Article
Biochemistry & Molecular Biology
Wenqiang Sun, Lihong He, He Zhang, Xiaodong Tian, Zhihua Bai, Lei Sun, Limin Yang, Xiaojuan Jia, Yuhai Bi, Tingrong Luo, Gong Cheng, Wenhui Fan, Wenjun Liu, Jing Li
Summary: The study developed an mRNA vaccine based on ferritin-formed nanoparticles for SARS-CoV-2, showing adequate protection and broad-spectrum neutralizing antibodies in mice, with the mRNA template easily modifiable to address viral mutations.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Biology
Rudra Palash Mukherjee, Geok-Yong Yow, Samuel Sarakbi, Stefano Menegatti, Patrick V. Gurgel, Ruben G. Carbonell, Benjamin G. Bobay
Summary: This study reports the rational design and screening of trimeric peptides as ligands for the purification of butyrylcholinesterase (BChE). The selected peptides exhibited high affinity for BChE and achieved a significant purification factor. The study also revealed the correlation between conformational changes of BChE and the ionic strength and pH of the aqueous environment, providing insights for ligand design and affinity maturation.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Dan Wang, Jing Zhang, Zhiyong Huang, Yuhang Yang, Ting Fu, Yu Yang, Yifan Lyu, Jianhui Jiang, Liping Qiu, Zehui Cao, Xiaobing Zhang, Qimin You, Yuankui Lin, Zilong Zhao, Weihong Tan
Summary: By using a robust covalent aptamer strategy, it is possible to stably bind aptamers and proteins even in harsh environments, leading to improved detection sensitivity and therapeutic effect. This strategy can be applied in accurate molecular modification, disease biomarker discovery, and other fields.
ACS CENTRAL SCIENCE
(2023)
Article
Environmental Sciences
Yu Chen, Luping Xu, Guangmin Wang, Bo Yan, Jingrong Sun
Summary: SVSF is a new-style filter that is more robust compared to the Kalman filter, while ISVSF combines Bayesian theory to improve estimation accuracy and shows high robustness in dealing with modeling uncertainties and noise. The proposed ISVSF can deliver satisfying performance even in the presence of sudden changes in system state, outperforming existing filters in target tracking simulations.
Article
Chemistry, Physical
Chao Chen, Yunchuan Xie, Meirong Zhang, Jing Li, Xiaoyong Wei, Zhicheng Zhang
Summary: A new sandwich-structured composite material has been developed, which shows improved breakdown strength and electrical polarization, resulting in a significant increase in discharged energy density.
APPLIED SURFACE SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Sheng Tong, Min Yuan, Yu Liu, Xianbi Li, Dan Jin, Xi Cheng, Dongmei Lin, Haichun Ling, Danni Yang, Yang Wang, Ajing Mao, Yan Pei, Yanhua Fan
Summary: Constructing fusion antifungal peptides that target fungal cells is an effective strategy to enhance the activity of disease-resistant genes and obtain improved disease resistance. The fusion gene BbAFP1::ErBD has the potential to defend against plant fungal diseases by exhibiting enhanced disease resistance against V. dahliae.
PLANT BIOTECHNOLOGY JOURNAL
(2021)
Article
Multidisciplinary Sciences
Jun Young Park, Ye Lim Cho, Ju Ri Chae, Jung Hwan Lee, Won Jun Kang
Summary: This study evaluates the biological characterization of 3'-idT modified ErbB2 aptamer and compares it with the unmodified aptamer using nuclear imaging. The results show that the idT modified aptamer has a longer blood circulation time and higher uptake in the tumor compared to the unmodified aptamer.
Article
Materials Science, Ceramics
Guohua Shi, Xiaohong Sun, Ning Dai, Zhongyan Wang, Nan Liu, Zhongkai Xu, Zhe Chen, Shu Cai, Xuming Lv, Chunming Zheng, Jian Zhang, Yao Han, Bingqing Zhang
Summary: In this study, AlN/YAlO3 composites with different YAlO3 contents were prepared, and the impact of YAlO3 content on the mechanical properties and thermal shock resistance of the composites was investigated. Results showed that the addition of 3 wt% and 5 wt% YAlO3 improved the densification and the grain refinement of AlN, leading to improved flexural strength and fracture toughness of the composites. Moreover, the thermal shock resistance of the composites was significantly improved due to various strengthening mechanisms such as crack deflection, crack branching, and microcrack toughening.
