Towards a unifying mechanism for ClpB/Hsp104-mediated protein disaggregation and prion propagationThis paper is one of a selection of papers published in this special issue entitled 8th International Conference on AAA Proteins and has undergone the Journal's usual peer review process.

Stability of the two wings of the coiled-coil domain of ClpB chaperone is critical for its disaggregation activity

(2009) Yo-hei Watanabe et al.   BIOCHEMICAL JOURNAL

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

The Yeast AAA+ Chaperone Hsp104 Is Part of a Network That Links the Actin Cytoskeleton with the Inheritance of Damaged Proteins

(2009) P. Tessarz et al.   MOLECULAR AND CELLULAR BIOLOGY

Motor Mechanism for Protein Threading through Hsp104

(2009) Petra Wendler et al.   MOLECULAR CELL

The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion

(2009) Basant K. Patel et al.   NATURE CELL BIOLOGY

A prion of yeast metacaspase homolog (Mca1p) detected by a genetic screen

(2009) Julie Nemecek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Walker-A threonine couples nucleotide occupancy with the chaperone activity of the AAA+ ATPase ClpB

(2009) Maria Nagy et al.   PROTEIN SCIENCE

Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions

(2008) James Shorter et al.   EMBO JOURNAL

Peptide and Protein Binding in the Axial Channel of Hsp104

(2008) Ronnie Lum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

(2008) Christophe Lo Bianco et al.   JOURNAL OF CLINICAL INVESTIGATION

Coupling and Dynamics of Subunits in the Hexameric AAA+ Chaperone ClpB

(2008) Nicolas D. Werbeck et al.   JOURNAL OF MOLECULAR BIOLOGY

Variant-specific [PSI+] Infection Is Transmitted by Sup35 Polymers within [PSI+] Aggregates with Heterogeneous Protein Composition

(2008) Sviatoslav N. Bagriantsev et al.   MOLECULAR BIOLOGY OF THE CELL

Diverse Pore Loops of the AAA+ ClpX Machine Mediate Unassisted and Adaptor-Dependent Recognition of ssrA-Tagged Substrates

(2008) Andreas Martin et al.   MOLECULAR CELL

In Vivo Monitoring of the Prion Replication Cycle Reveals a Critical Role for Sis1 in Delivering Substrates to Hsp104

(2008) Kimberly A. Tipton et al.   MOLECULAR CELL

Substrate threading through the central pore of the Hsp104 chaperone as a common mechanism for protein disaggregation and prion propagation

(2008) Peter Tessarz et al.   MOLECULAR MICROBIOLOGY

The heat-shock protein ClpB of Francisella tularensis is involved in stress tolerance and is required for multiplication in target organs of infected mice

(2008) Karin L. Meibom et al.   MOLECULAR MICROBIOLOGY

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae

(2008) Zhiqiang Du et al.   NATURE GENETICS

Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments

(2008) Tobias Haslberger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Specificity of the J-protein Sis1 in the propagation of 3 yeast prions

(2008) T. Higurashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion Switching in Response to Environmental Stress

(2008) Jens Tyedmers et al.   PLOS BIOLOGY

The AAA+ superfamily of functionally diverse proteins

(2008) Jamie Snider et al.   GENOME BIOLOGY