Article
Plant Sciences
Xueying Jin, Yufei Long, Shiqi Xiong, Zhen Yang, Wei Chen, Amangul Hawar, Xiaoyu Chi, Yaxin Chen, Huilian Luo, Jinliang Qi, Guihua Lu, Lingyan Dai, Yonghua Yang, Bo Sun
Summary: This study characterized a sorghum TF, SbNAC2, which is strongly induced by abiotic stresses and plays a crucial role in enhancing plant drought tolerance and inducing antioxidant enzyme activity. Furthermore, SbNAC2 directly activates the expression of stress responsive genes by binding to specific motifs, suggesting its potential as a regulator for improving crop yields under adverse environmental conditions.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Medicine, Research & Experimental
Ting Jiang, Hongji Zhang, Yiming Li, Preethi Jayakumar, Hong Liao, Hai Huang, Timothy R. Billiar, Meihong Deng
Summary: TLR9 agonist can enhance the efficacy of anti-PD-1 therapy for colorectal peritoneal metastases by suppressing retinoid metabolism genes expression, reducing PRMs numbers, and enhancing CD8+ T cell antitumor immunity.
Article
Engineering, Biomedical
Mayara Santos de Castro, Marta Miyazawa, Ester Siqueira Caixeta Nogueira, Jorge Kleber Chavasco, Gustavo Andrade Brancaglion, Claudio Daniel Cerdeira, Denismar Alves Nogueira, Marisa Ionta, Joao Adolfo Costa Hanemann, Maisa Ribeiro Pereira Lima Brigagao, Felipe Fornias Sperandio
Summary: This study evaluates the effects of PBM on human monocytes, revealing that PBM significantly increases intracellular and extracellular ROS production, enhances fungicidal capacity, and induces the expression of TNF-alpha and the production of NO in monocytes without impairing cell viability.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Vadim Ershov, Natalia Tarasova, Evgeny Abkhalimov, Alexey Safonov, Vladimir Sorokin, Boris Ershov
Summary: Silver nanoparticles have great potential as antibacterial and antiviral agents and are widely used in various fields. The preparation of silver nanoparticles and their inhibitory effects on bacteria have been studied.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Jianhua Liu, Jiakun Wang, Xiao Sun, Liting Dong, Shougang Chen
Summary: This study reports the design of sulfur-doped NiCo2O4 nanoneedles with hollow structures, which exhibit excellent antibacterial effects against both Gram-negative and Gram-positive bacteria at low AC voltage. These nanoneedles can be used as instantaneous sterilization devices in air purification due to their increased local electric field strength and reactive oxygen species yield.
ACS APPLIED NANO MATERIALS
(2023)
Article
Environmental Sciences
Chien-Liang Fang, Catherine Reena Paul, Cecilia Hsuan Day, Ruey-Lin Chang, Chia-Hua Kuo, Tsung-Jung Ho, Dennis Jine-Yuan Hsieh, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang
Summary: Poria cocos extract showed significant protective effects against H2O2-induced cell death, with a reduction in ROS accumulation. The extract suppressed the expression of metallomatrix proteinases, inflammatory markers, and skin aging markers while increasing TGF-beta 1 levels and antioxidant related proteins.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Oluwaseyi T. Shofolawe-Bakare, Judith U. de Mel, Sushil K. Mishra, Mehjabeen Hossain, Christine M. Hamadani, Mercedes C. Pride, Gaya S. Dasanayake, Wake Monroe, Eric W. Roth, Eden E. L. Tanner, Robert J. Doerksen, Adam E. Smith, Thomas A. Werfel
Summary: The study reports the development of glycopolymeric nanoparticles capable of targeting macrophages and releasing drugs in the presence of reactive oxygen species. These nanoparticles have desirable properties for drug delivery and are taken up by macrophages at a significantly higher rate compared to other nanoparticles. This study introduces unique glycopolymeric nanoparticles that can be useful in immunotherapeutic settings.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Microbiology
Lizhen Si, Jing Gu, Mi Wen, Ruiqi Wang, Joy Fleming, Jinyue Li, Jintian Xu, Lijun Bi, Jiaoyu Deng
Summary: This study revealed the previously unknown bactericidal effects of sulfonamides, deepening our understanding of their mechanisms of action and potentially aiding in the design of new potentiators.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Nutrition & Dietetics
V. A. Shiva Ayyadurai, Prabhakar Deonikar
Summary: Aging is a result of cellular damage caused by biochemical processes, and plant-derived bioactive molecules have been shown to ameliorate oxidative stress. This study uses a computational systems biology approach to uncover the mechanisms of action of bioactive compounds from fruit/berry/vegetable juice powder in mitigating oxidative stress. The compounds in juice powder affected two oxidative stress pathways by reducing reactive oxygen species production and increasing antioxidant enzyme production. The combination of bioactive compounds in juice powder attenuates aging by affecting multiple oxidative stress pathways.
