Article
Chemistry, Inorganic & Nuclear
Xinyue Wang, Bingbing Zhang, Daqing Yang, Ying Wang
Summary: A new cesium hydroxyborate compound (CsB3O4(OH)(2)) was successfully designed and synthesized using a hydrothermal method. The compound features novel [B3O4(OH)(2)](infinity) chains formed by [B3O4(OH)(2)] fundamental building blocks (FBBs). This discovery enriches the structural diversity of hydroxyborates and exhibits a wide transparent window and large birefringence.
DALTON TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Franziska Ragaller, Luca Andronico, Jan Sykora, Waldemar Kulig, Tomasz Rog, Yagmur Balim Urem, Abhinav, Dmytro I. I. Danylchuk, Martin Hof, Andrey Klymchenko, Mariana Amaro, Ilpo Vattulainen, Erdinc Sezgin
Summary: The plasma membrane, a complex organelle in cells, plays a crucial role in various cellular processes. Understanding its biophysical properties is important for comprehending biological processes. In this study, different probes were characterized and their sensitivity to various membrane properties was examined. The findings provide a toolbox for selecting the appropriate probe for specific research questions.
Article
Endocrinology & Metabolism
Lei Wu, Yan Zhang, Hong Zhao, Guodong Rong, Peijun Huang, Fang Wang, Ting Xu
Summary: This study found that APOE gene polymorphisms are associated with CAD with or without T2DM and have an influence on lipid profiles in both T2DM and CAD patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Angela Flavia Serpico, Caterina Pisauro, Domenico Grieco
Summary: Taxanes exert anticancer activity by killing cancer cells and stimulating inflammation and immune response. A study found that at low doses, Paclitaxel induces a proinflammatory response and also upregulates the expression of PD-L1 in cancer cells, inhibiting the adaptive immune response. The combination of Taxanes with Immune Checkpoint Inhibitors could be beneficial in managing more cancer types and stages.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Eric J. Rubin, Lindsey R. Baden, Penny L. Moore, Stephen Morrissey
Summary: This article discusses the impact of SARS-CoV-2 virus on the host immune system and invites South African virologist Penny Moore to join the discussion.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biophysics
Rishi S. Gupta, Daniel Berrellez, Neha Chhugani, Carlos Luna Lopez, Amir Maldonado, Sameer B. Shah
Summary: This study showed that paclitaxel treatment significantly increased the tensile viscoelastic properties of nerves at the tissue level in experimentally treated mice, indicating heterogeneous effects on nerve biomechanical properties.
JOURNAL OF BIOMECHANICS
(2021)
Article
Chemistry, Multidisciplinary
Huanhuan Liu, Siyuan Liu, Shoufu Cao, Jingrui Zhang, Hao Ni, Xiaojing Lin, Xiaodong Chen, Shuxian Wei, Qi Hou, Zhaojie Wang, Xiaoqing Lu
Summary: Developing efficient and low-cost electrocatalysts for hydrogen evolution through water splitting is crucial. In this study, it was discovered that anion-exchange between phosphate and hydroxide can lead to cobalt hydroxide nanosheets incorporated with phosphate, which greatly improves the alkaline hydrogen evolution efficiency and stability. This research has important implications for industrial water electrolysis and the design of improved electrocatalysts.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Plant Sciences
Reena Rani, Ghulam Raza, Hamza Ashfaq, Muhammad Rizwan, Muhammad Khuram Razzaq, Muhammad Qandeel Waheed, Hussein Shimelis, Allah Ditta Babar, Muhammad Arif
Summary: Soybean is a significant crop globally, and this study used genome-wide association studies to identify genes and functional markers associated with soybean agronomic traits, providing valuable data for future breeding programs.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Electrochemistry
Chen Hao, Yaning Guo, Wenting Ren, Xiaohong Wang, Linli Zhu, Xiaokun Wang, Jingbo Wu
