoAnne L. Flynn, Mario Roederer, Robert A. Seder, Abraham Pinter, Sarah Fortune, Galit Alter
Summary: Alter and colleagues demonstrate that IgM titers in plasma and bronchoalveolar lavage fluid are markers of reduced Mtb burden in rhesus macaques vaccinated intravenously with Bacille Calmette-Guerin. This study suggests the potential importance of IgM responses as a marker and mediator of protection against TB, highlighting the superior antibody responses induced by intravenous BCG compared to traditional intradermal administration.
Article
Biochemistry & Molecular Biology
Saar T. Halperin, Bert A. 't Hart, Antonio Luchicchi, Geert J. Schenk
Summary: Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system, and its exact etiology remains unclear. Recent research suggests that autoimmune processes underlying MS may be triggered by pathological processes within the CNS. This review focuses on the potential role of the relatively unexplored immune cell, B1 lymphocyte, in MS pathology, and proposes novel therapeutic approaches to restore its beneficial functions.
Article
Microbiology
Carlos Henrique D. Barbosa, Louis Lantier, Joseph Reynolds, Jinyong Wang, Fabio Re
Summary: Immunization with Ft LPS triggers production of IL-25, which promotes activation and differentiation of B1 cells into IgM secreting cells through stimulation of IL-5 release by ILC2. This IL-25-ILC2-IL-5 axis represents a potential novel strategy to improve vaccination against T-independent bacterial antigens.
Review
Immunology
Karla Ruiz-Cortes, Daniel N. Villageliu, Derrick R. Samuelson
Summary: Alcohol use can impact the function of both innate and adaptive immune cells, leading to immune dysfunction and organ damage. The role of innate lymphocytes, particularly liver-resident natural killer cells, in alcohol-induced pathogenesis is of increasing interest. However, the specific role of innate lymphocytes in alcohol-induced end-organ damage remains unclear.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fabian Bohlaender, Sabrina Weissmueller, Dennis Riehl, Marcus Gutscher, Joerg Schuettrumpf, Stefanie Faust
Summary: The study aims to investigate the functional aspects of the IgA component in trimodulin, a new plasma-derived polyvalent immunoglobulin preparation, and demonstrates its potent immunomodulatory and anti-pathogenic effects, especially on neutrophil function.
Article
Oncology
Mireia Bachiller, Lorena Perez-Amill, Anthony Matthew Battram, Sebastian Ciro Carne, Amer Najjar, Els Verhoeyen, Manel Juan, Alvaro Urbano-Ispizua, Beatriz Martin-Antonio
Summary: This study demonstrates the important immunoregulatory role of CB-NK collaborating with CAR-T cells to enhance their antitumor activity. Combinatorial treatment based on CAR-T and CAR-NK cells or CB-NK and CAR-T cells showed that CB-NK required high doses for effectiveness, while a low number of CB-NK in the CAR-T product promoted early activation of CAR-T cells and enhanced anti-MM efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Alvaro Haroun-Izquierdo, Marianna Vincenti, Herman Netskar, Hanna van Ooijen, Bin Zhang, Laura Bendzick, Minoru Kanaya, Pouria Momayyezi, Shuo Li, Merete Thune Wiiger, Hanna Julie Hoel, Silje Zandstra Krokeide, Veronika Kremer, Geir Tjonnfjord, Stephanie Berggren, Kristina Wikstroem, Pontus Blomberg, Evren Alici, Martin Felices, Bjoern oenfelt, Petter Hoeglund, Bahram Valamehr, Hans-Gustaf Ljunggren, Andreas Bjoerklund, Quirin Hammer, Lise Kveberg, Frank Cichocki, Jeffrey S. Miller, Karl-Johan Malmberg, Ebba Sohlberg
Summary: This study demonstrates the feasibility of off-the-shelf therapy with a non-engineered, yet highly specific, NK cell population for hematological malignancies. The expanded adaptive NK cells retained high cytotoxicity and efficiently killed leukemia cells from AML patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Ecology
Coraline Bichet, Maria Moiron, Kevin D. Matson, Oscar Vedder, Sandra Bouwhuis
Summary: Studies on common tern populations have shown no clear signs of senescence in haemagglutination titre and haptoglobin concentration, possibly due to immune parameter canalisation or the colonial breeding behavior of the study species. Further longitudinal studies are needed to investigate the links between species characteristics and immunosenescence in wild animals.
JOURNAL OF ANIMAL ECOLOGY
(2022)
Article
Biology
Ioannis Sarrigeorgiou, Theodora Stivarou, Gerasimina Tsinti, Apostolos Patsias, Evgenia Fotou, Vasiliki Moulasioti, Dimitra Kyriakou, Constantinos Tellis, Maria Papadami, Vassilios Moussis, Vasileios Tsiouris, Vassilios Tsikaris, Demokritos Tsoukatos, Peggy Lymberi
Summary: Poultry industry is the most efficient system to meet the increasing demand for protein. However, intensive selection of broilers raises welfare concerns. Alternative housing systems and higher disease resistance in poultry are becoming popular. This study explores naturally occurring antibodies as potential biomarkers for poultry welfare and productivity.