Article
Biochemistry & Molecular Biology
Therese B. Deramaudt, Ahmad Chehaitly, Theo Charriere, Julie Arnaud, Marcel Bonay
Summary: This study found that repetitive magnetic stimulation (rMS) can enhance the host's defense against bacterial infection by activating the non-canonical Nrf2 pathway and modulating macrophage function.
Article
Nanoscience & Nanotechnology
Miao Xu, Xiaohuan Ji, Jingjing Huo, Jingjie Chen, Nian Liu, Ziyue Li, Qingyan Jia, Bin Sun, Meifang Zhu, Peng Li
Summary: In this study, AgNPs were modified and embedded into CA hydrogel to create a multifunctional material for wound healing. The CA/Ag hydrogel exhibited on-demand photodynamic antibacterial efficacy and effective hemostatic ability. Furthermore, it promoted wound healing by downregulating proinflammatory cytokines. Overall, the CA/Ag nanocomposite hydrogel has excellent prospects as an advanced wound dressing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Environmental
Cong Liu, Wei Wang, Mutian Zhang, Chenyang Zhang, Chengcheng Ma, Lin Cao, Debao Kong, Huimeng Feng, Wen Li, Shougang Chen
Summary: Combining the advantages of heterojunction formed by two-dimensional materials and metal oxide nanoparticles is an effective strategy for enhancing the efficiency of photocatalytic sterilization. In this study, a stable semiconductor TpPa-1-COF was grown on Ti3C2-MXene and anchored with Cu2O NPs, leading to improved carrier migration rate and reduced photocorrosion. The obtained nanocomposites showed excellent antibacterial rates, providing a new idea for developing photocatalytic bactericides for marine antifouling applications.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Wei Fan, Jingyu Cui, Qi Li, Yang Huo, Dan Xiao, Xia Yang, Hongbin Yu, Chunliang Wang, Peter Jarvis, Tao Lyu, Mingxin Huo
Summary: The novel visible light photocatalytic water disinfection technology coupled with micro/nano bubbles (MNBs) demonstrated superior efficiency in inactivating bacterial spores. Reactive species such as H2O2 and center dot OH were identified as the primary active species responsible for spore inactivation. The mechanism of MNB technology enhancing photocatalytic reaction was also explored, providing new insights for advanced water treatment.
Review
Environmental Sciences
Rekha Pachaiappan, Saravanan Rajendran, Pau Loke Show, Kovendhan Manavalan, Mu Naushad
Summary: Many microbial species causing infectious disease have become a social burden and threat to communities worldwide. The emergence of nanoparticles has shown potential in targeting and destroying microbes. Metal and metal oxide nanocomposites have gained interest for their antibacterial properties by damaging bacterial cell walls and leading to bacterial death.
