期刊
BIOCHEMISTRY AND CELL BIOLOGY
卷 87, 期 1, 页码 27-34出版社
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/O08-108
关键词
noncoding RNA; Hox; miRNA; transcriptional interference; epigenetic
资金
- NIGMS NIH HHS [R01 GM075141] Funding Source: Medline
There is growing awareness of the importance of noncoding (nc)RNAs in the regulation of gene expression during pattern formation in development. Spatial regulation of Hox gene expression in development controls positional identity along the antero-posterior axis. In this review, we will focus on the role of short ncRNAs that repress Hox genes in Drosophila and mammals by RNA interference (RNAi), on long ncRNAs that may repress a Hox in cis in Drosophila by transcriptional interference, and on a novel long ncRNA that functions in trans to regulate Hox genes mammals.
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