CERAMICS INTERNATIONAL
(2023)
Article
Nanoscience & Nanotechnology
Ruitao Qu, Shaojie Wu, Cynthia A. Volkert, Zhefeng Zhang, Feng Liu
Summary: In this study, a significant size effect on the strength, plasticity, and fracture behavior of the VNbMoTaW RHEA was shown. The brittle cracking behavior of RHEA was greatly suppressed as the sample size decreased from millimeter to sub-micrometer scale, resulting in enhanced strength and plasticity. The improved mechanical properties can be attributed to the disappearance of crack initiation sites, size-dependent dislocation plasticity, and size-dependent competition in thermodynamics.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2023)
Article
Chemistry, Multidisciplinary
Sara Puglioli, Eleonore Schmidt, Christian Pellegrino, Luca Prati, Sebastian Oehler, Roberto De Luca, Andrea Galbiati, Claudia Comacchio, Lisa Nadal, Jorg Scheuermann, Markus G. Manz, Dari Neri, Samuele Cazzamalli, Gabriele Bassi, Nicholas Favalli
Summary: This article emphasizes the importance of obtaining ultra-high-affinity small organic ligands specific to accessible cancer antigens for efficient and selective tumor targeting applications. Through affinity-maturation DNA-encoded chemical libraries, highly potent FAP inhibitors were identified using propargylglycine derivatives. The most potent novel ligand (named OncoFAP-11'') showed tumor localization in mice with high tumor-to-blood ratios, while a dimeric derivative (named BiOncoFAP-11'') enhanced tumor residence time with low uptake in healthy organs.
Article
Pharmacology & Pharmacy
Paramita Saha, Prabhjeet Singh, Himanshu Kathuria, Deepak Chitkara, Murali Monohar Pandey
Summary: This study developed lecithin-chitosan nanoparticles (RTG-LCNP) to improve the delivery of rotigotine (RTG) to the brain via the nose. The results showed that RTG-LCNP enhanced the brain availability of RTG and demonstrated potential for clinical application.
Article
Chemistry, Medicinal
Shimpei Iikuni, Yuta Tarumizu, Kazuma Nakashima, Yusuke Higaki, Hiroaki Ichikawa, Hiroyuki Watanabe, Masahiro Ono
Summary: The radioligand PSMA-DA1 shows promising potential as a PSMA-targeting radiotheranostic agent, with significant tumor uptake and retention capabilities in preclinical studies. PSMA-DA1 produced clear tumor images in mice and inhibited tumor growth, indicating its potential as an effective radiotherapeutic agent.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Li -Juan Wang, Sha Bai, Ying-Feng Han
Summary: In this study, a water-soluble molecular cage was synthesized for the selective separation of structurally similar molecules under ambient conditions. The cage demonstrated good solubility and stability in aqueous media and exhibited excellent performance in the separation of alkanes, xylene, and other aromatic compounds.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Rachele Maschio, Federica Buonsanti, Federico Crivellin, Fulvio Ferretti, Luciano Lattuada, Federico Maisano, Laura Orio, Lorena Pizzuto, Raphael Campanella, Anthony Clouet, Camilla Cavallotti, Giovanni B. Giovenzana
Summary: Optical imaging is a non-invasive diagnostic imaging technology that utilizes fluorescent molecules emitting light in the near-infrared region to achieve tumor imaging. It has potential clinical applications.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yena Liu, Qiuping Ran, Jiaqi Guo, Wenyuan Zhu, Rani Bushra, Xuguo Duan, Yang Huang, Zhengbing Jiang, Mohammad Rizwan Khan, Yongcan Jin, Huining Xiao, Junlong Song
Summary: A genetically engineered Family 3 Carbohydrate-Binding Module (CBM3) was used to modify bacterial cellulose (BC), resulting in improved wet strength and mechanical properties of BC films. The CBM3-BC films showed excellent performance in various environments and had potential applications in food packaging, paper straw, battery separator, and other fields. Furthermore, the in situ modification strategy used in this study could be applied to functional modifications of other BC materials.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)