Article
Construction & Building Technology
Anand Sreeram, Ahmad Masad, Zahra Sootodeh Nia, Daniel Maschauer, Johannes Mirwald, Bernhard Hofko, Amit Bhasin
Summary: Efficient and practical techniques for simulating aging of asphalt mixtures are important for practitioners worldwide. This study developed a laboratory procedure for accelerated aging of loose asphalt specimens using highly oxidative gas, and the results showed promising chemomechanical correlations between the ROS aging method and conventional aging methods. The procedure serves as a proof of concept and provides encouraging results for further development and standardization.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Microbiology
Susu Duan, Victoria A. Meliopoulos, Jennifer L. McClaren, Xi-Zhi J. Guo, Catherine J. Sanders, Heather S. Smallwood, Richard J. Webby, Stacey L. Schultz-Cherry, Peter C. Doherty, Paul G. Thomas
Article
Biochemistry & Molecular Biology
Suriyan Ponnusamy, Quynh T. Tran, Innocence Harvey, Heather S. Smallwood, Thirumagal Thiyagarajan, Souvik Banerjee, Daniel L. Johnson, James T. Dalton, Ryan D. Sullivan, Duane D. Miller, Dave Bridges, Ramesh Narayanan
Article
Cell Biology
Heather S. Smallwood, Susu Duan, Marie Morfouace, Svetlana Rezinciuc, Barry L. Shulkin, Anang Shelat, Erika E. Zink, Sandra Milasta, Resha Bajracharya, Ajayi J. Oluwaseum, Martine F. Roussel, Douglas R. Green, Ljiljana Pasa-Tolic, Paul G. Thomas
Article
Chemistry, Medicinal
Heather S. Smallwood, Daniel Lopez-Ferrer, P. Elis Eberlein, David J. Watson, Thomas C. Squier
CHEMICAL RESEARCH IN TOXICOLOGY
(2009)
Article
Immunology
Brendan E. Russ, Moshe Olshanksy, Heather S. Smallwood, Jasmine Li, Alice E. Denton, Julia E. Prier, Angus T. Stock, Hayley A. Croom, Jolie G. Cullen, Michelle L. T. Nguyen, Stephanie Rowe, Matthew R. Olson, David B. Finkelstein, Anne Kelso, Paul G. Thomas, Terry P. Speed, Sudha Rao, Stephen J. Turner
Article
Immunology
Liang Shi, Saiful M. Chowdhury, Heather S. Smallwood, Hyunjin Yoon, Heather M. Mottaz-Brewer, Angela D. Norbeck, Jason E. McDermott, Therese R. W. Clauss, Fred Heffron, Richard D. Smith, Joshua N. Adkins
INFECTION AND IMMUNITY
(2009)
Article
Biochemical Research Methods
Natacha Lourette, Heather Smallwood, Si Wu, Errol W. Robinson, Thomas C. Squier, Richard D. Smith, Ljiljana Pasa-Tolic
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2010)
Article
Microbiology
Christine M. Oshansky, Sook-San Wong, Trushar Jeevan, Heather S. Smallwood, Richard J. Webby, Shira C. Shafir, Paul G. Thomas
Article
Immunology
Alex J. Freemerman, Liyang Zhao, Ajeeth K. Pingili, Bin Teng, Alyssa J. Cozzo, Ashley M. Fuller, Amy R. Johnson, J. Justin Milner, Maili F. Lim, Joseph A. Galanko, Melinda A. Beck, James E. Bear, Jeremy D. Rotty, Lavanya Bezavada, Heather S. Smallwood, Michelle A. Puchowicz, Juan Liu, Jason W. Locasale, Douglas P. Lee, Brian J. Bennett, E. Dale Abel, Jeff C. Rathmell, Liza Makowski
JOURNAL OF IMMUNOLOGY
(2019)
Review
Immunology
Azadeh Bahadoran, Lavanya Bezavada, Heather S. Smallwood
IMMUNOLOGICAL REVIEWS
(2020)
Article
Cell Biology
Kim S. LeMessurier, Robert Rooney, Hazem E. Ghoneim, Baoming Liu, Kui Li, Heather S. Smallwood, Amali E. Samarasinghe
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Joseph F. Pierre, Oguz Akbilgic, Heather Smallwood, Xueyuan Cao, Elizabeth A. Fitzpatrick, Senen Pena, Stephen P. Furmanek, Julio A. Ramirez, Colleen B. Jonsson
SCIENTIFIC REPORTS
(2020)
Article
Virology
Svetlana Rezinciuc, Zhixin Tian, Si Wu, Shawna Hengel, Ljiljana Pasa-Tolic, Heather S. Smallwood
Article
Oncology
Raisa I. Krutilina, Hilaire Playa, Danielle L. Brooks, Luciana P. Schwab, Deanna N. Parke, Damilola Oluwalana, Douglas R. Layman, Meiyun Fan, Daniel L. Johnson, Junming Yue, Heather Smallwood, Tiffany N. Seagroves
Summary: This study identified creatine kinase, brain isoform (CKB) as a downstream gene of HIF-1 transcription factor that promotes invasion and metastasis in ER-negative breast cancer. Inhibition of CKB or creatine kinase activity using cCr suppressed cell invasion, invadopodia formation, and lung metastasis. In combination with conventional chemotherapy agents, cCr enhanced growth inhibition. These findings suggest that targeting CKB and cellular metabolism may be effective in treating metastatic breast cancer.