Article
Endocrinology & Metabolism
Samuel T. Robinson, Peter T. Shyu, X. Edward Guo
Summary: Intermittent injections of parathyroid hormone (PTH) and mechanical loading both lead to a net increase in bone mass, with PTH inducing bone accumulation indiscriminately and loading having a stronger effect on plates than rods. The interactions of PTH and loading show synergistic effects on anabolic modeling in trabecular bone and on catabolic modeling on cortical surfaces.
Article
Biophysics
A. A. R. Rabiatul, S. J. Fatihhi, Amir Putra Md Saad, Zulfadzli Zakaria, M. N. Harun, M. R. A. Kadir, Andreas ochsner, Tunku Kamarul Zaman, Ardiyansyah Syahrom
Summary: The study investigated the fluid characteristic and mechanical properties of trabecular bone using the FSI approach, finding moderate correlations between permeability and porosity, surface area in both longitudinal and transverse orientations. Transverse orientation limits fluid flow through trabeculae due to high shear stress. Compared to the longitudinal orientation, transverse orientation exhibits higher permeability.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Lei Deng, Yue Yao, A. -Li Shang, Tongtong Du, Jingbin Zhang, Quanxin Yang, Jianying Li, Qian Wang, Xiaohui Li
Summary: The study evaluated the feasibility of using DECT and CT values for opportunistic screening of osteoporosis in postmenopausal females. The results showed a moderate-high correlation between HAP and CT value with DXA measurements for diagnosing osteoporosis. The cutoff values of HAP and CT value for diagnosing osteoporosis were determined to be 142.05 mg/cm3 and 132 HU, respectively.
SCIENTIFIC REPORTS
(2022)
Review
Engineering, Biomedical
Fangxing Wang, Florian Metzner, Georg Osterhoff, Leyu Zheng, Stefan Schleifenbaum
Summary: Bone marrow plays an important role in the mechanical properties of trabecular bone, with its contribution varying depending on different loading types and test settings. To accurately obtain the mechanical properties of trabecular bone, both the bone marrow and the solid matrix should be considered simultaneously.
BIOMEDICAL ENGINEERING ONLINE
(2022)
Article
Engineering, Biomedical
Mahtab Vafaeefar, Kevin M. Moerman, Majid Kavousi, Ted J. Vaughan
Summary: This study evaluates the performance of three algorithms as computational models of trabecular bone architecture, and finds that the newly-developed dual-lattice structures better capture both morphometric parameters and mechanical properties compared to the gyroid-and spinodoid-based structures. These computational algorithms provide useful platforms for investigating trabecular bone mechanics and designing biomimetic structures, and the software for creating these structures is freely available to the community through the open source toolbox GIBBON.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Mathematics
Maria Jose Cervantes, Lucas O. Basiuk, Ana Gonzalez-Suarez, C. Manuel Carlevaro, Ramiro M. Irastorza
Summary: This study investigated the relationship between the electrical conductivity of trabecular bone and the conductivity of its constituents, including free water content. Computer simulations using microCT images of bovine trabecular samples were conducted to build realistic geometries. The results showed that the conductivity of bone marrow needs to be higher in order to match experimental data, and anisotropy cannot be detected in small trabecular samples. The simulations also demonstrated good fitting of the Bruggeman mixture model, which could be useful for whole-bone electrical simulations.
Article
Orthopedics
Wenting Xu, Cheng Ni, Yuxuan Wang, Guoqing Zheng, Jinshan Zhang, Youjia Xu
Summary: The study revealed a decline in serum Gal-1 levels in mice and men with age-related trabecular bone loss, indicating its potential as a biomarker for BMSC senescence, early osteoporosis diagnosis, and trabecular bone loss monitoring. Gal-1 was positively correlated with bone mineral density and showed differential secretion by BMSC, HSC, and MP in aged mice.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Engineering, Biomedical
Cecilia E. Ramirez, Abel Hurtado-Macias, Roberto Talamantes, Edgardo Flores, Hector Perez Ladron de Guevar, J. Ivan Delgado, Ruben Anguiano Estrella, Juan Manuel Riestra, Jesus Maximo Montes, Karen Esmonde-White, Martha Vardaki, J. Gonzalez-Hernandez, Juan M. Viveros
Summary: This study characterizes the anatomy, structural, surface morphological, chemical composition, and nanomechanical properties of ostrich and equine trabecular bone for potential use in guided bone regeneration surgeries. Ostrich bone shows promising properties for native tissue scaffolds, with similarities to human trabecular bone that could reduce stress shielding. These findings contribute to innovative advancements in biomedical research and applications.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Anthropology
Jaap P. P. Saers, Lily J. DeMars, Nicholas B. Stephens, Tea Jashashvili, Kristian J. Carlson, Adam D. Gordon, Colin N. Shaw, Timothy M. Ryan, Jay T. Stock
Summary: The study compared trabecular and cortical bone properties of athletes and sedentary controls, revealing unique combinations of biomechanical properties in different sports modalities and associations between specific properties and loading types.