Summary: A ternary Ni(OH)(2)/Co(OH)(2)/Mg(OH)(2) with rod-like structure was successfully synthesized via the seed method and the solvothermal method. The NCM-2 (Ni(OH)(2)/Co(OH)2/Mg(OH)(2)-2) with a load to template mass ratio of 1:1 exhibited the best electrochemical characteristics, including a specific capacity of 666.8 C g(-1) at 1 A g(-1) and a cyclic stability of 92.68% after 5000 cycles. Furthermore, when NCM-2 was used as the positive electrode and AC as the negative electrode in a supercapacitor, it showed a specific capacity of 214 C g(-1) at 1 A g(-1) and an energy density of 55.3 Wh kg(-1) at a power density of 930.2 Wh kg(-1). The NCM-2//AC hybrid supercapacitor also demonstrated practical application value by powering four different colors of LEDs.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Zhipeng Zhang, Zhichao Liu, Fazhou Wang, Shuguang Hu
Summary: The synergy of carbonation of portlandite and Mg-based binders can enhance the CO2 uptake, mechanical property, and thermodynamic stability of Mg- and Ca-based binders. The study reveals that the compressive strength and degree of carbonation of compacts initially increase and then decrease with the increase of Ca(OH)2 content. The mixing of Mg(OH)2 and Ca(OH)2 significantly enhances the carbonation degree of both hydroxides.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Endocrinology & Metabolism
Suyan Duan, Fang Lu, Buyun Wu, Chengning Zhang, Guangyan Nie, Lianqin Sun, Zhimin Huang, Honglei Guo, Bo Zhang, Changying Xing, Yanggang Yuan
Summary: This study found that decreased levels of 25-hydroxyvitamin D (25(OH)D) in patients with type 2 diabetes mellitus (T2DM) were associated with deteriorated renal function and increased risk of chronic kidney disease (CKD) progression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Physical
Yingxuan Dong, Le Gao, Zhi Su
Summary: A new hydroxyl strontium borate, Sr-5[BO2(OH)](3)(OH)(3)F, has been synthesized for the first time using the hydrothermal method. It crystallizes in the monoclinic space group with unique unit cell parameters and is the first hydroxyborate fluoride with the [BO2(OH)](2-) fundamental building block. This compound shows promising characteristics in terms of symmetry and stability.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Multidisciplinary
Shendong Tan, Xiaomeng Zhang, Yongjian Lian, Xi Chen, Shi Yin, Lin Du, Maofa Ge
Summary: Organosulfates (OSs) are commonly found in atmospheric aerosol particles and their formation mechanism is crucial to understand. This study investigates the reaction of alpha-hydroxy acids (HAs) with SO3 at the surface of liquid aerosols, revealing the significant impact of OH group orientation on the formation of OSs. The air-water interface plays a crucial role in the physicochemical behaviors of alpha-hydroxy acids, leading to different properties for the SO3 colliding reaction.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Xue Gu, Dan Liu, Yongkui Yu, Hui Wang, Dong Long
Summary: In this study, the authors developed a robust approach for mapping the orientations of peripheral membrane proteins on lipid bilayers using paramagnetic relaxation enhancement (PRE) data. They demonstrated that distortion of PRE observables can be suppressed by transient membrane anchoring, allowing for accurate derivation of orientational ensembles. Applying this approach to KRas4B, they identified four distinct orientational states, including one without the hypervariable region (HVR) that had a broader range of orientations. Furthermore, they found that the HVR selectively interacts with anionic lipids.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Crystallography
Felix Eder, Matthias Weil, Prativa Pramanik, Roland Mathieu
Summary: Previously unknown Co-2(TeO3)(OH)(2) and Co-15(TeO3)(14)(OH)(2) were obtained from alkaline solutions under mild hydrothermal conditions. Their crystal structures were determined, and magnetic measurements showed antiferromagnetic behavior at low temperatures. The main difference between the two phases is the replacement of F by OH in the crystal structure.
