期刊
BIOCHEMISTRY
卷 48, 期 8, 页码 1675-1680出版社
AMER CHEMICAL SOC
DOI: 10.1021/bi802233v
关键词
-
资金
- CRUK
- EU (FP6 Project on Molecular Cancer Medicine)
A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据