Review
Oncology
Anneloes van Duijn, Sjoerd H. Van der Burg, Ferenc A. Scheeren
Summary: This article focuses on the interactions between myeloid immune cells and anti-tumor immune responses in the tumor microenvironment. Blocking the CD47/SIRP alpha axis can enhance adaptive immune response. The potential therapeutic role of CD47/SIRP alpha axis is discussed in tumors with acquired resistance to classic immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Chemistry, Multidisciplinary
Annemiek Uvyn, Marle Elisabeth Jacqueline Vleugels, Bas de Waal, Ahmed Emad Ibrahim Hamouda, Shikha Dhiman, Benoit Louage, Lorenzo Albertazzi, Damya Laoui, E. W. Meijer, Bruno G. De Geest
Summary: This study successfully recruited endogenous antibodies to the surface of cancer cells using functionalized poly(propyleneimine) dendrimers, addressing the challenges of low affinity of endogenous antibodies and unidentified target receptors in most solid tumors.
ADVANCED MATERIALS
(2023)
Review
Immunology
Yue Zhang, Xiaobin Zhou, Shuyi Chen, Xinchen Sun, Chenglin Zhou
Summary: Viral myocarditis is a major cause of dilated cardiomyopathy, leading to heart failure and sudden cardiac death. Current therapies for chronic myocarditis are unsatisfactory, possibly due to persistent viral or immunological insults to the heart. Cellular and mouse models using CVB3 virus infection have shed light on the pathophysiology of viral myocarditis. This review discusses the immunological mechanisms of innate and adaptive immunity in the development of CVB3-induced myocarditis.
Review
Biochemistry & Molecular Biology
Clara Chivasso, Julie Sarrand, Jason Perret, Christine Delporte, Muhammad Shahnawaz Soyfoo
Summary: Sjogren's syndrome is a chronic autoimmune disease characterized by infiltration of exocrine glands, leading to dry eyes and mouth symptoms. The pathophysiology of the disease is not well understood, but evidence suggests that different factors interact to initiate and perpetuate the disease. Immune system, both innate and adaptive, play a crucial role in the pathogenesis of SS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Man Lun Hsu, Moncef Zouali
Summary: While the role of the NLRP3 pathway in innate immunity has been well-studied, its contribution to adaptive immunity has been given less attention. This study demonstrates that NLRP3 is involved in B cell development, homing, and retention in lymphoid organs. Mechanistically, the absence of NLRP3 leads to upregulation of the transcription factor IRF4, which in turn reduces the expression of chemokine receptors on B cells. Overall, this research highlights the importance of NLRP3 activation in B cell functions.
LIFE SCIENCE ALLIANCE
(2022)
Article
Fisheries
Jing Wu, Yifan Nie, Yanping Ma, Le Hao, Zhenxing Liu, Yugu Li
Summary: The phagocytic activity of B cells in fish has been confirmed. This study produced five monoclonal antibodies (MAbs) against largemouth bass IgM and demonstrated their ability to specifically recognize the membrane-bound IgM molecule. Flow cytometry analysis revealed the distribution of largemouth bass mIgM+ lymphocytes in different tissues. qPCR analysis showed the upregulation of various cytokines and genes related to the phagocytic signaling pathway in mIgM+ lymphocytes. These findings are important for understanding the role of mIgM+ lymphocytes in largemouth bass and the involvement of Fc gamma R in phagocytosis.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Alexander V. Klimovich, Marina P. Samoylovich, Irina V. Gryazeva, Lidiya A. Terekhina, Alexander N. Suvorov, Vladimir B. Klimovich
Review
Biochemistry & Molecular Biology
V. B. Klimovich, M. P. Samoilovich, B. V. Klimovich
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
(2008)
Article
Multidisciplinary Sciences
Sebastian Fraune, Rene Augustin, Friederike Anton-Erxleben, Joerg Wittlieb, Christoph Gelhaus, Vladimir B. Klimovich, Marina P. Samoilovich, Thomas C. G. Bosch
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2010)
Article
Biochemistry & Molecular Biology
OP Bliznyukov, LD Kozmin, LL Vysotskaya, AK Golenkov, VM Tishchenko, MP Samoylovich, VB Klimovich
BIOCHEMISTRY-MOSCOW
(2005)
Article
Biochemistry & Molecular Biology
OP Bliznukov, LD Kozmin, VB Klimovich, YI Tsybovsky, ZI Kravchuk, SP Martsev
BIOCHEMISTRY-MOSCOW
(2001)