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY
(2021)
Article
Pathology
Ayush Batra, Triet M. Bui, Jacob F. Rehring, Lenore K. Yalom, William A. Muller, David P. Sullivan, Ronen Sumagin
Summary: Peripheral monocyte-derived CX3C chemokine receptor 1 positive (CX3CR1(+)) cells have been shown to play important roles in tissue homeostasis and immune repopulation of gut and brain in response to inflammation. This study found temporal differences in immune repopulation of the gut and brain, and demonstrated that gut inflammation can impact immune responses within the brain.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Jana Brankovic, Jakob Leskovec, Sabina Sturm, Vesna Cerkvenik-Flajs, Sasa Sterpin, Josko Osredkar, Estera Pogorevc, David Antolinc, Milka Vrecl
Summary: This study investigated the effects of short-term dietary exposure to bisphenol A (BPA) on femoral morphology, metabolism, mineral content, and biomechanical behavior in rams aged 9-12 months. The results showed that BPA had no significant effects on most of the parameters studied, except for decreased manganese and increased copper content in the femurs of BPA-exposed rams. These findings indicate that a 2-month, low-dose exposure to BPA did not affect the histomorphology, metabolism, and biomechanical behavior of femurs in growing rams, but it did affect the composition of microelements, which could have long-term effects on bone.
Article
Materials Science, Multidisciplinary
Atul Babbar, Vivek Jain, Dheeraj Gupta, Deepak Agrawal, Chander Prakash, Sunpreet Singh, Linda Yongling Wu, H. Y. Zheng, Grzegorz Krolczyk, Marta Bogdan-Chudy
Summary: The study investigated burr wear with different shaped grinding burrs, revealing that convex shape burrs experienced minimum wear, while cylindrical burrs caused the highest wear. Different shapes of burrs have an impact on the thermal and mechanical conditions of surgery.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Endocrinology & Metabolism
F. M. F. Grizzo, M. de Andrade Pereira, L. B. M. Marchiotti, F. Guilhem, T. da Silva Santos, C. M. Dell' Agnolo, W. A. de Melo, M. de Medeiros Pinheiro, M. D. de Barros Carvalho, S. M. Pelloso
Summary: The study found significant decrease in bone mineral density at specific time points in lactating women, but significant increase in spine BMD after 12 months, with no significant changes in trabecular bone score.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Jonathan D. Rupp, Lauren Zaseck, Carl S. Miller, Anne C. Bonifas, Matthew P. Reed, Don Sherman, John M. Cavanaugh, Kyle Ott, Constantine K. Demetropolous
Summary: By conducting three series of tests with higher velocity and shorter duration floor and seat inputs, researchers were able to produce pelvic and foot/ankle fractures in post-mortem human surrogates equipped with military personal protective equipment, providing more injurious whole-body conditions for simulating under-body blast events.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Engineering, Environmental
Haoliang Wang, Biyu Zhang, Xiangyang Li, Yiting Xiao, Chao Yang
Summary: In this study, a new procedure is developed to model drag force on particles in dense systems using inline experimental measurements. The newly developed model shows excellent characteristics in predicting flow field, solid holdup distributions, and maintaining mass conservation compared to other commonly used models. Further studies are needed to quantitatively explain the evaluation results.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biophysics
Thomas A. Metzger, Ted J. Vaughan, Laoise M. McNamara, Glen L. Niebur
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2017)
Article
Orthopedics