Article
Plant Sciences
Christopher Charles Presley, Ana Lisa Valenciano, Maria L. Fernandez-Murga, Yongle Du, Narasimhamurthy Shanaiah, Maria B. Cassera, Michael Goetz, Jason A. Clement, David G. I. Kingston
JOURNAL OF NATURAL PRODUCTS
(2018)
Article
Biochemical Research Methods
Yongle Du, Long Xia, Ami Jo, Richey M. Davis, Philippe Bissel, Marion F. Ehrich, David G. I. Kingston
BIOCONJUGATE CHEMISTRY
(2018)
Article
Plant Sciences
Rolly G. Fuentes, Kirk C. Pearce, Yongle Du, Andriamalala Rakotondrafara, Ana L. Valenciano, Maria B. Cassera, Vincent E. Rasamison, T. Daniel Crawford, David G. I. Kingston
JOURNAL OF NATURAL PRODUCTS
(2019)
Article
Biochemical Research Methods
Tak Ian Chio, Han Gu, Kamalika Mukherjee, L. Nathan Tumey, Susan L. Bane
BIOCONJUGATE CHEMISTRY
(2019)
Article
Biochemical Research Methods
Han Gu, Saptarshi Ghosh, Richard J. Staples, Susan L. Bane
BIOCONJUGATE CHEMISTRY
(2019)
Article
Plant Sciences
Yongle Du, Ana Lisa Valenciano, Yumin Dai, Yi Zheng, Feng Zhang, Yan Zhang, Jason Clement, Michael Goetz, David G. I. Kingston, Maria B. Cassera
JOURNAL OF NATURAL PRODUCTS
(2020)
Article
Chemistry, Multidisciplinary
Tak Ian Chio, Breanna R. Demestichas, Brittany M. Brems, Susan L. Bane, L. Nathan Tumey
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Plant Sciences
Yongle Du, Brooke A. Martin, Ana Lisa Valenciano, Jason A. Clement, Michael Goetz, Maria B. Cassera, David G. I. Kingston
JOURNAL OF NATURAL PRODUCTS
(2020)
Article
Biochemical Research Methods
Matthew T. Olson, Alfred L. Yergey, Kamalika Mukherjee, Melissa R. Pergande, Susan L. Bane, Stephanie M. Cologna, Dan L. Sackett
JOURNAL OF PROTEOME RESEARCH
(2020)
Review
Plant Sciences
David G. Kingston
Summary: The author discusses his 60-year career in studying the chemistry of natural products, including structural, synthetic, and biosynthetic studies of various natural products like insect pigments, antibiotics, fecal mutagens, taxol, anticancer drugs, and antimalarial drugs. One compound, napabucasin, is highlighted as now being in phase III clinical trials as an anticancer drug.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Plant Sciences
Kirk C. Pearce, Rolly G. Fuentes, Susana Calderon, Rageshwari Marolikar, David G. Kingston, T. Daniel Crawford
Summary: Eight phloroglucinols isolated from Garcinia dauphinensis showed good to moderate antiplasmodial and anticancer activities, with their absolute configurations deduced through chiroptical properties calculation and comparison with experimental data. ECD spectra and specific rotations were computed for all stereoisomers of each compound to arrive at stereochemical assignments, with molecular orbital analyses conducted for the most energetically favorable conformers. Absolute configurations of all eight phloroglucinols were reported for the first time.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Multidisciplinary
Kamalika Mukherjee, Tak Ian Chio, Han Gu, Dan L. Sackett, Susan L. Bane, Sanja Sever
Summary: Drug-induced kidney injury often results in aborted clinical trials and drug withdrawals. A new fluorogenic assay using the TFCH sensor has been developed to detect mild forms of renal injury with greater sensitivity than standard assays. This sensor can be applied in live kidney cells and renal tissue, potentially aiding in preclinical decisions regarding unsafe drug candidates.
Article
Biochemistry & Molecular Biology
Tak Ian Chio, Akiva J. Grimaldi, Thomas Radford, Susan L. Bane
Summary: Given the popular usage of BODIPY fluorophores in biological research, it is necessary to pay more attention to their tendency to aggregate in aqueous solution and its impact on their spectroscopic properties. This study focuses on a particular probe and reveals that it exhibits a much-reduced fluorescence in aqueous solution due to aggregation-caused quenching (ACQ). However, it is capable of responding to complementary reactive substrates and generates a substantial turn-on signal. The probe assumes a disaggregated form and unleashes a significant fluorescence enhancement through disaggregation-induced emission (DIE). The results suggest that the probe functions via a target-mediated inhibition of probe aggregation instead of dispersing from preformed aggregates to react with the target.
Article
Biochemistry & Molecular Biology
Ajoy Kumar Bauri, Yongle Du, Peggy Jane Brodie, Sabine Foro, David G. I. Kingston
Summary: Phytochemical investigation of the methanol extract of Myristica malabarica fruit rind led to the isolation of eight known compounds. In vitro assay showed that these compounds exhibited moderate anti-proliferative activity against human ovarian cancer cells.
CHEMISTRY & BIODIVERSITY
(2022)
Meeting Abstract
Chemistry, Multidisciplinary
Tak Ian Chio, Han Gu, Kamalika Mukherjee, L. Nathan Tumey, Susan Bane
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)