Erin N. Cresswell, Thu M. Nguyen, Michael W. Horsfield, Adrian J. Alepuz, Thomas A. Metzger, Glen L. Niebur, Christopher J. Hernandez
JOURNAL OF ORTHOPAEDIC RESEARCH
(2018)
Article
Endocrinology & Metabolism
Kimberly J. Curtis, Thomas R. Coughlin, Devon E. Mason, Joel D. Boerckel, Glen L. Niebur
Meeting Abstract
Oncology
Ricardo Romero-Moreno, Thomas Coughlin, Kimberly Curtis, Shourik Dutta, Glen Niebur, Laurie E. Littlepage
Article
Cell Biology
Eun-Kyoung Breuer, Daniela Fukushiro-Lopes, Annika Dalheim, Miranda Burnette, Jeremiah Zartman, Simon Kaja, Claire Wells, Loredana Campo, Kimberly J. Curtis, Ricardo Romero-Moreno, Laurie E. Littlepage, Glen L. Niebur, Kent Hoskins, Michael I. Nishimura, Saverio Gentile
CELL DEATH & DISEASE
(2019)
Review
Multidisciplinary Sciences
Kimberly J. Curtis, Alyssa G. Oberman, Glen L. Niebur
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2020)
Article
Cell & Tissue Engineering
Kimberly J. Curtis, Thomas R. Coughlin, Mary A. Varsanik, Glen L. Niebur
CELLULAR AND MOLECULAR BIOENGINEERING
(2019)
Article
Multidisciplinary Sciences
Ricardo Romero-Moreno, Kimberly J. Curtis, Thomas R. Coughlin, Maria Cristina Miranda-Vergara, Shourik Dutta, Aishwarya Natarajan, Beth A. Facchine, Kristen M. Jackson, Lukas Nystrom, Jun Li, William Kaliney, Glen L. Niebur, Laurie E. Littlepage
NATURE COMMUNICATIONS
(2019)
Article
Cell Biology
Kimberly J. Curtis, Christine Mai, Hannah Martin, Alyssa G. Oberman, Laura Alderfer, Ricardo Romero-Moreno, Mark Walsh, Stephen F. Mitros, Scott G. Thomas, Joseph A. Dynako, David Zimmer, Laoise M. McNamara, Laurie E. Littlepage, Glen L. Niebur
Summary: Metastatic breast cancer cells preferentially migrate toward trabecular bone, influenced by tissue culture environment, growth factors (such as leptin and interleukins), and the biomechanical properties of bone. Migration speed is not solely dependent on matrix stiffness, but also on chemotactic signals.
MOLECULAR BIOLOGY OF THE CELL
(2021)
Review
Biochemistry & Molecular Biology
Anup Pant, Elliot Paul, L. Glen Niebur, Ali Vahdati
Summary: Bone remodeling is a complex physiological process regulated by multiple factors; computer modeling and simulation offer a powerful method to gain insights into mechano-adaptive bone remodeling; integrating personalized bone mechanics with mechanobiology at multiscale level can deepen our understanding of bone remodeling and provide ample opportunities for future research.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2021)
Article
Engineering, Manufacturing
Saikumar R. Yeratapally, Christapher G. Lang, Albert R. Cerrone, Glen L. Niebur, Karl Cronberger
Summary: The influence of process parameters on the mechanical behavior of Ti-6Al-4V alloy produced via laser powder bed fusion is investigated. The study demonstrates the importance of pore clustering and grain orientation on fatigue performance.
ADDITIVE MANUFACTURING
(2022)
Article
Multidisciplinary Sciences
Kimberly J. Curtis, Jessica Schiavi, Myles J. Mc Garrigle, Vatsal Kumar, Laoise M. McNamara, Glen L. Niebur
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2020)
Review
Pharmacology & Pharmacy
Thomas R. Coughlin, Ricardo Romero-Moreno, Devon E. Mason, Lukas Nystrom, Joel D. Boerckel, Glen L. Niebur, Laurie E. Littlepage
CURRENT DRUG TARGETS
(2017)
Article
Education, Scientific Disciplines
Ian M. Sander, Matthew T. McGoldrick, My N. Helms, Aislinn Betts, Anthony van Avermaete, Elizabeth Owers, Evan Doney, Taimi Liepert, Glen Niebur, Douglas Liepert, W. Matthew Leevy
ANATOMICAL SCIENCES EDUCATION
(2017)
Article
Engineering, Biomedical
Holly E. Weiss-Bilka, Matthew J. Meagher, Joshua A. Gargac, Glen L. Niebur, Ryan K. Roeder, Diane R. Wagner
BIOMATERIALS RESEARCH
(2019)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)